Home Other Building Blocks 11-DEHYDROCORTICOSTERONE

11-DEHYDROCORTICOSTERONE

CAS No.:
72-23-1
Catalog Number:
AG00FB0D
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00FB0D
Chemical Name:
11-DEHYDROCORTICOSTERONE
CAS Number:
72-23-1
MDL Number:
MFCD00046217
IUPAC Name:
(8S,9S,10R,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11-dione
InChI:
InChI=1S/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-16,19,22H,3-8,10-11H2,1-2H3/t14-,15-,16+,19+,20-,21-/m0/s1
InChI Key:
FUFLCEKSBBHCMO-KJQYFISQSA-N
EC Number:
200-776-2
UNII:
FO4V44A3G3
Properties
Complexity:
677  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
0
Exact Mass:
344.199g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
344.451g/mol
Monoisotopic Mass:
344.199g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
71.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.8  
Literature
Title Journal
Effects of Ziram on Rat and Human 11β-Hydroxysteroid Dehydrogenase Isoforms. Chemical research in toxicology 20160321
11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice. Molecular metabolism 20140801
Resveratrol inhibits 11β-hydroxysteroid dehydrogenase type 1 activity in rat adipose microsomes. The Journal of endocrinology 20130901
Local metabolism of glucocorticoids in Prague hereditary hypertriglyceridemic rats--effect of hypertriglyceridemia and gender. Steroids 20111101
Changes in 11beta-hydroxysteroid dehydrogenase type 2 expression in a low-protein rat model of intrauterine growth restriction. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101001
Microglia express functional 11 beta-hydroxysteroid dehydrogenase type 1. Glia 20100801
Effects of dehydroepiandrosterone sulfate on the conversion of corticosterone into 11-dehydrocorticosterone in stress: a regulatory scheme. Neuroscience and behavioral physiology 20090901
11beta-hydroxysteroid dehydrogenases are regulated during the pulmonary granulomatous response to the mycobacterial glycolipid trehalose-6,6'-dimycolate. Neuroimmunomodulation 20090101
Functional state of adrenocortical system in rats with manifest alloxan-induced diabetes mellitus. Bulletin of experimental biology and medicine 20081201
[Dehydroepiandrosterone sulfate effect at the conversion of corticosterone to 11-dehydrocorticosterone in stress conditions: the scheme of regulation]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20080801
Suppression of 11beta-hydroxysteroid dehydrogenase type 1 with RNA interference substantially attenuates 3T3-L1 adipogenesis. Physiological genomics 20080219
Renal interstitial corticosterone and 11-dehydrocorticosterone in conscious rats. American journal of physiology. Renal physiology 20070701
Development of an enzyme-linked immunosorbent assay for serum 11-dehydrocorticosterone in rat and mouse. Biological & pharmaceutical bulletin 20070301
Distinct features of dehydrocorticosterone reduction into corticosterone in the liver and duodenum of the domestic fowl (Gallus gallus domesticus). General and comparative endocrinology 20070101
MDCK cells express serotonin-regulable 11beta-hydroxysteroid dehydrogenase type 2. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20061201
Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes. Journal of immunology (Baltimore, Md. : 1950) 20060615
Cross talk between corticosteroids and alpha-adrenergic signalling augments cardiomyocyte hypertrophy: a possible role for SGK1. Cardiovascular research 20060601
[The activity of 11beta-hydroxysteroid dehydrogenase of rat kidney and liver at inherited stress-induced arterial hypertension]. Biomeditsinskaia khimiia 20060101
Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated. Molecular and cellular endocrinology 20051124
Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species. Journal of molecular endocrinology 20050801
Effect of high-fat diet on KKAy and ob/ob mouse liver and adipose tissue corticosterone and 11-dehydrocorticosterone concentrations. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050701
Ratio between the contents of 11-dehydrocorticosterone and corticosterone after acute and repeated stress: effect of dehydroepiandrosterone sulfate. Bulletin of experimental biology and medicine 20040801
Colitis up-regulates local glucocorticoid activation and down-regulates inactivation in colonic tissue. Scandinavian journal of gastroenterology 20040601
Transgenic expression of 11beta-hydroxysteroid dehydrogenase type 2 in osteoblasts reveals an anabolic role for endogenous glucocorticoids in bone. Endocrinology 20040201
Regulation of 11 beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol. American journal of physiology. Endocrinology and metabolism 20030801
Placental 11beta-hydroxysteroid dehydrogenase in Dahl and spontaneously hypertensive rats. American journal of hypertension 20030501
The severe form of hypertension caused by the activating S810L mutation in the mineralocorticoid receptor is cortisone related. Endocrinology 20030201
Glucocorticoid metabolism by 11-beta hydroxysteroid dehydrogenase type 2 modulates human mineralocorticoid receptor transactivation activity. The Journal of steroid biochemistry and molecular biology 20030201
Correction of age-related polyuria by dDAVP: molecular analysis of aquaporins and urea transporters. American journal of physiology. Renal physiology 20030101
11beta-hydroxysteroid dehydrogenase type 1: a new regulator of fetal lung maturation. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20021001
Foetal lung maturation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20021001
Annexin 1 (lipocortin 1) mimics inhibitory effects of glucocorticoids on testosterone secretion and enhances effects of interleukin-1beta. Endocrine 20020601
Reduced 11beta-hydroxysteroid dehydrogenase activity in experimental nephrotic syndrome. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020501
11 beta-Hydroxysteroid dehydrogenase antisense affects vascular contractile response and glucocorticoid metabolism. Steroids 20020301
Effect of cellular differentiation on 11beta-hydroxysteroid dehydrogenase activity in the intestine. Steroids 20020201
11Beta-hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart. Endocrinology 20020101
[Influence of diet without added bran on the contents of corticosteroid hormones in adrenal gland and blood plasma of rats]. Voprosy pitaniia 20020101
Therapeutic effect of glycyrrhetinic acid in MRL lpr/lpr mice: implications of alteration of corticosteroid metabolism. Life sciences 20011005
Oxidized glucocorticoids counteract glucocorticoid-induced apoptosis in murine thymocytes in vitro. Life sciences 20010518
Cloning and in vitro characterization of alpha 1(I)-collagen 11 beta-hydroxysteroid dehydrogenase type 2 transgenes as models for osteoblast-selective inactivation of natural glucocorticoids. Endocrinology 20010301
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