Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4h-chromene-3-carboxylate
| Title | Journal |
|---|---|
| The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells. | British journal of cancer 20120214 |
| Apoptosis sensitizers enhance cytotoxicity in hepatoblastoma cells. | Pediatric surgery international 20120201 |
| Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione. | Free radical biology & medicine 20120115 |
| BH3 mimetics activate multiple pro-autophagic pathways. | Oncogene 20110915 |
| Mitochondrial targeting by use of lipid nanocapsules loaded with SV30, an analogue of the small-molecule Bcl-2 inhibitor HA14-1. | Journal of controlled release : official journal of the Controlled Release Society 20110410 |
| Transient mitochondrial permeability transition pore opening after neonatal cardioplegic arrest. | The Journal of thoracic and cardiovascular surgery 20110401 |
| Blockade of electron transport during ischemia preserves bcl-2 and inhibits opening of the mitochondrial permeability transition pore. | FEBS letters 20110323 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Bcl-2 sustains hormetic response by inducing Nrf-2 nuclear translocation in L929 mouse fibroblasts. | Free radical biology & medicine 20101015 |
| Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death. | Apoptosis : an international journal on programmed cell death 20101001 |
| Inhibitors of Bcl-2 protein family deplete ER Ca2+ stores in pancreatic acinar cells. | Pflugers Archiv : European journal of physiology 20101001 |
| HA14-1 sensitizes TNF-alpha-induced apoptosis via inhibition of the NF-kappaB signaling pathway: involvement of reactive oxygen species and JNK. | Cancer letters 20100601 |
| Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells. | Cancer letters 20100428 |
| Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death. | Apoptosis : an international journal on programmed cell death 20100401 |
| Induction of apoptosis by esculetin in human leukemia U937 cells: roles of Bcl-2 and extracellular-regulated kinase signaling. | Toxicology in vitro : an international journal published in association with BIBRA 20100301 |
| Repeated cocaine administration increases B-cell leukemia/lymphoma 2 phosphorylation in the rat dorsal striatum. | Neuroscience letters 20100104 |
| Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells. | Breast cancer research and treatment 20100101 |
| Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum. | Journal of neuroscience research 20091201 |
| Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells. | Molecular cancer therapeutics 20091101 |
| Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways. | Biochemical and biophysical research communications 20091030 |
| Dual mechanisms of sHA 14-1 in inducing cell death through endoplasmic reticulum and mitochondria. | Molecular pharmacology 20090901 |
| Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. | Brain research 20090804 |
| Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress. | Cancer biology & therapy 20090501 |
| Piling up the JNK: drug synergy through ER stress. | Cancer biology & therapy 20090501 |
| Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells. | Toxicology in vitro : an international journal published in association with BIBRA 20090301 |
| Bcl-2 family members as molecular targets in cancer therapy. | Biochemical pharmacology 20081015 |
| Bcl2 mitigates Ca2+ entry and mitochondrial Ca2+ overload through downregulation of L-type Ca2+ channels in PC12 cells. | Cell calcium 20081001 |
| BH3 mimetics reactivate autophagic cell death in anoxia-resistant malignant glioma cells. | Neoplasia (New York, N.Y.) 20080801 |
| [Progress in small-molecule inhibitors of Bcl-2 family proteins]. | Yao xue xue bao = Acta pharmaceutica Sinica 20080701 |
| Effects of selective Bcl-2 inhibitor HA14-1 treatments on functional activity of magnocellular vasopressinergic neurons of rat hypothalamus. | Neuroscience letters 20080523 |
| Combined proteasome and Bcl-2 inhibition stimulates apoptosis and inhibits growth in EBV-transformed lymphocytes: a potential therapeutic approach to EBV-associated lymphoproliferative diseases. | European journal of haematology 20080501 |
| RhoA prevents apoptosis during zebrafish embryogenesis through activation of Mek/Erk pathway. | Oncogene 20080306 |
| sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell. | Cancer letters 20080208 |
| The Bcl-2 antagonist HA14-1 forms a fluorescent albumin complex that can be mistaken for several oxidized ROS probes. | Photochemistry and photobiology 20080101 |
| HA14-1 is able to reconstitute the impaired mitochondrial pathway of apoptosis in renal cell carcinoma cell lines. | Cellular oncology : the official journal of the International Society for Cellular Oncology 20080101 |
| Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL. | The Journal of biological chemistry 20071214 |
| Brefeldin A triggers apoptosis associated with mitochondrial breach and enhances HA14-1- and anti-Fas-mediated cell killing in follicular lymphoma cells. | Leukemia research 20071201 |
| Exploitation of drug-induced Bcl-2 overexpression for restoring normal apoptosis function: a promising new approach to the treatment of multidrug resistant cancer. | Cancer letters 20070808 |
| HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells. | Leukemia research 20070601 |
| Initiation of apoptosis and autophagy by the Bcl-2 antagonist HA14-1. | Cancer letters 20070508 |
| Small-molecule Bcl-2 inhibitors sensitise tumour cells to immune-mediated destruction. | British journal of cancer 20070226 |
| Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor. | Oncogene 20070201 |
| Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment. | Neurobiology of disease 20070201 |
| Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor. | Oncology reports 20070201 |
| Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis. | Molecular pharmaceutics 20070101 |
| Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. | Journal of medicinal chemistry 20061228 |
| Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells. | Experimental hematology 20061201 |
| Multiparametric analysis of HA14-1-induced apoptosis in follicular lymphoma cells. | Leukemia research 20060901 |
| Protection of Bcl-2 by salubrinal. | Biochemical and biophysical research communications 20060811 |
| Ceramide response post-photodamage is absent after treatment with HA14-1. | Biochemical and biophysical research communications 20060630 |
| The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death. | Cancer research 20060301 |
| Protective effect of donepezil on retinal ganglion cells in vitro and in vivo. | Current eye research 20060101 |
| Inhibition of CD95-mediated apoptosis through beta 1 integrin in the HSG epithelial cell line. | Cell communication & adhesion 20060101 |
| Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors. | The Journal of pharmacology and experimental therapeutics 20051201 |
| Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function. | Cell death and differentiation 20051101 |
| Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2. | Molecular cancer therapeutics 20051001 |
| Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl-2/Bcl-x(L) versus induction of the BH3-only protein Bim. | Journal of neurochemistry 20050701 |
| Susceptibility of myelomonocytic leukemia U937 cells to the induction of apoptosis by the non-peptidic Bcl-2 ligand HA14-1 is cell cycle phase-dependent. | Cancer letters 20050428 |
| Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells. | Cancer research 20050215 |
| Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20041215 |
| The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism. | Molecular cancer therapeutics 20041201 |
| Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2/Bcl-XL bispecific antisense oligonucleotides in HER-2 gene--amplified breast cancer cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20041115 |
| Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1. | Journal of hepatology 20041101 |
| A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2. | The Journal of biological chemistry 20040813 |
| A mechanism for the proapoptotic activity of ursodeoxycholic acid: effects on Bcl-2 conformation. | Cell death and differentiation 20040801 |
| Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells. | Cancer research 20040515 |
| Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor. | The Journal of biological chemistry 20040430 |
| Differential susceptibilities of murine hepatoma 1c1c7 and Tao cells to the lysosomal photosensitizer NPe6: influence of aryl hydrocarbon receptor on lysosomal fragility and protease contents. | Molecular pharmacology 20040401 |
| PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation. | Leukemia 20040301 |
| HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death. | Leukemia 20031101 |
| Bcl-2-related proteins as drug targets. | Current medicinal chemistry 20030801 |
| The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics. | Current medicinal chemistry. Anti-cancer agents 20030501 |
| The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195. | Molecular cancer therapeutics 20021001 |
| Apoptotic response to photodynamic therapy versus the Bcl-2 antagonist HA14-1. | Photochemistry and photobiology 20020901 |
| Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia. | Blood 20020501 |