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Gw4869

CAS No.:
6823-69-4
Catalog Number:
AG00FBIT
Molecular Formula:
C30H32Cl2N6O3
Molecular Weight:
595.5195
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥90%
1 week
United States
$112
- +
2mg
95%
1 week
United States
$182
- +
5mg
95%
1 week
United States
$237
- +
10mg
95%
1 week
United States
$362
- +
25mg
95%
1 week
United States
$696
- +
50mg
95%
1 week
United States
$1154
- +
100mg
95%
1 week
United States
$1862
- +
Product Description
Catalog Number:
AG00FBIT
Chemical Name:
Gw4869
CAS Number:
6823-69-4
Molecular Formula:
C30H32Cl2N6O3
Molecular Weight:
595.5195
MDL Number:
MFCD06411564
IUPAC Name:
(E)-3-[4-[(E)-3-[4-(4,5-dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide;dihydrochloride
InChI:
InChI=1S/C30H28N6O2.2ClH/c37-27(35-25-11-7-23(8-12-25)29-31-17-18-32-29)15-5-21-1-2-22(4-3-21)6-16-28(38)36-26-13-9-24(10-14-26)30-33-19-20-34-30;;/h1-16H,17-20H2,(H,31,32)(H,33,34)(H,35,37)(H,36,38);2*1H/b15-5+,16-6+;;
InChI Key:
NSFKAZDTKIKLKT-CLEIDKRQSA-N
SMILES:
O=C(Nc1ccc(cc1)C1=NCCN1)/C=C/c1ccc(cc1)/C=C/C(=O)Nc1ccc(cc1)C1=NCCN1.O.Cl.Cl
Properties
Complexity:
856  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
2  
Exact Mass:
576.181g/mol
Formal Charge:
0
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0
Molecular Weight:
577.51g/mol
Monoisotopic Mass:
576.181g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
107A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs. Oncotarget 20170321
Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells. The Journal of biological chemistry 20150424
Ceramide/sphingomyelin cycle involvement in gentamicin-induced cochlear hair cell death. Archives of toxicology 20150301
γ-Synuclein: seeding of α-synuclein aggregation and transmission between cells. Biochemistry 20120612
Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells. Journal of cellular biochemistry 20120601
The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice. Biochemical and biophysical research communications 20120504
Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral sphingomyelinase. Journal of vascular research 20120101
A key role for matrix metalloproteinases and neutral sphingomyelinase-2 in transplant vasculopathy triggered by anti-HLA antibody. Circulation 20111213
Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries. American journal of physiology. Cell physiology 20110701
An obligate role for membrane-associated neutral sphingomyelinase activity in orienting chemotactic migration of human neutrophils. American journal of respiratory cell and molecular biology 20110201
Identification and evaluation of neutral sphingomyelinase 2 inhibitors. Archives of pharmacal research 20110201
Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase. PloS one 20110101
Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice. Journal of neuroscience research 20101001
Secretory mechanisms and intercellular transfer of microRNAs in living cells. The Journal of biological chemistry 20100604
Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels. American journal of physiology. Gastrointestinal and liver physiology 20100601
Neutral sphingomyelinase 2 induces dopamine uptake through regulation of intracellular calcium. Cellular signalling 20100501
Purification of neutral sphingomyelinase 2 from bovine brain and its calcium-dependent activation. Journal of neurochemistry 20100201
Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Molecular cancer 20100101
Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors. Journal of neurochemistry 20090601
Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak(1)-1 and A-498 cells. Toxicology 20070105
Apolipoprotein C-I induces apoptosis in human aortic smooth muscle cells via recruiting neutral sphingomyelinase. Arteriosclerosis, thrombosis, and vascular biology 20040201
Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. The Journal of biological chemistry 20030418
Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. The Journal of biological chemistry 20021025
Properties