Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice.

PloS one 20120101

Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR.

Journal of medicinal chemistry 20110922

The effect of oxycholesterols on thermo-induced membrane dynamics.

Biochimica et biophysica acta 20110901

Oxysterols direct B-cell migration through EBI2.

Nature 20110727

Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols.

Biochemical and biophysical research communications 20110617

Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress?

Free radical biology & medicine 20110615

Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime.

Aging cell 20110601

Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta.

Nutrition, metabolism, and cardiovascular diseases : NMCD 20110301

Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1.

Lipids in health and disease 20110101

Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: effective protection by epigallocatechin-3-gallate.

Free radical biology & medicine 20101215

Isolation and identification of two steroid compounds from Oviductus Ranae.

Natural product research 20101001

Dansylation of unactivated alcohols for improved mass spectral sensitivity and application to analysis of cytochrome P450 oxidation products in tissue extracts.

Analytical chemistry 20100915

Dimethyl sulfoxide prevents 7β-hydroxycholesterol-induced apoptosis by preserving lysosomes and mitochondria.

Journal of cardiovascular pharmacology 20100901

Prevention of 7β-hydroxycholesterol-induced cell death by mangafodipir is mediated through lysosomal and mitochondrial pathways.

European journal of pharmacology 20100825

The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice.

Neuroscience 20100811

Cholesterol 7alpha-hydroxylase (CYP7A1) activity is modified after chronic ingestion of depleted uranium in the rat.

The Journal of steroid biochemistry and molecular biology 20100501

Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands.

The Journal of biological chemistry 20100212

Antiapoptotic and proliferative effects of low concentrations of 7β-hydroxycholesterol in human endothelial cells via ERK activation.

Journal of vascular research 20100101

Effects of different rearing and feeding systems on lipid oxidation and antioxidant capacity of freeze-dried egg yolks.

Journal of agricultural and food chemistry 20091223

4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man.

International journal of clinical pharmacology and therapeutics 20091201

Oxidation of cholesterol and beta-sitosterol and prevention by natural antioxidants.

Journal of agricultural and food chemistry 20091014

Oxysterol-induced rearrangement of the liquid-ordered phase: a possible link to Alzheimer's disease?

Journal of the American Chemical Society 20090902

Efficient chemoenzymatic synthesis, cytotoxic evaluation, and SAR of epoxysterols.

Journal of medicinal chemistry 20090709

Increase of cholesterol oxidation and decrease of PUFA as a result of thermal processing and storage in eggs enriched with n-3 fatty acids.

Journal of agricultural and food chemistry 20090610

Elucidation of functions of human cytochrome P450 enzymes: identification of endogenous substrates in tissue extracts using metabolomic and isotopic labeling approaches.

Analytical chemistry 20090415

7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent.

Cell biology and toxicology 20090401

7beta-hydroxycholesterol induces apoptosis and regulates cyclooxygenase 2 in head and neck squamous cell carcinoma.

Archives of otolaryngology--head & neck surgery 20090301

Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS.

Journal of lipid research 20090201

A single step solid-phase extraction method for complete separation of sterol oxidation products in food lipids.

Journal of chromatography. A 20090102

Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis.

Atherosclerosis 20090101

7beta-hydroxycholesterol induces natural killer cell death via oxidative lysosomal destabilization.

Free radical research 20090101

The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide.

Journal of biochemical and molecular toxicology 20090101

Oxysterol as a marker of atherogenic dyslipidemia in adolescence.

The Journal of clinical endocrinology and metabolism 20081101

Plasma oxysterols in normal and cholestatic children as indicators of the two pathways of bile acid synthesis.

Clinica chimica acta; international journal of clinical chemistry 20080901

Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol.

Current eye research 20080901

Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells.

The British journal of nutrition 20080801

Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation.

Journal of lipid research 20080701

Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample.

Free radical biology & medicine 20080401

Ox-LDL induces monocyte-to-macrophage differentiation in vivo: Possible role for the macrophage colony stimulating factor receptor (M-CSF-R).

Atherosclerosis 20080201

Anthocyanin-rich Aronox extract from Aronia melanocarpa E protects against 7beta-hydroxycholesterol-induced apoptosis of endothelial cells.

Annals of nutrition & metabolism 20080101

Degradation of 24S-hydroxycholesterol in men is not regulated by CYP7A1.

International journal of clinical pharmacology and therapeutics 20071101

Novel LC-MS/MS method for assay of 7alpha-hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070901

In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress.

Free radical biology & medicine 20070901

Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease.

Clinica chimica acta; international journal of clinical chemistry 20070701

Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase.

Journal of internal medicine 20070501

Levels of lipid peroxidation in human plasma and erythrocytes: comparison between fatty acids and cholesterol.

Lipids 20070501

Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol.

FEBS letters 20070417

Effect of storage on cholesterol oxide formation and fatty acid alterations in egg powder.

Journal of agricultural and food chemistry 20070404

Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy.

Free radical biology & medicine 20070301

25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages.

Free radical research 20070301

Oxidative status of human low density lipoprotein isolated by anion-exchange high-performance liquid chromatography--assessment by total hydroxyoctadecadienoic acid, 7-hydroxycholesterol, and 8-iso-prostaglandin F(2alpha).

Analytica chimica acta 20070227

Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus.

Diabetes/metabolism research and reviews 20070101

Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7beta-hydroxysitosterol and 7beta-hydroxycholesterol triggered apoptosis in human colon cancer cells.

Apoptosis : an international journal on programmed cell death 20070101

Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids.

PloS one 20070101

Chemical constituents of the red alga Laurencia tristicha.

Journal of Asian natural products research 20070101

Death-signaling pathways in human myeloid cells by oxLDL and its cytotoxic components 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide.

Journal of biochemical and molecular toxicology 20070101

Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7beta-hydroxycholesterol and 7beta-hydroxysitosterol.

International journal of oncology 20061201

Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio.

Free radical biology & medicine 20061001

Formation of cholesterol oxidation products in marinated foods during heating.

Journal of agricultural and food chemistry 20060628

Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta(12,14)-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms.

The Journal of biological chemistry 20060519

Species differences among various rodents in the conversion of 7alpha-hydroxycholesterol in liver microsomes.

Steroids 20060501

Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat.

Archives of toxicology 20060401

Cholesterol-metabolizing cytochromes P450.

Drug metabolism and disposition: the biological fate of chemicals 20060401

High circulating levels of 7beta- and 7alpha-hydroxycholesterol and presence of apoptotic and oxidative markers in arterial lesions of normocholesterolemic atherosclerotic patients undergoing endarterectomy.

Pathologie-biologie 20060201

Kaempferol inhibits apoptosis in vascular smooth muscle induced by a component of oxidized LDL.

European journal of pharmacology 20060104

Skeletal muscle and liver oxysterols during fasting and alcohol exposure.

Metabolism: clinical and experimental 20060101

7beta-hydroxycholesterol reduces the extent of reactive gliosis caused by iron deposition in the hippocampus but does not attenuate the iron-induced seizures in rats.

Neuroscience 20060101

Involvement of calcium in 7beta -hydroxycholesterol and cholesterol-5beta,6beta -epoxide-induced apoptosis.

International journal of toxicology 20060101

An isocratic high-performance liquid chromatography assay for CYP7A1-catalyzed cholesterol 7alpha-hydroxylation.

Methods in molecular biology (Clifton, N.J.) 20060101

High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20051201

Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon carcinoma cell line (Caco-2).

Inflammation 20051201

7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death.

Journal of molecular and cellular cardiology 20051101

Foam cell death induced by 7beta-hydroxycholesterol is mediated by labile iron-driven oxidative injury: mechanisms underlying induction of ferritin in human atheroma.

Free radical biology & medicine 20051001

TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol.

Biochemical and biophysical research communications 20050812

Cytotoxic effect of 7beta-hydroxycholesterol on human NCI-H460 lung cancer cells.

Biological & pharmaceutical bulletin 20050801

Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species.

Journal of molecular endocrinology 20050801

Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages.

European journal of clinical investigation 20050801

Effects of dietary fat and oxidized cholesterol on gene expression in rat liver as assessed by cDNA expression array analysis.

European journal of nutrition 20050601

Effect of cholesterol and 7-beta hydroxycholesterol on glutathione status and nitric oxide production in murine peritoneal macrophages.

Indian journal of experimental biology 20050601

A minimally invasive technique for the evaluation of the regulatory steps of the two major pathways of bile acid synthesis.

Clinica chimica acta; international journal of clinical chemistry 20050501

Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis.

Biochemistry 20050308

Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.

The Journal of biological chemistry 20050225

Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells.

Cell death and differentiation 20050201

Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort.

Nephron. Clinical practice 20050101

[Cholesterol oxidation products in fresh and frozen shrimps, raw and grilled].

Nutricion hospitalaria 20050101

Activation of caspase-3-dependent and -independent pathways during 7-ketocholesterol- and 7beta-hydroxycholesterol-induced cell death: a morphological and biochemical study.

Journal of biochemical and molecular toxicology 20050101

Enhanced expression of natural resistance-associated macrophage protein 1 in atherosclerotic lesions may be associated with oxidized lipid-induced apoptosis.

Annals of the New York Academy of Sciences 20041201

Does brain specific 24S-hydroxycholesterol in plasma indicate the disruption of the blood-brain barrier in patients with ischemic stroke?

Neuroscience letters 20040923

Cytotoxicity of oxidized low-density lipoprotein in cultured RPE cells is dependent on the formation of 7-ketocholesterol.

Investigative ophthalmology & visual science 20040801

Detection of lipid peroxidation in vivo: total hydroxyoctadecadienoic acid and 7-hydroxycholesterol as oxidative stress marker.

Free radical research 20040801

Vitamin E is not deficient in human atherosclerotic plaques.

Arteriosclerosis, thrombosis, and vascular biology 20040701

Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme.

The Journal of biological chemistry 20040430

Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040401

Application of water-soluble radical initiator, 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride, to a study of oxidative stress.

Free radical research 20040401

Effect of cholesterol and 7beta-hydroxycholesterol on glutathione status and expression of Hsp70 in cultured murine peritoneal macrophages.

Indian journal of biochemistry & biophysics 20040201

Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque.

Arteriosclerosis, thrombosis, and vascular biology 20040101

Generation of an oxidative stress precedes caspase activation during 7beta-hydroxycholesterol-induced apoptosis in U937 cells.

Journal of biochemical and molecular toxicology 20040101

New internal standard for quantitative determination of oxyphytosterols by gas chromatography.

Journal of AOAC International 20040101

Inhibitory effects of red wine extracts on endothelial-dependent adhesive interactions with monocytes induced by oxysterols.

Biological research 20040101

Oral alpha-tocopherol supplementation inhibits lipid oxidation in established human atherosclerotic lesions.

Free radical research 20031101

Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man.

Free radical biology & medicine 20031015

Synthesis of deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids.

Steroids 20031001

Identification and quantification of cholesterol and cholesterol oxidation products in different types of Iberian hams.

Journal of agricultural and food chemistry 20030910

On the origin of the cholestenoic acids in human circulation.

Steroids 20030901

Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20030701

Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor.

Arteriosclerosis, thrombosis, and vascular biology 20030501

Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate.

Biochemical and biophysical research communications 20030411

Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line.

Life sciences 20030207

Serum 7alpha-hydroxycholesterol levels during liver regeneration after hepatectomy in humans.

Hepato-gastroenterology 20030101

Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation.

European journal of pharmacology 20021205

Simultaneous evaluation of HMG-CoA reductase and cholesterol 7alpha-hydroxylase activities by electrospray tandem MS.

Lipids 20021101

Cholesterol oxides, cholesterol, total lipid, and fatty acid composition in turkey meat.

Journal of agricultural and food chemistry 20021009

Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis.

The Journal of biological chemistry 20020913

Protection of superoxide-induced cholesterol oxidation by antioxidants in protic conditions.

International journal of food sciences and nutrition 20020901

Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals.

Biochemical pharmacology 20020801

A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken.

Steroids 20020701

Effect of oxysterols on hematopoietic progenitor cells.

Experimental hematology 20020701

Characteristics of 7 beta-hydroxycholesterol-induced cell death in a human monocytic blood cell line, U937, and a human hepatoma cell line, HepG2.

Toxicology in vitro : an international journal published in association with BIBRA 20020601

Effect of chronic ethanol feeding on oxysterols in rat liver.

Free radical research 20020601

Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters.

The British journal of nutrition 20020501

Cholesterol, hydroxycholesterols, and bile acids.

Biochemical and biophysical research communications 20020419

Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats.

Bioscience, biotechnology, and biochemistry 20020401

Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?

The Journal of laboratory and clinical medicine 20020201

Effects of combinations of 7beta-hydroxycholesterol and anticancer drugs or ionizing radiation on the proliferation of cultured tumor cells.

Anticancer research 20020101

Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

The Journal of biological chemistry 20011019

Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis.

American journal of physiology. Gastrointestinal and liver physiology 20011001

Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products.

Arteriosclerosis, thrombosis, and vascular biology 20011001

alpha-Tocopherol, but not gamma-tocopherol inhibits 7 beta-hydroxycholesterol-induced apoptosis in human U937 cells.

Free radical research 20010901

Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in humans.

Hepatology (Baltimore, Md.) 20010801

Apoptotic death of inflammatory cells in human atheroma.

Arteriosclerosis, thrombosis, and vascular biology 20010701

Influence of 7beta-hydroxycholesterol on glutathione status and nitric oxide production in macrophages: in vitro studies.

Indian journal of biochemistry & biophysics 20010601

Selective distribution of oxysterols in atherosclerotic lesions and human plasma lipoproteins.

Free radical research 20010501

Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols.

Atherosclerosis 20010401

Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells.

American journal of physiology. Cell physiology 20010301

Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration.

Journal of lipid research 20010301

Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX.

Journal of lipid research 20010201

Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study.

Journal of lipid research 20010101

Formation of cholesterol oxides in irradiated raw and cooked chicken meat during storage.

Poultry science 20010101

Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death.

Cell death and differentiation 20010101

Effect of 7beta-hydroxycholesterol on cellular redox status and heat shock protein 70 expression in macrophages.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20010101

Oxysterols, but not cholesterol, inhibit human immunodeficiency virus replication in vitro.

Antiviral chemistry & chemotherapy 19981101

Reduction of oxysterol levels up-regulates HMG-CoA reductase activity in rat liver.

Atherosclerosis 19970601

Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase.

FEBS letters 19900730