Home Other Building Blocks 3,3',4,4',5-PENTACHLOROBIPHENYL

3,3',4,4',5-PENTACHLOROBIPHENYL

CAS No.:
57465-28-8
Catalog Number:
AG00E9KL
Molecular Formula:
Molecular Weight:
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Purity
Availability
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Product Description
Catalog Number:
AG00E9KL
Chemical Name:
3,3',4,4',5-PENTACHLOROBIPHENYL
CAS Number:
57465-28-8
MDL Number:
MFCD00152730
IUPAC Name:
1,2,3-trichloro-5-(3,4-dichlorophenyl)benzene
InChI:
InChI=1S/C12H5Cl5/c13-8-2-1-6(3-9(8)14)7-4-10(15)12(17)11(16)5-7/h1-5H
InChI Key:
REHONNLQRWTIFF-UHFFFAOYSA-N
UNII:
TSH69IA9XF
Properties
Complexity:
247  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
325.88g/mol
Formal Charge:
0
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
0
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
326.422g/mol
Monoisotopic Mass:
323.883g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
0A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
7.3  
Literature
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Aquatic contaminants alter genes involved in neurotransmitter synthesis and gonadotropin release in largemouth bass. Aquatic toxicology (Amsterdam, Netherlands) 20091019
PCB126 enhanced the genotoxicity of BaP in HepG2 cells by modulating metabolic enzyme and DNA repair activities. Toxicology letters 20090910
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. Endocrine-related cancer 20090901
Hypoxia inhibits induction of aryl hydrocarbon receptor activity in topminnow hepatocarcinoma cells in an ARNT-dependent manner. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090901
Aryl hydrocarbon receptor activation and overexpression upregulated fibroblast growth factor-9 in human lung adenocarcinomas. International journal of cancer 20090815
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Polychlorinated biphenyls PCB 153 and PCB 126 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms. Neurotoxicity research 20090801
Low levels of the air pollutant 1-nitropyrene induce DNA damage, increased levels of reactive oxygen species and endoplasmic reticulum stress in human endothelial cells. Toxicology 20090728
New cytochrome P450 1B1, 1C2 and 1D1 genes in the killifish Fundulus heteroclitus: Basal expression and response of five killifish CYP1s to the AHR agonist PCB126. Aquatic toxicology (Amsterdam, Netherlands) 20090726
Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat: Part 1: Effects on somatic growth, growth hormone-axis activity and bone mass in the offspring. Toxicology and applied pharmacology 20090601
Effects of 3,3',4,4',5-pentachlorobiphenyl (PCB126) on vertebral bone mineralization and on thyroxin and vitamin D levels in Sprague-Dawley rats. Toxicology letters 20090601
Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent. Toxicology and applied pharmacology 20090515
Toxicity of polybrominated diphenyl ethers (DE-71) in chicken (Gallus gallus), mallard (Anas platyrhynchos), and American kestrel (Falco sparverius) embryos and hatchlings. Environmental toxicology and chemistry 20090501
Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2. Drug metabolism and disposition: the biological fate of chemicals 20090401
An Assessment of Mutagenic Effect of 3, 3', 4, 4', 5 Pentachlorobiphenyl (PCB126) in Muta Mouse Fetuses. The Journal of veterinary medical science 20090401
Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population. Environmental health perspectives 20090401
Protective effects of vitamin E against 3,3',4,4',5-pentachlorobiphenyl (PCB126) induced toxicity in zebrafish embryos. Ecotoxicology and environmental safety 20090301
Impacts of multiple stressors on growth and metabolic rate of Malaclemys terrapin. Environmental toxicology and chemistry 20090201
Cytochrome P450 1D1: a novel CYP1A-related gene that is not transcriptionally activated by PCB126 or TCDD. Archives of biochemistry and biophysics 20090201
Role of N-methyl-D-aspartate receptors in polychlorinated biphenyl mediated neurotoxicity. Toxicology letters 20090110
Altered stress-induced cortisol levels in goats exposed to polychlorinated biphenyls (PCB 126 and PCB 153) during fetal and postnatal development. Journal of toxicology and environmental health. Part A 20090101
Selection of suitable housekeeping genes for expression analysis in glioblastoma using quantitative RT-PCR. BMC molecular biology 20090101
Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers. Toxicological sciences : an official journal of the Society of Toxicology 20081201
Novel mammalian cell lines expressing reporter genes for the detection of environmental chemicals activating endogenous aryl hydrocarbon receptors (ArhR) or estrogen receptors (ER). Toxicology in vitro : an international journal published in association with BIBRA 20081201
In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides using a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-1A induction by propanil, diuron and linuron. Chemosphere 20081201
In vivo alternative testing with zebrafish in ecotoxicology. Journal of veterinary science 20081201
Coplanar polychlorinated biphenyl-induced CYP1A1 is regulated through caveolae signaling in vascular endothelial cells. Chemico-biological interactions 20081125
Prolonged ELS test with the marine flatfish sole (Solea solea) shows delayed toxic effects of previous exposure to PCB 126. Aquatic toxicology (Amsterdam, Netherlands) 20081121
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Association of organochlorine pesticides with peripheral neuropathy in patients with diabetes or impaired fasting glucose. Diabetes 20081101
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A possible role of multidrug resistance-associated protein 2 (Mrp2) in hepatic excretion of PCB126, an environmental contaminant: PBPK/PD modeling. Toxicological sciences : an official journal of the Society of Toxicology 20080701
Estrogenic effect of dioxin-like aryl hydrocarbon receptor (AhR) agonist (PCB congener 126) in salmon hepatocytes. Marine environmental research 20080701
Non-dioxin-like polychlorinated biphenyls induce a release of arachidonic acid in liver epithelial cells: a partial role of cytosolic phospholipase A(2) and extracellular signal-regulated kinases 1/2 signalling. Toxicology 20080502
Long-term effects of polychlorinated biphenyls and dioxins on pregnancy outcomes in women affected by the Yusho incident. Environmental health perspectives 20080501
Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. Chemical research in toxicology 20080401
Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDS/PCDFS and PCBS. Toxicology and applied pharmacology 20080315
Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice. Toxicological sciences : an official journal of the Society of Toxicology 20080301
Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay. Toxicology and applied pharmacology 20080301
Activation of estrogen receptor signaling by the dioxin-like aryl hydrocarbon receptor agonist, 3,3',4,4',5-pentachlorobiphenyl (PCB126) in salmon in vitro system. Toxicology and applied pharmacology 20080301
Effects of diazinon on mummichog (Fundulus heteroclitus) larvae produced from eggs differentially treated with PCB126. Archives of environmental contamination and toxicology 20080201
Quantitative analysis of liver GST-P foci promoted by a chemical mixture of hexachlorobenzene and PCB 126: implication of size-dependent cellular growth kinetics. Archives of toxicology 20080201
The effects of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on mink (Mustela vison) reproduction and kit survivability and growth. Archives of environmental contamination and toxicology 20080101
Developmental exposure to polychlorinated biphenyls PCB153 or PCB126 impairs learning ability in young but not in adult rats. The European journal of neuroscience 20080101
Alteration of gene expression profiles in the brain of Japanese medaka (Oryzias latipes) exposed to KC-400 or PCB126. Marine pollution bulletin 20080101
Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological sciences : an official journal of the Society of Toxicology 20071101
Effect of In Ovo exposure to an organochlorine mixture extracted from double crested cormorant eggs (Phalacrocorax auritus) and PCB 126 on immune function of juvenile chickens. Archives of environmental contamination and toxicology 20071101
Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport. Drug metabolism and disposition: the biological fate of chemicals 20071001
Polychlorinated biphenyls alter the expression of endothelial nitric oxide synthase mRNA in human umbilical vein endothelial cells. Human & experimental toxicology 20071001
Spermatogenesis in aged rats after prenatal 3,3',4,4',5-pentachlorobiphenyl exposure. Toxicology 20070905
Activity patterns of biotransformation enzymes in juvenile chickens after in ovo dosage of PCB126. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070901
Co-planar 3,3',4,4',5-pentachlorinated biphenyl and non-co-planar 2,2',4,6,6'-pentachlorinated biphenyl differentially induce recruitment of oestrogen receptor alpha to aryl hydrocarbon receptor target genes. The Biochemical journal 20070901
Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver 'stem-like' cells. Toxicological sciences : an official journal of the Society of Toxicology 20070901
Perinatal co-exposure to methylmercury and PCB153 or PCB126 in rats alters the cerebral cholinergic muscarinic receptors at weaning and puberty. Toxicology 20070816
Effects of vertically transferred 3,3',4,4',5-pentachlorobiphenyl on gene expression in the ovaries of immature Sprague-Dawley rats. The Journal of reproduction and development 20070801
An in vitro approach to assess the toxicity of certain food contaminants: methylmercury and polychlorinated biphenyls. Toxicology 20070731
Association of serum concentrations of persistent organic pollutants with the prevalence of learning disability and attention deficit disorder. Journal of epidemiology and community health 20070701
Pathways and products of the degradation of PCBs by the sodium dispersion method. Chemosphere 20070601
Low-dose effects of ammonium perchlorate on the hypothalamic-pituitary-thyroid axis of adult male rats pretreated with PCB126. Toxicological sciences : an official journal of the Society of Toxicology 20070601
Effects of some endocrine disruptors on the proliferation and viability of human endometrial endothelial cells in vitro. Reproductive toxicology (Elmsford, N.Y.) 20070601
Prenatal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) promotes anxiogenic behavior in rats. The Tohoku journal of experimental medicine 20070601
Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Toxicology and applied pharmacology 20070515
The aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl induces distinct patterns of gene expression between hepatoma and glioma cells: chromatin remodeling as a mechanism for selective effects. Neurotoxicology 20070501
The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. Toxicological sciences : an official journal of the Society of Toxicology 20070501
Interacting influence of potassium and polychlorinated biphenyl on cortisol and aldosterone biosynthesis. Toxicology and applied pharmacology 20070501
Oxidative stress induced in PCB 126-exposed northern leopard frogs, Rana pipiens. Journal of toxicology and environmental health. Part A 20070415
Effects of in ovo exposure to PCBs 126 and 77 on mortality, deformities and post-hatch immune function in chickens. Journal of toxicology and environmental health. Part A 20070315
A physiologically based pharmacokinetic model for lactational transfer of PCB 153 with or without PCB 126 in mice. Archives of toxicology 20070201
Effect of iron and ascorbate on uroporphyria in ascorbate-requiring mice as a model for porphyria cutanea tarda. Hepatology (Baltimore, Md.) 20070101
A critical comparison of murine pathology and epidemiological data of TCDD, PCB126, and PeCDF. Toxicologic pathology 20070101
Pulmonary lesions in female Harlan Sprague-Dawley rats following two-year oral treatment with dioxin-like compounds. Toxicologic pathology 20070101
Suppression of peroxisomal enzyme activities and cytochrome P450 4A isozyme expression by congeneric polybrominated and polychlorinated biphenyls. PPAR research 20070101
Cell death mechanisms in AtT20 pituitary cells exposed to polychlorinated biphenyls (PCB 126 and PCB 153) and methylmercury. Toxicology letters 20061215
Fungal bioconversion of toxic polychlorinated biphenyls by white-rot fungus, Phlebia brevispora. Applied microbiology and biotechnology 20061201
Effects of vertically transferred 3,3',4,4',5-pentachlorobiphenyl (PCB-126) on the reproductive development of female rats. The Journal of reproduction and development 20061201
Hepatic gene downregulation following acute and subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological sciences : an official journal of the Society of Toxicology 20061201
Perinatal exposure to PCB 153, but not PCB 126, alters bone tissue composition in female goat offspring. Toxicology 20061110
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. Journal of molecular graphics & modelling 20061101
Exposure to 3,3',4,4',5-pentachlorobiphenyl during embryonic development has a minimal effect on the cytochrome P4501A response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in cultured chicken embryo hepatocytes. Environmental toxicology and chemistry 20061101
Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (Cas No. 31508-00-6) in female Harlan Sprague-Dawley rats (gavage studies). National Toxicology Program technical report series 20061101
Cytochrome P4501A induction in rainbow trout gills and liver following exposure to waterborne indigo, benzo[a]pyrene and 3,3',4,4',5-pentachlorobiphenyl. Aquatic toxicology (Amsterdam, Netherlands) 20060912
Determination of in vitro relative potency (REP) values for mono-ortho polychlorinated biphenyls after purification with active charcoal. Toxicology letters 20060910
Toxicology and carcinogenesis studies of a mixture of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (Cas No. 1746-01-6), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) (Cas No. 57117-31-4), and 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) in female Harlan Sprague-Dawley rats (gavage studies). National Toxicology Program technical report series 20060901
Induction of ROS formation, poly(ADP-ribose) polymerase-1 activation, and cell death by PCB126 and PCB153 in human T47D and MDA-MB-231 breast cancer cells. Chemico-biological interactions 20060825
Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds. Toxicological sciences : an official journal of the Society of Toxicology 20060801
Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (gavage studies). National Toxicology Program technical report series 20060801
Evaluating the interactions of vertebrate receptors with persistent pollutants and antifouling pesticides using recombinant yeast assays. Analytical and bioanalytical chemistry 20060701
Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methylcholanthrene. Toxicology and applied pharmacology 20060601
Effects of deBDE and PCB-126 on hepatic concentrations of PBDEs and methoxy-PBDEs in Atlantic tomcod. Environmental science & technology 20060515
Effects of PCBs and MeSO2-PCBs on adrenocortical steroidogenesis in H295R human adrenocortical carcinoma cells. Chemosphere 20060501
Assessment of effects in mink caused by consumption of carp collected from the Saginaw River, Michigan, USA. Archives of environmental contamination and toxicology 20060501
Relative cancer potencies of selected dioxin-like compounds on a body-burden basis: comparison to current toxic equivalency factors (TEFs). Journal of toxicology and environmental health. Part A 20060501
NTP technical report on the toxicology and carcinogenesis studies of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (Gavage studies). National Toxicology Program technical report series 20060501
Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6. Life sciences 20060404
Effects of single non-ortho, mono-ortho, and di-ortho chlorinated biphenyls on human sperm functions in vitro. Reproductive toxicology (Elmsford, N.Y.) 20060401
Comparison of hepatic and extra hepatic induction of cytochrome P4501A by graded doses of aryl hydrocarbon receptor agonists in Atlantic tomcod from two populations. Aquatic toxicology (Amsterdam, Netherlands) 20060310
Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat. Toxicological sciences : an official journal of the Society of Toxicology 20060301
Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation. Endocrinology 20060301
3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Cancer research 20060215
Prenatal 3,3',4,4',5-pentachlorobiphenyl exposure modulates induction of rat hepatic CYP 1A1, 1B1, and AhR by 7,12-dimethylbenz[a]anthracene. Toxicology and applied pharmacology 20060201
Effects of infection with Anguillicola crassus and simultaneous exposure with Cd and 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the levels of cortisol and glucose in European eel ( Anguilla anguilla ). Parasitology 20060201
AhR-agonist-induced transcriptional changes of genes involved in thyroid function in primary porcine thyrocytes. Toxicological sciences : an official journal of the Society of Toxicology 20060201
Induction of cytochrome P4501A in African brown house snake (Lamprophis fuliginosus) primary hepatocytes. Environmental toxicology and chemistry 20060201
Perinatal exposure to low doses of PCB 153 and PCB 126 affects maternal and neonatal immunity in goat kids. Journal of toxicology and environmental health. Part A 20060108
The chlorinated AHR ligand 3,3',4,4',5-pentachlorobiphenyl (PCB126) promotes reactive oxygen species (ROS) production during embryonic development in the killifish (Fundulus heteroclitus). Aquatic toxicology (Amsterdam, Netherlands) 20060105
NTP toxicology and carcinogenesis studies of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) in female Harlan Sprague-Dawley rats (Gavage Studies). National Toxicology Program technical report series 20060101
Influence of polychlorinated biphenyls on LH-stimulated secretion of progestereone and oxytocin from bovine luteal cells. Polish journal of veterinary sciences 20060101
The influence of polychlorinated biphenyls (PCBs) and phytoestrogens in vitro on functioning of reproductive tract in cow. Reproductive biology 20060101
Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland. Environmental health : a global access science source 20060101
Apoptosis in bovine cumulus-oocyte complexes after exposure to polychlorinated biphenyl mixtures during in vitro maturation. Reproduction (Cambridge, England) 20051201
Polychlorinated biphenyl 126 affects expression of genes involved in stress-immune interaction in primary cultures of rainbow trout anterior kidney cells. Environmental toxicology and chemistry 20051201
Aromatic hydrocarbon receptor (AhR) in the porcine theca and granulosa cells: effect of TCDD, PCB 126 and PCB 153 on the expression of AhR. Endocrine regulations 20051201
Effects of 17beta-estradiol, 4-nonylphenol and PCB 126 on the estrogenic activity and phase 1 and 2 biotransformation enzymes in male sea bass (Dicentrarchus labrax). Aquatic toxicology (Amsterdam, Netherlands) 20051130
Probing the control elements of the CYP1A1 switching module in H4IIE hepatoma cells. Toxicological sciences : an official journal of the Society of Toxicology 20051101
Differential expression of CYP1A, 2B, and 3A genes in the F344 rat following exposure to a polybrominated diphenyl ether mixture or individual components. Toxicological sciences : an official journal of the Society of Toxicology 20051101
Effects of long-term maternal exposure to low doses of PCB126 and PCB153 on the reproductive system and related hormones of young male goats. Reproduction (Cambridge, England) 20051101
Coplanar polychlorinated biphenyls activate the aryl hydrocarbon receptor in developing tissues of two TCDD-responsive lacZ mouse lines. Toxicological sciences : an official journal of the Society of Toxicology 20051001
Comparison of TCDD and PCB CYP1A induction sensitivities in fresh hepatocytes from human donors, sprague-dawley rats, and rhesus monkeys and HepG2 cells. Toxicological sciences : an official journal of the Society of Toxicology 20051001
Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug metabolism and disposition: the biological fate of chemicals 20050901
Polychlorinated biphenyls (PCB 153 and PCB 126) action on conversion of 20-hydroxylated cholesterol to progesterone, androstenedione to testosterone, and testosterone to estradiol 17beta. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20050901
CYP1 and AhR expression in 7,12-dimethylbenz[a]anthracene-induced mammary carcinoma of rats prenatally exposed to 3,3',4,4',5-pentachlorobiphenyl. Toxicology 20050801
EROD induction and PCDD/F levels in fish liver from the Biobio River in Chile. Chemosphere 20050801
Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. Drug metabolism and disposition: the biological fate of chemicals 20050701
Coplanar PCB congeners increase uterine weight and frontal cortical dopamine in the developing rat: implications for developmental neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology 20050701
Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors. Environmental health perspectives 20050701
Cytochrome P450 1A1 and 1B1 in human blood lymphocytes are not suitable as biomarkers of exposure to dioxin-like compounds: polymorphisms and interindividual variation in expression and inducibility. Toxicological sciences : an official journal of the Society of Toxicology 20050501
PCB126 induces differential changes in androgen, cortisol, and aldosterone biosynthesis in human adrenocortical H295R cells. Toxicological sciences : an official journal of the Society of Toxicology 20050501
Activation of mitogen activated protein kinases by PCB126 (3,3',4,4',5-pentachlorobiphenyl) in HepG2 cells. Toxicological sciences : an official journal of the Society of Toxicology 20050401
Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals. Toxicological sciences : an official journal of the Society of Toxicology 20050401
Effects of PCB 126 on primary immune organs and thymocyte apoptosis in chicken embryos. Journal of toxicology and environmental health. Part A 20050326
Squamous epithelial lesion of the mandibles and maxillae of wild mink (Mustela vison) naturally exposed to polychlorinated biphenyls. Environmental toxicology and chemistry 20050301
Population genetic structure of a nonmigratory estuarine fish (Fundulus heteroclitus) across a strong gradient of polychlorinated biphenyl contamination. Environmental toxicology and chemistry 20050301
Population genetic structure and tolerance to dioxin-like compounds of a migratory marine fish (Menidia menidia) at polychlorinated biphenyl-contaminated and reference sites. Environmental toxicology and chemistry 20050301
Cultured gill epithelial cells from tilapia (Oreochromis niloticus): a new in vitro assay for toxicants. Aquatic toxicology (Amsterdam, Netherlands) 20050118
Gingival carcinogenicity in female Harlan Sprague-Dawley rats following two-year oral treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds. Toxicological sciences : an official journal of the Society of Toxicology 20050101
Effects of maternal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) or 3,3',4,4',5,5'-hexachlorobiphenyl (PCB169) on testicular steroidogenesis and spermatogenesis in male offspring rats. Journal of andrology 20050101
Olfactory epithelial metaplasia and hyperplasia in female Harlan Sprague-Dawley rats following chronic treatment with polychlorinated biphenyls. Toxicologic pathology 20050101
Lineage-specific effects of polychlorinated biphenyls (PCB) on gene expression in the rabbit blastocyst. Reproductive toxicology (Elmsford, N.Y.) 20050101
Structural basis for preferential binding of non-ortho-substituted polychlorinated biphenyls by the monoclonal antibody S2B1. Journal of molecular recognition : JMR 20050101
Hazardous waste sites and stroke in New York State. Environmental health : a global access science source 20050101
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells. Molecular pharmacology 20041201
Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus. Environmental health perspectives 20041201
Effects of gestational and lactational exposure to low doses of PCBs 126 and 153 on anterior pituitary and gonadal hormones and on puberty in female goats. Reproductive toxicology (Elmsford, N.Y.) 20041101
Evaluation of relative potencies of PCB126 and PCB169 for the immunotoxicities in ovalbumin (OVA)-immunized mice. Toxicology 20041101
Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression. Environmental health perspectives 20041101
Interaction between halogenated aromatic compounds in the Ah receptor signal transduction pathway. Environmental toxicology 20041001
Effect of PCB-126 on intracellular accumulation and transepithelial transport of vinblastine in LLC-PK1 and its transformant cells expressing human P-glycoprotein. The Journal of veterinary medical science 20040901
Development of an exonuclease protection mediated PCR bioassay for sensitive detection of Ah receptor agonists. Toxicological sciences : an official journal of the Society of Toxicology 20040701
Estrogen supplementation modulates effects of the endocrine disrupting pollutant PCB126 in rat bone and uterus: diverging effects in ovariectomized and intact animals. Toxicology 20040701
Effects of perinatal exposure to low doses of PCB 153 and PCB 126 on lymphocyte proliferation and hematology in goat kids. Journal of toxicology and environmental health. Part A 20040611
The dioxin-like pollutant PCB 126 (3,3',4,4',5-pentachlorobiphenyl) affects risk factors for cardiovascular disease in female rats. Toxicology letters 20040502
Reduction of androgen receptor expression by benzo[alpha]pyrene and 7,8-dihydro-9,10-epoxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene in human lung cells. Biochemical pharmacology 20040415
Single cell analysis of switch-like induction of CYP1A1 in liver cell lines. Toxicological sciences : an official journal of the Society of Toxicology 20040401
Induction of CYP1A1 in primary rat hepatocytes by 3,3',4,4',5-pentachlorobiphenyl: evidence for a switch circuit element. Toxicological sciences : an official journal of the Society of Toxicology 20040401
Individual and combined effects of cadmium and 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the humoral immune response in European eel (Anguilla anguilla) experimentally infected with larvae of Anguillicola crassus (Nematoda). Parasitology 20040401
Altered thyroid status in lake trout (Salvelinus namaycush) exposed to co-planar 3,3',4,4',5-pentachlorobiphenyl. Aquatic toxicology (Amsterdam, Netherlands) 20040330
A comparative study on the effects of 2,3,7,8,-tetrachlorodibenzo-p-dioxin polychlorinated biphenyl126 and estrogen in human bronchial epithelial cells. Toxicology and applied pharmacology 20040215
Polychlorinated biphenyl 126 stimulates basal and inducible aldosterone biosynthesis of human adrenocortical H295R cells. Toxicology and applied pharmacology 20040215
Evaluation of toxic equivalency factors for induction of cytochromes P450 CYP1A1 and CYP1A2 enzyme activity by dioxin-like compounds. Toxicology and applied pharmacology 20040115
3,3',4,4',5-Pentachlorobiphenyl (PCB 126) impacts hepatic lipid peroxidation, membrane fluidity and beta-adrenoceptor kinetics in chick embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20040101
The DNA de-methylating agent 5-azacytidine does not restore CYP1A induction in PCB resistant Newark Bay killifish (Fundulus heteroclitus). Marine environmental research 20040101
Characterization of bronchiolar metaplasia of the alveolar epithelium in female Sprague-Dawley rats exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB126). Toxicologic pathology 20040101
Regional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153. Toxicologic pathology 20040101
Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action. Toxicological sciences : an official journal of the Society of Toxicology 20031101
Brominated dioxin-like compounds: in vitro assessment in comparison to classical dioxin-like compounds and other polyaromatic compounds. Environment international 20030901
Fatty acid metabolism in neonatal chickens (Gallus domesticus) treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3',4,4',5-pentachlorobiphenyl (PCB-126) in ovo. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030901
Estrous cyclicity and ovarian follicles in female rats after prenatal exposure to 3,3',4,4',5-pentachlorobiphenyl. Toxicology letters 20030828
Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines. Toxicology and applied pharmacology 20030801
A mixture of dioxins, furans, and non-ortho PCBs based upon consensus toxic equivalency factors produces dioxin-like reproductive effects. Toxicological sciences : an official journal of the Society of Toxicology 20030701
Survey of commercial pasteurised cows' milk in Wallonia (Belgium) for the occurrence of polychlorinated dibenzo-p-dioxins, dibenzofurans and coplanar polychlorinated biphenyls. Chemosphere 20030701
Effects of 3,3',4,4',5-pentachlorobiphenyl, a coplanar polychlorinated biphenyl congener, on cultured neonatal mouse testis. Toxicology in vitro : an international journal published in association with BIBRA 20030601
Effects of 2,3,7,8-TCDD and PCB 126 on human thymic epithelial cells in vitro. Archives of toxicology 20030601
Inhibition of CYP 1A2-dependent MROD activity in rat liver microsomes: an explanation of the hepatic sequestration of a limited subset of halogenated aromatic hydrocarbons. Environmental toxicology 20030401
CYP1A1 and CYP1B1 in blood-brain interfaces: CYP1A1-dependent bioactivation of 7,12-dimethylbenz(a)anthracene in endothelial cells. Drug metabolism and disposition: the biological fate of chemicals 20030301
Antagonism of aryl hydrocarbon receptor-dependent induction of CYP1A1 and inhibition of IgM expression by di-ortho-substituted polychlorinated biphenyls. Toxicology and applied pharmacology 20030215
Effects of single non-ortho, mono-ortho, and di-ortho chlorinated biphenyls on cell functions and proliferation of the human prostatic carcinoma cell line, LNCaP. Reproductive toxicology (Elmsford, N.Y.) 20030101
Congener-specific accumulation of polychlorinated biphenyls in ovarian follicular wall follows repeated exposure to PCB 126 and PCB 153. Comparison of tissue levels of PCB and biological changes. Chemosphere 20030101
Effect of PCB 126 and PCB 153 on incidence of apoptosis in cultured theca and granulosa cells collected from small, medium and large preovulatory follicles. Reproductive toxicology (Elmsford, N.Y.) 20030101
Increase in cardiovascular pathology in female Sprague-Dawley rats following chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,3',4,4',5-pentachlorobiphenyl. Cardiovascular toxicology 20030101
Possible range of dioxin concentration in human tissues: simulation with a physiologically based model. Journal of toxicology and environmental health. Part A 20021227
Induction of cytochrome P450 1B1 in MDA-MB-231 human breast cancer cells by non-ortho-substituted polychlorinated biphenyls. Toxicology in vitro : an international journal published in association with BIBRA 20021201
Turtle sex determination assay: mass balance and responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,3',4,4',5-pentachlorobiphenyl. Environmental toxicology and chemistry 20021101
Dietary accumulation and biochemical responses of juvenile rainbow trout (Oncorhynchus mykiss) to 3,3',4,4',5-pentachlorobiphenyl (PCB 126). Aquatic toxicology (Amsterdam, Netherlands) 20020924
Vesicular catecholamine release from rat PC12 cells on acute and subchronic exposure to polychlorinated biphenyls. Toxicology and applied pharmacology 20020915
Mammary gland differentiation in female rats after prenatal exposure to 3,3',4,4',5-pentachlorobiphenyl. Toxicology 20020815
Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL/6J mice exposed to TCDD-like and phenobarbital-like polychlorinated biphenyl congeners. Toxicological sciences : an official journal of the Society of Toxicology 20020801
Target cells for cytochrome p450-catalysed irreversible binding of 7,12-dimethylbenz[a]anthracene (DMBA) in rodent adrenal glands. Archives of toxicology 20020801
Metabolic disturbances in fish exposed to sodium pentachlorophenate (NaPCP) and 3,3',4,4',5-pentachlorobiphenyl (PCB126), individually or combined. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020801
Predicting the occurrence of genetic adaptation to dioxinlike compounds in populations of the estuarine fish Fundulus heteroclitus. Environmental toxicology and chemistry 20020701
Induction of oxidative stress in the tissues of rats after chronic exposure to TCDD, 2,3,4,7,8-pentachlorodibenzofuran, and 3,3',4,4',5-pentachlorobiphenyl. Journal of toxicology and environmental health. Part A 20020628
Effects of furazolidone, PCB77, PCB126, Aroclor 1248, paraquat and p,p'-DDE on transketolase activity in embryonal chicken brain. Toxicology 20020501
Circulating lysozyme and hepatic CYP1A activities during a chronic dietary exposure to tributyltin (TBT) and 3,3',4,4',5-pentachlorobiphenyl (PCB-126) mixtures in channel catfish, Ictalurus punctatus. Journal of toxicology and environmental health. Part A 20020426
Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron. Hepatology (Baltimore, Md.) 20020401
Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers. Toxicological sciences : an official journal of the Society of Toxicology 20020301
MFO induction potential of fish species native to the Swan-Canning Estuary, Western Australia. Environmental toxicology 20020201
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. The Journal of pharmacology and experimental therapeutics 20020101
Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways. The Journal of pharmacology and experimental therapeutics 20020101
Comparison of pharmacokinetic interactions and physiologically based pharmacokinetic modeling of PCB 153 and PCB 126 in nonpregnant mice, lactating mice, and suckling pups. Toxicological sciences : an official journal of the Society of Toxicology 20020101
Cytochrome P4501A induction and testosterone hydroxylation in cultured hepatocytes of four fish species. Chemosphere 20020101
Effects of single and combined exposures to benzo(a)pyrene and 3,3'4,4'5-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus. Marine environmental research 20020101
Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA. Marine environmental research 20020101
Pink snapper (Pagrus auratus) as a bioindicator of aquatic. Environmental health in Western Australia. Environmental toxicology 20011001
7-Ethoxyresorufin O-deethylase induction in rainbow trout gill epithelium cultured on permeable supports: asymmetrical distribution of substrate metabolites. Aquatic toxicology (Amsterdam, Netherlands) 20010901
Effects of PCBs on reactive oxygen species (ROS) production by the immune cells of Paracentrotus lividus (Echinodermata). Marine pollution bulletin 20010801
Mixture component effects on the in vitro dermal absorption of pentachlorophenol. Archives of toxicology 20010801
Dietary exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) or 2,3,7,8-tetrachlorodibenzo-p-dixon (TCDD) does not induce proliferation of squamous epithelium or osteolysis in the jaws of weanling rats. Veterinary and human toxicology 20010601
Disposition of polychlorinated dibenzo-p-dioxins, dibenzofurans, and non-ortho polychlorinated biphenyls in pregnant long evans rats and the transfer to offspring. Toxicology and applied pharmacology 20010601
Role of oxidative stress and antioxidant defense in 3,3',4,4',5-pentachlorobiphenyl-induced toxicity and species-differential sensitivity in chicken and duck embryos. Toxicology and applied pharmacology 20010501
Relative potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners to induce cytochrome P4501A mRNA in a zebrafish liver cell line. Environmental toxicology and chemistry 20010501
Effects of a highly toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl on intermediary metabolism: reduced triose phosphate content in rat liver cytosol. Fukuoka igaku zasshi = Hukuoka acta medica 20010501
[Suppression of stress proteins, GRP78, GRP94, calreticulin and calnexin in liver endoplasmic reticulum of rat treated with a highly toxic coplanar PCB]. Fukuoka igaku zasshi = Hukuoka acta medica 20010501
Induction and suppression of cytochrome P450 1A by 3,3',4,4',5-pentachlorobiphenyl and its relationship to oxidative stress in the marine fish scup (Stenotomus chrysops). Aquatic toxicology (Amsterdam, Netherlands) 20010401
Increased tumor necrosis factor-alpha production by peripheral blood leukocytes from TCDD-exposed rhesus monkeys. Toxicological sciences : an official journal of the Society of Toxicology 20010401
Toxicity of PCB-126 in European flounder (Platichthys flesus) with emphasis on histopathology and cytochrome P4501A induction in several organ systems. Archives of toxicology 20010401
The effects of tributyltin (TBT) and 3,3',4,4',5-pentachlorobiphenyl (PCB-126) mixtures on antibody responses and phagocyte oxidative burst activity in channel catfish, Ictalurus punctatus. Archives of environmental contamination and toxicology 20010401
Effects of PCB 126 on thymocyte surface marker expression and immune organ development in chicken embryos. Journal of toxicology and environmental health. Part A 20010209
Squamous epithelial proliferation in the jaws of mink fed diets containing 3,3',4,4',5-pentachlorobiphenyl (PCB 126) or 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD). Veterinary and human toxicology 20010201
Induction of 7-ethoxyresorufin-O-deethylase activity by planar chlorinated hydrocarbons and polycyclic aromatic hydrocarbons in cell lines from the rainbow trout pituitary. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20010201
Serum levels of TCDD and dioxin-like chemicals in Rhesus monkeys chronically exposed to dioxin: correlation of increased serum PCB levels with endometriosis. Toxicological sciences : an official journal of the Society of Toxicology 20010101
ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism. Journal of neurochemistry 20010101
Immunohistochemical localization of cytochrome P4501A induced by 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in multiple organs of northern leopard frogs, Rana pipiens. Environmental toxicology and chemistry 20010101
Method for evaluation of immunotoxicity of dioxin compounds using human T-lymphoblastic cell line, L-MAT. Chemosphere 20010101
Production of superoxide anion, lipid peroxidation and DNA damage in the hepatic and brain tissues of rats after subchronic exposure to mixtures of TCDD and its congeners. Journal of applied toxicology : JAT 20010101
Polichlorinated biphenyls (PCB126 and PCB 153) action on proliferation and progesterone secretion by cultured in vitro porcine luteal cells. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20010101
Cytochrome P450-catalysed irreversible binding examined in precision-cut adrenal slice culture. Advances in experimental medicine and biology 20010101
Dose-response relationships for induction of CYP1A1 and CYP1A2 enzyme activity in liver, lung, and skin in female mice following subchronic exposure to polychlorinated biphenyls. Toxicology and applied pharmacology 20000915
Endocrine disruptive effects of polychlorinated aromatic hydrocarbons on intestinal cholecystokinin in rats. Endocrinology 20000801
Toxicology of environmental chemicals in the flounder (Platichthys flesus) with emphasis on the immune system: field, semi-field (mesocosm) and laboratory studies. Toxicology letters 20000315
Serum alters the uptake and relative potencies of halogenated aromatic hydrocarbons in cell culture bioassays. Toxicological sciences : an official journal of the Society of Toxicology 20000201
Induction of aberrant mitosis with PCBs: particular efficiency of 2, 3,3',4,4'-pentachlorobiphenyl and synergism with triphenyltin. Mutagenesis 20000101
The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements. Molecular and cellular endocrinology 19991125
Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: greater insight into species differences in toxic potency of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners. Toxicology and applied pharmacology 19990815
Relative potencies of PAHs and PCBs based on the response of human cells. Environmental toxicology and pharmacology 19990301
Embryolethality and induction of 7-ethoxyresorufin O-deethylase in chick embryos by polychlorinated biphenyls and polycyclic aromatic hydrocarbons having Ah receptor affinity. Chemico-biological interactions 19920101
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