Home Other Building Blocks BAY 61-3606 dihydrochloride

BAY 61-3606 dihydrochloride

CAS No.:
648903-57-5
Catalog Number:
AG00ECCT
Molecular Formula:
C20H20Cl2N6O3
Molecular Weight:
463.3172
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$307
- +
10mg
98%
1 week
United States
$490
- +
50mg
98%
1 week
United States
$1657
- +
Product Description
Catalog Number:
AG00ECCT
Chemical Name:
BAY 61-3606 dihydrochloride
CAS Number:
648903-57-5
Molecular Formula:
C20H20Cl2N6O3
Molecular Weight:
463.3172
MDL Number:
MFCD08276916
IUPAC Name:
2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide;dihydrochloride
InChI:
InChI=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);2*1H
InChI Key:
SPMFEULFGGPQLN-UHFFFAOYSA-N
SMILES:
COc1cc(ccc1OC)c1nc(Nc2ncccc2C(=O)N)n2c(c1)ncc2.Cl.Cl
UNII:
96PPV9GQ7A
Properties
Complexity:
566  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
462.097g/mol
Formal Charge:
0
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
463.319g/mol
Monoisotopic Mass:
462.097g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
117A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells. PloS one 20160101
Jedi-1 and MEGF10 signal engulfment of apoptotic neurons through the tyrosine kinase Syk. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120919
Spleen tyrosine kinase mediates high glucose-induced transforming growth factor-β1 up-regulation in proximal tubular epithelial cells. Experimental cell research 20120910
ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways. Journal of thrombosis and haemostasis : JTH 20120601
BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PloS one 20120101
Comparison of the anti-allergic activity of Syk inhibitors with optimized Syk siRNAs in FcepsilonRI-activated RBL-2H3 basophilic cells. Cellular immunology 20100101
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proceedings of the National Academy of Sciences of the United States of America 20071218
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. The Journal of pharmacology and experimental therapeutics 20030901
Properties