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Home Other Building Blocks Necrostatin 2

Necrostatin 2

CAS No.:
852391-19-6
Catalog Number:
AG00G3PB
Molecular Formula:
C13H12ClN3O2
Molecular Weight:
277.7063
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$93
- +
5mg
≥98%
1 week
United States
$193
- +
10mg
≥98%
1 week
United States
$310
- +
50mg
99%
1 week
United States
$957
- +
Product Description
Catalog Number:
AG00G3PB
Chemical Name:
Necrostatin 2
CAS Number:
852391-19-6
Molecular Formula:
C13H12ClN3O2
Molecular Weight:
277.7063
MDL Number:
MFCD19443135
IUPAC Name:
(5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione
InChI:
InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m1/s1
InChI Key:
WIKGAEMMNQTUGL-SNVBAGLBSA-N
SMILES:
CN1C(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2Cl
Properties
Complexity:
403  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
277.062g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
277.708g/mol
Monoisotopic Mass:
277.062g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
65.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.9  
Literature
Title Journal
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature chemical biology 20080501
Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorganic & medicinal chemistry letters 20071215
Structure-activity relationship study of tricyclic necroptosis inhibitors. Journal of medicinal chemistry 20070419
Structure-activity relationship study of novel necroptosis inhibitors. Bioorganic & medicinal chemistry letters 20051115
Properties