Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes.

Toxicology and applied pharmacology 20140115

PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons.

Biochemical and biophysical research communications 20130802

The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs.

Journal of cellular physiology 20130101

Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Bioorganic & medicinal chemistry 20121115

Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells.

Biochemical pharmacology 20121101

Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages.

The Journal of nutritional biochemistry 20121001

Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts.

Arthritis and rheumatism 20121001

Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene.

Toxicology in vitro : an international journal published in association with BIBRA 20120901

uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells.

International journal of oncology 20120801

Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells.

The Journal of biological chemistry 20120727

Activation of neurokinin-1 receptors up-regulates substance P and neurokinin-1 receptor expression in murine pancreatic acinar cells.

Journal of cellular and molecular medicine 20120701

Ciliogenic RFX transcription factors regulate FGF1 gene promoter.

Journal of cellular biochemistry 20120701

Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway.

Biochemical pharmacology 20120701

Rottlerin and curcumin: a comparative analysis.

Annals of the New York Academy of Sciences 20120701

Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ.

Behavioural brain research 20120615

Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes.

Journal of cellular biochemistry 20120601

Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells.

Oncology reports 20120601

Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC).

International journal of pharmaceutics 20120530

Differential consequences of protein kinase C activation during early and late hepatic ischemic preconditioning.

The journal of physiological sciences : JPS 20120501

Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog.

Molecular and cellular neurosciences 20120501

Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism.

Chemico-biological interactions 20120415

PKCδ and ε regulate the morphological integrity of the ER-Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus.

Biochimica et biophysica acta 20120401

Role of retinal glial cell glutamate transporters in retinal ganglion cell survival following stimulation of NMDA receptor.

Current eye research 20120301

OX1 orexin/hypocretin receptor activation of phospholipase D.

British journal of pharmacology 20120201

Effect of pollen from Typha angustata on hydrogen peroxide induced toxicity in osteoblastic MC3T3-E1 cells.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20120201

Susceptibility to natural killer cell-mediated lysis of colon cancer cells is enhanced by treatment with epidermal growth factor receptor inhibitors through UL16-binding protein-1 induction.

Cancer science 20120101

Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation.

European journal of medicinal chemistry 20120101

Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits.

Journal of vascular research 20120101

Rottlerin and cancer: novel evidence and mechanisms.

TheScientificWorldJournal 20120101

Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells.

Molecular cancer 20120101

Protein kinase C-δ (PKC-δ) and PKC-α mediate Ca(2+)-dependent increases in CNP mRNA in human vascular cells.

Vascular pharmacology 20120101

Cigarette smoke extract stimulates rat pulmonary artery smooth muscle cell proliferation via PKC-PDGFB signaling.

Journal of biomedicine & biotechnology 20120101

Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.

Asian Pacific journal of cancer prevention : APJCP 20120101

Neuromedin S increases L-type Ca(2+) channel currents through G(i)α-protein and phospholipase C-dependent novel protein kinase C delta pathway in adult rat ventricular myocytes.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein kinase (PRAK).

PloS one 20120101

Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells.

Experimental & molecular medicine 20111231

Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors.

Endocrine-related cancer 20111201

Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells.

Journal of cellular and molecular medicine 20111001

Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts.

Circulation 20110913

Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation.

Cell biochemistry and biophysics 20110901

Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes.

Molecular and cellular neurosciences 20110901

Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme.

Biochimica et biophysica acta 20110901

Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.

The Journal of biological chemistry 20110826

Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes.

The Journal of biological chemistry 20110805

All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta.

Journal of leukocyte biology 20110801

Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line.

Toxicology and applied pharmacology 20110715

High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival.

Journal of biomolecular screening 20110701

Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer.

The Journal of clinical investigation 20110701

Nrf2-mediated adaptive response to cadmium-induced toxicity involves protein kinase C delta in human 1321N1 astrocytoma cells.

Environmental toxicology and pharmacology 20110701

Rottlerin exhibits antiangiogenic effects in vitro.

Chemical biology & drug design 20110601

Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast.

Biology of reproduction 20110501

Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay.

Free radical biology & medicine 20110501

Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells.

Carcinogenesis 20110501

EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells.

Journal of immunotherapy (Hagerstown, Md. : 1997) 20110501

Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells.

Nutrition research (New York, N.Y.) 20110401

Upregulation of heme oxygenase-1 as an adaptive mechanism for protection against crotonaldehyde in human umbilical vein endothelial cells.

Toxicology letters 20110325

A phospholipase A₂ isolated from Lachesis muta snake venom increases the survival of retinal ganglion cells in vitro.

Toxicon : official journal of the International Society on Toxinology 20110315

PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures.

Biochimie 20110201

Targeting transcription through inhibition of TBP.

Oncotarget 20110201

Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKCζ-mediated p47phox phosphorylation.

Chemico-biological interactions 20110115

Interleukin-32α production is regulated by MyD88-dependent and independent pathways in IL-1β-stimulated human alveolar epithelial cells.

Immunobiology 20110101

Biosynthesis of promatrix metalloproteinase-9/chondroitin sulphate proteoglycan heteromer involves a Rottlerin-sensitive pathway.

PloS one 20110101

PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells.

Molecular vision 20110101

Effect of protein kinase C delta (PKC-δ) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro.

PloS one 20110101

Protein kinase C regulates urea permeability in the rat inner medullary collecting duct.

American journal of physiology. Renal physiology 20101201

The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts.

Arthritis and rheumatism 20101201

Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ.

Clinical and experimental pharmacology & physiology 20101201

PKC-δ mediates TCDD-induced apoptosis of chondrocyte in ROS-dependent manner.

Chemosphere 20101101

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP.

The Journal of biological chemistry 20101008

3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea inhibits tumor cell invasion by regulating protein kinase C-delta-dependent matrix metalloproteinase-9 expression.

Toxicology letters 20101005

[Role of protein kinase C-delta in hyperthermia-induced apoptosis in tongue squamous cell carcinoma Tca8113 cells].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 20101001

Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase C.

Neurotoxicology 20100901

The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells.

Journal of tissue engineering and regenerative medicine 20100701

PKC-delta promotes renal tubular cell apoptosis associated with proteinuria.

Journal of the American Society of Nephrology : JASN 20100701

Gonadotropin-induced ovarian cancer cell migration and proliferation require extracellular signal-regulated kinase 1/2 activation regulated by calcium and protein kinase C{delta}.

Endocrine-related cancer 20100601

Rottlerin: bases for a possible usage in psoriasis.

Current drug metabolism 20100601

Rottlerin inhibits migration of follicular thyroid carcinoma cells by PKCdelta-independent destabilization of the focal adhesion complex.

Journal of cellular biochemistry 20100515

Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells.

Diabetologia 20100501

Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression.

Toxicology and applied pharmacology 20100415

Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells.

FEBS letters 20100305

Possible involvement of PKC-delta in the abrogated cardioprotective potential of ischemic preconditioning in hyperhomocysteinemic rat hearts.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100301

Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells.

Carcinogenesis 20100301

Inhibition of protein kinase Cdelta reduces tristetraprolin expression by destabilizing its mRNA in activated macrophages.

European journal of pharmacology 20100225

Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.

American journal of physiology. Gastrointestinal and liver physiology 20100101

Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation.

The Journal of steroid biochemistry and molecular biology 20100101

Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells.

Biochimie 20100101

Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro.

Molecular immunology 20100101

Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway.

PloS one 20100101

Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

Novel screening method for potential skin-whitening compounds by a luciferase reporter assay.

Bioscience, biotechnology, and biochemistry 20100101

Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon.

PloS one 20100101

Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells.

American journal of physiology. Heart and circulatory physiology 20091201

The infarct size-limiting effect of ischemic postconditioning (IPOC) is suppressed in isolated hyperhomocysteinemic (Hhcy) rat hearts: the reasonable role of PKC-delta.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20091201

Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction.

Experimental cell research 20091115

Plasma protein kinase C (PKC)alpha as a biomarker for the diagnosis of cancers.

Carcinogenesis 20091101

Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini.

Pancreas 20091101

Rottlerin inhibits (Na+, K+)-ATPase activity in brain tissue and alters D-aspartate dependent redistribution of glutamate transporter GLAST in cultured astrocytes.

Neurochemical research 20091001

PKCdelta influences p190 phosphorylation and activity: events independent of PKCdelta-mediated regulation of endothelial cell stress fiber and focal adhesion formation and barrier function.

Biochimica et biophysica acta 20091001

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nature chemical biology 20091001

Neurotrophins induce neuregulin release through protein kinase Cdelta activation.

The Journal of biological chemistry 20090925

Role of protein kinase C-delta in angiotensin II induced cardiac fibrosis.

Biochemical and biophysical research communications 20090904

Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways.

Journal of cellular biochemistry 20090801

Activation of PKCdelta and ERK1/2 in the sensitivity to UV-induced apoptosis of human cells harboring 4977 bp deletion of mitochondrial DNA.

Biochimica et biophysica acta 20090801

Fluid phase endocytosis contributes to transfection of DNA by PEI-25.

Molecular therapy : the journal of the American Society of Gene Therapy 20090801

Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation.

Neuroscience bulletin 20090801

Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways.

Experimental cell research 20090715

Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells.

Carcinogenesis 20090701

Phosphorylation of myristoylated alanine-rich C kinase substrate is involved in the cAMP-dependent amylase release in parotid acinar cells.

American journal of physiology. Gastrointestinal and liver physiology 20090601

Rottlerin: a multifaced regulator of keratinocyte cell cycle.

Experimental dermatology 20090601

Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells.

Carcinogenesis 20090501

A retrograde apoptotic signal originating in NGF-deprived distal axons of rat sympathetic neurons in compartmented cultures.

Cell research 20090501

Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells.

The Journal of nutrition 20090501

Integrin signaling and cell spreading alterations by rottlerin treatment of chick limb bud mesenchymal cells.

Biochimie 20090501

Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.

Cancer research 20090501

Promiscuous aggregate-based inhibitors promote enzyme unfolding.

Journal of medicinal chemistry 20090409

Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R.

The American journal of pathology 20090401

Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion.

Toxicology in vitro : an international journal published in association with BIBRA 20090201

Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells.

PloS one 20090101

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

PloS one 20090101

Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells.

Journal of biomedicine & biotechnology 20090101

Role of protein kinase C-delta in isoproterenol-induced amylase release in rat parotid acinar cells.

The journal of medical investigation : JMI 20090101

Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues.

Biochemical and biophysical research communications 20081114

Rottlerin induces pro-apoptotic endoplasmic reticulum stress through the protein kinase C-delta-independent pathway in human colon cancer cells.

Apoptosis : an international journal on programmed cell death 20081101

Protein kinase C subtypes and retinal ischemic preconditioning.

Experimental eye research 20081001

The effect of rottlerin in calcium regulation in HMC-1(560) cells is mediated by a PKC-delta independent effect.

Journal of cellular biochemistry 20080901

Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages.

Journal of leukocyte biology 20080901

Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.

Carcinogenesis 20080901

Protection of human colon epithelial cells against deoxycholate by rottlerin.

Apoptosis : an international journal on programmed cell death 20080901

Possible mechanism of rottlerin induced modulation of ischemia reperfusion injury in isolated rat hearts.

Biological & pharmaceutical bulletin 20080901

Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway.

Diabetes 20080801

Hypothalamic protein kinase C regulates glucose production.

Diabetes 20080801

Chlorpromazine attenuates pancreatic beta-cell function and mass through IRS2 degradation, while exercise partially reverses the attenuation.

Journal of psychopharmacology (Oxford, England) 20080701

Role of protein kinase Cdelta in paraquat-induced glial cell death.

Journal of neuroscience research 20080701

G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes.

Cellular signalling 20080701

Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis.

Autophagy 20080701

Erbin-regulated sensitivity of MCF-7 breast cancer cells to TRAIL via ErbB2/AKT/NF-kappaB pathway.

Journal of biochemistry 20080601

Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: CD36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixture.

Aging cell 20080601

Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes.

Journal of cellular physiology 20080601

House dust mite, Dermatophagoides pteronissinus increases expression of MCP-1, IL-6, and IL-8 in human monocytic THP-1 cells.

Cytokine 20080601

PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction.

Biochemical and biophysical research communications 20080516

Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase.

Experimental & molecular medicine 20080430

Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.

Bioorganic & medicinal chemistry 20080415

Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway.

Cancer research 20080415

Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells.

Regulatory peptides 20080410

Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells.

American journal of respiratory cell and molecular biology 20080401

Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes.

Hepatology (Baltimore, Md.) 20080401

Rottlerin inhibits the nuclear factor kappaB/cyclin-D1 cascade in MCF-7 breast cancer cells.

Life sciences 20080312

Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells.

American journal of physiology. Cell physiology 20080301

Protein kinase Cdelta regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation.

American journal of physiology. Lung cellular and molecular physiology 20080301

Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts.

Hypertension (Dallas, Tex. : 1979) 20080301

Small-molecule aggregates inhibit amyloid polymerization.

Nature chemical biology 20080301

Aggregator compounds confound amyloid fibrillization assay.

Nature chemical biology 20080301

STI571 (Glivec) affects histamine release and intracellular pH after alkalinisation in HMC-1560, 816.

Journal of cellular biochemistry 20080215

Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma.

Free radical biology & medicine 20080201

Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta.

Experimental and molecular pathology 20080201

Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholine.

Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20080201

Differential effects of dialysis and ultrafiltrate from individuals with CKD, with or without diabetes, on platelet phosphatidylserine externalization.

American journal of physiology. Renal physiology 20080101

[Production of chemoattractant-induced reactive oxygen species in human neutrophils--role of protein kinase C isoforms].

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20080101

The selectivity of protein kinase inhibitors: a further update.

The Biochemical journal 20071215

Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells.

Biochimica et biophysica acta 20071201

Rottlerin causes pulmonary edema in vivo: a possible role for PKCdelta.

Journal of applied physiology (Bethesda, Md. : 1985) 20071201

Protein kinase C delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes.

Neurobiology of disease 20071201

Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta.

Basic & clinical pharmacology & toxicology 20071201

Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCepsilon and PKCdelta, in adult cardiac muscle cells.

Journal of molecular and cellular cardiology 20071201

Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein.

The American journal of pathology 20071201

Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin.

Cellular signalling 20071101

P2Y nucleotide receptor signaling through MAPK/ERK is regulated by extracellular matrix: involvement of beta3 integrins.

Journal of cellular physiology 20071001

The replicon initiation burst released by reoxygenation of hypoxic T24 cells is accompanied by changes of MCM2 and Cdc7.

Journal of biochemistry and molecular biology 20070930

The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCdelta/Nrf2/ARE signaling to up-regulation of heme oxygenase-1.

Journal of ethnopharmacology 20070905

Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase.

Brain research 20070905

Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 43.

American journal of physiology. Heart and circulatory physiology 20070901

Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells.

American journal of physiology. Endocrinology and metabolism 20070901

Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.

The Journal of pharmacology and experimental therapeutics 20070901

Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta.

Trends in pharmacological sciences 20070901

Protein kinase C delta is a critical regulator of CD1d-mediated antigen presentation.

European journal of immunology 20070901

Expression of cyclin D3 through Sp1 sites by histone deacetylase inhibitors is mediated with protein kinase C-delta (PKC-delta) signal pathway.

Journal of cellular biochemistry 20070701

Protein kinase C delta activated adhesion regulates vascular smooth muscle cell migration.

The Journal of surgical research 20070701

Advanced glycation end products elicit externalization of phosphatidylserine in a subpopulation of platelets via 5-HT2A/2C receptors.

American journal of physiology. Cell physiology 20070701

STAT3 and PKC differentially regulate telomerase activity during megakaryocytic differentiation of K562 cells.

Cell cycle (Georgetown, Tex.) 20070615

Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase.

Arteriosclerosis, thrombosis, and vascular biology 20070601

Protein kinase C delta stimulates antigen presentation by Class II MHC in murine dendritic cells.

International immunology 20070601

Curcumin-induced GADD153 upregulation: modulation by glutathione.

Journal of cellular biochemistry 20070515

Protein kinase Calpha is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the (A)gamma globin-promoter in cellular models of hemoglobin switching.

Journal of cellular biochemistry 20070515

Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta.

Oncogene 20070510

Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells.

The Journal of biological chemistry 20070420

Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn.

Journal of immunology (Baltimore, Md. : 1950) 20070415

TGF-beta-regulated collagen type I accumulation: role of Src-based signals.

American journal of physiology. Cell physiology 20070401

Regulation of anion exchanger Slc26a6 by protein kinase C.

American journal of physiology. Cell physiology 20070401

Role of PKCdelta in IFN-gamma-inducible CIITA gene expression.

Molecular immunology 20070401

Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells.

Journal of cellular physiology 20070301

Tissue transglutaminase inhibits autophagy in pancreatic cancer cells.

Molecular cancer research : MCR 20070301

Osmotic stress-dependent repression is mediated by histone H3 phosphorylation and chromatin structure.

The Journal of biological chemistry 20070216

Rottlerin inhibits human T cell responses.

Biochemical pharmacology 20070215

Targeting the hypoxia inducible factor pathway with mitochondrial uncouplers.

Molecular and cellular biochemistry 20070201

Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role.

Journal of leukocyte biology 20070201

Protein kinase C-mediated modulation of glutamate transporter activity in rat retina.

Current eye research 20070201

Microarray-based kinase inhibition assay by gold nanoparticle probes.

Analytical chemistry 20070115

Involvement of protein kinase Cdelta in iron chelator-induced IL-8 production in human intestinal epithelial cells.

Life sciences 20070109

Rottlerin inhibits P2X(7) receptor-stimulated phospholipase D activity in chronic lymphocytic leukaemia B-lymphocytes.

Immunology and cell biology 20070101

N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro.

The Journal of endocrinology 20070101

Activation-induced upregulation of inhibitory killer Ig-like receptors is regulated by protein kinase C.

Immunology and cell biology 20070101

PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells.

Autophagy 20070101

Distinct inhibitory mechanisms of isoquercitrin gallate and its aglycone on zymosan-induced peroxynitrite production in macrophages.

Nitric oxide : biology and chemistry 20070101

The epsilon-isoform of PKC mediates the hypertonic activation of cation channels in confluent monolayers of rat hepatocytes.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation.

Blood 20061215

Interpreting steep dose-response curves in early inhibitor discovery.

Journal of medicinal chemistry 20061214

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.

Journal of medicinal chemistry 20061214

Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes.

Cancer letters 20061208

[Phosphorylation of PKCdelta participates in the toxicity of 6-hydroxydopamine on dopaminergic neuroblastoma cell].

Zhonghua yi xue za zhi 20061205

Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells.

The Journal of pharmacology and experimental therapeutics 20061201

Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator.

The Journal of pharmacology and experimental therapeutics 20061101

Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.

Nature cell biology 20061101

STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-alpha.

Journal of immunology (Baltimore, Md. : 1950) 20061001

Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells.

Gastroenterology 20061001

High-glucose-altered endothelial cell function involves both disruption of cell-to-cell connection and enhancement of force development.

The Journal of pharmacology and experimental therapeutics 20060801

[The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism].

Zhonghua zhong liu za zhi [Chinese journal of oncology] 20060801

Involvement of protein kinase C delta in the alteration of mitochondrial mass in human cells under oxidative stress.

Free radical biology & medicine 20060615

Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages.

Atherosclerosis 20060601

Rottlerin, a specific inhibitor of protein kinase C-delta, impedes barrier repair response by increasing intracellular free calcium.

The Journal of investigative dermatology 20060601

Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22.

Journal of leukocyte biology 20060601

Multiple actions of lysophosphatidylcholine in human Jurkat T cells.

Acta pharmacologica Sinica 20060601

Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling.

Cardiovascular research 20060501

Lysophosphatidic acid-induced changes in cAMP profiles in young and senescent human fibroblasts as a clue to the ageing process.

Mechanisms of ageing and development 20060501

Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060501

Effect of protein kinase C inhibitors on porcine oocyte activation.

Journal of experimental zoology. Part A, Comparative experimental biology 20060401

Involvement of protein kinase Cdelta in the activation of NADPH oxidase and the phagocytosis of neutrophils.

Free radical research 20060401

Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes.

Biochemical and biophysical research communications 20060324

Regulation of radiation-induced protein kinase Cdelta activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma cell lines.

Mutation research 20060320

6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta.

The Journal of biological chemistry 20060303

Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL.

Leukemia 20060301

Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2.

Apoptosis : an international journal on programmed cell death 20060301

Contact inhibition causes strong downregulation of expression of MICA in human fibroblasts and decreased NK cell killing.

Human immunology 20060301

Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.

Journal of cellular biochemistry 20060201

Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways.

Pharmacological research 20060201

Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms.

The international journal of biochemistry & cell biology 20060201

Role of PKC isoforms in the Fc(gamma)R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages.

Journal of leukocyte biology 20060201

BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappaB activation in rat brain astrocytes.

Journal of cellular physiology 20060101

Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function.

Arteriosclerosis, thrombosis, and vascular biology 20060101

Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism.

Biochimica et biophysica acta 20060101

Regulation of CD93 cell surface expression by protein kinase C isoenzymes.

Microbiology and immunology 20060101

Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle.

Lung 20060101

Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis.

Arthritis research & therapy 20060101

Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation.

The international journal of biochemistry & cell biology 20060101

TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-delta-independent.

Journal of endotoxin research 20060101

Acrylonitrile-induced extracellular signal-regulated kinase (ERK) activation via protein kinase C (PKC) in SK-N-SH neuroblastoma cells.

Journal of applied toxicology : JAT 20060101

Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.

The Journal of biological chemistry 20051230

NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.

The EMBO journal 20051221

Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells.

Cancer letters 20051218

Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.

Cancer chemotherapy and pharmacology 20051201

Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice.

American journal of physiology. Lung cellular and molecular physiology 20051201

Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C.

Neurochemistry international 20051201

Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells.

Immunology 20051201

Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia.

Biochemical and biophysical research communications 20051111

Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells.

FEBS letters 20051107

PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis.

Journal of cellular biochemistry 20051015

Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice.

The Journal of pharmacology and experimental therapeutics 20051001

Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20051001

PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy.

The Biochemical journal 20050915

Activation of the BK (SLO1) potassium channel by mallotoxin.

The Journal of biological chemistry 20050902

Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.

Molecular biology of the cell 20050801

Effect of protein kinase C activation on intracellular Ca2+ signaling and integrity of intestinal epithelial cells.

European journal of pharmacology 20050725

Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.

Brain : a journal of neurology 20050701

Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis.

The Journal of biological chemistry 20050701

PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells.

Cardiovascular research 20050701

The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade.

Life sciences 20050624

Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.

The Journal of biological chemistry 20050501

Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue.

The Journal of steroid biochemistry and molecular biology 20050501

Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells.

Oncogene 20050428

Regulation of cadmium-induced apoptosis by PKCdelta in U937 human promonocytic cells.

Biochimica et biophysica acta 20050415

Gefitinib ('Iressa', ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.

Cancer chemotherapy and pharmacology 20050401

Central role of PKCdelta in glycoxidation-dependent apoptosis of human neurons.

Free radical biology & medicine 20050401

Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.

The Journal of biological chemistry 20050304

VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium.

American journal of physiology. Lung cellular and molecular physiology 20050201

Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205.

Cellular signalling 20050201

Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1.

Molecular biology of the cell 20050201

Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}.

Journal of immunology (Baltimore, Md. : 1950) 20050201

Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1.

Diabetes 20050201

Protein kinase Ctheta activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line.

The FEBS journal 20050201

Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP.

Oncogene 20050127

Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model.

Journal of vascular research 20050101

Mechanism of endothelin-1 activation of MAP kinases in neonatal pulmonary vascular smooth muscle.

Lung 20050101

Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells.

Arteriosclerosis, thrombosis, and vascular biology 20041201

Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells.

Journal of immunology (Baltimore, Md. : 1950) 20041201

Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death.

Annals of the New York Academy of Sciences 20041201

Role of protein kinase Cdelta in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction.

The Journal of pharmacology and experimental therapeutics 20041101

IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes.

Microbes and infection 20041101

Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes.

Journal of immunology (Baltimore, Md. : 1950) 20041101

Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes.

Anesthesia and analgesia 20041101

Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells.

American journal of physiology. Gastrointestinal and liver physiology 20041001

Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.

The Journal of biological chemistry 20040924

The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta.

Biochemical and biophysical research communications 20040903

A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium.

Biochemical and biophysical research communications 20040827

Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells.

Regulatory peptides 20040815

Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes.

Cardiovascular research 20040815

B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta.

The Journal of biological chemistry 20040716

Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation.

Journal of molecular biology 20040716

Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes.

Biochemical pharmacology 20040701

Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation.

Molecules and cells 20040630

PKC-epsilon regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth.

American journal of physiology. Heart and circulatory physiology 20040601

Selective activation of protein kinase C delta in human neutrophils following ischemia reperfusion of skeletal muscle.

Shock (Augusta, Ga.) 20040601

Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C delta signaling pathway.

The Journal of investigative dermatology 20040601

Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK.

American journal of physiology. Heart and circulatory physiology 20040501

Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway.

The Journal of biological chemistry 20040409

Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complex.

The Journal of biological chemistry 20040326

Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins.

Circulation research 20040319

Laminin 5 deposition regulates keratinocyte polarization and persistent migration.

Journal of cell science 20040315

Down-regulation of Bcl-2 is associated with cisplatin resistance in human small cell lung cancer H69 cells.

Molecular cancer therapeutics 20040301

Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells.

European journal of pharmacology 20040220

IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta.

Cellular signalling 20040201

Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells.

Journal of molecular endocrinology 20040201

Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel.

The Journal of biological chemistry 20040130

Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B.

The Journal of biological chemistry 20031219

The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis.

The Journal of biological chemistry 20031212

Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression.

International immunology 20031201

Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta.

Journal of enzyme inhibition and medicinal chemistry 20031201

Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism.

International journal of molecular medicine 20031101

A novel role of protein kinase C-delta in cell signaling triggered by glutathione depletion.

Biochemical pharmacology 20031015

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).

The Journal of biological chemistry 20031003

Okadaic acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils.

Archives of biochemistry and biophysics 20030901

Role of PKC-delta activity in glutathione-depleted neuroblastoma cells.

Free radical biology & medicine 20030901

Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.

British journal of pharmacology 20030901

Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C.

Cancer research 20030815

Asbestos-induced apoptosis is protein kinase C delta-dependent.

American journal of respiratory cell and molecular biology 20030801

Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent.

Journal of neurochemistry 20030801

Effect of detergent on 'promiscuous' inhibitors.

Journal of medicinal chemistry 20030731

A generic time-resolved fluorescence assay for serine/threonine kinase activity: application to Cdc7/Dbf4.

Journal of biochemistry and molecular biology 20030731

Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness.

The Journal of biological chemistry 20030718

Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes.

The Biochemical journal 20030715

Activation of protein kinase C delta by IFN-gamma.

Journal of immunology (Baltimore, Md. : 1950) 20030701

Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart.

Journal of molecular and cellular cardiology 20030701

Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor.

International archives of allergy and immunology 20030601

Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis.

British journal of haematology 20030601

Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).

Journal of molecular endocrinology 20030601

Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes.

Biochemical and biophysical research communications 20030523

Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones.

Journal of neuroendocrinology 20030501

Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function.

American journal of respiratory cell and molecular biology 20030501

Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes.

Chemical research in toxicology 20030501

Kinase inhibitors: not just for kinases anymore.

Journal of medicinal chemistry 20030410

Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity.

American journal of physiology. Gastrointestinal and liver physiology 20030401

The second phase activation of protein kinase C delta at late G1 is required for DNA synthesis in serum-induced cell cycle progression.

Genes to cells : devoted to molecular & cellular mechanisms 20030401

Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts.

Arthritis and rheumatism 20030301

Protein kinase C delta is a prosurvival factor in human breast tumor cell lines.

Molecular cancer therapeutics 20030301

Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways.

The Journal of biological chemistry 20030227

Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance.

Cancer research 20030215

Stability of actin cytoskeleton and PKC-delta binding to actin regulate NKCC1 function in airway epithelial cells.

American journal of physiology. Cell physiology 20030201

Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation.

The Journal of biological chemistry 20030131

The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2.

The Journal of biological chemistry 20030103

A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.

Neuroscience 20030101

Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain.

Journal of vascular research 20030101

Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration.

Neuroscience 20030101

Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells.

Molecular endocrinology (Baltimore, Md.) 20021201

Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src.

The Journal of biological chemistry 20021122

Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens.

Journal of immunology (Baltimore, Md. : 1950) 20021115

Differential regulation of extrinsic and intrinsic cell death pathways by protein kinase C.

International journal of molecular medicine 20021101

Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors.

Endocrine research 20021101

Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells.

Free radical research 20021101

Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells.

Experimental cell research 20021015

Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation.

Endocrinology 20021001

Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages.

The Journal of biological chemistry 20020927

Lysophosphatidic acid-induced nuclear localization of protein kinase C delta in bovine theca cells stimulated with luteinizing hormone.

Biology of reproduction 20020901

Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity.

Hepatology (Baltimore, Md.) 20020901

Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta.

The Biochemical journal 20020815

Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway.

Experimental cell research 20020815

Regulation of p53 stabilization by DNA damage and protein kinase C.

Molecular cancer therapeutics 20020801

A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil.

American journal of physiology. Cell physiology 20020701

Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway.

American journal of physiology. Heart and circulatory physiology 20020701

Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts.

Toxicology and applied pharmacology 20020701

FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway.

Biochemical and biophysical research communications 20020517

Modulation of Na-K-2Cl cotransport by intracellular Cl(-) and protein kinase C-delta in Calu-3 cells.

American journal of physiology. Lung cellular and molecular physiology 20020501

Fas activation opposes PMA-stimulated changes in the localization of PKCdelta: a mechanism for reducing neutrophil adhesion to endothelial cells.

Journal of leukocyte biology 20020501

Protein kinase Cdelta overexpression enhances radiation sensitivity via extracellular regulated protein kinase 1/2 activation, abolishing the radiation-induced G(2)-M arrest.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20020501

Antagonists of protein kinase C inhibit rat retinal glutamate transport activity in situ.

Journal of neurochemistry 20020501

Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

The Journal of biological chemistry 20020419

Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C.

The Journal of biological chemistry 20020405

Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCdelta-independent fashion.

American journal of physiology. Renal physiology 20020401

Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells.

The Journal of clinical investigation 20020315

Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells.

The Journal of biological chemistry 20020308

The role of protein kinase C-delta in PTH stimulation of IGF-binding protein-5 mRNA in UMR-106-01 cells.

American journal of physiology. Endocrinology and metabolism 20020301

Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20020301

Transforming growth factor-beta stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-delta, and p38.

American journal of respiratory cell and molecular biology 20020201

Effect of protein kinase C on endoplasmic reticulum cholesterol.

Biochemical and biophysical research communications 20020111

PKC-delta inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats.

Basic research in cardiology 20020101

Rottlerin stimulates metallothionein gene expression but inhibits metal transport in Chinese hamster ovary cells.

Toxicology and applied pharmacology 20011215

Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells.

The Journal of biological chemistry 20011214

Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta.

Journal of cellular physiology 20011201

Protein kinase C-epsilon is a trigger of delayed cardioprotection against myocardial ischemia of kappa-opioid receptor stimulation in rat ventricular myocytes.

The Journal of pharmacology and experimental therapeutics 20011101

Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts.

The Journal of clinical investigation 20011101

Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide.

Journal of molecular and cellular cardiology 20011101

A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAFI/CIP1) induction.

Cancer letters 20011022

Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation.

The Journal of biological chemistry 20011012

Oxidant-dependent phosphorylation of p40phox in B lymphocytes.

Biochemical and biophysical research communications 20011005

Fibroblast growth factor activation of the rat PRL promoter is mediated by PKCdelta.

Molecular endocrinology (Baltimore, Md.) 20010901

Involvement of protein kinase C-delta in DNA damage-induced apoptosis.

Cell death and differentiation 20010901

Involvement of protein kinase Cdelta in contact-dependent inhibition of growth in human and murine fibroblasts.

Oncogene 20010823

Protein kinase C delta and eta isoenzymes control the shedding of the interleukin 6 receptor alpha in myeloma cells.

The Biochemical journal 20010815

Rottlerin-independent attenuation of pervanadate-induced tyrosine phosphorylation events by protein kinase C-delta in hemopoietic cells.

Laboratory investigation; a journal of technical methods and pathology 20010801

PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.

Biochemical and biophysical research communications 20010713

NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cdelta. Correlation to nuclear Ikappa Balpha.

The Journal of biological chemistry 20010608

Insulin-induced c-Jun N-terminal kinase activation is negatively regulated by protein kinase C delta.

Endocrinology 20010601

Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950) 20010501

Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle.

Molecular endocrinology (Baltimore, Md.) 20010401

Rottlerin induces a transformed phenotype in human keratinocytes.

Biochemical and biophysical research communications 20010330

Essential activation of PKC-delta in opioid-initiated cardioprotection.

American journal of physiology. Heart and circulatory physiology 20010301

The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells.

Biochemical and biophysical research communications 20010112

Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed.

American journal of physiology. Lung cellular and molecular physiology 20010101

Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells.

IUBMB life 20010101

Specificity and mechanism of action of some commonly used protein kinase inhibitors.

The Biochemical journal 20001001

Aldosterone regulates rapid trafficking of epithelial sodium channel subunits in renal cortical collecting duct cells via protein kinase D activation.

Molecular endocrinology (Baltimore, Md.)