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Nestoron

CAS No.:
7759-35-5
Catalog Number:
AG00G2C9
Molecular Formula:
C23H30O4
Molecular Weight:
370.4819
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥95%
1 week
United States
$105
- +
10mg
≥95%
1 week
United States
$144
- +
25mg
≥95%
1 week
United States
$264
- +
50mg
99%
1 week
United States
$471
- +
Product Description
Catalog Number:
AG00G2C9
Chemical Name:
Nestoron
CAS Number:
7759-35-5
Molecular Formula:
C23H30O4
Molecular Weight:
370.4819
MDL Number:
MFCD01711303
IUPAC Name:
[(8R,9S,10R,13S,14S,17R)-17-acetyl-13-methyl-16-methylidene-3-oxo-2,6,7,8,9,10,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
InChI:
InChI=1S/C23H30O4/c1-13-11-21-20-7-5-16-12-17(26)6-8-18(16)19(20)9-10-22(21,4)23(13,14(2)24)27-15(3)25/h12,18-21H,1,5-11H2,2-4H3/t18-,19+,20+,21-,22-,23-/m0/s1
InChI Key:
CKFBRGLGTWAVLG-GOMYTPFNSA-N
SMILES:
CC(=O)O[C@]1(C(=O)C)C(=C)C[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=CC(=O)CC[C@H]12
UNII:
9AMX4Q13CC
Properties
Complexity:
762  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
0
Exact Mass:
370.214g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
370.489g/mol
Monoisotopic Mass:
370.214g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
60.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.9  
Literature
Title Journal
Increased impact of a contraceptive vaginal ring with ethinyl estradiol and nestorone on C-reactive protein. Steroids 20121101
A new combination of testosterone and nestorone transdermal gels for male hormonal contraception. The Journal of clinical endocrinology and metabolism 20121001
Discriminant analysis of the metabolic effects of a new combined contraceptive vaginal ring containing Nestorone/EE vs. a second-generation oral contraceptive containing levonorgestrel/EE. Contraception 20120901
Progesterone receptors: a key for neuroprotection in experimental stroke. Endocrinology 20120801
Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors. Endocrinology 20111001
Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat. Molecular and cellular endocrinology 20101026
Central modifications of allopregnanolone and beta-endorphin following subcutaneous administration of Nestorone. The Journal of steroid biochemistry and molecular biology 20090801
Combined transdermal testosterone gel and the progestin nestorone suppresses serum gonadotropins in men. The Journal of clinical endocrinology and metabolism 20090701
Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion. BMC cancer 20080101
Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen. Contraception 20070601
Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables. American journal of obstetrics and gynecology 20060701
New progestagens for contraceptive use. Human reproduction update 20060101
Feasibility study of Nestorone-ethinylestradiol vaginal contraceptive ring for emergency contraception. Contraception 20060101
Serum Nestorone and ethinyl estradiol levels, and ovulation inhibition in women using three different dosage combinations of a Nestorone progestogen-ethinyl estradiol contraceptive vaginal ring on a bleeding-signaled regimen. Contraception 20050701
Clinical performance and menstrual bleeding patterns with three dosage combinations of a Nestorone progestogen/ethinyl estradiol contraceptive vaginal ring used on a bleeding-signaled regimen. Contraception 20050701
Contraceptive vaginal rings releasing Nestorone and ethinylestradiol: a 1-year dose-finding trial. Contraception 20050201
The effect of Nestorone on gonadotropic cells in pituitary of rats. Contraception 20040601
Nestorone: clinical applications for contraception and HRT. Steroids 20031101
Enlarged ovarian follicles in users of a levonorgestrel-releasing intrauterine system and contraceptive implant. The Journal of reproductive medicine 20030801
Steroidal contraceptive vaginal rings. International journal of clinical practice 20030601
Subdermal progestin implant (Nestorone) in the treatment of endometriosis: clinical response to various doses. Acta obstetricia et gynecologica Scandinavica 20030201
Recent developments in contraceptive implants at the Population Council. Contraception 20020101
Implant contraception. Seminars in reproductive medicine 20011201
Contraceptive vaginal rings. Seminars in reproductive medicine 20011201
Ovarian function during use of vaginal rings delivering three different doses of Nestorone. Contraception 20010501
Properties