CONCANAMYCIN A
| Title | Journal |
|---|---|
| Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells. | Toxicology and applied pharmacology 20161215 |
| Combined effects of EGFR tyrosine kinase inhibitors and vATPase inhibitors in NSCLC cells. | Toxicology and applied pharmacology 20150815 |
| Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation. | Archives of toxicology 20150701 |
| Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects. | International journal of molecular sciences 20150101 |
| Modulation of vH+-ATPase is part of the functional adaptation of sheep rumen epithelium to high-energy diet. | American journal of physiology. Regulatory, integrative and comparative physiology 20121101 |
| Inhibitors of intravesicular acidification protect against Shiga toxin in a pH-independent manner. | Traffic (Copenhagen, Denmark) 20120301 |
| Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell. | Pflugers Archiv : European journal of physiology 20120301 |
| Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens. | Molecular & cellular proteomics : MCP 20120301 |
| Herpesvirus glycoproteins undergo multiple antigenic changes before membrane fusion. | PloS one 20120101 |
| Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles. | PloS one 20120101 |
| Increased production of reactive oxygen species by the vacuolar-type (H(+))-ATPase inhibitors bafilomycin A1 and concanamycin A in RAW 264 cells. | The Journal of toxicological sciences 20120101 |
| Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation. | PloS one 20120101 |
| Ca²⁺ influx slows single synaptic vesicle endocytosis. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20111109 |
| Angiotensin II stimulates H⁺-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20111101 |
| An enzyme-free quartz crystal microbalance biosensor for sensitive glucose detection in biological fluids based on glucose/dextran displacement approach. | Analytica chimica acta 20110207 |
| Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110202 |
| Perforin-dependent cytotoxic mechanism in killing by CD8 positive T cells in ginbuna crucian carp, Carassius auratus langsdorfii. | Developmental and comparative immunology 20110101 |
| Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate. | Molecular vision 20110101 |
| Acidification of the Golgi apparatus is indispensable for maturation but not for cell surface delivery of Ret. | Journal of neurochemistry 20101101 |
| Spiroindolones, a potent compound class for the treatment of malaria. | Science (New York, N.Y.) 20100903 |
| 1-Cinnamoyl-3,11-dihydroxymeliacarpin delays glycoprotein transport restraining virus multiplication without cytotoxicity. | Biochemical and biophysical research communications 20100226 |
| Cellular mechanisms of acid secretion in the posterior midgut of the larval mosquito (Aedes aegypti). | The Journal of experimental biology 20100115 |
| Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins. | Journal of cell science 20091001 |
| Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats. | Gastroenterology 20090901 |
| NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles. | American journal of physiology. Renal physiology 20090801 |
| Inhibitors of V-ATPases: old and new players. | The Journal of experimental biology 20090201 |
| Ligation of CD44 leads to killing activity in human peripheral mononuclear cells via MAP kinase and tyrosine kinases. | Hematology (Amsterdam, Netherlands) 20080801 |
| Vacuolar and plasma membrane proton pumps collaborate to achieve cytosolic pH homeostasis in yeast. | The Journal of biological chemistry 20080718 |
| A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites. | Journal of cell science 20080515 |
| Intracellular pH homeostasis and serotonin-induced pH changes in Calliphora salivary glands: the contribution of V-ATPase and carbonic anhydrase. | The Journal of experimental biology 20080301 |
| Interaction of spin-labeled inhibitors of the vacuolar H+-ATPase with the transmembrane Vo-sector. | Biophysical journal 20080115 |
| Productive entry of type C foot-and-mouth disease virus into susceptible cultured cells requires clathrin and is dependent on the presence of plasma membrane cholesterol. | Virology 20071205 |
| HCO(-3)-dependent pHi recovery and overacidification induced by NH+4 pulse in rat lung alveolar type II cells: HCO(-3)-dependent NH3 excretion from lungs? | Pflugers Archiv : European journal of physiology 20071101 |
| Interactions between antiplasmodial 3,6-diamino-1'-dimethyl-9-anilinoacridine and hematin and concanamycin A. | The Southeast Asian journal of tropical medicine and public health 20071101 |
| Cellular environment is important in controlling V-ATPase dissociation and its dependence on activity. | The Journal of biological chemistry 20070824 |
| Characterisation of exogenous folate transport in Plasmodium falciparum. | Molecular and biochemical parasitology 20070701 |
| Intimate cell conjugate formation and exchange of membrane lipids precede apoptosis induction in target cells during antibody-dependent, granulocyte-mediated cytotoxicity. | Journal of immunology (Baltimore, Md. : 1950) 20070701 |
| Function of the anion transporter AtCLC-d in the trans-Golgi network. | The Plant journal : for cell and molecular biology 20070501 |
| A vacuolar-type H+-ATPase and a Na+/H+ exchanger contribute to intracellular pH regulation in cockroach salivary ducts. | The Journal of experimental biology 20070401 |
| Colony-stimulating factor-1 increases osteoclast intracellular pH and promotes survival via the electroneutral Na/HCO3 cotransporter NBCn1. | Endocrinology 20070201 |
| Synaptic vesicles recycling spontaneously and during activity belong to the same vesicle pool. | Nature neuroscience 20070201 |
| Neurotransmitter depletion by bafilomycin is promoted by vesicle turnover. | Neuroscience letters 20070129 |
| Degradation of oxidized proteins by autophagy during oxidative stress in Arabidopsis. | Plant physiology 20070101 |
| Biosynthetic origin of the methoxyl extender unit in bafilomycin and concanamycin using stereospecifically labeled precursors. | The Journal of antibiotics 20070101 |
| The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20061201 |
| Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha. | Molecular pharmacology 20061201 |
| Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. | The Journal of pharmacology and experimental therapeutics 20061101 |
| A model for the proteolipid ring and bafilomycin/concanamycin-binding site in the vacuolar ATPase of Neurospora crassa. | The Journal of biological chemistry 20061020 |
| Analysis of strains with mutations in six genes encoding subunits of the V-ATPase: eukaryotes differ in the composition of the V0 sector of the enzyme. | The Journal of biological chemistry 20060915 |
| Effects of human a3 and a4 mutations that result in osteopetrosis and distal renal tubular acidosis on yeast V-ATPase expression and activity. | The Journal of biological chemistry 20060908 |
| Antimalarial activity of concanamycin A alone and in combination with pyronaridine. | The Southeast Asian journal of tropical medicine and public health 20060701 |
| Fluorescence measurements of serotonin-induced V-ATPase-dependent pH changes at the luminal surface in salivary glands of the blowfly Calliphora vicina. | The Journal of experimental biology 20060501 |
| Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM. | Organic letters 20060316 |
| Vacuolar H+-ATPase activity is required for endocytic and secretory trafficking in Arabidopsis. | The Plant cell 20060301 |
| Cathepsin B-mediated yolk protein degradation during killifish oocyte maturation is blocked by an H+-ATPase inhibitor: effects on the hydration mechanism. | American journal of physiology. Regulatory, integrative and comparative physiology 20060201 |
| Time- and temperature-dependent activation of hepatitis C virus for low-pH-triggered entry. | Journal of virology 20060201 |
| Characterization of the urinary albumin degradation pathway in the isolated perfused rat kidney. | The Journal of laboratory and clinical medicine 20060101 |
| Subunit a of the yeast V-ATPase participates in binding of bafilomycin. | The Journal of biological chemistry 20051209 |
| Phorbol esters target the activity-dependent recycling pool and spare spontaneous vesicle recycling. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20051123 |
| Concanamycin and indolyl pentadieneamide inhibitors of the vacuolar H+-ATPase bind with high affinity to the purified proteolipid subunit of the membrane domain. | Biochemistry 20051115 |
| Structural and functional separation of the N- and C-terminal domains of the yeast V-ATPase subunit H. | The Journal of biological chemistry 20051104 |
| The death receptor pathway is not involved in alloreactive T-cell induced mitochondrial membrane permeability. | Leukemia & lymphoma 20050801 |
| Effect of lesions of cerebellar fastigial nuclei on lymphocyte functions of rats. | Neuroscience research 20050301 |
| Vacuolar ATPase regulates zymogen activation in pancreatic acini. | The Journal of biological chemistry 20050218 |
| An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmission. | Neuron 20050217 |
| Expression profiling of immune-related genes from Japanese flounder Paralichthys olivaceus kidney cells using cDNA microarrays. | Developmental and comparative immunology 20050101 |
| Age-related alterations in the carbohydrate residue composition of the cell surface in the unexposed normal human epidermis. | Gerontology 20050101 |
| H+-ATPase of crude homogenate of the outer mantle epithelium of Anodonta cygnea. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20041201 |
| The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells. | Protoplasma 20041201 |
| Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes. | Clinical cancer research : an official journal of the American Association for Cancer Research 20041101 |
| Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A. | The Journal of antibiotics 20041001 |
| Interaction of inhibitors of the vacuolar H(+)-ATPase with the transmembrane Vo-sector. | Biochemistry 20040928 |
| V-type ATPase is involved in biogenesis of GLUT4 vesicles. | American journal of physiology. Endocrinology and metabolism 20040901 |
| NK cells use perforin rather than granulysin for anticryptococcal activity. | Journal of immunology (Baltimore, Md. : 1950) 20040901 |
| Glucose activates H(+)-ATPase in kidney epithelial cells. | American journal of physiology. Cell physiology 20040701 |
| Endosome disruption enhances the functional nuclear delivery of Tat-fusion proteins. | Biochemical and biophysical research communications 20040618 |
| Activated T killer cells induce apoptosis in lung epithelial cells and the release of pro-inflammatory cytokine TNF-alpha. | European journal of immunology 20040601 |
| Incorporation of the V-ATPase inhibitors concanamycin and indole pentadiene in lipid membranes. Spin-label EPR studies. | Biochimica et biophysica acta 20040527 |
| Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040310 |
| SING: a novel strategy for identifying tumor-specific, CTL-recognized tumor antigens. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040301 |
| Differences in endosomal targeting of human (beta)1- and (beta)2-adrenergic receptors following clathrin-mediated endocytosis. | Journal of cell science 20040215 |
| A link of Ca2+ to cAMP oscillations in Dictyostelium: the calmodulin antagonist W-7 potentiates cAMP relay and transiently inhibits the acidic Ca2+-store. | BMC developmental biology 20040101 |
| Identification of a new chondropsin class of antitumor compound that selectively inhibits V-ATPases. | The Journal of biological chemistry 20031107 |
| The flow cytometric PKH-26 assay for the determination of T-cell mediated cytotoxic activity. | Methods (San Diego, Calif.) 20031001 |
| Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae. | The Journal of biological chemistry 20030418 |
| A reversible hydrogel membrane for controlling the delivery of macromolecules. | Biotechnology and bioengineering 20030405 |
| In bafilomycin A1-resistant cells, bafilomycin A1 raised lysosomal pH and both prodigiosins and concanamycin A inhibited growth through apoptosis. | FEBS letters 20030227 |
| Receptor occupancy limits synaptic depression at climbing fiber synapses. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030115 |
| CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15. | Journal of immunology (Baltimore, Md. : 1950) 20021115 |
| Xenogeneic human NK cytotoxicity against porcine endothelial cells is perforin/granzyme B dependent and not inhibited by Bcl-2 overexpression. | Xenotransplantation 20020901 |
| Proton pump activity is required for active uptake of chloride in isolated amphibian skin exposed to freshwater. | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20020801 |
| Proteome analysis of Aspergillus nidulans reveals proteins associated with the response to the antibiotic concanamycin A, produced by Streptomyces species. | Molecular genetics and genomics : MGG 20020801 |
| Studies on the synthesis of bafilomycin A(1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C25) segment. | The Journal of organic chemistry 20020614 |
| V-type H+-ATPase in the human eccrine sweat duct: immunolocalization and functional demonstration. | American journal of physiology. Cell physiology 20020601 |
| Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway. | The Journal of biological chemistry 20020426 |
| Determinants of the phagosomal pH in neutrophils. | The Journal of biological chemistry 20020222 |
| Mutations in subunit C of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site. | The Journal of biological chemistry 20020208 |
| Inhibition of natural killer cytotoxicity in vitro by clinical grade serine protease inhibitors. | Haematologia 20020101 |
| In situ measurements of the pH of mammalian peroxisomes using the fluorescent protein pHluorin. | The Journal of biological chemistry 20011228 |
| Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors. | The Journal of biological chemistry 20011116 |
| Activation-induced cell death of human T-cell subsets is mediated by Fas and granzyme B but is independent of TNF-alpha. | Journal of leukocyte biology 20011101 |
| Granule-dependent killing of Toxoplasma gondii by CD8+ T cells. | Immunology 20011101 |
| Mildly oxidized LDL induces activation of platelet-derived growth factor beta-receptor pathway. | Circulation 20011009 |
| Inverse correlation between pink-eyed dilution protein expression and induction of melanogenesis by bafilomycin A1. | Pigment cell research 20011001 |
| On the mechanism of sodium-proton exchange in crayfish. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20010401 |
| Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39. | Cancer research 20010401 |
| Entry of poliovirus into cells is blocked by valinomycin and concanamycin A. | Biochemistry 20010327 |
| Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes. | Biochemistry 20010306 |
| Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy. | Biochimica et biophysica acta 20010209 |
| Enhancement of human cord blood CD34+ cell-derived NK cell cytotoxicity by dendritic cells. | Journal of immunology (Baltimore, Md. : 1950) 20010201 |
| Glycolipid antigen processing for presentation by CD1d molecules. | Science (New York, N.Y.) 20010126 |
| Involvement of vacuolar proton ATPase in Junin virus multiplication. | Archives of virology 20010101 |