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sultiame

CAS No.:
61-56-3
Catalog Number:
AG00EBXR
Molecular Formula:
C10H14N2O4S2
Molecular Weight:
290.3592
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Purity
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Product Description
Catalog Number:
AG00EBXR
Chemical Name:
sultiame
CAS Number:
61-56-3
Molecular Formula:
C10H14N2O4S2
Molecular Weight:
290.3592
MDL Number:
MFCD00865304
IUPAC Name:
4-(1,1-dioxothiazinan-2-yl)benzenesulfonamide
InChI:
InChI=1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16)
InChI Key:
HMHVCUVYZFYAJI-UHFFFAOYSA-N
SMILES:
O=S1(=O)CCCCN1c1ccc(cc1)S(=O)(=O)N
EC Number:
200-511-0
UNII:
I00Q766CZ2
Properties
Complexity:
481  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
290.039g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
290.352g/mol
Monoisotopic Mass:
290.039g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
114A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.1  
Literature
Title Journal
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Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. Bioorganic & medicinal chemistry letters 20091201
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates? Chemical biology & drug design 20090901
Rational treatment options with AEDs and ketogenic diet in Landau-Kleffner syndrome: still waiting after all these years. Epilepsia 20090801
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorganic & medicinal chemistry 20090715
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Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES). Epilepsia 20090601
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Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate. Journal of medicinal chemistry 20090423
Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings. Bioorganic & medicinal chemistry letters 20090215
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Treatment of epilepsy in Rett syndrome. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20070101
A single dose of sulthiame induces a selective increase in resting motor threshold in human motor cortex: A transcranial magnetic stimulation study. Epilepsy research 20061101
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Recurrent absence status epilepticus (spike-and-wave stupor) associated with lamotrigine therapy. Journal of child neurology 20060901
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Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain. Experimental neurology 20050601
Perisylvian polymicrogyria in Landau-Kleffner syndrome. Neurology 20050510
Visually self-induced seizures sensitive to round objects. Epilepsia 20050501
Effect of antiepileptic drug polytherapy on crystalluria. Pediatric neurology 20050201
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[The risk of second seizure in children with benign childhood epilepsy with centrotemporal spikes without treatment--a prospective study]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20050101
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Effect of antiepileptic drug monotherapy on crystalluria in children and young adults. Journal of neurology 20031001
Treatment with Sulthiame (Ospolot) in benign partial epilepsy of childhood and related syndromes: an open clinical and EEG study. Neuropediatrics 20030401
The influence of sulthiame on EEG in children with benign childhood epilepsy with centrotemporal spikes (BECTS). Epilepsia 20030201
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Phenytoin (Dilantin) intoxication. Acta neurologica Scandinavica 19670101
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