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Boc-d-fmk

CAS No.:
634911-80-1
Catalog Number:
AG00ECD6
Molecular Formula:
Molecular Weight:
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
95%
1 week
United States
$140
- +
5mg
95%
1 week
United States
$307
- +
10mg
95%
1 week
United States
$432
- +
50mg
95%
1 week
United States
$1487
- +
Product Description
Catalog Number:
AG00ECD6
Chemical Name:
Boc-d-fmk
CAS Number:
634911-80-1
MDL Number:
MFCD03453073
IUPAC Name:
methyl 5-fluoro-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxopentanoate
InChI:
InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)
InChI Key:
MXOOUCRHWJYCAL-UHFFFAOYSA-N
Properties
Complexity:
324  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
263.117g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
263.265g/mol
Monoisotopic Mass:
263.117g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
81.7A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
0.9  
Literature
Title Journal
α7 Nicotinic receptor activation reduces β-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling. Journal of neurochemistry 20111101
Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling. Hearing research 20090901
Pan-caspase inhibition suppresses polyethylene particle-induced osteolysis. Apoptosis : an international journal on programmed cell death 20090201
Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge. Journal of gastroenterology and hepatology 20080801
New insights into peripherin expression in cochlear neurons. Neuroscience 20071130
Flow cytometry analysis of single-strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20071101
Broad-spectrum caspase inhibitors: from myth to reality? Cell death and differentiation 20070201
Novel cell death pathways induced by N-(4-hydroxyphenyl)retinamide: therapeutic implications. Molecular cancer therapeutics 20070101
Silvestrol, a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7. Anticancer research 20070101
zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells. Experimental & molecular medicine 20061231
Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Molecular cancer therapeutics 20060901
The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006. Oncogene 20051020
Inhibition of N-methyl-D-aspartate receptors increases paraoxon-induced apoptosis in cultured neurons. Toxicology and applied pharmacology 20051001
Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes. Free radical biology & medicine 20050901
Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway. Biochemical and biophysical research communications 20050603
Tirapazamine cytotoxicity for neuroblastoma is p53 dependent. Clinical cancer research : an official journal of the American Association for Cancer Research 20050401
Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways. Molecular cancer therapeutics 20050301
Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney. European journal of pharmacology 20041025
A cell-based screen for drugs to treat Huntington's disease. Neurobiology of disease 20040801
Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors. Clinical cancer research : an official journal of the American Association for Cancer Research 20040601
Silica-exposed mice generate autoantibodies to apoptotic cells. Toxicology 20040215
Caspase-3 activation in systemic anaplastic large-cell lymphoma. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20040101
Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction. Clinical cancer research : an official journal of the American Association for Cancer Research 20031001
Protein kinase C inhibition induces DNA fragmentation in COLO 205 cells which is blocked by cysteine protease inhibition but not mediated through caspase-3. Experimental cell research 20030910
Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis : an international journal on programmed cell death 20030801
Caspase-dependent and -independent apoptosis of mast cells induced by withdrawal of IL-3 is prevented by Toll-like receptor 4-mediated lipopolysaccharide stimulation. European journal of immunology 20030801
Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats. Experimental neurology 20030601
The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway. Cell death and differentiation 20010701
Properties