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DCEBIO

CAS No.:
60563-36-2
Catalog Number:
AG00E9Q3
Molecular Formula:
C9H8Cl2N2O
Molecular Weight:
231.0786
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
95%
1 week
United States
$546
- +
Product Description
Catalog Number:
AG00E9Q3
Chemical Name:
DCEBIO
CAS Number:
60563-36-2
Molecular Formula:
C9H8Cl2N2O
Molecular Weight:
231.0786
MDL Number:
MFCD04040030
IUPAC Name:
5,6-dichloro-3-ethyl-1H-benzimidazol-2-one
InChI:
InChI=1S/C9H8Cl2N2O/c1-2-13-8-4-6(11)5(10)3-7(8)12-9(13)14/h3-4H,2H2,1H3,(H,12,14)
InChI Key:
LKHRMULASXZCLG-UHFFFAOYSA-N
SMILES:
CCn1c(=O)[nH]c2c1cc(Cl)c(c2)Cl
Properties
Complexity:
249  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
230.001g/mol
Formal Charge:
0
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
231.076g/mol
Monoisotopic Mass:
230.001g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
32.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.4  
Literature
Title Journal
Role of small conductance calcium-activated potassium channels expressed in PVN in regulating sympathetic nerve activity and arterial blood pressure in rats. American journal of physiology. Regulatory, integrative and comparative physiology 20120801
An intermediate-conductance Ca2+-activated K+ channel is important for secretion in pancreatic duct cells. American journal of physiology. Cell physiology 20120715
Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon. American journal of physiology. Gastrointestinal and liver physiology 20100901
Ictal activity induced by group I metabotropic glutamate receptor activation and loss of afterhyperpolarizations. Neuropharmacology 20100101
Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090401
Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. British journal of pharmacology 20070701
Effects of modulators of Ca(2+)-activated, intermediate-conductance potassium channels on motility of the rat small intestine, in vivo. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20070501
DCEBIO-mediated dilations are attenuated in the female rat middle cerebral artery. Journal of vascular research 20070101
Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Current medicinal chemistry 20070101
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
DCEBIO stimulates Cl- secretion in the mouse jejunum. American journal of physiology. Cell physiology 20060101
Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons. The Journal of biological chemistry 20051216
Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis. American journal of physiology. Cell physiology 20050701
Electrical parameters and water permeability properties of monolayers formed by T84 cells cultured on permeable supports. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20050101
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. The Journal of pharmacology and experimental therapeutics 20010201
Properties