Home Halogens 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane

1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane

CAS No.:
66504-40-3
Catalog Number:
AG00FXUN
Molecular Formula:
C11H11Cl2N
Molecular Weight:
228.1177
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Product Description
Catalog Number:
AG00FXUN
Chemical Name:
1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane
CAS Number:
66504-40-3
Molecular Formula:
C11H11Cl2N
Molecular Weight:
228.1177
MDL Number:
MFCD22381599
IUPAC Name:
1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
InChI:
InChI=1S/C11H11Cl2N/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11/h1-3,8,14H,4-6H2
InChI Key:
BSMNRYCSBFHEMQ-UHFFFAOYSA-N
SMILES:
Clc1ccc(cc1Cl)C12CNCC2C1
Properties
Complexity:
245  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
227.027g/mol
Formal Charge:
0
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
228.116g/mol
Monoisotopic Mass:
227.027g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
12A^2
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0
XLogP3:
3  
Literature
Title Journal
Effects of the triple reuptake inhibitor amitifadine on extracellular levels of monoamines in rat brain regions and on locomotor activity. Synapse (New York, N.Y.) 20120501
Efficacy and tolerability of the novel triple reuptake inhibitor amitifadine in the treatment of patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial. Journal of psychiatric research 20120101
The triple reuptake inhibitor DOV216,303 exhibits limited antidepressant-like properties in the differential reinforcement of low-rate 72-second responding assay, likely due to dopamine reuptake inhibition. Journal of psychopharmacology (Oxford, England) 20111001
The secrets of a successful clinical trial: compliance, compliance, and compliance. Molecular interventions 20110401
Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. The international journal of neuropsychopharmacology 20110301
The potential and limitations of DOV 216,303 as a triple reuptake inhibitor for the treatment of major depression: a microdialysis study in olfactory bulbectomized rats. Pharmacology, biochemistry, and behavior 20110101
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors. Bioorganic & medicinal chemistry 20110101
The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. The Journal of pharmacology and experimental therapeutics 20101201
Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. Bioorganic & medicinal chemistry letters 20100915
The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. European journal of pharmacology 20100510
The triple monoaminergic reuptake inhibitor DOV 216,303 has antidepressant effects in the rat olfactory bulbectomy model and lacks sexual side effects. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20081201
Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. Bioorganic & medicinal chemistry letters 20081201
Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorganic & medicinal chemistry letters 20080701
The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity. The Journal of pharmacology and experimental therapeutics 20080301
Triple reuptake inhibitors ('broad spectrum' antidepressants). CNS & neurological disorders drug targets 20070401
Preclinical and clinical pharmacology of DOV 216,303, a 'triple' reuptake inhibitor. CNS drug reviews 20060101
DOV 216,303, a 'triple' reuptake inhibitor: safety, tolerability, and pharmacokinetic profile. Journal of clinical pharmacology 20041201
'Broad spectrum' antidepressants: is more better for the treatment of depression? Life sciences 20031107
Antidepressant-like actions of DOV 21,947: a 'triple' reuptake inhibitor. European journal of pharmacology 20030214
Properties