Home Other Building Blocks 4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol

4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol

CAS No.:
7448-02-4
Catalog Number:
AG00FDSE
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00FDSE
Chemical Name:
4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol
CAS Number:
7448-02-4
MDL Number:
MFCD00945030
IUPAC Name:
(3S,5R,10S,13R,14R,17R)-4,4,10,13-tetramethyl-17-[(2R)-6-methylhept-5-en-2-yl]-1,2,3,5,6,7,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ol
InChI:
InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1
InChI Key:
CHGIKSSZNBCNDW-QGBOJXOESA-N
Properties
Complexity:
723  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Defined Bond Stereocenter Count:
0
Exact Mass:
412.371g/mol
Formal Charge:
0
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
412.702g/mol
Monoisotopic Mass:
412.371g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
20.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
8.4  
Literature
Title Journal
Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Cancer discovery 20130101
Analysis of hypoxia and hypoxia-like states through metabolite profiling. PloS one 20110101
Characterization of sterol lipids in Kluyveromyces lactis strain M-16 accumulating a high amount of steryl glucoside. Journal of oleo science 20090101
Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. PloS one 20080101
Essential gene identification and drug target prioritization in Aspergillus fumigatus. PLoS pathogens 20070301
Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis. The Journal of biological chemistry 20051028
The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p). Biochimica et biophysica acta 20041108
Enzymological properties of sterol-C4-methyl-oxidase of yeast sterol biosynthesis. Biochimica et biophysica acta 20030721
In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity. Biochimica et biophysica acta 20030704
PF1163A, a novel antifungal agent, inhibit ergosterol biosynthesis at C-4 sterol methyl oxidase. The Journal of antibiotics 20021101
Sterol-dependent regulation of sphingolipid metabolism in Saccharomyces cerevisiae. The Journal of biological chemistry 20020719
The effect of the erg26-1 mutation on the regulation of lipid metabolism in Saccharomyces cerevisiae. The Journal of biological chemistry 20010420
Properties