Ns 11394
| Title | Journal |
|---|---|
| A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling. | Molecular pharmacology 20130401 |
| Effects of positive allosteric modulators on single-cell oscillatory Ca2+ signaling initiated by the type 5 metabotropic glutamate receptor. | Molecular pharmacology 20091201 |
| Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold. | Bioorganic & medicinal chemistry letters 20080715 |
| N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. | Molecular pharmacology 20080301 |
| Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA. | Bioorganic & medicinal chemistry letters 20070301 |
| The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices. | European journal of pharmacology 20060501 |
| Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia. | Current topics in medicinal chemistry 20060101 |
| Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes. | The Journal of pharmacology and experimental therapeutics 20051201 |
| A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. | The Journal of pharmacology and experimental therapeutics 20050401 |
| Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. | Journal of medicinal chemistry 20041118 |
| A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. | The Journal of pharmacology and experimental therapeutics 20040501 |
| Difference in mGluR5 interaction between positive allosteric modulators from two structural classes. | Annals of the New York Academy of Sciences 20031101 |