Home Sulfos Sodium tanshinone IIA sulfonate

Sodium tanshinone IIA sulfonate

CAS No.:
69659-80-9
Catalog Number:
AG00FEIY
Molecular Formula:
C19H17NaO6S
Molecular Weight:
396.3894
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
98%
In Stock USA
United States
$200
- +
1g
98%
In Stock USA
United States
$500
- +
Product Description
Catalog Number:
AG00FEIY
Chemical Name:
Sodium tanshinone IIA sulfonate
CAS Number:
69659-80-9
Molecular Formula:
C19H17NaO6S
Molecular Weight:
396.3894
MDL Number:
MFCD09028094
IUPAC Name:
sodium;1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-2-sulfonate
InChI:
InChI=1S/C19H18O6S.Na/c1-9-13-15(20)16(21)14-10-5-4-8-19(2,3)12(10)7-6-11(14)17(13)25-18(9)26(22,23)24;/h6-7H,4-5,8H2,1-3H3,(H,22,23,24);/q;+1/p-1
InChI Key:
AZEZEAABTDXEHR-UHFFFAOYSA-M
SMILES:
O=C1c2c(ccc3c2CCCC3(C)C)c2c(C1=O)c(C)c(o2)S(=O)(=O)[O-].[Na+]
UNII:
IVJ88KQ4XN
Properties
Complexity:
742  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
396.064g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
396.389g/mol
Monoisotopic Mass:
396.064g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
113A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Sodium tanshinone IIA sulfonate prevents hypoxic trophoblast-induced endothelial cell dysfunction via targeting HMGB1 release. Journal of biochemical and molecular toxicology 20170701
Tanshinone IIA protects rabbits against LPS-induced disseminated intravascular coagulation (DIC). Acta pharmacologica Sinica 20121001
Anti-PRRSV effect and mechanism of sodium tanshinone IIA sulfonate in vitro. Journal of Asian natural products research 20120101
A novel protocol for the preparation of sodium tanshinone sulphonates by direct ultrasound-assisted sulphonation of the crude extract of the roots of Salvia miltiorrhiza Bunge and following counter-current chromatography purification. Phytochemical analysis : PCA 20110101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Tanshinone IIA improves impaired nerve functions in experimental diabetic rats. Biochemical and biophysical research communications 20100813
Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function. American journal of respiratory cell and molecular biology 20091201
Sodium tanshinone IIA sulfonate increased intestinal hemodynamics without systemic circulatory changes in healthy newborn piglets. American journal of physiology. Heart and circulatory physiology 20091001
Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro. Experimental & molecular medicine 20090731
Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090701
Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers. Xenobiotica; the fate of foreign compounds in biological systems 20090701
Changes of c-fos and c-jun mRNA expression in angiotensin II-induced cardiomyocyte hypertrophy and effects of sodium tanshinone IIA sulfonate. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20081001
Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-kappaB and IFN-gamma/STAT1 pathways. Journal of clinical immunology 20080901
Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism. Chinese journal of integrative medicine 20080901
Effect of sodium tanshinone II A sulfonate on phosphorylation of extracellular signal-regulated kinase 1/2 in angiotensin II-induced hypertrophy of myocardial cells. Chinese journal of integrative medicine 20080601
Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation. Journal of cardiovascular pharmacology 20080401
[Changes of c-fos, c-jun mRNA expressions in cardiomyocyte hypertrophy induced by angiotensin II and effects of tanshinone II A]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401
Determination of sodium tanshinone IIA sulfonate in plasma by liquid chromatography-electrospray ionisation-tandem mass spectrometry. Biomedical chromatography : BMC 20071101
Pharmacological activity of cardiovascular agents from herbal medicine. Cardiovascular & hematological agents in medicinal chemistry 20071001
Ion-pair reversed-phase HPLC method for determination of sodium tanshinone IIA sulfonate in biological samples and its pharmacokinetics and biodistribution in mice. Chemical & pharmaceutical bulletin 20070501
A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. Journal of immunology (Baltimore, Md. : 1950) 20070315
Ion-pair reversed-phase HPLC: assay validation of sodium tanshinone IIA sulfonate in mouse plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202
Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochemical pharmacology 20020815
Properties