P-Selectin Inhibitor
| Title | Journal |
|---|---|
| Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury. | Journal of medicinal chemistry 20100826 |
| P-selectin antagonism reduces thrombus formation in humans. | Journal of thrombosis and haemostasis : JTH 20091101 |
| Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis. | The Journal of pharmacology and experimental therapeutics 20080201 |
| Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation. | Thrombosis and haemostasis 20070301 |
| 2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists. | Journal of medicinal chemistry 20070111 |
| Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis. | Journal of vascular surgery 20060901 |