Home Other Building Blocks ALPHA-HYDROXYMETOPROLOL

ALPHA-HYDROXYMETOPROLOL

CAS No.:
56392-16-6
Catalog Number:
AG00EBW8
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00EBW8
Chemical Name:
ALPHA-HYDROXYMETOPROLOL
CAS Number:
56392-16-6
MDL Number:
MFCD00871829
IUPAC Name:
1-[4-(1-hydroxy-2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
InChI:
InChI=1S/C15H25NO4/c1-11(2)16-8-13(17)9-20-14-6-4-12(5-7-14)15(18)10-19-3/h4-7,11,13,15-18H,8-10H2,1-3H3
InChI Key:
OFRYBPCSEMMZHR-UHFFFAOYSA-N
Properties
Complexity:
242  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
283.178g/mol
Formal Charge:
0
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
283.368g/mol
Monoisotopic Mass:
283.178g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
71A^2
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0
XLogP3:
0.3  
Literature
Title Journal
Mineralization of metoprolol by electro-Fenton and photoelectro-Fenton processes. The journal of physical chemistry. A 20110224
Simultaneous RP-HPLC determination of sotalol, metoprolol, alpha-hydroxymetoprolol, paracetamol and its glucuronide and sulfate metabolites in human urine. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20090601
Influence of CYP2D6*10 on the pharmacokinetics of metoprolol in healthy Korean volunteers. Journal of clinical pharmacy and therapeutics 20081001
Inhibition of metoprolol metabolism and potentiation of its effects by paroxetine in routinely treated patients with acute myocardial infarction (AMI). European journal of clinical pharmacology 20080301
The relevance of CYP2D6 genetic polymorphism on chronic metoprolol therapy in cardiovascular patients. Journal of clinical pharmacy and therapeutics 20060201
Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study. Clinical pharmacology and therapeutics 20051001
Stereoselective analysis of metoprolol and its metabolites in rat plasma with application to oxidative metabolism. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050905
Stereoselective metabolism of metoprolol: enantioselectivity of alpha-hydroxymetoprolol in plasma and urine. Chirality 20030601
Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment. Pharmacogenetics 20020801
Influence of input rate on the stereospecific and nonstereospecific first pass metabolism and pharmacokinetics of metoprolol extended release formulations. Chirality 20020505
The influence of first pass metabolism on the development and validation of an IVIVC for metoprolol extended release tablets. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020501
Enantiomeric separation of metoprolol and alpha-hydroxymetoprolol by liquid chromatography and fluorescence detection using a chiral stationary phase. Journal of chromatography. B, Biomedical sciences and applications 20010715
Properties