GSK 189254A
| Title | Journal |
|---|---|
| Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon. | Psychopharmacology 20121001 |
| Antagonism of supraspinal histamine H3 receptors modulates spinal neuronal activity in neuropathic rats. | The Journal of pharmacology and experimental therapeutics 20121001 |
| A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor. | Bioorganic & medicinal chemistry letters 20120715 |
| Histamine h3 receptor: a novel therapeutic target in alcohol dependence? | Frontiers in systems neuroscience 20120101 |
| Pharmacological characterization of GSK1004723, a novel, long-acting antagonist at histamine H(1) and H(3) receptors. | British journal of pharmacology 20111101 |
| Amine-constrained pyridazinone histamine H₃ receptor antagonists. | Bioorganic & medicinal chemistry letters 20110915 |
| Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. | Journal of medicinal chemistry 20110714 |
| Histamine H3 receptor as a drug discovery target. | Journal of medicinal chemistry 20110113 |
| Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. | The Journal of pharmacology and experimental therapeutics 20110101 |
| Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain. | Journal of medicinal chemistry 20101111 |
| Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems. | Brain research 20101001 |
| Evaluation of 11C-GSK189254 as a novel radioligand for the H3 receptor in humans using PET. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100701 |
| When reversible ligands do not reverse, and other modelers' dilemmas. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100701 |
| Regional differential effects of the novel histamine H3 receptor antagonist 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) on histamine release in the central nervous system of freely moving rats. | The Journal of pharmacology and experimental therapeutics 20100101 |
| 11C-GSK189254: a selective radioligand for in vivo central nervous system imaging of histamine H3 receptors by PET. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20091201 |
| H3 receptor antagonism enhances NCAM PSA-mediated plasticity and improves memory consolidation in odor discrimination and delayed match-to-position paradigms. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20091101 |
| 5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity. | Journal of medicinal chemistry 20090709 |
| Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice. | British journal of pharmacology 20090501 |
| Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice. | British journal of pharmacology 20090501 |
| Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists. | Journal of medicinal chemistry 20081113 |
| Piperidine variations in search for non-imidazole histamine H(3) receptor ligands. | Bioorganic & medicinal chemistry 20080915 |
| Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain. | Pain 20080815 |
| GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. | The Journal of pharmacology and experimental therapeutics 20070601 |
| Soraprazan: setting new standards in inhibition of gastric acid secretion. | The Journal of pharmacology and experimental therapeutics 20070601 |