MK 0974, Telcagepant
| Title | Journal |
|---|---|
| Identification of potent CNS-penetrant thiazolidinones as novel CGRP receptor antagonists. | Bioorganic & medicinal chemistry letters 20140201 |
| CGRP receptor antagonism and migraine therapy. | Current protein & peptide science 20130801 |
| Management of acute and chronic migraine. | Current opinion in supportive and palliative care 20120601 |
| CGRP receptor antagonists: an expanding drug class for acute migraine? | Expert opinion on investigational drugs 20120601 |
| [Therapy and prophylaxis of migraine]. | MMW Fortschritte der Medizin 20120419 |
| A randomized, placebo-controlled study of the effects of telcagepant on exercise time in patients with stable angina. | Clinical pharmacology and therapeutics 20120301 |
| Randomized, controlled study of telcagepant in patients with migraine and coronary artery disease. | Headache 20120201 |
| High-throughput polymer monolith in-tip SPME fiber preparation and application in drug analysis. | Bioanalysis 20111201 |
| ACS chemical neuroscience molecule spotlight on Telcagepant (MK-0974). | ACS chemical neuroscience 20110720 |
| Optimal balance of efficacy and tolerability of oral triptans and telcagepant: a review and a clinical comment. | The journal of headache and pain 20110601 |
| Treatment of migraine: update on new therapies. | Current opinion in neurology 20110601 |
| Effect of telcagepant on spontaneous ischemia in cardiovascular patients in a randomized study. | Headache 20110601 |
| EuroQol (EQ-5D) health utility scores for patients with migraine. | Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 20110501 |
| Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918. | Bioorganic & medicinal chemistry letters 20110501 |
| The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men. | British journal of clinical pharmacology 20110501 |
| Possible site of action of CGRP antagonists in migraine. | Cephalalgia : an international journal of headache 20110401 |
| Randomized controlled study of telcagepant plus ibuprofen or acetaminophen in migraine. | Headache 20110401 |
| Pain freedom at 2 hours in migraine after telcagepant 300 mg. | CNS drugs 20110301 |
| Current understanding and treatment of headache disorders: five new things. | Neurology 20110215 |
| Sustained pain freedom and no adverse events as an endpoint in clinical trials of acute migraine treatments: application to patient-level data from a trial of the CGRP receptor antagonist, telcagepant, and zolmitriptan. | Cephalalgia : an international journal of headache 20110201 |
| Antimigraine efficacy of telcagepant based on patient's historical triptan response. | Headache 20110101 |
| Excellent tolerability but relatively low initial clinical efficacy of telcagepant in migraine. | Headache 20110101 |
| Long-term tolerability of telcagepant for acute treatment of migraine in a randomized trial. | Headache 20110101 |
| Single- and multiple-dose pharmacokinetics and tolerability of telcagepant, an oral calcitonin gene-related peptide receptor antagonist, in adults. | Journal of clinical pharmacology 20101201 |
| Randomized, controlled trial of telcagepant over four migraine attacks. | Cephalalgia : an international journal of headache 20101201 |
| [Calcitonin gene-related peptide and migraine. Increases understanding of physiopathology can lead to new drug therapy]. | Lakartidningen 20101201 |
| Effect of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant in human cranial arteries. | Cephalalgia : an international journal of headache 20101001 |
| Asymmetric hydrogenation of protected allylic amines. | Organic letters 20100917 |
| Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. | Structure (London, England : 1993) 20100908 |
| Characterization of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) in human isolated coronary arteries. | The Journal of pharmacology and experimental therapeutics 20100901 |
| New drugs in migraine treatment and prophylaxis: telcagepant and topiramate. | Lancet (London, England) 20100821 |
| Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine. | CNS drugs 20100701 |
| Calcitonin gene-related peptide receptor antagonists for migraine. | Expert opinion on investigational drugs 20100701 |
| Comparison of the vasoconstrictor effects of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) and zolmitriptan in human isolated coronary arteries. | Journal of cardiovascular pharmacology 20100501 |
| CGRP receptor antagonism and migraine. | Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20100401 |
| Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding. | Biochemical and biophysical research communications 20100326 |
| Randomized, controlled trial of telcagepant for the acute treatment of migraine. | Neurology 20100323 |
| Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74. | Biochemical and biophysical research communications 20100101 |
| Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974). | British journal of clinical pharmacology 20100101 |
| Is there an inherent limit to the efficacy of calcitonin gene-related peptide receptor antagonists in the acute treatment of migraine? A comment. | The journal of headache and pain 20091201 |
| New drugs for migraine. | The journal of headache and pain 20091201 |
| The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs. | Pharmacology & therapeutics 20091201 |
| Is there an inherent limit to acute migraine treatment efficacy? | The journal of headache and pain 20091201 |
| Calcitonin gene-related peptide receptor antagonists for the treatment of migraine: a patent review. | Expert opinion on therapeutic patents 20091201 |
| CGRP antagonists: hope for a new era in acute migraine treatment. | Acta neurologica Belgica 20091201 |
| Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines. | Bioorganic & medicinal chemistry letters 20091115 |
| Randomized, controlled trial of telcagepant for the acute treatment of migraine. | Neurology 20090922 |
| [Migraine can signal a risk for heart and brain]. | MMW Fortschritte der Medizin 20090910 |
| The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists. | Bioorganic & medicinal chemistry letters 20090815 |
| Telcagepant, a calcitonin gene-related peptide antagonist for the treatment of migraine. | Current opinion in investigational drugs (London, England : 2000) 20090701 |
| Elimination of diastereomer interference to determine Telcagepant (MK-0974) in human plasma using on-line turbulent-flow technology and off-line solid-phase extraction coupled with liquid chromatography/tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090601 |
| A flexible and high throughput liquid chromatography-tandem mass spectrometric assay for the quantitation of telcagepant in human plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090515 |
| [CGRP antagonists: novel concept for treatment of migraine]. | Medizinische Monatsschrift fur Pharmazeuten 20090501 |
| Migraine: Telcagepant provides new hope for people with migraine. | Nature reviews. Neurology 20090501 |
| [Gepants: the beginning of a new age in the symptomatic treatment of migraine?]. | Revista de neurologia 20090401 |
| An oral calcitonin gene-related peptide receptor antagonist for acute migraine management: sign of a possible new chapter in headache medicine. | Current neurology and neuroscience reports 20090301 |
| Molecule of the month. Telcagepant. | Drug news & perspectives 20090301 |
| CGRP receptors in the control of pain and inflammation. | Current opinion in pharmacology 20090201 |
| Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine. | European journal of pharmacology 20090114 |
| Preclinical pharmacokinetics of MK-0974, an orally active calcitonin-gene related peptide (CGRP)-receptor antagonist, mechanism of dose dependency and species differences. | Xenobiotica; the fate of foreign compounds in biological systems 20090101 |
| Calcitonin gene-related peptide receptor antagonists for the treatment of migraine. | Progress in medicinal chemistry 20090101 |
| Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. | Lancet (London, England) 20081220 |
| CGRP-receptor antagonism in migraine treatment. | Lancet (London, England) 20081220 |
| Reversed-phase chiral liquid chromatography on polysaccharide-based stationary phase coupled with tandem mass spectrometry for simultaneous determination of four stereoisomers of MK-0974 in human plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081001 |
| Clinical and preclinical rationale for CGRP-receptor antagonists in the treatment of migraine. | Headache 20080901 |
| Synthesis of the (3R,6S)-3-amino-6-(2,3-difluorophenyl)azepan-2-one of telcagepant (MK-0974), a calcitonin gene-related peptide receptor antagonist for the treatment of migraine headache. | Organic letters 20080807 |
| Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine. | Neurology 20080415 |
| [A new therapeutic principle for migraine]. | Ugeskrift for laeger 20080317 |
| Strategies on efficient method development of on-line extraction assays for determination of MK-0974 in human plasma and urine using turbulent-flow chromatography and tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080215 |
| Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine. | The Journal of pharmacology and experimental therapeutics 20080201 |
| Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system. | The journal of headache and pain 20080201 |
| The tortuous road to an ideal CGRP function blocker for the treatment of migraine. | Current topics in medicinal chemistry 20080101 |
| Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974). | Journal of medicinal chemistry 20071115 |
| CGRP antagonists: unravelling the role of CGRP in migraine. | Trends in pharmacological sciences 20071101 |