FOSMIDOMYCIN, SODIUM SALT
| Title | Journal |
|---|---|
| IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters. | Journal of medicinal chemistry 20131024 |
| Improved efficacy of fosmidomycin against Plasmodium and Mycobacterium species by combination with the cell-penetrating peptide octaarginine. | Antimicrobial agents and chemotherapy 20131001 |
| DXR inhibition by potent mono- and disubstituted fosmidomycin analogues. | Journal of medicinal chemistry 20130808 |
| Isoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum. | Eukaryotic cell 20130201 |
| Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR). | Bioorganic & medicinal chemistry letters 20121101 |
| α-Substituted β-oxa isosteres of fosmidomycin: synthesis and biological evaluation. | Journal of medicinal chemistry 20120726 |
| The isoprenoid-precursor dependence of Plasmodium spp. | Natural product reports 20120701 |
| Crystal structure of Brucella abortus deoxyxylulose-5-phosphate reductoisomerase-like (DRL) enzyme involved in isoprenoid biosynthesis. | The Journal of biological chemistry 20120504 |
| Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents. | European journal of medicinal chemistry 20120501 |
| Changes in the hydrocarbon-synthesizing activity during growth of Botryococcus braunii B70. | Bioresource technology 20120401 |
| Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts. | Metabolic engineering 20120101 |
| Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr): a review of the synthesis and biological evaluation of recent inhibitors. | Current topics in medicinal chemistry 20120101 |
| Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs. | Bioorganic & medicinal chemistry letters 20111201 |
| Floral odor bouquet loses its ant repellent properties after inhibition of terpene biosynthesis. | Journal of chemical ecology 20111201 |
| Synthesis of functionalized cinnamaldehyde derivatives by an oxidative Heck reaction and their use as starting materials for preparation of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors. | The Journal of organic chemistry 20111104 |
| New N-acetyltransferase fold in the structure and mechanism of the phosphonate biosynthetic enzyme FrbF. | The Journal of biological chemistry 20111014 |
| Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr). | Journal of medicinal chemistry 20111013 |
| Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ. | Chemical communications (Cambridge, England) 20110928 |
| Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20110915 |
| Resistance of the Burkholderia cepacia complex to fosmidomycin and fosmidomycin derivatives. | International journal of antimicrobial agents 20110901 |
| Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum. | PLoS biology 20110801 |
| Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase. | Journal of medicinal chemistry 20110728 |
| Isoprene synthesis in plants: lessons from a transgenic tobacco model. | Plant, cell & environment 20110601 |
| Induction of a longer term component of isoprene release in darkened aspen leaves: origin and regulation under different environmental conditions. | Plant physiology 20110601 |
| A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. | Biochemistry 20110503 |
| A high-throughput screening assay for simultaneous selection of inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate synthase (Dxs) or 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr). | Journal of biomolecular screening 20110301 |
| Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors. | Bioorganic & medicinal chemistry 20110201 |
| Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways. | PloS one 20110101 |
| Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites. | Current topics in medicinal chemistry 20110101 |
| Evidence of isoprenoid precursor toxicity in Bacillus subtilis. | Bioscience, biotechnology, and biochemistry 20110101 |
| Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis. | Proceedings of the National Academy of Sciences of the United States of America 20101012 |
| Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin. | ChemMedChem 20101004 |
| Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding. | Journal of structural biology 20100601 |
| Isoprenoid biosynthesis via the methylerythritol phosphate pathway: structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase. | The Journal of organic chemistry 20100521 |
| Effects of fosmidomycin on plant photosynthesis as measured by gas exchange and chlorophyll fluorescence. | Photosynthesis research 20100401 |
| A high-throughput colorimetric-based bioassay method for determination of fosmidomycin in plasma and urine and application for pharmacokinetic study. | Journal of pharmacological and toxicological methods 20100101 |
| The malarial drug target Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR): development of a 3-D model for identification of novel, structural and functional features and for inhibitor screening. | Protein and peptide letters 20100101 |
| Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. | Journal of medicinal chemistry 20091112 |
| Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. | Nature chemical biology 20091101 |
| The carotenogenesis pathway via the isoprenoid-beta-carotene interference approach in a new strain of Dunaliella salina isolated from Baja California Mexico. | Marine drugs 20090301 |
| The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells. | The Plant cell 20090101 |
| Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. | Genome biology 20090101 |
| The biosynthesis and accumulation of beta-carotene in Dunaliella salina proceed via the glyceraldehyde 3-phosphate/pyruvate pathway. | Natural product research 20090101 |
| Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). | PloS one 20090101 |
| Isoprene and nitric oxide reduce damages in leaves exposed to oxidative stress. | Plant, cell & environment 20081201 |
| Studies addressing the importance of charge in the binding of fosmidomycin-like molecules to deoxyxylulosephosphate reductoisomerase. | ChemMedChem 20080801 |
| Significance of terpenoids in induced indirect plant defence against herbivorous arthropods. | Plant, cell & environment 20080401 |
| Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors. | Chemistry & biodiversity 20080401 |
| Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates. | Bioorganic & medicinal chemistry 20080315 |
| Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake. | BMC microbiology 20080101 |
| Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria. | Malaria journal 20080101 |
| gamma-Substituted bis(pivaloyloxymethyl)ester analogues of fosmidomycin and FR900098. | Archiv der Pharmazie 20071201 |
| Synthesis and evaluation of alpha,beta-unsaturated alpha-aryl-substituted fosmidomycin analogues as DXR inhibitors. | Bioorganic & medicinal chemistry letters 20070901 |
| Assessment of in vitro antimalarial interactions between dihydroartemisinin and fosmidomycin. | The Southeast Asian journal of tropical medicine and public health 20070901 |
| The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: presence and sensitivity to fosmidomycin. | Experimental parasitology 20070801 |
| An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling. | Microbiology (Reading, England) 20070801 |
| Molecular epidemiology of malaria in Cameroon. XXV. In vitro activity of fosmidomycin and its derivatives against fresh clinical isolates of Plasmodium falciparum and sequence analysis of 1-deoxy-D-xylulose 5-phosphate reductoisomerase. | The American journal of tropical medicine and hygiene 20070801 |
| Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. | The Journal of biological chemistry 20070706 |
| Conformationally restrained aromatic analogues of fosmidomycin and FR900098. | Archiv der Pharmazie 20070701 |
| Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin. | Acta crystallographica. Section F, Structural biology and crystallization communications 20070601 |
| Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum. | Memorias do Instituto Oswaldo Cruz 20070601 |
| Divergent strategy for the synthesis of alpha-aryl-substituted fosmidomycin analogues. | The Journal of organic chemistry 20070511 |
| Bioassay for determination of fosmidomycin in plasma and urine: application for pharmacokinetic dose optimisation. | Journal of microbiological methods 20070401 |
| Pharmacokinetics and pharmacodynamics of fosmidomycin monotherapy and combination therapy with clindamycin in the treatment of multidrug resistant falciparum malaria. | Malaria journal 20070101 |
| [Evaluation of in vitro antibacterial activity of fosmidomycin and its derivatives]. | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20070101 |
| Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. | Journal of medicinal chemistry 20061214 |
| Arylmethyl substituted derivatives of Fosmidomycin: synthesis and antimalarial activity. | European journal of medicinal chemistry 20061201 |
| Isoprenoid biosynthesis in plants - 2C-methyl-D-erythritol-4-phosphate synthase (IspC protein) of Arabidopsis thaliana. | The FEBS journal 20061001 |
| Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098. | Bioorganic & medicinal chemistry 20060801 |
| The relationship between the methyl-erythritol phosphate pathway leading to emission of volatile isoprenoids and abscisic acid content in leaves. | Plant physiology 20060801 |
| Plastid cues posttranscriptionally regulate the accumulation of key enzymes of the methylerythritol phosphate pathway in Arabidopsis. | Plant physiology 20060501 |
| Involvement of 2-C-methyl-D-erythritol-4-phosphate pathway in biosynthesis of aphidicolin-like tetracyclic diterpene of Scoparia dulcis. | Chemical & pharmaceutical bulletin 20060501 |
| Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors. | Journal of medicinal chemistry 20060420 |
| Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase. | Bioorganic & medicinal chemistry 20060401 |
| Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors. | Bioorganic & medicinal chemistry letters 20060401 |
| A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. | Chembiochem : a European journal of chemical biology 20051001 |
| Fosmidomycin analogues as inhibitors of monoterpenoid indole alkaloid production in Catharanthus roseus cells. | Phytochemistry 20050801 |
| Alkoxycarbonyloxyethyl ester prodrugs of FR900098 with improved in vivo antimalarial activity. | Archiv der Pharmazie 20050701 |
| AFMoC enhances predictivity of 3D QSAR: a case study with DOXP-reductoisomerase. | Journal of medicinal chemistry 20050519 |
| Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations. | Journal of medicinal chemistry 20050505 |
| Isoprene decreases the concentration of nitric oxide in leaves exposed to elevated ozone. | The New phytologist 20050501 |
| [Effects of fosmidomycin and lovastatin treatment on taxol biosynthesis in suspension culture cells of Taxus chinensis]. | Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology 20050401 |
| Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase. | The Biochemical journal 20050215 |
| The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation. | Journal of molecular biology 20050107 |
| [Prevalence of nonmevalonate and mevalonate pathways for isoprenoid biosynthesis among bacteria of different systematic groups]. | Mikrobiologiia 20050101 |
| [Isoprenoid pigments in representatives of the family Microbacteriaceae]. | Mikrobiologiia 20050101 |
| The plastid of Plasmodium spp.: a target for inhibitors. | Current topics in microbiology and immunology 20050101 |
| The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum. | The Journal of biological chemistry 20041210 |
| 1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview. | Bioorganic chemistry 20041201 |
| Synthesis and biological evaluation with plant cells of new fosmidomycin analogues containing a benzoxazolone or oxazolopyridinone ring. | Journal of enzyme inhibition and medicinal chemistry 20041201 |
| Substrate analogs for the investigation of deoxyxylulose 5-phosphate reductoisomerase inhibition: synthesis and evaluation. | Bioorganic & medicinal chemistry letters 20041101 |
| Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum malaria. | The Journal of infectious diseases 20041101 |
| Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes. | Journal of the American Chemical Society 20040908 |
| Determination of fosmidomycin in human serum and urine by capillary electrophoresis. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040705 |
| Impact of ozone on monoterpene emissions and evidence for an isoprene-like antioxidant action of monoterpenes emitted by Quercus ilex leaves. | Tree physiology 20040401 |
| Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children. | The Journal of infectious diseases 20040301 |
| Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. | The Plant cell 20040101 |
| The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs. | Current pharmaceutical design 20040101 |
| Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq. | BMC plant biology 20040101 |
| Methyl palmitate: a novel product of the Medfly (Ceratitis capitata) corpus allatum. | Insect biochemistry and molecular biology 20031201 |
| New antimalarial drugs. | Angewandte Chemie (International ed. in English) 20031110 |
| Fosmidomycin resistance in adenylate cyclase deficient (cya) mutants of Escherichia coli. | Bioscience, biotechnology, and biochemistry 20030901 |
| Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells. | The Journal of biological chemistry 20030718 |
| Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity. | Bioorganic & medicinal chemistry letters 20030707 |
| High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition. | Journal of biomolecular screening 20030601 |
| Fosmidomycin for the treatment of malaria. | Parasitology research 20030601 |
| Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development. | The Journal of biological chemistry 20030516 |
| Natural abundance carbon isotope composition of isoprene reflects incomplete coupling between isoprene synthesis and photosynthetic carbon flow. | Plant physiology 20030401 |
| Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata. | Journal of biotechnology 20030306 |
| Fosmidomycin, a novel chemotherapeutic agent for malaria. | Antimicrobial agents and chemotherapy 20030201 |
| Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. | Biotechnology progress 20030101 |
| [Effect of fosfidomycin on development of various infections in mice]. | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20030101 |
| Alternative pathways of carotenoid biosynthesis in prokaryotes and eukaryotes. | Doklady. Biochemistry and biophysics 20030101 |
| Fosmidomycin for malaria. | Lancet (London, England) 20021214 |
| Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. | Plant physiology 20021101 |
| On-line analysis of the (13)CO(2) labeling of leaf isoprene suggests multiple subcellular origins of isoprene precursors. | Planta 20021001 |
| Mevalonate and nonmevalonate pathways for the biosynthesis of isoprene units. | Bioscience, biotechnology, and biochemistry 20020801 |
| Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. | Planta 20020601 |
| E. coli MEP synthase: steady-state kinetic analysis and substrate binding. | Biochemistry 20020108 |
| Isoprene produced by leaves protects the photosynthetic apparatus against ozone damage, quenches ozone products, and reduces lipid peroxidation of cellular membranes. | Plant physiology 20011201 |
| Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria. | Plant physiology 20011001 |
| 1-Deoxy-D-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening. | The Plant journal : for cell and molecular biology 20010801 |
| Isoprene increases thermotolerance of fosmidomycin-fed leaves. | Plant physiology 20010401 |
| Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. | Science (New York, N.Y.) 19990903 |