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daurisoline

CAS No.:
70553-76-3
Catalog Number:
AG00FBFY
Molecular Formula:
C37H42N2O6
Molecular Weight:
610.7392
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$173
- +
10mg
98%
1 week
United States
$257
- +
25mg
98%
1 week
United States
$507
- +
50mg
98%
1 week
United States
$840
- +
Product Description
Catalog Number:
AG00FBFY
Chemical Name:
daurisoline
CAS Number:
70553-76-3
Molecular Formula:
C37H42N2O6
Molecular Weight:
610.7392
MDL Number:
MFCD00221740
IUPAC Name:
(1R)-1-[[3-[4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]phenoxy]-4-hydroxyphenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
InChI:
InChI=1S/C37H42N2O6/c1-38-15-13-26-20-36(43-4)37(44-5)22-29(26)30(38)16-23-6-9-27(10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(42-3)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1
InChI Key:
BURJAQFYNVMZDV-FIRIVFDPSA-N
SMILES:
COc1cc2c(cc1OC)CCN([C@@H]2Cc1ccc(cc1)Oc1cc(ccc1O)C[C@H]1N(C)CCc2c1cc(O)c(c2)OC)C
Properties
Complexity:
917  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
610.304g/mol
Formal Charge:
0
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
610.751g/mol
Monoisotopic Mass:
610.304g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
83.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6.4  
Literature
Title Journal
Effect of daurisoline on HERG channel electrophysiological function and protein expression. Journal of natural products 20120928
Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium current. The American journal of Chinese medicine 20100101
[Effect of phenolic alkaloids of Menispermum dauricum on thrombosis and platelet aggregation]. Yao xue xue bao = Acta pharmaceutica Sinica 20051001
[Protective effects of phenolic alkaloids from Menispermum dauricum on inflammatory injury following focal cerebral ischemia-reperfusion in rats]. Yao xue xue bao = Acta pharmaceutica Sinica 20040801
[Determination of daurisoline in rabbit plasma and study on its pharmacokinetics]. Yao xue xue bao = Acta pharmaceutica Sinica 20031201
Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs. Acta pharmacologica Sinica 20031001
Interaction of multidrug resistance reversal agents with P-glycoprotein ATPase activity on blood-brain barrier. Acta pharmacologica Sinica 20020501
Properties