N-[3-[[[2-[(2,3-Dihydro-2-oxo-1h-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-n-methyl-methanesulfonamide
| Title | Journal |
|---|---|
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells. | International journal of cancer 20120715 |
| Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks. | Journal of medicinal chemistry 20120614 |
| Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. | Arthritis and rheumatism 20120501 |
| Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. | Molecular cancer therapeutics 20111101 |
| Clinical importance and potential use of small molecule inhibitors of focal adhesion kinase. | Anti-cancer agents in medicinal chemistry 20110901 |
| Transforming growth factor-β-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression. | Oncogene 20101209 |
| Bioluminescent imaging study: FAK inhibitor, PF-562,271, preclinical study in PC3M-luc-C6 local implant and metastasis xenograft models. | Cancer biology & therapy 20100701 |
| Emerging targets in osteoporosis disease modification. | Journal of medicinal chemistry 20100610 |
| Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model. | Cancer biology & therapy 20090501 |
| Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis. | Breast cancer research : BCR 20090101 |
| Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors: implications for bone metastases. | Cancer 20080515 |
| Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. | Cancer research 20080315 |