21-HYDROXYALLOPREGNANOLONE
| Title | Journal |
|---|---|
| Urinary corticosteroid excretion predicts left ventricular mass and proteinuria in chronic kidney disease. | Clinical science (London, England : 1979) 20120901 |
| Novel steroid inhibitors of glucose 6-phosphate dehydrogenase. | Journal of medicinal chemistry 20120510 |
| Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20111214 |
| Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments. | Neuropharmacology 20110601 |
| Pharmacological enhancement of δ-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice. | Pain 20110601 |
| Neurosteroid modulation of benzodiazepine-sensitive GABAA tonic inhibition in supraoptic magnocellular neurons. | American journal of physiology. Regulatory, integrative and comparative physiology 20110601 |
| Retrochalcone derivatives are positive allosteric modulators at synaptic and extrasynaptic GABA(A) receptors in vitro. | British journal of pharmacology 20110301 |
| Kindling alters neurosteroid-induced modulation of phasic and tonic GABAA receptor-mediated currents: role of phosphorylation. | Journal of neurochemistry 20110301 |
| Differential effects of two major neurosteroids on cerebellar and cortical GABA(A) receptor binding and function. | European journal of pharmacology 20110110 |
| Chronic ethanol exposure produces tolerance to elevations in neuroactive steroids: mechanisms and reversal by exogenous ACTH. | Journal of neurochemistry 20101001 |
| Mechanism of potentiation of a dysfunctional epilepsy-linked mutated GABA(A) receptor by a neurosteroid (3alpha, 21-dihydroxy-5alpha-pregnan-20-one): transient kinetic investigations. | Biochemistry 20100914 |
| Conjugated equine estrogen, with medroxyprogesterone acetate, enhances formation of 5alpha-reduced progestogens and reduces anxiety-like behavior of middle-aged rats. | Behavioural pharmacology 20100901 |
| Acute neurosteroids inhibit the spinal reflex potentiation via GABAergic neurotransmission. | American journal of physiology. Renal physiology 20100701 |
| Mnemonic effects of progesterone to mice require formation of 3alpha,5alpha-THP. | Neuroreport 20100602 |
| Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity. | Neuroscience letters 20100412 |
| Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans. | Alcoholism, clinical and experimental research 20100301 |
| Mirtazapine does not influence tetrahydrodeoxycorticosterone levels in depressed patients. | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20100301 |
| Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100217 |
| Neuroactive steroids after estrogen exposure in depressed postmenopausal women treated with sertraline and asymptomatic postmenopausal women. | Archives of women's mental health 20100201 |
| Structure of alpha6 beta3 delta GABA(A) receptors and their lack of ethanol sensitivity. | Journal of neurochemistry 20091201 |
| Changes in CCK-4 induced panic after treatment with the GABA-reuptake inhibitor tiagabine are associated with an increase in 3alpha,5alpha-tetrahydrodeoxycorticosterone concentrations. | Psychoneuroendocrinology 20091101 |
| Infusions of bicuculline to the ventral tegmental area attenuates sexual, exploratory, and anti-anxiety behavior of proestrous rats. | Pharmacology, biochemistry, and behavior 20091001 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Neurosteroids differentially modulate P2X ATP-gated channels through non-genomic interactions. | Journal of neurochemistry 20090701 |
| Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice. | Journal of pharmacological sciences 20090501 |
| Unanticipated structural and functional properties of delta-subunit-containing GABAA receptors. | The Journal of biological chemistry 20090320 |
| Conserved site for neurosteroid modulation of GABA A receptors. | Neuropharmacology 20090101 |
| Etomidate, propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant alpha4beta3delta and alpha4beta3 GABA A receptors expressed in HEK cells. | Neuropharmacology 20090101 |
| Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats. | Pharmacology, biochemistry, and behavior 20081201 |
| Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area. | Behavioural brain research 20081121 |
| Tonic GABAergic inhibition of sympathetic preganglionic neurons: a novel substrate for sympathetic control. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20081119 |
| In the ventral tegmental area, progestogens' membrane-mediated actions for lordosis of rats involve the second-messenger phospholipase C. | Brain research 20080916 |
| Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy. | Journal of neurochemistry 20080901 |
| GABAA receptor-mediated tonic currents in substantia gelatinosa neurons of rat spinal trigeminal nucleus pars caudalis. | Neuroscience letters 20080829 |
| Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080801 |
| Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy. | Epilepsia 20080701 |
| Cell type-specific GABA A receptor-mediated tonic inhibition in mouse neocortex. | Journal of neurophysiology 20080701 |
| alpha1beta2delta, a silent GABAA receptor: recruitment by tracazolate and neurosteroids. | British journal of pharmacology 20080301 |
| Infusions of 3alpha,5alpha-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3alpha,5alpha-THP in midbrain, hippocampus, diencephalon, and cortex of female rats. | Behavioural brain research 20080211 |
| The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy. | Metabolic brain disease 20071201 |
| Influence of epipregnanolone on the modulation of rapid tolerance to ethanol by neurosteroids. | Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20071201 |
| GABAA and glycine receptor-mediated transmission in rat lamina II neurones: relevance to the analgesic actions of neuroactive steroids. | The Journal of physiology 20070915 |
| PKC activation sets an upper limit to the functional plasticity of GABAergic transmission induced by endogenous neurosteroids. | The European journal of neuroscience 20070901 |
| Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex. | Cerebral cortex (New York, N.Y. : 1991) 20070801 |
| Acute effects of neurosteroids in a rodent model of primary paroxysmal dystonia. | Hormones and behavior 20070801 |
| Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070711 |
| Neurosteroid modulation of neuronal excitability and synaptic transmission in the rat medial vestibular nuclei. | The European journal of neuroscience 20070701 |
| Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities. | The Journal of physiology 20070615 |
| The neurosteroid THDOC differentially affects spatial behavior and anesthesia in Slow and Fast kindling rat strains. | Behavioural brain research 20070328 |
| Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070227 |
| Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites. | Nature 20061123 |
| Inhibition by alpha-tetrahydrodeoxycorticosterone (THDOC) of pre-sympathetic parvocellular neurones in the paraventricular nucleus of rat hypothalamus. | British journal of pharmacology 20061101 |
| Neurosteroid modulation of recombinant rat alpha5beta2gamma2L and alpha1beta2gamma2L GABA(A) receptors in Xenopus oocyte. | European journal of pharmacology 20061010 |
| Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma. | Neurochemistry international 20060901 |
| Kindling-induced alterations in GABAA receptor-mediated inhibition and neurosteroid activity in the rat piriform cortex. | The European journal of neuroscience 20060901 |
| GABAergic tonic inhibition of substantia gelatinosa neurons in mouse spinal cord. | Neuroreport 20060821 |
| In the ventral tegmental area, progestins have actions at D1 receptors for lordosis of hamsters and rats that involve GABA A receptors. | Hormones and behavior 20060801 |
| Increased neuroactive steroid concentrations in women with bipolar disorder or major depressive disorder. | Journal of clinical psychopharmacology 20060801 |
| Plastic neuronal changes in GABA(A) receptor gene expression induced by progesterone metabolites: in vitro molecular and functional studies. | Pharmacology, biochemistry, and behavior 20060801 |
| Tonic GABA(A) receptor-mediated currents in human brain. | The European journal of neuroscience 20060801 |
| Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions. | Pharmacology, biochemistry, and behavior 20060801 |
| Observational study on the stability of the psychological status during normal pregnancy and increased blood levels of neuroactive steroids with GABA-A receptor agonist activity. | Psychoneuroendocrinology 20060501 |
| Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3alpha,5alpha-THP-facilitated lordosis. | Psychopharmacology 20060501 |
| The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol. | The Journal of pharmacology and experimental therapeutics 20060301 |
| Action of two neuroactive steroids against motor seizures induced by pentetrazol in rats during ontogeny. | Physiological research 20060101 |
| Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls. | Prostaglandins, leukotrienes, and essential fatty acids 20060101 |
| Anticonvulsant action of three neurosteroids against cortical epileptic afterdischarges in immature rats. | Brain research bulletin 20051230 |
| The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses. | Epilepsia 20051201 |
| High affinity, heterogeneous displacement of [3H]EBOB binding to cerebellar GABA A receptors by neurosteroids and GABA agonists. | Neuropharmacology 20050901 |
| Neurosteroids exhibit differential effects on mIPSCs recorded from normal and seizure prone rats. | Journal of neurophysiology 20050901 |
| Systemic ethanol administration elevates deoxycorticosterone levels and chronic ethanol exposure attenuates this response. | Brain research 20050705 |
| Plasma concentrations of anxiolytic neuroactive steroids in men with panic disorder. | Psychiatry research 20050630 |
| Rapid non-genomic effect of glucocorticoid metabolites and neurosteroids on the gamma-aminobutyric acid-A receptor. | The European journal of neuroscience 20050401 |
| Attenuating 5alpha-pregnane-3alpha-ol-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures. | Epilepsy & behavior : E&B 20050301 |
| Type 10 17beta-hydroxysteroid dehydrogenase catalyzing the oxidation of steroid modulators of gamma-aminobutyric acid type A receptors. | Molecular and cellular endocrinology 20050114 |
| Panic induction with cholecystokinin-tetrapeptide (CCK-4) Increases plasma concentrations of the neuroactive steroid 3alpha, 5alpha tetrahydrodeoxycorticosterone (3alpha, 5alpha-THDOC) in healthy volunteers. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050101 |
| Preliminary evidence for an association between aggressive and hostile behaviour and 3alpha,5alpha-tetrahydroprogesterone plasma levels in schizophrenia. | Journal of psychiatry & neuroscience : JPN 20050101 |
| Effect of pregnancy and 5alpha-pregnan-3alpha-ol-20-one on atrial receptor afferent discharge in rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20041201 |
| Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040929 |
| Effects of the active neurosteroid allotetrahydrodeoxycorticosterone on long-term potentiation in the rat hippocampus: implications for depression. | Progress in neuro-psychopharmacology & biological psychiatry 20040901 |
| Long-term treatment with clozapine does not affect morning circulating levels of allopregnanolone and THDOC in patients with schizophrenia: a preliminary study. | Journal of clinical psychopharmacology 20040801 |
| Sites of positive allosteric modulation by neurosteroids on ionotropic gamma-aminobutyric acid receptor subunits. | FEBS letters 20040521 |
| Psychological effect of the oral contraceptive formulation containing 3 mg of drospirenone plus 30 microg of ethinyl estradiol. | Fertility and sterility 20040301 |
| Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats. | European journal of pharmacology 20040126 |
| Plasma concentrations of anxiolytic neurosteroids in men with normal anxiety scores: a correlation analysis. | Neuropsychobiology 20040101 |
| In the ventral tegmental area, G-proteins and cAMP mediate the neurosteroid 3alpha,5alpha-THP's actions at dopamine type 1 receptors for lordosis of rats. | Neuroendocrinology 20040101 |
| Fluoxetine may influence lordosis of rats through effects on midbrain 3 alpha,5 alpha-THP concentrations. | Annals of the New York Academy of Sciences 20031201 |
| Neurosteroids shift partial agonist activation of GABA(A) receptor channels from low- to high-efficacy gating patterns. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20031126 |
| Effects of olanzapine infusions to the ventral tegmental area on lordosis and midbrain 3alpha,5alpha-THP concentrations in rats. | Psychopharmacology 20031101 |
| Neurosteroid secretion in panic disorder. | Psychiatry research 20030530 |
| Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics. | The Journal of pharmacology and experimental therapeutics 20030501 |
| Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit. | Journal of neurophysiology 20030301 |
| Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions? | Trends in pharmacological sciences 20030301 |
| Gender differences in the regulation of 3 alpha-hydroxysteroid dehydrogenase in rat brain and sensitivity to neurosteroid-mediated stress protection. | Neuroscience 20030101 |
| Changes in expression of the neuropeptide Y Y1 receptor gene in the medial amygdala of transgenic mice during pregnancy and after delivery. | Journal of neurochemistry 20020901 |
| Alpha1 and alpha6 subunits specify distinct desensitization, deactivation and neurosteroid modulation of GABA(A) receptors containing the delta subunit. | Neuropharmacology 20020901 |
| GABA(A) receptor delta subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons. | Neuropharmacology 20020901 |
| Membrane-initiated events account for progesterone's ability to regulate intracellular free calcium levels and inhibit rat granulosa cell mitosis. | Biology of reproduction 20020801 |
| The clinical potentials of endogenous neurosteroids. | Drugs of today (Barcelona, Spain : 1998) 20020701 |
| Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine. | Journal of psychopharmacology (Oxford, England) 20020601 |
| Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501 |
| GABA(B) receptor-mediated increase of neurosteroids by gamma-hydroxybutyric acid. | Neuropharmacology 20020501 |
| Pregnenolone sulfate, dehydroepiandrosterone sulfate and allotetrahydrodeoxycorticosterone affect rapid tolerance to the hypothermic effect of ethanol. | Brain research bulletin 20020501 |
| A rapid method for obtaining finasteride, a 5alpha-reductase inhibitor, from commercial tablets. | Brain research. Brain research protocols 20020401 |
| The effects of the neuroactive steroid 3 alpha,5 alpha-THDOC on sleep in the rat. | Neuroreport 20020325 |
| Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020301 |
| Antinociceptive activity of a neurosteroid tetrahydrodeoxycorticosterone (5alpha-pregnan-3alpha-21-diol-20-one) and its possible mechanism(s) of action. | Indian journal of experimental biology 20011201 |
| 3Alpha-hydroxy-5alpha-pregnan-20-one levels and GABA(A) receptor-mediated 36Cl(-) flux across development in rat cerebral cortex. | Brain research. Developmental brain research 20011126 |
| Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011001 |
| Increased expression of the neuropeptide Y receptor Y(1) gene in the medial amygdala of transgenic mice induced by long-term treatment with progesterone or allopregnanolone. | Journal of neurochemistry 20011001 |
| Prolonged exposure to hypobaric hypoxia transiently reduces GABA(A) receptor number in mice cerebral cortex. | Brain research 20010309 |
| Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. | Epilepsia 20010301 |
| Heterogeneity of hippocampal GABA(A) receptors: regulation by corticosterone. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010101 |
| Age-related differences in neurosteroid potentiation of muscimol-stimulated 36Cl(-) flux following chronic ethanol treatment. | Neuroscience 20010101 |
| Stress and neuroactive steroids. | International review of neurobiology 20010101 |