TOMATIDINE
| Title | Journal |
|---|---|
| Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2α branch of the endoplasmic reticulum. | The Journal of steroid biochemistry and molecular biology 20170701 |
| Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression. | Chemico-biological interactions 20130525 |
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. | Bioorganic & medicinal chemistry 20121115 |
| Tomatidine promotes the inhibition of 24-alkylated sterol biosynthesis and mitochondrial dysfunction in Leishmania amazonensis promastigotes. | Parasitology 20120901 |
| Structure-activity relationships of α-, β(1)-, γ-, and δ-tomatine and tomatidine against human breast (MDA-MB-231), gastric (KATO-III), and prostate (PC3) cancer cells. | Journal of agricultural and food chemistry 20120418 |
| Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting acyl-CoA:cholesterol acyl-transferase (ACAT). | Journal of agricultural and food chemistry 20120314 |
| Tomatidine acts in synergy with aminoglycoside antibiotics against multiresistant Staphylococcus aureus and prevents virulence gene expression. | The Journal of antimicrobial chemotherapy 20120301 |
| The side population in human lung cancer cell line NCI-H460 is enriched in stem-like cancer cells. | PloS one 20120101 |
| Footprinting of inhibitor interactions of in silico identified inhibitors of trypanothione reductase of Leishmania parasite. | TheScientificWorldJournal 20120101 |
| ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma. | Oncogene 20111208 |
| GLYCOALKALOID METABOLISM1 is required for steroidal alkaloid glycosylation and prevention of phytotoxicity in tomato. | The Plant cell 20111201 |
| Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration. | British journal of cancer 20110510 |
| Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping. | PloS one 20110101 |
| Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. | PloS one 20110101 |
| Identification of novel functional inhibitors of acid sphingomyelinase. | PloS one 20110101 |
| Gli2 expression and human bladder transitional carcinoma cell invasiveness. | The Journal of urology 20100701 |
| Distortion of trichome morphology by the hairless mutation of tomato affects leaf surface chemistry. | Journal of experimental botany 20100201 |
| Smoothened as a new therapeutic target for human osteosarcoma. | Molecular cancer 20100101 |
| Resistance of wild Solanum accessions to aphids and other potato pests in Quebec field conditions. | Journal of insect science (Online) 20100101 |
| Chemoprotective Effect of Sobatum against Lithium-Induced Oxidative Damage in Rats. | Journal of young pharmacists : JYP 20100101 |
| Plant antimicrobial agents and their effects on plant and human pathogens. | International journal of molecular sciences 20090801 |
| Tomatine-containing green tomato extracts inhibit growth of human breast, colon, liver, and stomach cancer cells. | Journal of agricultural and food chemistry 20090708 |
| Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2. | International journal of molecular sciences 20090701 |
| Evidence for allosteric interactions of antagonist binding to the smoothened receptor. | The Journal of pharmacology and experimental therapeutics 20090601 |
| Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. | Nature 20090409 |
| Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers. | British journal of cancer 20090127 |
| Autonomous Hedgehog signalling is undetectable in PC-3 prostate cancer cells. | Biochemical and biophysical research communications 20080815 |
| Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages. | FEBS letters 20080709 |
| Simultaneously cycled NMR spectroscopy. | Journal of the American Chemical Society 20080409 |
| Heterologous expression of Fusarium oxysporum tomatinase in Saccharomyces cerevisiae increases its resistance to saponins and improves ethanol production during the fermentation of Agave tequilana Weber var. azul and Agave salmiana must. | Antonie van Leeuwenhoek 20080301 |
| Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy. | BMC cancer 20080101 |
| Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation. | FEBS letters 20071222 |
| Hedgehog signaling pathway is inactive in colorectal cancer cell lines. | International journal of cancer 20071215 |
| Efficient conversion of tomatidine into neuritogenic pregnane derivative. | Chemical & pharmaceutical bulletin 20070701 |
| Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer. | PloS one 20060101 |
| Identification of a tomatinase in the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382. | Molecular plant-microbe interactions : MPMI 20051001 |
| Influence of incorporated wild Solanum genomes on potato properties in terms of starch nanostructure and glycoalkaloid content. | Journal of agricultural and food chemistry 20050629 |
| Glycoalkaloid aglycone accumulations associated with infection by Clavibacter michiganensis ssp. sepedonicus in potato species Solanum acaule and Solanum tuberosum and their interspecific somatic hybrids. | Plant cell reports 20050301 |
| A novel glucosyltransferase involved in steroid saponin biosynthesis in Solanum aculeatissimum. | Plant molecular biology 20050101 |
| Tomatidine and lycotetraose, hydrolysis products of alpha-tomatine by Fusarium oxysporum tomatinase, suppress induced defense responses in tomato cells. | FEBS letters 20040730 |
| Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. | Journal of agricultural and food chemistry 20040519 |
| Dehydrotomatine and alpha-tomatine content in tomato fruits and vegetative plant tissues. | Journal of agricultural and food chemistry 20040407 |
| Activation of the hedgehog pathway in advanced prostate cancer. | Molecular cancer 20040101 |
| Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. | Nature 20030320 |
| Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030101 |
| Determination of glycoalkaloids and relative aglycones by nonaqueous capillary electrophoresis coupled with electrospray ionization-ion trap mass spectrometry. | Electrophoresis 20020901 |
| Non-aqueous capillary electrophoresis with diode array and electrospray mass spectrometric detection for the analysis of selected steroidal alkaloids in plant extracts. | Journal of chromatography. A 20010713 |
| Inhibitory effect of steroidal alkaloids on drug transport and multidrug resistance in human cancer cells. | Anticancer research 20010101 |