Name: Name:RGB-286638 free base
Brand: Angene
SKU: AG00G3PU
Rating: 90 (10 reviews)

RGB-286638 free base

CAS No.:

784210-88-4

Catalog Number:

AG00G3PU

Molecular Formula:

C29H35N7O4

Molecular Weight:

545.6327

Pack Size

Purity

Availability

Location

Price(USD)

Quantity

5mg

98%

1 week

United States

$307

- +

10mg

98%

1 week

United States

$473

- +

50mg

98%

1 week

United States

$1890

- +

100mg

98%

1 week

United States

$3390

- +

Product Description

Catalog Number:

AG00G3PU

Chemical Name:

RGB-286638 free base

CAS Number:

784210-88-4

Molecular Formula:

C29H35N7O4

Molecular Weight:

545.6327

MDL Number:

MFCD18633230

IUPAC Name:

1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea

InChI:

InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38)

InChI Key:

XLSYZSRXVVCHLS-UHFFFAOYSA-N

SMILES:

COCCN1CCN(CC1)Cc1ccc(cc1)c1n[nH]c2c1C(=O)c1c2cccc1NC(=O)NN1CCOCC1

UNII:

1GAJ98SC2X

Properties

Complexity:

857

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

545.275g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

545.644g/mol

Monoisotopic Mass:

545.275g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

115A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

Literature

Title	Journal
Phase I study of RGB-286638, a novel, multitargeted cyclin-dependent kinase inhibitor in patients with solid tumors.	Clinical cancer research : an official journal of the American Association for Cancer Research 20140915
Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs.	Leukemia 20131201
Validated bioanalytical method for the quantification of RGB-286638, a novel multi-targeted protein kinase inhibitor, in human plasma and urine by liquid chromatography/tandem triple-quadrupole mass spectrometry.	Journal of pharmaceutical and biomedical analysis 20091205

Properties