Home Other Building Blocks ZIMELIDINE DIHYDROCHLORIDE

ZIMELIDINE DIHYDROCHLORIDE

CAS No.:
56775-88-3
Catalog Number:
AG00EB3L
Molecular Formula:
Molecular Weight:
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
Product Description
Catalog Number:
AG00EB3L
Chemical Name:
ZIMELIDINE DIHYDROCHLORIDE
CAS Number:
56775-88-3
MDL Number:
MFCD00865433
IUPAC Name:
(Z)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-3-ylprop-2-en-1-amine
InChI:
InChI=1S/C16H17BrN2/c1-19(2)11-9-16(14-4-3-10-18-12-14)13-5-7-15(17)8-6-13/h3-10,12H,11H2,1-2H3/b16-9-
InChI Key:
OYPPVKRFBIWMSX-SXGWCWSVSA-N
UNII:
3J928617DW
Properties
Complexity:
293  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
316.058g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
317.23g/mol
Monoisotopic Mass:
316.058g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
16.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9  
Literature
Title Journal
Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. Chemical research in toxicology 20170515
A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicological sciences : an official journal of the Society of Toxicology 20140101
Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicological sciences : an official journal of the Society of Toxicology 20131201
Medial amygdaloid nucleus 5-HT₂c receptors are involved in the hypophagic effect caused by zimelidine in rats. Neuropharmacology 20120801
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Comparison of a genomic and a multiplex cell imaging approach for the detection of phospholipidosis. Toxicology in vitro : an international journal published in association with BIBRA 20111001
Serotonin released from amacrine neurons is scavenged and degraded in bipolar neurons in the retina. Journal of neurochemistry 20091001
Reactivity of 5-HT1A receptor in adult rats after neonatal noradrenergic neurons' lesion--implications for antidepressant-like action. Brain research 20081106
Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicological sciences : an official journal of the Society of Toxicology 20070301
Desensitization of 5-HT(1A) autoreceptors induced by neonatal DSP-4 treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070115
Zimelidine decreases seizure susceptibility in stressed mice. Journal of neural transmission (Vienna, Austria : 1996) 20061201
Post-stress facilitation of serotonergic, but not noradrenergic, neurotransmission in the dorsal hippocampus prevents learned helplessness development in rats. Brain research 20060504
A selective serotonin reuptake inhibitor reduces REM sleep in the homing pigeon. Physiology & behavior 20060330
Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry. Neurochemistry international 20051001
Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities. Brain research 20050928
A role for norepinephrine in the regulation of context-dependent ZENK expression in male zebra finches (Taeniopygia guttata). The European journal of neuroscience 20050401
A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicological sciences : an official journal of the Society of Toxicology 20050201
Synthesis and evaluation of radiolabeled analogs of the antidepressant drug zimelidine as potential SPECT-ligands for the serotonin transporter. Nuclear medicine and biology 20040701
Activation of post-synaptic 5-HT(1A) receptors in the dorsal hippocampus prevents learned helplessness development. Brain research 20030718
Effects of autoshaping procedures on 3H-8-OH-DPAT-labeled 5-HT1a binding and 125I-LSD-labeled 5-HT2a binding in rat brain. Brain research 20030613
Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac). British journal of pharmacology 20030301
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Hospital outcomes in major teaching, minor teaching, and nonteaching hospitals in New York state. The American journal of medicine 20020301
A paradigm shift in brain research. Science (New York, N.Y.) 20011102
Antagonism of nicotinic acetylcholine receptors by inhibitors of monoamine uptake. Molecular psychiatry 20010901
Antidepressant drug-induced alterations in neuron-localized tumor necrosis factor-alpha mRNA and alpha(2)-adrenergic receptor sensitivity. The Journal of pharmacology and experimental therapeutics 20010501
Correction: a note on the discovery of selective serotonin reuptake inhibitors. Life sciences 19970101
Amphetamine and antidepressant drug effects on GABA- and NMDA-related seizures. Brain research bulletin 19930101
The specificity of the zimelidine reaction. International clinical psychopharmacology 19890101
Acute effects of maprotiline, doxepin and zimeldine with alcohol in healthy volunteers. Archives internationales de pharmacodynamie et de therapie 19880101
Increased adult behavioral 'despair' in rats neonatally exposed to desipramine or zimeldine: an animal model of depression? Pharmacology, biochemistry, and behavior 19871101
EEG assessment of the sedative and excitatory properties of CNS-active compounds in the patients with depression. Neuropsychobiology 19870101
The effect of zimelidine, a serotonin-reuptake blocker, on cataplexy and daytime sleepiness of narcoleptic patients. Clinical neuropharmacology 19860101
Effects of zimeldine, mianserin and amitriptyline on psychomotor skills and their interaction with ethanol a placebo controlled cross-over study. European journal of clinical pharmacology 19840101
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. Neuropsychobiology 19840101
[Adverse effects and zimelidine therapy. Headache, muscle pain and liver involvement--a new disease entity in zimelidine therapy]. Lakartidningen 19830105
Pharmacokinetic study of zimelidine using a new GLC method. Clinical pharmacokinetics 19830101
Comparison between zimeldine and amitriptyline of efficacy and adverse symptoms--a combined analysis of four British clinical trials in depression. Acta psychiatrica Scandinavica. Supplementum 19830101
A double-blind, controlled evaluation of zimeldine, imipramine and placebo in patients with primary affective disorders. Acta psychiatrica Scandinavica. Supplementum 19830101
Severe headache and disturbed liver function during treatment with zimelidine. British medical journal (Clinical research ed.) 19821113
Severe headache and disturbed liver function during treatment with zimelidine. British medical journal (Clinical research ed.) 19821009
An open trial of zimelidine in patients with endogenous depression. International pharmacopsychiatry 19820101
Chronic treatment with antidepressants: protentiation of clonidine-induced aggression in mice via noradrenergic mechanism. Journal of neural transmission 19810101
Event recording in a clinical trial of a new medicine. British medical journal 19800503
Cardiovascular effects of amitriptyline, mianserin and zimelidine in depressed patients. Progress in neuro-psychopharmacology 19800101
Properties