Home Other Building Blocks DL-MANDELIC ACID BENZYL ESTER

DL-MANDELIC ACID BENZYL ESTER

CAS No.:
80409-16-1
Catalog Number:
AG00G2QH
Molecular Formula:
Molecular Weight:
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Purity
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Product Description
Catalog Number:
AG00G2QH
Chemical Name:
DL-MANDELIC ACID BENZYL ESTER
CAS Number:
80409-16-1
MDL Number:
MFCD00021856
IUPAC Name:
benzyl 2-hydroxy-2-phenylacetate
InChI:
InChI=1S/C15H14O3/c16-14(13-9-5-2-6-10-13)15(17)18-11-12-7-3-1-4-8-12/h1-10,14,16H,11H2
InChI Key:
JFKWZVQEMSKSBU-UHFFFAOYSA-N
NSC Number:
9522
Properties
Complexity:
253  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
242.094g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
242.274g/mol
Monoisotopic Mass:
242.094g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
46.5A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7  
Literature
Title Journal
Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Molecular pharmaceutics 20150105
Benefits and harms of pharmacologic treatment for urinary incontinence in women: a systematic review. Annals of internal medicine 20120619
Once-daily trospium chloride 60 mg extended-release provides effective, long-term relief of overactive bladder syndrome symptoms. Neurourology and urodynamics 20110901
Once-daily administration of trospium chloride extended release provides 24-hr coverage of nocturnal and diurnal symptoms of overactive bladder: an integrated analysis of two phase III trials. Neurourology and urodynamics 20110401
Trospium chloride once-daily extended release is efficacious and tolerated in elderly subjects (aged ≥ 75 years) with overactive bladder syndrome. BJU international 20110201
Oxybutynin and trospium are substrates of the human organic cation transporters. Naunyn-Schmiedeberg's archives of pharmacology 20110201
Once-daily trospium chloride 60 mg extended release in subjects with overactive bladder syndrome who use multiple concomitant medications: Post hoc analysis of pooled data from two randomized, placebo-controlled trials. Drugs & aging 20110201
Safety and efficacy of once-daily trospium chloride extended-release in male patients with overactive bladder. Urology 20110101
New once-daily formulation for trospium in overactive bladder. International journal of clinical practice 20101001
New strategies for medical management of overactive bladder in children. Current opinion in urology 20100701
Determination of the quaternary ammonium compound trospium in human plasma by LC-MS/MS: application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100415
Effects of combined use of trospium chloride and melatonin on in vitro contractility of rat urinary bladder. Urology 20100401
Editorial comment. Urology 20100401
Pharmacokinetics of once-daily trospium chloride 60 mg extended release and twice-daily trospium chloride 20 mg in healthy adults. Journal of clinical pharmacology 20100201
Extended-release trospium chloride improves quality of life in overactive bladder. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20100101
Dose escalation improves therapeutic outcome: post hoc analysis of data from a 12-week, multicentre, double-blind, parallel-group trial of trospium chloride in patients with urinary urge incontinence. BMC urology 20100101
[Sexual dysfunction in women with overactive bladder and their correction with m-cholinolytic spasmex]. Urologiia (Moscow, Russia : 1999) 20100101
Trospium chloride extended release is effective and well tolerated in women with overactive bladder syndrome. International urogynecology journal and pelvic floor dysfunction 20091201
Trospium chloride once-daily extended release is effective and well tolerated for the treatment of overactive bladder syndrome: an integrated analysis of two randomised, phase III trials. International journal of clinical practice 20091201
Trospium chloride and oxybutynin hydrochloride in a german study of adults with urinary urge incontinence: results of a 12-week, multicenter, randomized, double-blind, parallel-group, flexible-dose noninferiority trial. Clinical therapeutics 20091101
Trospium and cognition in patients with late onset Alzheimer disease. The journal of nutrition, health & aging 20091001
The role of p-glycoprotein in limiting brain penetration of the peripherally acting anticholinergic overactive bladder drug trospium chloride. Drug metabolism and disposition: the biological fate of chemicals 20090701
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[Spasmex in the treatment of overactive bladder. Russian experience]. Urologiia (Moscow, Russia : 1999) 20090101
The effects of reformulation: improved therapeutic index. Current urology reports 20081101
Effective treatment of neurogenic detrusor dysfunction by combined high-dosed antimuscarinics without increased side-effects. European urology 20080501
Overactive bladder disease: the urge for better therapies. Journal of managed care pharmacy : JMCP 20080501
Trospium 60 mg once daily (QD) for overactive bladder syndrome: results from a placebo-controlled interventional study. Urology 20080301
Role of trospium chloride in brachytherapy-related detrusor overactivity. Urology 20080301
[Comparative characteristics of M-cholinolytics in combined treatment of mixed urinary incontinence in women]. Urologiia (Moscow, Russia : 1999) 20080101
New drugs and dosage forms. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070915
Comparison of the efficacy and tolerability of solifenacin succinate with or without previous use of trospium chloride. International urogynecology journal and pelvic floor dysfunction 20070901
Once daily trospium chloride is effective and well tolerated for the treatment of overactive bladder: results from a multicenter phase III trial. The Journal of urology 20070901
Treatment of overactive bladder: selective use of anticholinergic agents with low drug-drug interaction potential. Geriatrics 20070501
[M-cholinolytic spasmex and its role in preoperative preparation of patients with urine incontinence]. Urologiia (Moscow, Russia : 1999) 20070101
[Trospium chloride (spasmex) in the treatment of lower urinary tract symptoms in patients with neurogenic hyperactive urinary bladder caused by vertebrogenic lesions]. Urologiia (Moscow, Russia : 1999) 20070101
Trospium chloride in patients with neurogenic detrusor overactivity: is dose titration of benefit to the patients? International journal of clinical pharmacology and therapeutics 20061201
Trospium chloride: Distinct among other anticholinergic agents available for the treatment of overactive bladder. The Urologic clinics of North America 20061101
Treatment of the overactive bladder syndrome with muscarinic receptor antagonists: a matter of metabolites? Naunyn-Schmiedeberg's archives of pharmacology 20061101
Predictive power of an in vitro system to assess drug interactions of an antimuscarinic medication: a comparison of in vitro and in vivo drug-drug interaction studies of trospium chloride with digoxin. Journal of clinical pharmacology 20060701
Using anticholinergics to treat overactive bladder: the issue of treatment tolerability. The American journal of medicine 20060301
Neurogenic bladder treatment by doubling the recommended antimuscarinic dosage. Neurourology and urodynamics 20060101
[Tuberculosis of the urinary bladder: diagnosis and treatment]. Urologiia (Moscow, Russia : 1999) 20060101
Trospium chloride: an anticholinergic quaternary ammonium compound for the treatment of overactive bladder. Expert opinion on pharmacotherapy 20050701
Overactive bladder. Cleveland Clinic journal of medicine 20050701
The overactive bladder-symptom composite score: a composite symptom score of toilet voids, urgency severity and urge urinary incontinence in patients with overactive bladder. The Journal of urology 20050501
Trospium chloride for the treatment of overactive bladder with urge incontinence. Clinical therapeutics 20050501
Effects on sleep of anticholinergics used for overactive bladder treatment in healthy volunteers aged > or = 50 years. BJU international 20050201
Antimuscarinic agents exhibit local inhibitory effects on muscarinic receptors in bladder-afferent pathways. Urology 20050201
Clinical pharmacokinetics of trospium chloride. Clinical pharmacokinetics 20050101
[Neurological aspect of the hyperactive urinary bladder syndrome]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101
[Trospium chloride in the treatment of idiopathic and neurogenic detrusor overactivity]. Urologiia (Moscow, Russia : 1999) 20050101
Preview of new drugs for overactive bladder and incontinence: darifenacin, solifenacin, trospium, and duloxetine. Current urology reports 20041001
Elevating our therapeutic expectations in overactive bladder. Journal of the American Academy of Nurse Practitioners 20041001
Trospium chloride improves overactive bladder symptoms: a multicenter phase III trial. The Journal of urology 20040601
[The combined treatment of interstitial cystitis in women with spasmex]. Urologiia (Moscow, Russia : 1999) 20040101
[Combined treatment of voiding disorders in women with m-cholinolytic and alpha 1-adrenoblocker]. Urologiia (Moscow, Russia : 1999) 20040101
Trospium chloride in the management of overactive bladder. Drugs 20040101
Trospium chloride: a quaternary amine with unique pharmacologic properties. Current urology reports 20031201
Update on overactive bladder: pharmacologic approaches on the horizon. Current urology reports 20031001
Controlled, double-blind, multicentre clinical trial to investigate long-term tolerability and efficacy of trospium chloride in patients with detrusor instability. World journal of urology 20030501
[Urinary incontinence--treatment]. Deutsche medizinische Wochenschrift (1946) 20030404
[Spasmex treatment of patients with hyperactive urinary bladder]. Urologiia (Moscow, Russia : 1999) 20030101
Trospium chloride--an effective drug in the treatment of overactive bladder and detrusor hyperreflexia. World journal of urology 20011101
Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous system. Journal of clinical pharmacology 20010601
Properties