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Tasimelteon

CAS No.:
609799-22-6
Catalog Number:
AG00ECGF
Molecular Formula:
C15H19NO2
Molecular Weight:
245.3169
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$91
- +
5mg
99%
1 week
United States
$140
- +
10mg
99%
1 week
United States
$182
- +
50mg
99%
1 week
United States
$460
- +
100mg
99%
1 week
United States
$737
- +
Product Description
Catalog Number:
AG00ECGF
Chemical Name:
Tasimelteon
CAS Number:
609799-22-6
Molecular Formula:
C15H19NO2
Molecular Weight:
245.3169
MDL Number:
MFCD09033789
IUPAC Name:
N-[[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl]propanamide
InChI:
InChI=1S/C15H19NO2/c1-2-15(17)16-9-10-8-13(10)11-4-3-5-14-12(11)6-7-18-14/h3-5,10,13H,2,6-9H2,1H3,(H,16,17)/t10-,13+/m0/s1
InChI Key:
PTOIAAWZLUQTIO-GXFFZTMASA-N
SMILES:
CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2
EC Number:
612-059-5
UNII:
SHS4PU80D9
Properties
Complexity:
318  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
245.142g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
245.322g/mol
Monoisotopic Mass:
245.142g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
38.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.2  
Literature
Title Journal
Tasimelteon: a selective and unique receptor binding profile. Neuropharmacology 20150401
Tasimelteon for the treatment of non-24-hour sleep-wake disorder. Drugs of today (Barcelona, Spain : 1998) 20150101
Mechanism of action of tasimelteon in non-24 sleep-wake syndrome: treatment for a circadian rhythm disorder in blind patients. CNS spectrums 20141201
Cardiovascular effects of melatonin receptor agonists. Expert opinion on investigational drugs 20121101
Melatonin and synthetic melatonergic agonists: actions and metabolism in the central nervous system. Central nervous system agents in medicinal chemistry 20120901
Circadian and wakefulness-sleep modulation of cognition in humans. Frontiers in molecular neuroscience 20120101
cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents. PloS one 20120101
Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction. TheScientificWorldJournal 20120101
Recent progress in the development of agonists and antagonists for melatonin receptors. Current medicinal chemistry 20120101
Melatonin receptor agonists: new options for insomnia and depression treatment. CNS neuroscience & therapeutics 20111201
Therapeutic potential of melatonin and its analogs in Parkinson's disease: focus on sleep and neuroprotection. Therapeutic advances in neurological disorders 20110901
Tasimelteon for insomnia. Expert opinion on investigational drugs 20110701
Melatonin agonists in primary insomnia and depression-associated insomnia: are they superior to sedative-hypnotics? Progress in neuro-psychopharmacology & biological psychiatry 20110601
Neurochemical and neuropharmacological aspects of circadian disruptions: an introduction to asynchronization. Current neuropharmacology 20110601
Melatonin and the metabolic syndrome: physiopathologic and therapeutical implications. Neuroendocrinology 20110101
Disrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin. Neuro endocrinology letters 20110101
Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. Advances in therapy 20101101
[The newer sedative-hypnotics]. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20100901
A systematic, updated review on the antidepressant agomelatine focusing on its melatonergic modulation. Current neuropharmacology 20100901
Investigational melatonin receptor agonists. Expert opinion on investigational drugs 20100601
Melatonin agonists and insomnia. Expert review of neurotherapeutics 20100201
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20100101
Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders. Current opinion in investigational drugs (London, England : 2000) 20090701
Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat. Neuroscience letters 20090626
New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists. Neuropsychiatric disease and treatment 20090101
Melatonin and its agonists: an update. The British journal of psychiatry : the journal of mental science 20081001
Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: method validation and application. Journal of pharmaceutical and biomedical analysis 20050901
Preclinical pharmacokinetics and metabolism of BMS-214778, a novel melatonin receptor agonist. Journal of pharmaceutical sciences 20030401
Properties