5-FLUORO-DIHYDRO-PYRIMIDINE-2,4-DIONE
| Title | Journal |
|---|---|
| Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers. | Angiogenesis 20120601 |
| Time-dependent pharmacokinetics of 5-fluorouracil and association with treatment tolerability in the adjuvant setting of colorectal cancer. | Journal of clinical pharmacology 20120301 |
| Analysis of polymorphisms and haplotype structure of the human thymidylate synthase genetic region: a tool for pharmacogenetic studies. | PloS one 20120101 |
| Population pharmacokinetic analysis of 5-FU and 5-FDHU in colorectal cancer patients: search for biomarkers associated with gastro-intestinal toxicity. | Current topics in medicinal chemistry 20120101 |
| Determination of 5-fluorouracil and dihydrofluorouracil levels by using a liquid chromatography-tandem mass spectrometry method for evaluation of dihydropyrimidine dehydrogenase enzyme activity. | Cancer chemotherapy and pharmacology 20110801 |
| Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil. | PloS one 20110101 |
| Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies. | OncoTargets and therapy 20110101 |
| Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines. | Cancer chemotherapy and pharmacology 20100801 |
| N(3)-o-toluyl-fluorouracil inhibits human hepatocellular carcinoma cell growth via sustained release of 5-FU. | Cancer chemotherapy and pharmacology 20100501 |
| A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma. | Biomedical chromatography : BMC 20100401 |
| Abdominal irradiation modulates 5-Fluorouracil pharmacokinetics. | Journal of translational medicine 20100101 |
| Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer. | British journal of cancer 20090519 |
| Pharmacokinetic study of S-1. | International journal of clinical pharmacology and therapeutics 20090101 |
| A Stability-Indicating RP-HPLC Assay Method for 5-Fluorouracil. | Indian journal of pharmaceutical sciences 20090101 |
| 5-fluorouracil pharmacokinetics predicts disease-free survival in patients administered adjuvant chemotherapy for colorectal cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20080501 |
| Improved chemical syntheses of 5,6-dihydro-5-fluorouracil. | The Journal of organic chemistry 20071026 |
| Alternative pharmacokinetics of S-1 components, 5-fluorouracil, dihydrofluorouracil and alpha-fluoro-beta-alanine after oral administration of S-1 following total gastrectomy. | Cancer science 20071001 |
| [Pro or con the phenotyping/genotyping of patients treated by 5-Fluorouracil to prevent adverse drug reactions?]. | Therapie 20070101 |
| A pharmacokinetic-based test to prevent severe 5-fluorouracil toxicity. | Clinical pharmacology and therapeutics 20061001 |
| Sensitive MS/MS-liquid chromatography assay for simultaneous determination of tegafur, 5-fluorouracil and 5-fluorodihydrouracil in plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925 |
| Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells. | British journal of cancer 20050725 |
| Improved analysis of 5-Fluorouracil and 5,6-dihydro-5-Fluorouracil by HPLC with diode array detection for determination of cellular dihydropyrimidine dehydrogenase activity and pharmacokinetic profiling. | Therapeutic drug monitoring 20050601 |
| 5-Fluorouracil catabolism to 5-fluoro-5,6-dihydrouracil is reduced by acute liver impairment in mice. | Toxicology and applied pharmacology 20050301 |
| A simple and sensitive fully validated HPLC-UV method for the determination of 5-fluorouracil and its metabolite 5,6-dihydrofluorouracil in plasma. | Therapeutic drug monitoring 20050201 |
| Feasibility of measuring 5-fluorouracil catabolic potential by oral loading. | The Journal of international medical research 20050101 |
| Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes. | Anti-cancer drugs 20041101 |
| Simple determination of capecitabine and its metabolites by liquid chromatography with ultraviolet detection in a single injection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040925 |
| Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients. | Pharmacological research 20040801 |
| [Assay method for uracil, dihydrouracil, 5-fluorouracil and 5-fluoro-5, 6-dihydrouracil by high-performance liquid chromatography]. | Gan to kagaku ryoho. Cancer & chemotherapy 20040301 |
| Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma. | British journal of cancer 20030818 |
| Extensive hepatic replacement due to liver metastases has no effect on 5-fluorouracil pharmacokinetics. | Cancer chemotherapy and pharmacology 20030201 |
| Limited sampling model for the analysis of 5-fluorouracil pharmacokinetics in adjuvant chemotherapy for colorectal cancer. | Clinical pharmacology and therapeutics 20021201 |
| Severe 5-fluorouracil toxicity associated with a marked alteration of pharmacokinetics of 5-fluorouracil and its catabolite 5-fluoro-5,6-dihydrouracil: a case report. | European journal of clinical pharmacology 20021201 |
| Relationship between plasma concentrations of 5-fluorouracil and 5-fluoro-5,6-dihydrouracil and toxicity of 5-fluorouracil infusions in cancer patients. | Therapeutic drug monitoring 20021001 |
| Simultaneous HPLC determination of 5-fluorouracil and its metabolites in plasma of cancer patients. | Biomedical chromatography : BMC 20021001 |
| Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene. | British journal of cancer 20020408 |
| Prognostic significance of dihydropyrimidine dehydrogenase expression in breast cancer. | British journal of cancer 20020121 |
| Synthesis and evaluation of N-acyl-2-(5-fluorouracil-1-yl)-D,L-glycine as a colon-specific prodrug of 5-fluorouracil. | Journal of pharmaceutical sciences 20011101 |
| High-performance liquid chromatographic assay with ultraviolet detection for quantification of dihydrofluorouracil in human lymphocytes: application to measurement of dihydropyrimidine dehydrogenase activity. | Journal of chromatography. B, Biomedical sciences and applications 20011025 |
| Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients. | Annals of oncology : official journal of the European Society for Medical Oncology 20010901 |