N-DESETHYL AMODIAQUINE DIHCL
| Title | Journal |
|---|---|
| Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations. | Chemical research in toxicology 20180219 |
| Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity. | Toxicology letters 20170605 |
| In vitro and in vivo combination of cepharanthine with anti-malarial drugs. | Malaria journal 20140101 |
| In vitro assessment of drug resistance in Plasmodium falciparum in five States of India. | The Indian journal of medical research 20120401 |
| In vitro activity of antiretroviral drugs against Plasmodium falciparum. | Antimicrobial agents and chemotherapy 20111101 |
| In vitro activity of Proveblue (methylene blue) on Plasmodium falciparum strains resistant to standard antimalarial drugs. | Antimicrobial agents and chemotherapy 20110501 |
| Comparative oral bioavailability of non-fixed and fixed combinations of artesunate and amodiaquine in healthy Indian male volunteers. | European journal of clinical pharmacology 20110301 |
| Plasmodium falciparum: Solanum nudum SN-1 steroid antiplasmodial activity when combined with antimalarial drugs. | Experimental parasitology 20110101 |
| Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene. | The Journal of antimicrobial chemotherapy 20100701 |
| In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire). | African health sciences 20100601 |
| In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda. | Antimicrobial agents and chemotherapy 20100301 |
| Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda. | The Journal of infectious diseases 20091201 |
| Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable 'back-up' compound for N-tert-butyl isoquine. | Journal of medicinal chemistry 20090409 |
| Biological measure of compliance to Artesunate plus Amodiaquine association: interest in a Mono-Desethyl-Amodiaquine blood assay? | Acta tropica 20090401 |
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. | Journal of medicinal chemistry 20090312 |
| Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090215 |
| Pharmacokinetics and pharmacodynamics of a new ACT formulation: Artesunate/Amodiaquine (TRIMALACT) following oral administration in African malaria patients. | European journal of drug metabolism and pharmacokinetics 20090101 |
| Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt. | Parasitology 20080401 |
| Determination of N-desethylamodiaquine by hydrophilic interaction liquid chromatography with tandem mass spectrometry: application to in vitro drug metabolism studies. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080215 |
| Simultaneous determination of amodiaquine and its active metabolite in human blood by ion-pair liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201 |
| Short report: polymorphisms in the pfcrt and pfmdr1 genes of Plasmodium falciparum and in vitro susceptibility to amodiaquine and desethylamodiaquine. | The American journal of tropical medicine and hygiene 20071201 |
| A field-adapted HPLC method for determination of amodiaquine and its metabolite in whole blood dried on filter paper. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071101 |
| Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum malaria. | Journal of pharmacokinetics and pharmacodynamics 20071001 |
| Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. | Clinical pharmacology and therapeutics 20070801 |
| Prevalent pfmdr1 n86y mutant Plasmodium falciparum in Madagascar despite absence of pfcrt mutant strains. | The American journal of tropical medicine and hygiene 20070601 |
| Practical HPLC methods for the quantitative determination of common antimalarials in Africa. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301 |
| Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y. | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20060701 |
| Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo. | European journal of clinical pharmacology 20060701 |
| In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda. | Transactions of the Royal Society of Tropical Medicine and Hygiene 20060601 |
| Short report: lack of prediction of amodiaquine efficacy in treating Plasmodium falciparum malaria by in vitro tests. | The American journal of tropical medicine and hygiene 20040901 |
| Validated assays for human cytochrome P450 activities. | Drug metabolism and disposition: the biological fate of chemicals 20040601 |
| Selective and sensitive liquid chromatographic assay of amodiaquine and desethylamodiaquine in whole blood spotted on filter paper. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040105 |
| Molecular epidemiology of malaria in Cameroon. XV. Experimental studies on serum substitutes and supplements and alternative culture media for in vitro drug sensitivity assays using fresh isolates of Plasmodium falciparum. | The American journal of tropical medicine and hygiene 20030801 |
| Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine. | Malaria journal 20030101 |
| Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. | European journal of clinical pharmacology 20021101 |
| Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. | The Journal of pharmacology and experimental therapeutics 20020201 |
| Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. | Drug metabolism and disposition: the biological fate of chemicals 20010101 |