Ly404039
| Title | Journal |
|---|---|
| Effects of a novel mGlu₂/₃ receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid. | Psychopharmacology 20120201 |
| Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: exemplified by activity of an mGlu2/3 receptor agonist. | Psychopharmacology 20110301 |
| Reduced cAMP, Akt activation and p65-c-Rel dimerization: mechanisms involved in the protective effects of mGluR3 agonists in cultured astrocytes. | PloS one 20110101 |
| LY-2140023, a prodrug of the group II metabotropic glutamate receptor agonist LY-404039 for the potential treatment of schizophrenia. | Current opinion in investigational drugs (London, England : 2000) 20100701 |
| Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2(High) receptor. | Synapse (New York, N.Y.) 20091001 |
| Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039). | The Journal of pharmacology and experimental therapeutics 20080701 |
| Glutamate agonists for schizophrenia stimulate dopamine D2High receptors. | Schizophrenia research 20080201 |
| Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial. | Nature medicine 20070901 |
| In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders. | Psychopharmacology 20070701 |
| Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039). | The Journal of pharmacology and experimental therapeutics 20070401 |
| Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors. | Journal of medicinal chemistry 20070125 |