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DESMETHYL MIRTAZAPINE

CAS No.:
61337-68-6
Catalog Number:
AG00EBXP
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00EBXP
Chemical Name:
DESMETHYL MIRTAZAPINE
CAS Number:
61337-68-6
MDL Number:
MFCD09840377
IUPAC Name:
2,5,19-triazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene
InChI:
InChI=1S/C16H17N3/c1-2-6-14-12(4-1)10-13-5-3-7-18-16(13)19-9-8-17-11-15(14)19/h1-7,15,17H,8-11H2
InChI Key:
FGLAMNFOHWVQOH-UHFFFAOYSA-N
Properties
Complexity:
319  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
251.142g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
251.333g/mol
Monoisotopic Mass:
251.142g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
28.2A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8  
Literature
Title Journal
Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: a pilot study. Veterinary journal (London, England : 1997) 20120501
Enantiomeric separation of mirtazapine and its metabolite in rat plasma by reverse polar ionic liquid chromatography using fluorescence and polarimetric detectors connected in series. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110701
Enantioselective analysis of mirtazapine, demethylmirtazapine and 8-hydroxy mirtazapine in human urine after solid-phase microextraction. Journal of separation science 20100201
Steady-state concentrations of mirtazapine, N-desmethylmirtazapine, 8-hydroxymirtazapine and their enantiomers in relation to cytochrome P450 2D6 genotype, age and smoking behaviour. Clinical pharmacokinetics 20090101
No influence of dialysis on mirtazapine - a case report. Pharmacopsychiatry 20081101
Capillary electrophoretic chiral determination of mirtazapine and its main metabolites in human urine after enzymatic hydrolysis. Electrophoresis 20080901
Enantioselective separation of the novel antidepressant mirtazapine and its main metabolites by CEC. Electrophoresis 20070801
Transfer of the antidepressant mirtazapine into breast milk. British journal of clinical pharmacology 20070301
Therapeutic drug monitoring of mirtazapine, desmethylmirtazapine, 8-hydroxymirtazapine, and mirtazapine-N-oxide by enantioselective HPLC with fluorescence detection. Therapeutic drug monitoring 20061201
Tissue distribution of mirtazapine and desmethylmirtazapine in a case of mirtazapine poisoning. Forensic science international 20060127
Mirtazapine enantiomers in blood and cerebrospinal fluid. Neuropsychobiology 20060101
Inter- and intraindividual pharmacokinetic variations of mirtazapine and its N-demethyl metabolite in patients treated for major depressive disorder: a 6-month therapeutic drug monitoring study. Therapeutic drug monitoring 20050801
Chirality in the new generation of antidepressants: stereoselective analysis of the enantiomers of mirtazapine, N-demethylmirtazapine, and 8-hydroxymirtazapine by LC-MS. Therapeutic drug monitoring 20040801
Therapeutic drug monitoring of mirtazapine and its metabolite desmethylmirtazapine by HPLC with fluorescence detection. Therapeutic drug monitoring 20040601
Therapeutic drug monitoring of the antidepressant mirtazapine and its N-demethylated metabolite in human serum. Therapeutic drug monitoring 20040201
Properties