Name: Name:10-HYDROXYWARFARIN
Brand: Angene
SKU: AG00G281
Rating: 90 (10 reviews)

Catalog Number:

AG00G281

Chemical Name:

10-HYDROXYWARFARIN

CAS Number:

83219-99-2

MDL Number:

MFCD00272676

IUPAC Name:

4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)chromen-2-one

InChI:

InChI=1S/C19H16O5/c1-11(20)17(21)15(12-7-3-2-4-8-12)16-18(22)13-9-5-6-10-14(13)24-19(16)23/h2-10,15,17,21-22H,1H3

InChI Key:

BPZSPAZBZFZZBN-UHFFFAOYSA-N

Complexity:

532

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

1

Defined Atom Stereocenter Count:

0

Defined Bond Stereocenter Count:

0

Exact Mass:

324.1g/mol

Formal Charge:

0

Heavy Atom Count:

24

Hydrogen Bond Acceptor Count:

5

Hydrogen Bond Donor Count:

2

Isotope Atom Count:

0

Molecular Weight:

324.332g/mol

Monoisotopic Mass:

324.1g/mol

Rotatable Bond Count:

4

Topological Polar Surface Area:

83.8A^2

Undefined Atom Stereocenter Count:

2

Undefined Bond Stereocenter Count:

0

XLogP3:

1.6

Title	Journal
Warfarin is an effective modifier of multiple UDP-glucuronosyltransferase enzymes: evaluation of its potential to alter the pharmacokinetics of zidovudine.	Journal of pharmaceutical sciences 20150101
Novel multi-mode ultra performance liquid chromatography-tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110501
Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.	Drug metabolism letters 20101201
Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes.	Journal of thrombosis and haemostasis : JTH 20101201
Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.	Chemical research in toxicology 20100517
The influence of co-treatment with carbamazepine, amiodarone and statins on warfarin metabolism and maintenance dose.	European journal of clinical pharmacology 20060401
Kinetic study of cytochrome P450 3A4 activity on warfarin by capillary electrophoresis with fluorescence detection.	Journal of chromatography. A 20050805
Determination of warfarin enantiomers and hydroxylated metabolites in human blood plasma by liquid chromatography with achiral and chiral separation.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425
Quantitative liquid chromatography/mass spectrometry/mass spectrometry warfarin assay for in vitro cytochrome P450 studies.	Analytical biochemistry 20011101
In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin.	Drug metabolism and disposition: the biological fate of chemicals 20010601