3-butyl-1-[(4-methylbenzene)sulfonyl]urea
| Title | Journal |
|---|---|
| Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models. | Toxicology and applied pharmacology 20170301 |
| In vitro metabolism of phenytoin in 36 CYP2C9 variants found in the Chinese population. | Chemico-biological interactions 20160625 |
| Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450. | The Journal of toxicological sciences 20160201 |
| Identification and Functional Assessment of a New CYP2C9 Allelic Variant CYP2C9*59. | Drug metabolism and disposition: the biological fate of chemicals 20150801 |
| Effect of Dimethoate on the Activity of Hepatic CYP450 Based on Pharmacokinetics of Probe Drugs. | Pharmacology 20150101 |
| Identification and characterization of a novel CYP2C9 allelic variant in a warfarin-sensitive patient. | Pharmacogenomics 20150101 |
| A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. | Toxicological sciences : an official journal of the Society of Toxicology 20140101 |
| Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. | Toxicology in vitro : an international journal published in association with BIBRA 20130901 |
| The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: comparison of the N-in-one and single substrate approaches. | Toxicology in vitro : an international journal published in association with BIBRA 20130801 |
| Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions. | Journal of applied toxicology : JAT 20130201 |
| Development and validation of a highly sensitive LC-MS/MS-ESI method for the determination of bicalutamide in mouse plasma: application to a pharmacokinetic study. | Biomedical chromatography : BMC 20121201 |
| SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells. | American journal of physiology. Endocrinology and metabolism 20121101 |
| Insulin reduces excitation in gastric-related neurons of the dorsal motor nucleus of the vagus. | American journal of physiology. Regulatory, integrative and comparative physiology 20121015 |
| cAMP-mediated and metabolic amplification of insulin secretion are distinct pathways sharing independence of β-cell microfilaments. | Endocrinology 20121001 |
| Triphenyltin impairs insulin secretion by decreasing glucose-induced NADP(H) and ATP production in hamster pancreatic β-cells. | Toxicology 20120928 |
| Enzyme kinetic and molecular docking studies on the metabolic interactions of 1-hydroxy-2,3,5-trimethoxy-xanthone, isolated from Halenia elliptica D. Don, with model probe substrates of human cytochrome P450 enzymes. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20120915 |
| A novel relay method for determining low-clearance values. | Drug metabolism and disposition: the biological fate of chemicals 20120901 |
| Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction. | Journal of hepatology 20120901 |
| Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion. | Endocrinology 20120901 |
| Synthesis, antidiabetic and hypolipidemic activities of new diethylamine and triethoxysilyl derivatives of tolbutamide on rats. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20120901 |
| Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour. | Diabetologia 20120901 |
| Distribution of CYP2C9*13 allele in the Chinese Han and the long-range haplotype containing CYP2C9*13 and CYP2C19*2. | Biopharmaceutics & drug disposition 20120901 |
| Proteome profiling of tolbutamide-treated rat primary hepatocytes using nano LC-MS/MS and label-free protein quantitation. | Electrophoresis 20120901 |
| Metabotropic actions of the volatile anaesthetic sevoflurane increase protein kinase M synthesis and induce immediate preconditioning protection of rat hippocampal slices. | The Journal of physiology 20120815 |
| Studying significance of apoptosis in mediating tolbutamide-induced teratogenesis in vitro. | Fundamental & clinical pharmacology 20120801 |
| Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping. | Journal of clinical pharmacology 20120801 |
| Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo. | Phytotherapy research : PTR 20120801 |
| Effect of P450 oxidoreductase variants on the metabolism of model substrates mediated by CYP2C9.1, CYP2C9.2, and CYP2C9.3. | Pharmacogenetics and genomics 20120801 |
| Down-regulation of hepatic CYP3A and CYP2C mediated metabolism in rats with moderate chronic kidney disease. | Drug metabolism and disposition: the biological fate of chemicals 20120801 |
| Ca(2+)-dependent desensitization of insulin secretion by strong potassium depolarization. | American journal of physiology. Endocrinology and metabolism 20120715 |
| Delta cell secretory responses to insulin secretagogues are not mediated indirectly by insulin. | Diabetologia 20120701 |
| Centrifugal air-assisted melt agglomeration for fast-release 'granulet' design. | International journal of pharmaceutics 20120701 |
| Effects of Bu-Zhong-Yi-Qi-Tang on hepatic drug-metabolizing enzymes and plasma tolbutamide concentration in rats. | Journal of ethnopharmacology 20120626 |
| The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine. | The Journal of physiology 20120615 |
| Quantitative pancreatic β cell MRI using manganese-enhanced Look-Locker imaging and two-site water exchange analysis. | Magnetic resonance in medicine 20120601 |
| Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.). | Molecular biology reports 20120601 |
| Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues. | Bioorganic & medicinal chemistry letters 20120601 |
| Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. | Journal of medicinal chemistry 20120524 |
| Improvac does not modify the expression and activities of the major drug metabolizing enzymes cytochrome P450 3A and 2C in pigs. | Vaccine 20120521 |
| Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells. | American journal of physiology. Endocrinology and metabolism 20120515 |
| Gliclazide may have an antiapoptotic effect related to its antioxidant properties in human normal and cancer cells. | Molecular biology reports 20120501 |
| Effect of Ginkgo biloba special extract EGb 761® on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers. | European journal of clinical pharmacology 20120501 |
| Verapamil does not modify catalytic activity of CYP450 in rainbow trout after long-term exposure. | Ecotoxicology and environmental safety 20120501 |
| In vitro modulatory effects of flavonoids on human cytochrome P450 2C8 (CYP2C8). | Naunyn-Schmiedeberg's archives of pharmacology 20120501 |
| Polysaccharide isolated from Triticum aestivum stimulates insulin release from pancreatic cells via the ATP-sensitive K+ channel. | International journal of molecular medicine 20120501 |
| Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies. | European journal of epidemiology 20120501 |
| Predicting drug candidate victims of drug-drug interactions, using microdosing. | Clinical pharmacokinetics 20120401 |
| Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. | Pharmacotherapy 20120401 |
| Identification of mutant Asp251Gly/Gln307His of cytochrome P450 BM3 for the generation of metabolites of diclofenac, ibuprofen and tolbutamide. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120319 |
| On potential interactions between non-selective cation channel TRPM4 and sulfonylurea receptor SUR1. | The Journal of biological chemistry 20120316 |
| Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine γ-lyase in the pancreatic β-cell. | Molecular and cellular endocrinology 20120305 |
| Serum deprivation induces glucose response and intercellular coupling in human pancreatic adenocarcinoma PANC-1 cells. | Pancreas 20120301 |
| Differential contribution of TM6 and TM12 to the pore of CFTR identified by three sulfonylurea-based blockers. | Pflugers Archiv : European journal of physiology 20120301 |
| Regulation of calcium in pancreatic α- and β-cells in health and disease. | Cell calcium 20120301 |
| Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A. | Pharmacogenetics and genomics 20120301 |
| Antihyperglycemic effects of the methanol leaf extract of Diaphananthe bidens in normoglycemic and streptozotocin-induced hyperglycemic rats. | Asian Pacific journal of tropical medicine 20120301 |
| Effects of Ougan juice on P450 activities using a cocktail method. | Die Pharmazie 20120301 |
| Relationships between serum adiponectin and soluble TNF-α receptors and glucose and lipid oxidation in lean and obese subjects. | Acta diabetologica 20120201 |
| Ethanol causes endoplasmic reticulum stress and impairment of insulin secretion in pancreatic β-cells. | Alcohol (Fayetteville, N.Y.) 20120201 |
| Dual microfluidic perifusion networks for concurrent islet perifusion and optical imaging. | Biomedical microdevices 20120201 |
| In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions. | Pharmaceutical research 20120201 |
| Variations in tissue selectivity amongst insulin secretagogues: a systematic review. | Diabetes, obesity & metabolism 20120201 |
| Structural nucleotide analogs are potent activators/inhibitors of pancreatic β cell KATP channels: an emerging mechanism supporting their use as antidiabetic drugs. | The Journal of pharmacology and experimental therapeutics 20120201 |
| Administration of insulin to newly hatched chicks improves growth performance via impairment of MyoD gene expression and enhancement of cell proliferation in chicken myoblasts. | General and comparative endocrinology 20120201 |
| Epac2: a sulfonylurea receptor? | Biochemical Society transactions 20120201 |
| Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs. | Journal of ethnopharmacology 20120106 |
| Role of viscosity in influencing the glass-forming ability of organic molecules from the undercooled melt state. | Pharmaceutical research 20120101 |
| Small conductance potassium channels drive ATP-activated chloride secretion in the oviduct. | American journal of physiology. Cell physiology 20120101 |
| Hypolipidemic Activity of Eryngium carlinae on Streptozotocin-Induced Diabetic Rats. | Biochemistry research international 20120101 |
| Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells. | PloS one 20120101 |
| Preventive pharmacotherapy in type 2 diabetes mellitus. | Indian journal of endocrinology and metabolism 20120101 |
| The metabolic syndrome in Africa: Current trends. | Indian journal of endocrinology and metabolism 20120101 |
| Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice. | Nutrition & metabolism 20120101 |
| Anti-diabetic effect of Wen-pi-tang-Hab-Wu-ling-san extract in streptozotocin-induced diabetic rats. | Indian journal of pharmacology 20120101 |
| Evaluation of the effects of glimepiride (Amaryl) and repaglinide (novoNorm) on atherosclerosis progression in high cholesterol-fed male rabbits. | Journal of cardiovascular disease research 20120101 |
| A pharmacological appraisal of medicinal plants with antidiabetic potential. | Journal of pharmacy & bioallied sciences 20120101 |
| In vitro phenotypic, genomic and proteomic characterization of a cytokine-resistant murine β-TC3 cell line. | PloS one 20120101 |
| Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101 |
| Insulinotropic effect of the non-steroidal compound STX in pancreatic β-cells. | PloS one 20120101 |
| Deregulation of CREB signaling pathway induced by chronic hyperglycemia downregulates NeuroD transcription. | PloS one 20120101 |
| An overview of the evidence and mechanisms of herb-drug interactions. | Frontiers in pharmacology 20120101 |
| Efficacy of various antidiabetic agents as add-on treatments to metformin in type 2 diabetes mellitus: systematic review and meta-analysis. | ISRN endocrinology 20120101 |
| Priapism, pomegranate juice, and sildenafil: Is there a connection? | Urology annals 20120101 |
| The exaptation of endocrine pharmacology. | Indian journal of endocrinology and metabolism 20120101 |
| The management of type 2 diabetic patients with hypoglycaemic agents. | ISRN endocrinology 20120101 |
| Suppression of the nuclear factor Eny2 increases insulin secretion in poorly functioning INS-1E insulinoma cells. | Experimental diabetes research 20120101 |
| Interaction of virstatin with human serum albumin: spectroscopic analysis and molecular modeling. | PloS one 20120101 |
| Functional herbal food ingredients used in type 2 diabetes mellitus. | Pharmacognosy reviews 20120101 |
| Pharmacological approaches to the management of type 2 diabetes in fasting adults during Ramadan. | Diabetes, metabolic syndrome and obesity : targets and therapy 20120101 |
| Critical evaluation of the efficacy and tolerability of azilsartan. | Vascular health and risk management 20120101 |
| A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral endopeptidase inhibitor racecadotril. | Frontiers in pharmacology 20120101 |
| Towards therapeutic applications of arthropod venom k(+)-channel blockers in CNS neurologic diseases involving memory acquisition and storage. | Journal of toxicology 20120101 |
| Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Calcium-sensing receptor activation increases cell-cell adhesion and β-cell function. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101 |
| Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats. | Biomedical research (Tokyo, Japan) 20120101 |
| Hypoglycemic Activity of Aqueous Extracts from Catharanthus roseus. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. | Toxicological sciences : an official journal of the Society of Toxicology 20111201 |
| Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. | Journal of neurophysiology 20111201 |
| Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays. | Pflugers Archiv : European journal of physiology 20111201 |
| Stimulatory effect of insulin on glucose uptake by muscle involves the central nervous system in insulin-sensitive mice. | Diabetes 20111201 |
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
| Involvement of ATP-sensitive potassium (K(ATP)) channels in the loss of beta-cell function induced by human islet amyloid polypeptide. | The Journal of biological chemistry 20111125 |
| Exendin-4 upregulates the expression of Wnt-4, a novel regulator of pancreatic β-cell proliferation. | American journal of physiology. Endocrinology and metabolism 20111101 |
| Ameliorative effect of Aegle marmelos leaf extract on early stage alloxan-induced diabetic cardiomyopathy in rats. | Pharmaceutical biology 20111101 |
| Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20111015 |
| In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions. | The Journal of clinical investigation 20111003 |
| Identification of the human liver cytochrome P450 isoenzymes responsible for the 5-methylhydroxylation of the novel anti-fibrotic drug AKF-PD. | Xenobiotica; the fate of foreign compounds in biological systems 20111001 |
| Preparation of human drug metabolites using fungal peroxygenases. | Biochemical pharmacology 20111001 |
| Comparable long-term mortality risk associated with individual sulfonylureas in diabetes patients with heart failure. | Diabetes research and clinical practice 20111001 |
| The Effects of Glyburide on Apoptosis and Endoplasmic Reticulum Stress in INS-1 Cells in a Glucolipotoxic Condition. | Diabetes & metabolism journal 20111001 |
| Alterations of colonic contractility in long-term diabetic rat model. | Journal of neurogastroenterology and motility 20111001 |
| Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20110915 |
| Type 2 diabetes quality of life patients treated with insulin and oral hypoglycemic medication. | Acta diabetologica 20110901 |
| Comprehensive quantitative and qualitative liquid chromatography-radioisotope-mass spectrometry analysis for safety testing of tolbutamide metabolites without standard samples. | Journal of pharmaceutical sciences 20110901 |
| Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous system only in insulin-sensitive mice. | Journal of lipid research 20110901 |
| Cholesterol elevation impairs glucose-stimulated Ca(2+) signaling in mouse pancreatic β-cells. | Endocrinology 20110901 |
| Remodeling of atrial ATP-sensitive K⁺ channels in a model of salt-induced elevated blood pressure. | American journal of physiology. Heart and circulatory physiology 20110901 |
| Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors. | Biopharmaceutics & drug disposition 20110901 |
| Effects of Ginkgo biloba extract on the pharmacokinetics and pharmacodynamics of tolbutamide in protein-restricted rats. | The Journal of pharmacy and pharmacology 20110901 |
| Lower expression of PKAα impairs insulin secretion in islets isolated from low-density lipoprotein receptor (LDLR(-/-)) knockout mice. | Metabolism: clinical and experimental 20110801 |
| Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study. | European heart journal 20110801 |
| In vitro inhibitory effects of Wen-pi-tang-Hab-Wu-ling-san on human cytochrome P450 isoforms. | Journal of clinical pharmacy and therapeutics 20110801 |
| Structure and dynamics of the membrane-bound cytochrome P450 2C9. | PLoS computational biology 20110801 |
| Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor γ Activity and on Glucose Uptake by Thiazolidinediones. | Diabetes & metabolism journal 20110801 |
| Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cells. | The Journal of biological chemistry 20110722 |
| From caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase. | Journal of neural transmission (Vienna, Austria : 1996) 20110701 |
| Blockade of the antinociception induced by diclofenac, but not of indomethacin, by sulfonylureas and biguanides. | Pharmacology, biochemistry, and behavior 20110701 |
| High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. | Nature neuroscience 20110701 |
| Glucosensing in parvocellular neurons of the rat hypothalamic paraventricular nucleus. | The European journal of neuroscience 20110701 |
| The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. | Journal of enzyme inhibition and medicinal chemistry 20110601 |
| Effects of multiple-dose pegylated interferon alfa-2b on the activity of drug-metabolizing enzymes in persons with chronic hepatitis C. | European journal of clinical pharmacology 20110601 |
| Development and validation of a LC-MS/MS method based on a new 96-well Hybrid-SPE™-precipitation technique for quantification of CYP450 substrates/metabolites in rat plasma. | Analytical and bioanalytical chemistry 20110601 |
| Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys. | Drug metabolism and pharmacokinetics 20110601 |
| High-throughput and simultaneous analysis of eight central-acting muscle relaxants in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry in the positive and negative ionization modes. | Analytical and bioanalytical chemistry 20110601 |
| Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes. | Diabetes 20110601 |
| Oral hypoglycaemic, antihyperglycaemic and antidiabetic activities of Sri Lankan Broken Orange Pekoe Fannings (BOPF) grade black tea (Camellia sinensis L.) in rats. | Journal of ethnopharmacology 20110517 |
| Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes. | Biotechnology journal 20110501 |
| Glucosensing by GnRH neurons: inhibition by androgens and involvement of AMP-activated protein kinase. | Molecular endocrinology (Baltimore, Md.) 20110501 |
| Effects of brucine combined with glycyrrhetinic acid or liquiritin on rat hepatic cytochrome P450 activities in vivo. | Yao xue xue bao = Acta pharmaceutica Sinica 20110501 |
| Use of peak decay analysis and affinity microcolumns containing silica monoliths for rapid determination of drug-protein dissociation rates. | Journal of chromatography. A 20110415 |
| A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening. | International journal of pharmaceutics 20110415 |
| Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 β-cell line. | Biochemical and biophysical research communications 20110415 |
| Diabetes treatment and cardiovascular safety. | Diabetes care 20110401 |
| Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis. | Aging 20110401 |
| A dual action of saturated fatty acids on electrical activity in rat pancreatic β-cells. Role of volume-regulated anion channel and KATP channel currents. | The Journal of physiology 20110315 |
| An aqueous extract of Curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro. | Phytotherapy research : PTR 20110301 |
| Evaluation of the efficacy and tolerability of miglitol in Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylureas. | Acta diabetologica 20110301 |
| Metabolic amplification of insulin secretion by glucose is independent of β-cell microtubules. | American journal of physiology. Cell physiology 20110301 |
| Inhibition of gastric motility by hyperglycemia is mediated by nodose ganglia KATP channels. | American journal of physiology. Gastrointestinal and liver physiology 20110301 |
| Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats. | Diabetes 20110301 |
| Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin. | Cell death & disease 20110301 |
| Induction of insulin secretion by an aqueous extract of Tabernanhte iboga Baill. (Apocynaceae) in rat pancreatic islets of Langerhans. | Journal of ethnopharmacology 20110216 |
| Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. | The Journal of biological chemistry 20110211 |
| Recognition of sulfonylurea receptor (ABCC8/9) ligands by the multidrug resistance transporter P-glycoprotein (ABCB1): functional similarities based on common structural features between two multispecific ABC proteins. | The Journal of biological chemistry 20110204 |
| Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance. | Xenobiotica; the fate of foreign compounds in biological systems 20110201 |
| Exchange protein directly activated by cyclic AMP isoform 2 is not a direct target of sulfonylurea drugs. | Assay and drug development technologies 20110201 |
| Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice. | Diabetes 20110201 |
| A newly identified CG301269 improves lipid and glucose metabolism without body weight gain through activation of peroxisome proliferator-activated receptor alpha and gamma. | Diabetes 20110201 |
| Relationship between gamma-glutamyl transferase and glucose intolerance in first degree relatives of type 2 diabetics patients. | Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20110201 |
| Binding of tolbutamide to glycated human serum albumin. | Journal of pharmaceutical and biomedical analysis 20110125 |
| Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. | Diabetes 20110101 |
| Congenital hyperinsulinism and glucose hypersensitivity in homozygous and heterozygous carriers of Kir6.2 (KCNJ11) mutation V290M mutation: K(ATP) channel inactivation mechanism and clinical management. | Diabetes 20110101 |
| Clinical drugs undergoing polymorphic metabolism by human cytochrome P450 2C9 and the implication in drug development. | Current medicinal chemistry 20110101 |
| TRP-ing down the path to insulin secretion. | Diabetes 20110101 |
| An in vitro, high throughput, seven CYP cocktail inhibition assay for the evaluation of new chemical entities using LC-MS/MS. | Drug metabolism letters 20110101 |
| Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey. | PloS one 20110101 |
| Evaluating compliance to a low glycaemic index (GI) diet in women with polycystic ovary syndrome (PCOS). | BMC research notes 20110101 |
| Sex differences in drug disposition. | Journal of biomedicine & biotechnology 20110101 |
| Cardiovascular safety of exenatide BID: an integrated analysis from controlled clinical trials in participants with type 2 diabetes. | Cardiovascular diabetology 20110101 |
| Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidis and human cells. | Genome biology 20110101 |
| Mucoadhesive drug delivery systems. | Journal of pharmacy & bioallied sciences 20110101 |
| Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes. | Diabetes, metabolic syndrome and obesity : targets and therapy 20110101 |
| Glycated albumin suppresses glucose-induced insulin secretion by impairing glucose metabolism in rat pancreatic β-cells. | Nutrition & metabolism 20110101 |
| Nateglinide stimulates glucagon-like peptide-1 release by human intestinal L cells via a K(ATP) channel-independent mechanism. | Biological & pharmaceutical bulletin 20110101 |
| Pharmacokinetics of tolbutamide in acute renal failure induced by glycerol: speculative thoughts and perspectives. | Drug metabolism and pharmacokinetics 20110101 |
| [Dissolution characteristics of composite particles using a spray freeze drying]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110101 |
| Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome. | BMC medical genomics 20110101 |
| Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics. | Cancer management and research 20110101 |
| A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets. | Theoretical biology & medical modelling 20110101 |
| Chronopharmacological assessment identified GLUT4 as a factor responsible for the circadian variation of the hypoglycemic effect of tolbutamide in rats. | Drug metabolism and pharmacokinetics 20110101 |
| Evaluation of antidiabetic and related actions of some Indian medicinal plants in diabetic rats. | Asian Pacific journal of tropical medicine 20110101 |
| Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. | BMJ (Clinical research ed.) 20110101 |
| Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women. | International journal of women's health 20110101 |
| Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance. | Clinical proteomics 20110101 |
| Control of the intracellular redox state by glucose participates in the insulin secretion mechanism. | PloS one 20110101 |
| Serum insulin-like growth factor-I in diabetic retinopathy. | Molecular vision 20110101 |
| Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population. | PloS one 20110101 |
| Prevalence and risk factors of diabetes and impaired fasting glucose in Nauru. | BMC public health 20110101 |
| Long-term use and tolerability of irbesartan for control of hypertension. | Integrated blood pressure control 20110101 |
| Medicinal chemistry of the anti-diabetic effects of momordica charantia: active constituents and modes of actions. | The open medicinal chemistry journal 20110101 |
| HIV protease inhibitors act as competitive inhibitors of the cytoplasmic glucose binding site of GLUTs with differing affinities for GLUT1 and GLUT4. | PloS one 20110101 |
| Early markers of glycaemic control in children with type 1 diabetes mellitus. | PloS one 20110101 |
| Attenuation of nonenzymatic glycation, hyperglycemia, and hyperlipidemia in streptozotocin-induced diabetic rats by chloroform leaf extract of Azadirachta indica. | Pharmacognosy magazine 20110101 |
| Functional evaluation of genetic and environmental regulators of p450 mRNA levels. | PloS one 20110101 |
| Molecular imaging: a promising tool to monitor islet transplantation. | Journal of transplantation 20110101 |
| Measurement of warfarin in the oral fluid of patients undergoing anticoagulant oral therapy. | PloS one 20110101 |
| Alternative therapies useful in the management of diabetes: A systematic review. | Journal of pharmacy & bioallied sciences 20110101 |
| Increased glutathione synthesis following Nrf2 activation by vanadyl sulfate in human chang liver cells. | International journal of molecular sciences 20110101 |
| Investigations on Piper betle grown in Sri Lanka. | Pharmacognosy reviews 20110101 |
| Extended hildebrand solubility approach: satranidazole in mixtures of dioxane and water. | Indian journal of pharmaceutical sciences 20110101 |
| Polymorphisms of human cytochrome P450 2C9 and the functional relevance. | Toxicology 20101205 |
| Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes. | Diabetes 20101201 |
| High levels of serum prolactin protect against diabetic retinopathy by increasing ocular vasoinhibins. | Diabetes 20101201 |
| A predictive ligand-based Bayesian model for human drug-induced liver injury. | Drug metabolism and disposition: the biological fate of chemicals 20101201 |
| Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency. | European journal of endocrinology 20101201 |
| Physiologic characterization of type 2 diabetes-related loci. | Current diabetes reports 20101201 |
| Effects of metformin on BRIN-BD11 beta-cell insulin secretory desensitization induced by prolonged exposure to sulphonylureas. | Diabetes, obesity & metabolism 20101201 |
| Drug structure-transport relationships. | Journal of pharmacokinetics and pharmacodynamics 20101201 |
| Influence of hepatic impairment on pharmacokinetics of the human GLP-1 analogue, liraglutide. | British journal of clinical pharmacology 20101201 |
| Hypoglycemic effect of methanolic extract of Anacardium occidentale leaves in alloxan-induced diabetic rats. | Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria 20101125 |
| Chromatographic studies of changes in binding of sulfonylurea drugs to human serum albumin due to glycation and fatty acids. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101115 |
| Inhibition of ATP-sensitive potassium channels increases HSV-tk/GCV bystander effect in U373 human glioma cells by enhancing gap junctional intercellular communication. | Neuropharmacology 20101101 |
| Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101101 |
| Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy. | Diabetes 20101101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions. | Bioorganic & medicinal chemistry 20101101 |
| Anti-hyperglycemic compound (GII) from fenugreek (Trigonella foenum-graecum Linn.) seeds, its purification and effect in diabetes mellitus. | Indian journal of experimental biology 20101101 |
| Antidiabetic effect of some medicinal plants of Oriental Morocco in neonatal non-insulin-dependent diabetes mellitus rats. | Human & experimental toxicology 20101001 |
| Gαo represses insulin secretion by reducing vesicular docking in pancreatic beta-cells. | Diabetes 20101001 |
| Drug binding to Sudlow's site I impairs allosterically human serum heme-albumin-catalyzed peroxynitrite detoxification. | IUBMB life 20101001 |
| Anti-Oxidative Effect of Cassia auriculata on Streptozotocin Induced Diabetic Rats. | Indian journal of clinical biochemistry : IJCB 20101001 |
| Functional expression of large-conductance Ca2+-activated potassium channels in lateral globus pallidus neurons. | Neuroscience 20100915 |
| Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. | The Journal of physiology 20100915 |
| Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo. | Drug metabolism and disposition: the biological fate of chemicals 20100901 |
| Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets. | Diabetes 20100901 |
| In vivo Studies on Antidiabetic Plants Used in South African Herbal Medicine. | Journal of clinical biochemistry and nutrition 20100901 |
| Biochemical and analytical development of the CIME cocktail for drug fate assessment in humans. | Rapid communications in mass spectrometry : RCM 20100830 |
| Simultaneous HPLC determination of tolbutamide, phenacetin and their metabolites as markers of cytochromes 1A2 and 2C6/11 in rat liver perfusate. | Journal of pharmaceutical and biomedical analysis 20100801 |
| Metabolic amplifying pathway increases both phases of insulin secretion independently of beta-cell actin microfilaments. | American journal of physiology. Cell physiology 20100801 |
| Counterpoint: postprandial glucose levels are not a clinically important treatment target. | Diabetes care 20100801 |
| Evaluation of Cassia occidentalis for in vitro cytotoxicity against human cancer cell lines and antibacterial activity. | Indian journal of pharmacology 20100801 |
| Rifampicin-induced thrombocytopenia. | Indian journal of pharmacology 20100801 |
| AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. | Molecular and cellular endocrinology 20100729 |
| In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica. | Journal of ethnopharmacology 20100720 |
| A protein-coated magnetic beads as a tool for the rapid drug-protein binding study. | Journal of pharmaceutical and biomedical analysis 20100708 |
| Conformational polymorphism of tolbutamide: A structural, spectroscopic, and thermodynamic characterization of Burger's forms I-IV. | Journal of pharmaceutical sciences 20100701 |
| Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis. | Diabetologia 20100701 |
| Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion. | Diabetes 20100701 |
| Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells. | Diabetes 20100701 |
| 2009 World Congress on the Insulin Resistance Syndrome: cardiovascular disease concepts. | Diabetes care 20100701 |
| Effects of K openers on the QT prolongation induced by HERG-blocking drugs in guinea-pigs. | The Journal of pharmacy and pharmacology 20100701 |
| Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment. | Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100611 |
| Peptide YY is critical for acylethanolamine receptor Gpr119-induced activation of gastrointestinal mucosal responses. | Cell metabolism 20100609 |
| Prevalence and correlates of inadequate glycaemic control: results from a nationwide survey in 6,671 adults with diabetes in Brazil. | Acta diabetologica 20100601 |
| The risk of overall mortality in patients with type 2 diabetes receiving glipizide, glyburide, or glimepiride monotherapy: a retrospective analysis. | Diabetes care 20100601 |
| LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo. | American journal of physiology. Endocrinology and metabolism 20100601 |
| Characterization of the binding of sulfonylurea drugs to HSA by high-performance affinity chromatography. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601 |
| Neuropathy, retinopathy, and glucose-lowering treatments. | Diabetes care 20100601 |
| Hypolipidaemic & hepatoprotective effects of Psidium guajava raw fruit peel in experimental diabetes. | The Indian journal of medical research 20100601 |
| Immediate but not long-term administration of nicardipine inhibits tolbutamide-induced insulin secretion from rat pancreatic beta cells. | Pancreas 20100501 |
| Effects of nicorandil on sympathetic neurotransmission in rat caudal artery. | Clinical and experimental pharmacology & physiology 20100501 |
| Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles. | Diabetes 20100501 |
| Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100501 |
| Change in tolbutamide permeability in rat jejunum and Caco-2 cells by Sho-saiko-to (Xiao Chai Hu Tang), a Chinese traditional medicine. | The Journal of pharmacy and pharmacology 20100501 |
| Effects of several pyrethroids on hepatic cytochrome P450 activities in rats. | The Journal of veterinary medical science 20100401 |
| Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels. | Journal of neurochemistry 20100401 |
| CYP2C9 genotype does not affect risk of tobacco-related cancer in the general population. | Cancer epidemiology 20100401 |
| Blockade of presynaptic K ATP channels reduces the zinc-mediated posttetanic depression at hippocampal mossy fiber synapses. | Brain research 20100312 |
| Pharmacokinetic interaction studies of tanshinones with tolbutamide, a model CYP2C11 probe substrate, using liver microsomes, primary hepatocytes and in vivo in the rat. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20100301 |
| Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control. | Diabetes care 20100301 |
| Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. | International journal of toxicology 20100301 |
| Facilitation of ß-cell K(ATP) channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac. | Islets 20100301 |
| Electrophysiological identification of glucose-sensing neurons in rat nodose ganglia. | The Journal of physiology 20100215 |
| Gap junctions and memory: an investigation using a single trial discrimination avoidance task for the neonate chick. | Neurobiology of learning and memory 20100201 |
| Pregnancy restores insulin secretion from pancreatic islets in cafeteria diet-induced obese rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20100201 |
| Predictive performance for population models using stochastic differential equations applied on data from an oral glucose tolerance test. | Journal of pharmacokinetics and pharmacodynamics 20100201 |
| Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channels. | British journal of pharmacology 20100201 |
| 2-hydroxy 4-methoxy benzoic acid isolated from roots of Hemidesmus indicus ameliorates liver, kidney and pancreas injury due to streptozotocin-induced diabetes in rats. | Indian journal of experimental biology 20100201 |
| Na, K-ATPase: Ubiquitous Multifunctional Transmembrane Protein and its Relevance to Various Pathophysiological Conditions. | Journal of clinical medicine research 20100201 |
| High performance liquid chromatography determination of cytochrome P450 1A and 2C activities in bovine liver microsomes. | Veterinary journal (London, England : 1997) 20100101 |
| Terminalia bellirica stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation in vitro. | The British journal of nutrition 20100101 |
| ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation. | Diabetes 20100101 |
| Glucocorticoids in vivo induce both insulin hypersecretion and enhanced glucose sensitivity of stimulus-secretion coupling in isolated rat islets. | Endocrinology 20100101 |
| Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. | Bioorganic & medicinal chemistry letters 20100101 |
| Anti-hyperglycemic and anti-hyperlipidemic effects of guava leaf extract. | Nutrition & metabolism 20100101 |
| Development of an LC-MS method for measuring TNF in human vaginal tissue. | Journal of chromatographic science 20100101 |
| Assessment of efficacy and tolerability of once-daily extended release metformin in patients with type 2 diabetes mellitus. | Diabetology & metabolic syndrome 20100101 |
| Advantages of the single delay model for the assessment of insulin sensitivity from the intravenous glucose tolerance test. | Theoretical biology & medical modelling 20100101 |
| Efficient gene delivery and silencing of mouse and human pancreatic islets. | BMC biotechnology 20100101 |
| Liraglutide in the treatment of type 2 diabetes mellitus: clinical utility and patient perspectives. | Patient preference and adherence 20100101 |
| Vitamin D intake is associated with insulin sensitivity in African American, but not European American, women. | Nutrition & metabolism 20100101 |
| Role of eslicarbazepine in the treatment of epilepsy in adult patients with partial-onset seizures. | Therapeutics and clinical risk management 20100101 |
| Diazoxide promotes oligodendrocyte precursor cell proliferation and myelination. | PloS one 20100101 |
| Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters. | BMC cell biology 20100101 |
| Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia. | PloS one 20100101 |
| Effect of the insulin plant (Costus igneus) leaves on dexamethasone-induced hyperglycemia. | International journal of Ayurveda research 20100101 |
| Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection. | Critical care (London, England) 20100101 |
| A systems biology approach to identify effective cocktail drugs. | BMC systems biology 20100101 |
| Effects of oral glucose-lowering drugs on long term outcomes in patients with diabetes mellitus following myocardial infarction not treated with emergent percutaneous coronary intervention--a retrospective nationwide cohort study. | Cardiovascular diabetology 20100101 |
| Exenatide once weekly: clinical outcomes and patient satisfaction. | Patient preference and adherence 20100101 |
| Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies. | BMC endocrine disorders 20100101 |
| Pharmacotherapy-Based Problems in the Management of Diabetes Mellitus: Needs Much More to be Done! | Journal of young pharmacists : JYP 20100101 |
| Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies. | Vascular health and risk management 20100101 |
| Cytokines in the Progression of Pancreatic β-Cell Dysfunction. | International journal of endocrinology 20100101 |
| ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies. | Particle and fibre toxicology 20100101 |
| Update on treatment of partial onset epilepsy: role of eslicarbazepine. | Neuropsychiatric disease and treatment 20100101 |
| Evaluation of the Hypoglycemic Activity of Cucumis metuliferus (Cucurbitaceae) Fruit Pulp Extract in Normoglycemic and Alloxan-Induced Hyperglycemic Rats. | Journal of young pharmacists : JYP 20100101 |
| A study on drug-drug interaction of esomeprazole and anti-diabetic drugs. | Journal of young pharmacists : JYP 20100101 |
| Pertussis toxin nullifies the depolarization of the membrane potential and the stimulation of the rapid phase of Ca entry through L-type calcium channels that are produced by follicle stimulating hormone in 10- to 12-day-old rat Sertoli cells. | Frontiers in physiology 20100101 |
| Preparation and characterization of microparticles of piroxicam by spray drying and spray chilling methods. | Research in pharmaceutical sciences 20100101 |
| Glargine and detemir: Safety and efficacy profiles of the long-acting basal insulin analogs. | Drug, healthcare and patient safety 20100101 |
| Antidiabetic activity and phytochemical screening of crude extract of Stevia rebaudiana in alloxan-induced diabetic rats. | Pharmacognosy research 20100101 |
| Protective role of glibenclamide against nicotinamide-streptozotocin induced nuclear damage in diabetic Wistar rats. | Journal of pharmacology & pharmacotherapeutics 20100101 |
| Cyclodextrins in delivery systems: Applications. | Journal of pharmacy & bioallied sciences 20100101 |
| Double-blind, placebo-controlled clinical evaluation of an Ayurvedic formulation (GlucoCare capsules) in non-insulin dependent diabetes mellitus. | Journal of Ayurveda and integrative medicine 20100101 |
| Semecarpus anacardium Linn.: A review. | Pharmacognosy reviews 20100101 |
| Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. | Pharmacognosy reviews 20100101 |
| Assessment of the antidiabetic potential of Cassia grandis using an in vivo model. | Journal of advanced pharmaceutical technology & research 20100101 |
| A comparative study of DNA damage in patients suffering from diabetes and thyroid dysfunction and complications. | Clinical pharmacology : advances and applications 20100101 |
| Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. | Cell metabolism 20091202 |
| Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2. | Biochimica et biophysica acta 20091201 |
| Beta-cell-mediated signaling predominates over direct alpha-cell signaling in the regulation of glucagon secretion in humans. | Diabetes care 20091201 |
| Pulsatility of insulin release--a clinically important phenomenon. | Upsala journal of medical sciences 20091201 |
| Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. | Cell metabolism 20091104 |
| Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress. | The Journal of clinical investigation 20091102 |
| Expression of the NH(2)-terminal fragment of RasGAP in pancreatic beta-cells increases their resistance to stresses and protects mice from diabetes. | Diabetes 20091101 |
| Attenuation of Helicteres isora L. bark extracts on streptozotocin-induced alterations in glycogen and carbohydrate metabolism in albino rats. | Human & experimental toxicology 20091101 |
| Nonpharmacologic therapy and exercise in the prevention of type 2 diabetes. | Diabetes care 20091101 |
| Glucose control and cardiovascular disease: is it important? No. | Diabetes care 20091101 |
| Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity or mortality? No. | Diabetes care 20091101 |
| Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity/mortality? Yes. | Diabetes care 20091101 |
| Acute action of rotenone on nigral dopaminergic neurons--involvement of reactive oxygen species and disruption of Ca2+ homeostasis. | The European journal of neuroscience 20091101 |
| Hypoglycemic activity of constituents from Astianthus viminalis in normal and streptozotocin-induced diabetic mice. | Journal of natural medicines 20091001 |
| Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. | Drug metabolism and disposition: the biological fate of chemicals 20091001 |
| Accuracy of Veterans Affairs databases for diagnoses of chronic diseases. | Preventing chronic disease 20091001 |
| Trace analysis of glyclazide in human plasma at microscale level by mass spectrometry. | Journal of separation science 20091001 |
| Effect of clonidine on blood glucose levels in euglycemic and alloxan-induced diabetic rats and its interaction with glibenclamide. | Indian journal of pharmacology 20091001 |
| A1C underestimates glycemia in HIV infection. | Diabetes care 20090901 |
| Antihyperlipidemic effect of Garlip, a polyherbal formulation in streptozotocin induced diabetic rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090901 |
| Transcription factor AP-2beta inhibits glucose-induced insulin secretion in cultured insulin-secreting cell-line. | Diabetes research and clinical practice 20090901 |
| Involvement of Ca2+/calmodulin kinase II (CaMK II) in genistein-induced potentiation of leucine/glutamine-stimulated insulin secretion. | Molecules and cells 20090901 |
| Trials review: cardiovascular outcome with intensive glycemic control and implications for patients with type 2 diabetes. | Postgraduate medicine 20090901 |
| Genetic polymorphism of the human cytochrome P450 2C9 gene and its clinical significance. | Current drug metabolism 20090901 |
| Malignant Lymphoma with Severe Infiltrative Growth into Skeletal Muscles in WBN/Kob Rats. | Journal of toxicologic pathology 20090901 |
| Differences between the measured and calculated free serum phenytoin concentrations in epileptic patients. | Yonsei medical journal 20090831 |
| Epac2: a molecular target for sulfonylurea-induced insulin release. | Science signaling 20090825 |
| ATP-sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injury. | Neuroscience 20090818 |
| Enhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells. | Diabetes 20090801 |
| Influence of Helicteres isora administration for diabetes mellitus: Its effect on erythrocyte membrane and antioxidant status. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090801 |
| Influence of Helicteres isora administration for diabetes mellitus: the effect on changes in tissue fatty acid composition. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090801 |
| Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells. | Diabetologia 20090801 |
| Plasma membrane depolarization as a determinant of the first phase of insulin secretion. | American journal of physiology. Endocrinology and metabolism 20090801 |
| Sulphonylurea physicochemical-pharmacokinetic relationships in the pancreas and liver. | Journal of pharmaceutical sciences 20090801 |
| Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance. | Diabetes 20090801 |
| The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. | Science (New York, N.Y.) 20090731 |
| Antidiabetic activities of Tecoma stans (L.) Juss. ex Kunth. | Journal of ethnopharmacology 20090715 |
| The effect of growth hormone treatment on metabolic and cardiovascular risk factors is similar in preterm and term short, small for gestational age children. | Clinical endocrinology 20090701 |
| An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1. | The Journal of clinical endocrinology and metabolism 20090701 |
| A comparative analysis of binding sites between mouse CYP2C38 and CYP2C39 based on homology modeling, molecular dynamics simulation and docking studies. | Biochimica et biophysica acta 20090701 |
| Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion. | Diabetes 20090701 |
| Relative impact of genotype and enzyme induction on the metabolic capacity of CYP2C9 in healthy volunteers. | Clinical pharmacology and therapeutics 20090701 |
| Inhibitory effects of leptin on pancreatic alpha-cell function. | Diabetes 20090701 |
| Hyperglycemic crises in adult patients with diabetes. | Diabetes care 20090701 |
| Particle characterization of poorly water-soluble drugs using a spray freeze drying technique. | Chemical & pharmaceutical bulletin 20090701 |
| A rice bran oil diet improves lipid abnormalities and suppress hyperinsulinemic responses in rats with streptozotocin/nicotinamide-induced type 2 diabetes. | Journal of clinical biochemistry and nutrition 20090701 |
| Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome. | PLoS computational biology 20090701 |
| Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage. | Experimental animals 20090701 |
| The phenomenon of seasonal pseudohypokalemia: effects of ambient temperature, plasma glucose and role for sodium-potassium-exchanging-ATPase. | Clinical biochemistry 20090601 |
| G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans. | Diabetes 20090601 |
| Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant. | Journal of chromatography. A 20090515 |
| ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity. | Carcinogenesis 20090501 |
| Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets. | Diabetes 20090501 |
| Association between increased platelet P-selectin expression and obesity in patients with type 2 diabetes: a BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) substudy. | Diabetes care 20090501 |
| Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization. | Archives of biochemistry and biophysics 20090501 |
| Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels. | The Journal of biological chemistry 20090403 |
| Activation of the Na+/K+-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells. | Pflugers Archiv : European journal of physiology 20090401 |
| Prediction of the effects of genetic polymorphism on the pharmacokinetics of CYP2C9 substrates from in vitro data. | Pharmaceutical research 20090401 |
| Alanine aminotransferase, gamma-glutamyltransferase, and incident diabetes: the British Women's Heart and Health Study and meta-analysis. | Diabetes care 20090401 |
| In vitro metabolism and inhibitory effects of pranlukast in human liver microsomes. | Biological & pharmaceutical bulletin 20090401 |
| A simplified method to determine five cytochrome p450 probe drugs by HPLC in a single run. | Biological & pharmaceutical bulletin 20090401 |
| Reevaluation of solubility of tolbutamide and polymorphic transformation from Form I to unknown crystal form. | International journal of pharmaceutics 20090318 |
| The insulinotropic effect of fluoroquinolones. | Biochemical pharmacology 20090315 |
| Involvement of hippocampal CA3 K(ATP) channels in contextual memory. | Neuropharmacology 20090301 |
| Insulin resistance without obesity induced by cotton pellet granuloma in mice. | Laboratory investigation; a journal of technical methods and pathology 20090301 |
| Anti-diabetic drugs in the private and public sector in Dar es Salaam, Tanzania. | East African medical journal 20090301 |
| A role for ATP-sensitive potassium channels in male sexual behavior. | Hormones and behavior 20090201 |
| Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function. | Diabetes 20090201 |
| Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells. | Diabetes 20090201 |
| Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice. | Diabetes 20090201 |
| Diabetes impairs the vascular recruitment of normal stem cells by oxidant damage, reversed by increases in pAMPK, heme oxygenase-1, and adiponectin. | Stem cells (Dayton, Ohio) 20090201 |
| Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells. | Diabetologia 20090201 |
| Topics in type 2 diabetes and insulin resistance. | Diabetes care 20090201 |
| Interaction of polyphenols with proteins: binding of (-)-epigallocatechin gallate to serum albumin, estimated by induced circular dichroism. | Chemical & pharmaceutical bulletin 20090201 |
| Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. | Cell 20090123 |
| Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas. | Regulatory peptides 20090108 |
| Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. | The Journal of clinical investigation 20090105 |
| Calcium influx into MIN6 insulinoma cells induces expression of Egr-1 involving extracellular signal-regulated protein kinase and the transcription factors Elk-1 and CREB. | European journal of cell biology 20090101 |
| Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2. | Endocrinology 20090101 |
| Kinetics of insulin secretion from MIN6 pseudoislets after encapsulation in a prototype device of a bioartificial pancreas. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090101 |
| Efficacy of peritoneal dialysis of tolbutamide in rats under conditions of the plasma unbound fraction being increased. | Biopharmaceutics & drug disposition 20090101 |
| Role of MAPK in apolipoprotein CIII-induced apoptosis in INS-1E cells. | Lipids in health and disease 20090101 |
| The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury. | PloS one 20090101 |
| FEM-based oxygen consumption and cell viability models for avascular pancreatic islets. | Theoretical biology & medical modelling 20090101 |
| Modulation of glucose induced oscillatory [Ca2+]i signals by nitric oxide in ob/ob mouse pancreatic beta-cells. | Mymensingh medical journal : MMJ 20090101 |
| Effects of a low-carbohydrate diet on glycemic control in outpatients with severe type 2 diabetes. | Nutrition & metabolism 20090101 |
| Human pancreatic islet isolation: Part II: purification and culture of human islets. | Journal of visualized experiments : JoVE 20090101 |
| Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. | Current medicinal chemistry 20090101 |
| The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load. | PloS one 20090101 |
| Rosiglitazone and myocardial infarction in patients previously prescribed metformin. | PloS one 20090101 |
| A cardiologic approach to non-insulin antidiabetic pharmacotherapy in patients with heart disease. | Cardiovascular diabetology 20090101 |
| Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample. | BMC medical genetics 20090101 |
| Interactions between herbal medicines and prescribed drugs: an updated systematic review. | Drugs 20090101 |
| Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation. | BMC cell biology 20090101 |
| Comparative study of increased plasma quinidine concentration in rats with glycerol- and cisplatin-induced acute renal failure. | Drug metabolism and pharmacokinetics 20090101 |
| A review of exenatide as adjunctive therapy in patients with type 2 diabetes. | Drug design, development and therapy 20090101 |
| A practical guide to rodent islet isolation and assessment. | Biological procedures online 20090101 |
| Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database. | BMJ (Clinical research ed.) 20090101 |
| Evaluation of the activity of P450 enzymes in rats: use of the single marker or combined drug administration. | Neuro endocrinology letters 20090101 |
| Glinide, but not sulfonylurea, can evoke insulin exocytosis by repetitive stimulation: imaging analysis of insulin exocytosis by secretagogue-induced repetitive stimulations. | Experimental diabetes research 20090101 |
| Role of potassium channels in stretch-promoted atrial natriuretic factor secretion. | Journal of the American Society of Hypertension : JASH 20090101 |
| Effect of 2-Hydroxy-4-Methoxy Benzoic Acid from the Roots of Hemidesmus indicus on Streptozotocin-induced Diabetic Rats. | Indian journal of pharmaceutical sciences 20090101 |
| Drugs impact on CYP-450 enzyme family: A pharmacogenetical study of response variation. | Indian journal of human genetics 20090101 |
| Update on terbinafine with a focus on dermatophytoses. | Clinical, cosmetic and investigational dermatology 20090101 |
| Glucose sensing in L cells: a primary cell study. | Cell metabolism 20081206 |
| Hypoglycemic effect of Mucuna pruriens seed extract on normal and streptozotocin-diabetic rats. | Fitoterapia 20081201 |
| Amplified hormonal counterregulatory responses to hypoglycemia in rats after systemic delivery of a SUR-1-selective K(+) channel opener? | Diabetes 20081201 |
| Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20081201 |
| Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels. | American journal of physiology. Endocrinology and metabolism 20081201 |
| Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes. | Acta pharmacologica Sinica 20081201 |
| Alpha-glucosidase inhibitors in the early treatment of type 2 diabetes. | Vascular health and risk management 20081201 |
| Long lasting synchronization of calcium oscillations by cholinergic stimulation in isolated pancreatic islets. | Biophysical journal 20081115 |
| A high-performance liquid chromatography-tandem mass spectrometry method for the clinical combination study of carboplatin and anti-tumor agent eribulin mesylate (E7389) in human plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081115 |
| Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. | The Journal of biological chemistry 20081114 |
| Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. | Journal of medicinal chemistry 20081113 |
| Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. | Diabetes care 20081101 |
| Chronic sustained and intermittent hypoxia reduce function of ATP-sensitive potassium channels in nucleus of the solitary tract. | American journal of physiology. Regulatory, integrative and comparative physiology 20081101 |
| Analyses of CYP2C in porcine microsomes. | Basic & clinical pharmacology & toxicology 20081101 |
| Metabolism-independent sugar sensing in central orexin neurons. | Diabetes 20081001 |
| K(ATP)-channels and glucose-regulated glucagon secretion. | Trends in endocrinology and metabolism: TEM 20081001 |
| Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells. | PLoS medicine 20081001 |
| Why treatment fails in type 2 diabetes. | PLoS medicine 20081001 |
| Important amino acid residues that confer CYP2C19 selective activity to CYP2C9. | Journal of biochemistry 20080901 |
| Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content. | Diabetes 20080901 |
| Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program. | Diabetes 20080901 |
| Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. | The Journal of endocrinology 20080901 |
| Longitudinal changes in insulin sensitivity and body composition of small-for-gestational-age adolescents after cessation of growth hormone treatment. | The Journal of clinical endocrinology and metabolism 20080901 |
| Bringing light to the dark side of insulin: a journey across the blood-brain barrier. | Diabetes 20080901 |
| Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. | Diabetes 20080801 |
| Regulation by glucose of oscillatory electrical activity and 5-HT/insulin release from single mouse pancreatic islets in absence of functional K(ATP) channels. | Endocrine journal 20080801 |
| Imaging aspects of cardiovascular disease at the cell and molecular level. | Histochemistry and cell biology 20080801 |
| Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080801 |
| Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel. | PLoS medicine 20080801 |
| [Bax is involved in K ATP-mediated protection of the hippocampal neurons against hypoxic exposure]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080801 |
| Proposed new addition to 3Rs for ethical and humane use of rats in pharmacokinetic studies--'Recycle'. | Drug metabolism letters 20080801 |
| Elevation in intracellular long-chain acyl-coenzyme A esters lead to reduced beta-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channels. | Endocrinology 20080701 |
| Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. III. In vitro-in vivo correlation with fluconazole. | Drug metabolism and disposition: the biological fate of chemicals 20080701 |
| Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. II. In vitro-in vivo correlation with ketoconazole. | Drug metabolism and disposition: the biological fate of chemicals 20080701 |
| Glucose metabolism in vivo in four commonly used inbred mouse strains. | Diabetes 20080701 |
| Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD/SCID mice. | Diabetes 20080701 |
| Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea. | Pharmacogenetics and genomics 20080701 |
| Cytochrome P450 2C9 mediated metabolism in people with and without cancer. | International journal of clinical pharmacology and therapeutics 20080701 |
| INGAP-PP up-regulates the expression of genes and proteins related to K+ ATP channels and ameliorates Ca2+ handling in cultured adult rat islets. | Regulatory peptides 20080605 |
| Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080601 |
| Hydrogen peroxide-induced translocation of glycolipid-anchored (c)AMP-hydrolases to lipid droplets mediates inhibition of lipolysis in rat adipocytes. | British journal of pharmacology 20080601 |
| Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical. | The AAPS journal 20080601 |
| Pharmaceutical particle engineering via spray drying. | Pharmaceutical research 20080501 |
| Low intense physical exercise in normobaric hypoxia leads to more weight loss in obese people than low intense physical exercise in normobaric sham hypoxia. | Sleep & breathing = Schlaf & Atmung 20080501 |
| Ovarian steroids stimulate adenosine triphosphate-sensitive potassium (KATP) channel subunit gene expression and confer responsiveness of the gonadotropin-releasing hormone pulse generator to KATP channel modulation. | Endocrinology 20080501 |
| A Kir6.2 mutation causing severe functional effects in vitro produces neonatal diabetes without the expected neurological complications. | Diabetologia 20080501 |
| Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. | The Journal of steroid biochemistry and molecular biology 20080501 |
| A novel ABCC8 (SUR1)-dependent mechanism of metabolism-excitation uncoupling. | The Journal of biological chemistry 20080404 |
| Resting energy expenditure in insulin resistance falls with decompensation of insulin secretion in obese children. | Journal of pediatric endocrinology & metabolism : JPEM 20080401 |
| Prevention of chemotherapy-induced nausea and vomiting: focus on fosaprepitant. | Therapeutics and clinical risk management 20080401 |
| Chronic hypoglycemic effect of Malmea depressa root on n5-streptozotocin diabetic rats. | Journal of ethnopharmacology 20080305 |
| Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta. | The Journal of endocrinology 20080301 |
| [Neonatal diabetes mellitus]. | Arquivos brasileiros de endocrinologia e metabologia 20080301 |
| Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel. | The Journal of biological chemistry 20080227 |
| Influence of chalcone analogues on serum glucose levels in hyperglycemic rats. | Chemico-biological interactions 20080215 |
| Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide. | Journal of ethnopharmacology 20080212 |
| Cytochrome P450 2C9 *2 and *3 polymorphisms and the dose and effect of sulfonylurea in type II diabetes mellitus. | Clinical pharmacology and therapeutics 20080201 |
| The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080201 |
| Impaired glucose-stimulated insulin secretion is coupled with exocrine pancreatic lesions in the Cohen diabetic rat. | Diabetes 20080201 |
| Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment. | European journal of clinical pharmacology 20080201 |
| Inhibitory effects of fruit juices on cytochrome P450 2C9 activity in vitro. | Bioscience, biotechnology, and biochemistry 20080201 |
| Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans. | Diabetic medicine : a journal of the British Diabetic Association 20080201 |
| Glucose induces synchronous mitochondrial calcium oscillations in intact pancreatic islets. | Cell calcium 20080101 |
| Inhibition of striatal dopamine release by CB1 receptor activation requires nonsynaptic communication involving GABA, H2O2, and KATP channels. | Neurochemistry international 20080101 |
| Protection of pancreatic beta-cells: is it feasible? | Nutrition, metabolism, and cardiovascular diseases : NMCD 20080101 |
| Attenuation of Biochemical Parameters in Streptozotocin-induced Diabetic Rats by Oral Administration of Extracts and Fractions of Cephalotaxus sinensis. | Journal of clinical biochemistry and nutrition 20080101 |
| PAX4 enhances beta-cell differentiation of human embryonic stem cells. | PloS one 20080101 |
| Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis. | BMC medical genetics 20080101 |
| Functional role of Ile264 in CYP2C8: mutations affect haem incorporation and catalytic activity. | Drug metabolism and pharmacokinetics 20080101 |
| Clinical drugs that interact with St. John's wort and implication in drug development. | Current pharmaceutical design 20080101 |
| Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling. | Theoretical biology & medical modelling 20080101 |
| Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome. | PloS one 20080101 |
| TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. | BMC medical genetics 20080101 |
| Drug-therapy networks and the prediction of novel drug targets. | Journal of biology 20080101 |
| Acne vulgaris, mental health and omega-3 fatty acids: a report of cases. | Lipids in health and disease 20080101 |
| Role of cytochrome P450 in drug interactions. | Nutrition & metabolism 20080101 |
| Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model. | Acta veterinaria Scandinavica 20080101 |
| Resveratrol inhibits electrical activity and insulin release from insulinoma cells by block of voltage-gated Ca+ channels and swelling-dependent Cl- currents. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101 |
| Limited applicability of 7-methoxy-4-trifluoromethylcoumarin as a CYP2C9-selective substrate. | Pharmacological reports : PR 20080101 |
| Hypoglycemic activity of Hemidesmus indicus R. Br. on streptozotocin-induced diabetic rats. | International journal of diabetes in developing countries 20080101 |
| Recent challenges in insulin delivery systems: a review. | Indian journal of pharmaceutical sciences 20080101 |
| Formulation and characterization of mucoadhesive buccal films of glipizide. | Indian journal of pharmaceutical sciences 20080101 |
| Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan-induced diabetic rats. | Indian journal of pharmacology 20080101 |
| Nutrient control of insulin secretion in perifused adult pig islets. | Diabetes & metabolism 20071201 |
| Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. | Diabetes 20071201 |
| Effect of methamphetamine on cytochrome P450 activity. | Xenobiotica; the fate of foreign compounds in biological systems 20071201 |
| Short- and long-term mortality after acute myocardial infarction: comparison of patients with and without diabetes mellitus. | European journal of epidemiology 20071201 |
| Antidiabetic properties of 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene from mulberry (Morus bombycis koidzumi) root in streptozotocin-induced diabetic rats. | Journal of medicinal food 20071201 |
| Summary of the 2007 European Society of Hypertension (ESH) and European Society of Cardiology (ESC) guidelines for the management of arterial hypertension. | Vascular health and risk management 20071201 |
| A review of nateglinide in the management of patients with type 2 diabetes. | Vascular health and risk management 20071201 |
| [A case-control study of risk factors for myelodysplastic syndromes]. | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20071201 |
| Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes. | Proceedings of the National Academy of Sciences of the United States of America 20071127 |
| Synthesis and antidiabetic activity of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines and thieno[2,3-b]pyridines. | Bioorganic & medicinal chemistry 20071101 |
| Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination. | Drug metabolism and disposition: the biological fate of chemicals 20071101 |
| Assessment of antidiabetic potential of Cynodon dactylon extract in streptozotocin diabetic rats. | Journal of ethnopharmacology 20071101 |
| Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced diabetic rats. | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20071101 |
| Attenuation of insulin secretion by insulin-like growth factor binding protein-1 in pancreatic beta-cells. | Biochemical and biophysical research communications 20071012 |
| High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. | Diabetologia 20071001 |
| Response normalized liquid chromatography nanospray ionization mass spectrometry. | Journal of the American Society for Mass Spectrometry 20071001 |
| Characterization of cytochrome P450-mediated drug metabolism in cats. | Journal of veterinary pharmacology and therapeutics 20071001 |
| A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes. | Vascular health and risk management 20071001 |
| Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070919 |
| The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells. | FEBS letters 20070904 |
| Sulfonylurea and glinide reduce insulin content, functional expression of K(ATP) channels, and accelerate apoptotic beta-cell death in the chronic phase. | Diabetes research and clinical practice 20070901 |
| Congenital hyperinsulinism associated ABCC8 mutations that cause defective trafficking of ATP-sensitive K+ channels: identification and rescue. | Diabetes 20070901 |
| Synthesis of 3,8,9-trisubstituted-1,7,9-triaza-fluorene-6-carboxylic acid derivatives as a new class of insulin secretagogues. | Bioorganic & medicinal chemistry 20070901 |
| Memantine inhibits ATP-dependent K+ conductances in dopamine neurons of the rat substantia nigra pars compacta. | The Journal of pharmacology and experimental therapeutics 20070801 |
| Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release. | The Journal of pharmacology and experimental therapeutics 20070801 |
| The role of mitochondria in protection of the heart by preconditioning. | Biochimica et biophysica acta 20070801 |
| [Protection mechanisms of ATP-sensitive K channels on hippocampal CA1 neurons during chronic severe hypoxia]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070801 |
| Dioscorea as the principal herb of Die-Huang-Wan, a widely used herbal mixture in China, for improvement of insulin resistance in fructose-rich chow-fed rats. | Journal of ethnopharmacology 20070725 |
| Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070701 |
| Nateglinide and mitiglinide, but not sulfonylureas, induce insulin secretion through a mechanism mediated by calcium release from endoplasmic reticulum. | The Journal of pharmacology and experimental therapeutics 20070701 |
| In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies. | Journal of mass spectrometry : JMS 20070701 |
| Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601 |
| Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator. | Diabetes 20070601 |
| A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. | PLoS biology 20070601 |
| Identification and partial characterization of a novel CYP2C9 splicing variant encoding a protein lacking eight amino acid residues. | Drug metabolism and pharmacokinetics 20070601 |
| [Simultaneous determination of the inhibitory potency of compounds on the activity of five cytochrome P-450 enzymes using a cocktail probe substrates method]. | Yao xue xue bao = Acta pharmaceutica Sinica 20070601 |
| Reversibility of enantiotropically related polymorphic transformations from a practical viewpoint: thermal analysis of kinetically reversible/irreversible polymorphic transformations. | Journal of pharmaceutical sciences 20070501 |
| Prolonged exposure to homocysteine results in diminished but reversible pancreatic beta-cell responsiveness to insulinotropic agents. | Diabetes/metabolism research and reviews 20070501 |
| Design, synthesis, and biological evaluation of substituted-N-(thieno[2,3-b]pyridin-3-yl)-guanidines, N-(1H-pyrrolo[2,3-b]pyridin-3-yl)-guanidines, and N-(1H-indol-3-yl)-guanidines. | Bioorganic & medicinal chemistry 20070501 |
| Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20070501 |
| Indian herbs and herbal drugs used for the treatment of diabetes. | Journal of clinical biochemistry and nutrition 20070501 |
| The Anti-Obesity Effect of the Palatinose-Based Formula Inslow is Likely due to an Increase in the Hepatic PPAR-alpha and Adipocyte PPAR-gamma Gene Expressions. | Journal of clinical biochemistry and nutrition 20070501 |
| Rapid inhibition of neurons in the dorsal motor nucleus of the vagus by leptin. | Endocrinology 20070401 |
| PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. | PLoS genetics 20070401 |
| Involvement of chloride channel coupled GABA(C) receptors in the peripheral antinociceptive effect induced by GABA(C) receptor agonist cis-4-aminocrotonic acid. | Life sciences 20070313 |
| Does the preferred orientation of crystallites in tablets affect the intrinsic dissolution? | Journal of pharmaceutical and biomedical analysis 20070312 |
| Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. | Drug metabolism and disposition: the biological fate of chemicals 20070301 |
| Characterization of the physiological spaces and distribution of tolbutamide in the perfused rat pancreas. | Pharmaceutical research 20070301 |
| Monoglycerides and fatty acids from Ibervillea sonorae root: isolation and hypoglycemic activity. | Planta medica 20070301 |
| Pharmacological and molecular characterization of ATP-sensitive K(+) conductances in CART and NPY/AgRP expressing neurons of the hypothalamic arcuate nucleus. | Neuroscience 20070209 |
| Adult pancreatic islets require differential pax6 gene dosage. | Biochemical and biophysical research communications 20070202 |
| Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. | Drug metabolism and disposition: the biological fate of chemicals 20070201 |
| Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance. | Drug metabolism and disposition: the biological fate of chemicals 20070201 |
| Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells. | Diabetologia 20070201 |
| Electrophysiological and pharmacological characterization of the K(ATP) channel involved in the K+-current responses to FSH and adenosine in the follicular cells of Xenopus oocyte. | The journal of physiological sciences : JPS 20070201 |
| Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum. | Journal of natural products 20070201 |
| An ATP-binding mutation (G334D) in KCNJ11 is associated with a sulfonylurea-insensitive form of developmental delay, epilepsy, and neonatal diabetes. | Diabetes 20070201 |
| Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1. | Diabetes 20070201 |
| The BIGTT test: a novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance. | Diabetes care 20070201 |
| Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the 'cocktail' approach. | Clinical pharmacology and therapeutics 20070201 |
| Impact of clinical characteristics of individual metabolic syndrome on the severity of insulin resistance in Chinese adults. | Journal of Korean medical science 20070201 |
| 3T3-L1 adipocytes induce dysfunction of MIN6 insulin-secreting cells via multiple pathways mediated by secretory factors in a co-culture system. | Endocrine 20070201 |
| Effect of crude extract and fractions from Vitex megapotamica leaves on hyperglycemia in alloxan-diabetic rats. | Journal of ethnopharmacology 20070103 |
| In vivo antidiabetic and antioxidant potential of Helichrysum plicatum ssp. plicatum capitulums in streptozotocin-induced-diabetic rats. | Journal of ethnopharmacology 20070103 |
| In silico prediction of pregnane X receptor activators by machine learning approaches. | Molecular pharmacology 20070101 |
| A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data. | Drug metabolism and disposition: the biological fate of chemicals 20070101 |
| Antagonism of the insulinotropic action of first generation imidazolines by openers of K(ATP) channels. | Biochemical pharmacology 20070101 |
| The effects induced by the sulphonylurea glibenclamide on the neonatal rat spinal cord indicate a novel mechanism to control neuronal excitability and inhibitory neurotransmission. | British journal of pharmacology 20070101 |
| CYP2C76-mediated species difference in drug metabolism: a comparison of pitavastatin metabolism between monkeys and humans. | Xenobiotica; the fate of foreign compounds in biological systems 20070101 |
| Homocysteine-induced impairment of insulin secretion from clonal pancreatic BRIN-BD11 beta-cells is not prevented by catalase. | Pancreas 20070101 |
| Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic beta-cells. | The Journal of endocrinology 20070101 |
| Effect of creatine on the pancreatic beta-cell. | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20070101 |
| The KATP channel is critical for calcium sequestration into non-ER compartments in mouse pancreatic beta cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101 |
| The blockade of K(+)-ATP channels has neuroprotective effects in an in vitro model of brain ischemia. | International review of neurobiology 20070101 |
| A discrete Single Delay Model for the Intra-Venous Glucose Tolerance Test. | Theoretical biology & medical modelling 20070101 |
| Induction of insulin secretion in engineered liver cells by nitric oxide. | BMC physiology 20070101 |
| Loss of sugar detection by GLUT2 affects glucose homeostasis in mice. | PloS one 20070101 |
| Pitfalls in diagnosing a small cystic insulinoma: a case report. | Journal of medical case reports 20070101 |
| An insulin-like modular basis for the evolution of glucose transporters (GLUT) with implications for diabetes. | Evolutionary bioinformatics online 20070101 |
| Cloning of a cDNA encoding a novel marmoset CYP2C enzyme, expression in yeast cells and characterization of its enzymatic functions. | Biochemical pharmacology 20061215 |
| A1 adenosine receptor-mediated modulation of neuronal ATP-sensitive K channels in rat substantia nigra. | Brain research 20061208 |
| CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles. | Drug metabolism and disposition: the biological fate of chemicals 20061201 |
| Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes. | Pflugers Archiv : European journal of physiology 20061201 |
| Improved outcomes in islet isolation and transplantation by the use of a novel hemoglobin-based O2 carrier. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20061201 |
| Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing. | Diabetes 20061201 |
| Nutrient control of insulin secretion in isolated normal human islets. | Diabetes 20061201 |
| Chick pancreatic B islets as an alternative in vitro model for screening insulin secretagogues. | Poultry science 20061201 |
| Stimulus-secretion coupling of hypotonicity-induced insulin release in BRIN-BD11 cells. | Endocrine 20061201 |
| In-vivo assessment of antidiabetic and antioxidant activities of grapevine leaves (Vitis vinifera) in diabetic rats. | Journal of ethnopharmacology 20061124 |
| Enzyme source effects on CYP2C9 kinetics and inhibition. | Drug metabolism and disposition: the biological fate of chemicals 20061101 |
| Improvement of insulin resistance by miracle fruit (Synsepalum dulcificum) in fructose-rich chow-fed rats. | Phytotherapy research : PTR 20061101 |
| Baclofen, an agonist at peripheral GABAB receptors, induces antinociception via activation of TEA-sensitive potassium channels. | British journal of pharmacology 20061101 |
| Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers. | Journal of clinical pharmacology 20061101 |
| Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress. | Biochemical Society transactions 20061101 |
| Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism. | The FEBS journal 20061101 |
| Antidiabetic, antioxidant and antihyperlipidemic status of Heliotropium zeylanicum extract on streptozotocin-induced diabetes in rats. | Biological & pharmaceutical bulletin 20061101 |
| OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. | PLoS medicine 20061101 |
| Human ether-a-go-go-related (HERG) gene and ATP-sensitive potassium channels as targets for adverse drug effects. | Pharmacology & therapeutics 20061001 |
| Iptakalim modulates ATP-sensitive K(+) channels in dopamine neurons from rat substantia nigra pars compacta. | The Journal of pharmacology and experimental therapeutics 20061001 |
| [The inhibition of CYP2C9 isoenzyme in Cunninghamella blakesleeana AS 3. 910]. | Yao xue xue bao = Acta pharmaceutica Sinica 20061001 |
| Modelling the electrical activity of pancreatic alpha-cells based on experimental data from intact mouse islets. | Journal of biological physics 20061001 |
| Biotransformation of tolbutamide to 4'-hydroxytolbutamide by the fungus Cunninghamella blakesleeana. | Applied microbiology and biotechnology 20060901 |
| Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: impact on prediction of first-pass metabolism. | The Journal of pharmacology and experimental therapeutics 20060901 |
| Acute insulin response (AIR): review of protocols and clinical interest in islet transplantation. | Diabetes & metabolism 20060901 |
| Molecular modelling of K(ATP) channel blockers-ADP/ ATP carrier interactions. | Systems biology 20060901 |
| Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide. | The Journal of endocrinology 20060901 |
| Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. | The New England journal of medicine 20060803 |
| Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. | The New England journal of medicine 20060803 |
| CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone. | Molecular pharmacology 20060801 |
| Antiallodynic effect of etidronate, a bisphosphonate, in rats with adjuvant-induced arthritis: involvement of ATP-sensitive K+ channels. | Neuropharmacology 20060801 |
| Polysaccharide peptides from COV-1 strain of Coriolus versicolor inhibit tolbutamide 4-hydroxylation in the rat in vitro and in vivo. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060801 |
| Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. | Glia 20060801 |
| K+-ATP-channel-related protein complexes: potential transducers in the regulation of epithelial tight junction permeability. | Journal of cell science 20060801 |
| In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia. | Circulation 20060801 |
| Development of dosage design of hepatic metabolizing drugs using serum albumin level in chronic hepatic failure. | Biological & pharmaceutical bulletin 20060801 |
| First phase of glucose-stimulated insulin secretion from MIN 6 cells does not always require extracellular calcium influx. | Journal of pharmacological sciences 20060801 |
| Cell specificity of the cytoplasmic Ca2+ response to tolbutamide is impaired in beta-cells from hyperglycemic mice. | The Journal of endocrinology 20060801 |
| Micronization and polymorphic conversion of tolbutamide and barbital by rapid expansion of supercritical solutions. | Drug development and industrial pharmacy 20060801 |
| Peripheral antinociceptive effect of pertussis toxin: activation of the arginine/NO/cGMP/PKG/ ATP-sensitive K channel pathway. | The European journal of neuroscience 20060801 |
| Peritoneal dialysis alters tolbutamide pharmacokinetics in rats with experimental acute renal failure. | Drug metabolism and pharmacokinetics 20060801 |
| Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. | The Journal of clinical investigation 20060703 |
| The clinical applications of a systems approach. | PLoS medicine 20060701 |
| Intracellular ATP-sensitive K+ channels in mouse pancreatic beta cells: against a role in organelle cation homeostasis. | Diabetologia 20060701 |
| Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling. | Xenobiotica; the fate of foreign compounds in biological systems 20060701 |
| Inhibitory effects of cytostatically active 6-aminobenzo[c]phenanthridines on cytochrome P450 enzymes in human hepatic microsomes. | Basic & clinical pharmacology & toxicology 20060701 |
| Host-guest chemistry of tolbutamide. | Molecules (Basel, Switzerland) 20060623 |
| Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: implications for ingestive behaviour. | The Journal of physiology 20060601 |
| Prediction of in vivo drug clearance from in vitro data. II: potential inter-ethnic differences. | Xenobiotica; the fate of foreign compounds in biological systems 20060601 |
| Role of site-specific binding to plasma albumin in drug availability to brain. | The Journal of pharmacology and experimental therapeutics 20060501 |
| Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. | Neuroscience letters 20060501 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| L-cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter. | Diabetes 20060501 |
| Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion. | The Journal of endocrinology 20060501 |
| Regulators for blood glucose level affect gene expression of aquaporin 3. | Biological & pharmaceutical bulletin 20060501 |
| In silico pharmacogenetics of warfarin metabolism. | Nature biotechnology 20060501 |
| Cynomolgus monkey cytochrome P450 2C43: cDNA cloning, heterologous expression, purification and characterization. | Journal of biochemistry 20060501 |
| MIN6 beta-cell-beta-cell interactions influence insulin secretory responses to nutrients and non-nutrients. | Biochemical and biophysical research communications 20060428 |
| The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel. | The Journal of biological chemistry 20060407 |
| Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus. | Journal of ethnopharmacology 20060406 |
| Depth profiling of compression-induced disorders and polymorphic transition on tablet surfaces with grazing incidence X-ray diffraction. | Pharmaceutical research 20060401 |
| Induction of cytochrome P450-dependent monooxygenase by extracts of the medicinal herb Salvia miltiorrhiza. | The Journal of pharmacy and pharmacology 20060401 |
| Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta-cells. | The Journal of endocrinology 20060401 |
| Effect of Helicteres isora bark extract on blood glucose and hepatic enzymes in experimental diabetes. | Die Pharmazie 20060401 |
| Dual mechanism of the potentiation by glucose of insulin secretion induced by arginine and tolbutamide in mouse islets. | American journal of physiology. Endocrinology and metabolism 20060301 |
| Glibenclamide-induced apoptosis is specifically enhanced by expression of the sulfonylurea receptor isoform SUR1 but not by expression of SUR2B or the mutant SUR1(M1289T). | The Journal of pharmacology and experimental therapeutics 20060301 |
| Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometry. | Drug metabolism and disposition: the biological fate of chemicals 20060301 |
| Possible activation of the NO-cyclic GMP-protein kinase G-K+ channels pathway by gabapentin on the formalin test. | Pharmacology, biochemistry, and behavior 20060301 |
| Supercritical fluid chromatography/tandem mass spectrometric method for analysis of pharmaceutical compounds in metabolic stability samples. | Journal of pharmaceutical and biomedical analysis 20060224 |
| Reduction in voltage-gated K+ currents in primary cultured rat pancreatic beta-cells by linoleic acids. | Endocrinology 20060201 |
| Neuronal responses to transient hypoglycaemia in the dorsal vagal complex of the rat brainstem. | The Journal of physiology 20060201 |
| 5-HT uptake blockade prevents the increasing effect of K(ATP) channel blockers on electrically evoked [3H]-5-HT release in rat and mouse neocortical slices. | Neurochemistry international 20060201 |
| Increased levels of cyclins D1 and D3 after inhibition of gap junctional communication in astrocytes. | Journal of neurochemistry 20060201 |
| Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing. | Diabetes 20060201 |
| Effect of oral administration of clinically relevant doses of dexamethasone on regulation of cytochrome P450 subfamilies in hepatic microsomes from dogs and rats. | American journal of veterinary research 20060201 |
| Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells. | PLoS biology 20060201 |
| Inhibition of human cytochrome P450 isoforms and NADPH-CYP reductase in vitro by 15 herbal medicines, including Epimedii herba. | Journal of clinical pharmacy and therapeutics 20060201 |
| Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism. | The Journal of pediatrics 20060201 |
| Development and validation of HTS flux assay for endogenously expressed chloride channels in a CHO-K1 cell line. | Assay and drug development technologies 20060201 |
| Drug nanoparticle formation from drug/HPMC/SDS ternary ground mixtures. | Die Pharmazie 20060201 |
| KATP channels in mouse spermatogenic cells and sperm, and their role in capacitation. | Developmental biology 20060115 |
| Diversity of Cl(-) channels. | Cellular and molecular life sciences : CMLS 20060101 |
| Hypoglycemic effects of the wood of Taxus yunnanensis on streptozotocin-induced diabetic rats and its active components. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20060101 |
| Serum aminotransferase activity as a predictor for estimation of total clearance of hepatically metabolized drugs in rats with acute hepatic failure. | Biological & pharmaceutical bulletin 20060101 |
| Influences of drugs on the oxygen uptake rate and biosorption of activated sludge. | Biological & pharmaceutical bulletin 20060101 |
| Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion. | Cell metabolism 20060101 |
| Antidiabetic and hypolipidaemic effects of a methanol/methylene-chloride extract of Laportea ovalifolia (Urticaceae), measured in rats with alloxan-induced diabetes. | Annals of tropical medicine and parasitology 20060101 |
| Ginkgo biloba: evaluation of CYP2C9 drug interactions in vitro and in vivo. | American journal of therapeutics 20060101 |
| Effects of sulfonylureas on mitochondrial ATP-sensitive K+ channels in cardiac myocytes: implications for sulfonylurea controversy. | Diabetes/metabolism research and reviews 20060101 |
| Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. | Annals of clinical microbiology and antimicrobials 20060101 |
| Ultra-low flow nanospray for the normalization of conventional liquid chromatography/mass spectrometry through equimolar response: standard-free quantitative estimation of metabolite levels in drug discovery. | Rapid communications in mass spectrometry : RCM 20060101 |
| Prediction models for insulin resistance in girls with premature adrenarche. The premature adrenarche insulin resistance score: PAIR score. | Hormone research 20060101 |
| Dimensional analysis of MINMOD leads to definition of the disposition index of glucose regulation and improved simulation algorithm. | Biomedical engineering online 20060101 |
| Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects. | BMC medical genetics 20060101 |
| Glucose induces anion conductance and cytosol-to-membrane transposition of ICln in INS-1E rat insulinoma cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101 |
| Effects of irsogladine on P450-isoform specific activities in human hepatic microsomes. | Arzneimittel-Forschung 20060101 |
| Inhibition of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells by sulfonylurea glibenclamide. | European journal of pharmacology 20051219 |
| Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver. | Life sciences 20051205 |
| Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians. | The Journal of pharmacology and experimental therapeutics 20051201 |
| Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells. | Pflugers Archiv : European journal of physiology 20051201 |
| Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers. | Drug metabolism and disposition: the biological fate of chemicals 20051201 |
| Probable activation of the opioid receptor-nitric oxide-cyclic GMP-K+ channels pathway by codeine. | Pharmacology, biochemistry, and behavior 20051201 |
| The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds. | International journal of pharmaceutics 20051123 |
| Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20051101 |
| Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes. | Diabetes care 20051101 |
| Oxygen and glucose deprivation induces major dysfunction in the somatosensory cortex of the newborn rat. | The European journal of neuroscience 20051101 |
| Hypoglycemic activity of a new carbohydrate isolated from the roots of Psacalium peltatum. | Chemical & pharmaceutical bulletin 20051101 |
| Testosterone rapidly stimulates insulin release from isolated pancreatic islets through a non-genomic dependent mechanism. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20051101 |
| Partial mitochondrial inhibition causes striatal dopamine release suppression and medium spiny neuron depolarization via H2O2 elevation, not ATP depletion. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20051026 |
| Acute effects of 6-hydroxydopamine on dopaminergic neurons of the rat substantia nigra pars compacta in vitro. | Neurotoxicology 20051001 |
| Protective role of hydrogen peroxide in oxygen-deprived dopaminergic neurones of the rat substantia nigra. | The Journal of physiology 20051001 |
| Changes in muscle mRNAs for hexokinase, phosphofructokinase-1 and glycogen synthase in acute and persistent hypoglycemia induced by tolbutamide in chickens. | Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20051001 |
| Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function. | The Journal of experimental biology 20051001 |
| Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20051001 |
| Adenovirus-mediated silencing of synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets. | FEBS letters 20050926 |
| Tungstate stimulates insulin release and inhibits somatostatin output in the perfused rat pancreas. | European journal of pharmacology 20050905 |
| Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. | The Journal of biological chemistry 20050902 |
| The use of sandwich-cultured rat hepatocytes to determine the intrinsic clearance of compounds with different extraction ratios: 7-ethoxycoumarin and warfarin. | Drug metabolism and disposition: the biological fate of chemicals 20050901 |
| Identification and quantification of 8 sulfonylureas with clinical toxicology interest by liquid chromatography-ion-trap tandem mass spectrometry and library searching. | Clinical chemistry 20050901 |
| ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapy. | Diabetes 20050901 |
| Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. | Biological & pharmaceutical bulletin 20050901 |
| Catalytic activities of human cytochrome P450 2C9*1, 2C9*3 and 2C9*13. | Xenobiotica; the fate of foreign compounds in biological systems 20050901 |
| Heme impairs allosterically drug binding to human serum albumin Sudlow's site I. | Biochemical and biophysical research communications 20050826 |
| Nateglinide, a non-sulfonylurea rapid insulin secretagogue, increases pancreatic islet blood flow in rats. | European journal of pharmacology 20050822 |
| Sulfhydryl oxidation reduces hippocampal susceptibility to hypoxia-induced spreading depression by activating BK channels. | Journal of neurophysiology 20050801 |
| Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa. | Drug metabolism and disposition: the biological fate of chemicals 20050801 |
| Pharmacological evidence for the activation of Ca2+-activated K+ channels by meloxicam in the formalin test. | Pharmacology, biochemistry, and behavior 20050801 |
| Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans. | Environmental health perspectives 20050801 |
| Improvement of insulin resistance by Acanthopanax senticosus root in fructose-rich chow-fed rats. | Clinical and experimental pharmacology & physiology 20050801 |
| The novel formulation design of self-emulsifying drug delivery systems (SEDDS) type O/W microemulsion I: enhancing effects on oral bioavailability of poorly water soluble compounds in rats and beagle dogs. | Drug metabolism and pharmacokinetics 20050801 |
| [Influence of cytochrom P450 CYP2C9 polymorphism on the pharmacokinetics of tolbutamide metabolism using oligonucleotide genotyping microarray]. | Yao xue xue bao = Acta pharmaceutica Sinica 20050801 |
| Cytosolic Cl- ions in the regulation of secretory and endocytotic activity in melanotrophs from mouse pituitary tissue slices. | The Journal of physiology 20050715 |
| Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism. | Drug metabolism and disposition: the biological fate of chemicals 20050701 |
| Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a cystic fibrosis transmembrane conductance regulator-independent mechanism. | Gastroenterology 20050701 |
| Twenty-four hour tolbutamide plasma concentration as a phenotypic measure of CYP2C9 activity. | European journal of clinical pharmacology 20050601 |
| Relationship of P450 2C9 genetic polymorphisms in Chinese and the pharmacokinetics of tolbutamide. | Journal of clinical pharmacy and therapeutics 20050601 |
| Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. | Diabetes 20050601 |
| Electrochemical characterisation of the human cytochrome P450 CYP2C9. | Biochemical pharmacology 20050515 |
| Effect of 17beta-estradiol on insulin secretion and cytosolic calcium in Min6 mouse insulinoma cells and human islets of Langerhans. | Pancreas 20050501 |
| Analysis of the mechanism underlying the peripheral antinociceptive action of sildenafil in the formalin test. | European journal of pharmacology 20050411 |
| Evaluation of the hypoglycemic effect and antioxidant activity of three Viscum album subspecies (European mistletoe) in streptozotocin-diabetic rats. | Journal of ethnopharmacology 20050408 |
| Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. | Journal of medicinal chemistry 20050407 |
| Delta-opioid receptor agonist SNC80 induces peripheral antinociception via activation of ATP-sensitive K+ channels. | European journal of pharmacology 20050404 |
| Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. | Drug metabolism and disposition: the biological fate of chemicals 20050401 |
| A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. | Diabetologia 20050401 |
| HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. | Journal of immunology (Baltimore, Md. : 1950) 20050401 |
| Similarities of K+ATP channel expression and Ca2+ changes in pancreatic beta cells and hypothalamic neurons. | Pancreas 20050401 |
| Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers. | Diabetic medicine : a journal of the British Diabetic Association 20050401 |
| Hypoglycemic and antihyperglycemic effect of Gmelina asiatica LINN. in normal and in alloxan induced diabetic rats. | Biological & pharmaceutical bulletin 20050401 |
| [Effects of Chinese herbal medicines on intestinal drug absorption]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050401 |
| Effect of Sanguis draxonis (a Chinese traditional herb) on the formation of insulin resistance in rats. | Diabetes research and clinical practice 20050401 |
| Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. | The Journal of investigative dermatology 20050401 |
| No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John's wort extract. | Planta medica 20050401 |
| The increase in gap junctional communication decreases the rate of glucose uptake in C6 glioma cells by releasing hexokinase from mitochondria. | Brain research 20050328 |
| Acute and chronic hypoglycemic effect of Ibervillea sonorae root extracts-II. | Journal of ethnopharmacology 20050321 |
| Oxymorphone extended release does not affect CYP2C9 or CYP3A4 metabolic pathways. | Journal of clinical pharmacology 20050301 |
| Improvement of insulin resistance by panax ginseng in fructose-rich chow-fed rats. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050301 |
| Hypoglycemic effects of Murraya koenigii on normal and alloxan-diabetic rabbits. | Journal of ethnopharmacology 20050227 |
| Metabotropic glutamate receptor activity induces a novel oscillatory pattern in neonatal rat hypoglossal motoneurones. | The Journal of physiology 20050215 |
| Lansoprazole enantiomer activates human liver microsomal CYP2C9 catalytic activity in a stereospecific and substrate-specific manner. | Drug metabolism and disposition: the biological fate of chemicals 20050201 |
| Genotype-phenotype correlations in children with congenital hyperinsulinism due to recessive mutations of the adenosine triphosphate-sensitive potassium channel genes. | The Journal of clinical endocrinology and metabolism 20050201 |
| Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas. | Biochemical pharmacology 20050201 |
| The pore-forming subunit of the K(ATP) channel is an important molecular target for LPS-induced vascular hyporeactivity in vitro. | British journal of pharmacology 20050201 |
| Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels. | British journal of pharmacology 20050201 |
| Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. | Planta medica 20050201 |
| Crystal forms of tolbutamide from acetonitrile and 1-octanol: effect of solvent, humidity and compression pressure. | International journal of pharmaceutics 20050120 |
| Sulfonylurea induced beta-cell apoptosis in cultured human islets. | The Journal of clinical endocrinology and metabolism 20050101 |
| Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide. | Biochemical pharmacology 20050101 |
| Prediction of in vitro intrinsic clearance from hepatocytes: comparison of suspensions and monolayer cultures. | Drug metabolism and disposition: the biological fate of chemicals 20050101 |
| Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus. | Diabetes 20050101 |
| Uncoupling of nutrient metabolism from insulin secretion by overexpression of cytosolic phospholipase A(2). | Diabetes 20050101 |
| Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050101 |
| Clinical consequences of cytochrome P450 2C9 polymorphisms. | Clinical pharmacology and therapeutics 20050101 |
| Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. | BMC physiology 20050101 |
| Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20050101 |
| Prolactin, an activator of epithelial Na+ channel, inhibits basolateral K+ channels in adult tree frog skin. | Zoological science 20050101 |
| Simultaneous determination of paracetamol and dextropropoxyphene in human plasma by liquid chromatography/tandem mass spectrometry: application to clinical bioequivalence studies. | Rapid communications in mass spectrometry : RCM 20050101 |
| The 'Statinth' wonder of the world: a panacea for all illnesses or a bubble about to burst. | Journal of negative results in biomedicine 20050101 |
| Cardiovascular risk factors associated with insulin resistance: effects of oral antidiabetic agents. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101 |
| Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats. | BMC complementary and alternative medicine 20050101 |
| High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20050101 |
| Hypoglycemic and antiperglycemic effects of Semecarpus anacardium linn in normal and alloxan-induced diabetic rats. | Journal of herbal pharmacotherapy 20050101 |
| Assay for high glucose-mediated islet cell sensitization to apoptosis induced by streptozotocin and cytokines. | Biological procedures online 20050101 |
| Bench-to-bedside review: Antidotal treatment of sulfonylurea-induced hypoglycaemia with octreotide. | Critical care (London, England) 20050101 |
| Effects of etodolac on P450 isoform-specific activities in human hepatic microsomes. | Arzneimittel-Forschung 20050101 |
| Exubera(®) (inhaled insulin): an evidence-based review of its effectiveness in the management of diabetes. | Core evidence 20050101 |
| ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells. | Diabetes 20041201 |
| Massive augmentation of stimulated insulin secretion induced by fatty acid-free BSA in rat pancreatic islets. | Diabetes 20041201 |
| Insulin resistance and impaired insulin secretion in prenatally androgenized male rhesus monkeys. | The Journal of clinical endocrinology and metabolism 20041201 |
| Hypoglycemic and antihyperglycemic effect of Semecarpus anacardium Linn in normal and streptozotocin-induced diabetic rats. | Methods and findings in experimental and clinical pharmacology 20041201 |
| Comparison of equivalence and determination of diagnostic utility of min-mod and clamp methods for insulin resistance in diabetes free subjects: a meta-analysis. | Endocrine 20041201 |
| A pancreatic islet-specific microRNA regulates insulin secretion. | Nature 20041111 |
| Detection of anti-diabetics in equine plasma and urine by liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041105 |
| A new ATP-sensitive K+ channel-independent mechanism is involved in glucose-excited neurons of mouse arcuate nucleus. | Diabetes 20041101 |
| Tolbutamide potentiates the volume-regulated anion channel current in rat pancreatic beta cells. | Diabetologia 20041101 |
| Insulin secretion, peripheral insulin sensitivity and insulin-receptor binding in subjects with different degrees of obesity. | Diabetes & metabolism 20041101 |
| Insulin secretory characteristics of monkey pancreatic islets: a simple method of islet isolation and the effect of various density gradients on separation. | Diabetes research and clinical practice 20041001 |
| Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy. | Diabetes 20041001 |
| The comparative interaction of human and bovine serum albumins with CYP2C9 in human liver microsomes. | Life sciences 20040917 |
| CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products. | The Journal of pharmacology and experimental therapeutics 20040901 |
| Taurine block of cloned ATP-sensitive K+ channels with different sulfonylurea receptor subunits expressed in Xenopus laevis oocytes. | Biochemical pharmacology 20040901 |
| Zinc inhibits glutamate release via activation of pre-synaptic K channels and reduces ischaemic damage in rat hippocampus. | Journal of neurochemistry 20040901 |
| A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study. | British journal of clinical pharmacology 20040901 |
| Improved dissolution of an insoluble drug using a 4-fluid nozzle spray-drying technique. | Chemical & pharmaceutical bulletin 20040901 |
| Familial leucine-sensitive hypoglycemia of infancy due to a dominant mutation of the beta-cell sulfonylurea receptor. | The Journal of clinical endocrinology and metabolism 20040901 |
| Pulses of external ATP aid to the synchronization of pancreatic beta-cells by generating premature Ca(2+) oscillations. | Biochemical pharmacology 20040815 |
| Modeling the in vitro intrinsic clearance of the slowly metabolized compound tolbutamide determined in sandwich-cultured rat hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20040801 |
| The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. | Diabetes 20040801 |
| Does the aspartic acid to asparagine substitution at position 76 in the pancreas duodenum homeobox gene (PDX1) cause late-onset type 2 diabetes? | Diabetes care 20040801 |
| Discovery of new potentially defective alleles of human CYP2C9. | Pharmacogenetics 20040801 |
| Establishment and application of in vitro membrane potential assays in cell lines with endogenous or recombinant expression of ATP-sensitive potassium channels (Kir6.2/SUR1) using a fluorescent probe kit. | Journal of biomolecular screening 20040801 |
| Enzyme activity analysis of CYP2C18 with exon 5 skipped. | Acta pharmacologica Sinica 20040801 |
| Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation. | Chemical research in toxicology 20040801 |
| Testosterone modulates K(+)ATP channels in Sertoli cell membrane via the PLC-PIP2 pathway. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040801 |
| Tolbutamide uptake via pH- and membrane-potential-dependent transport mechanism in mouse brain capillary endothelial cell line. | Drug metabolism and pharmacokinetics 20040801 |
| Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells. | The Journal of biological chemistry 20040730 |
| Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats. | Life sciences 20040716 |
| Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not transcription of K(ATP) channel components. | Pharmacological research 20040701 |
| An evaluation of the in vitro metabolism data for predicting the clearance and drug-drug interaction potential of CYP2C9 substrates. | Drug metabolism and disposition: the biological fate of chemicals 20040701 |
| Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets. | Diabetes 20040701 |
| Identification of a novel variant CYP2C9 allele in Chinese. | Pharmacogenetics 20040701 |
| Study of the involvement of K+ channels in the peripheral antinociception of the kappa-opioid receptor agonist bremazocine. | European journal of pharmacology 20040628 |
| New hypoglycaemic agents selected by molecular topology. | International journal of pharmaceutics 20040618 |
| Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells. | The Journal of physiology 20040615 |
| In vitro induction of adult hepatic progenitor cells into insulin-producing cells. | Biochemical and biophysical research communications 20040604 |
| Validated assays for human cytochrome P450 activities. | Drug metabolism and disposition: the biological fate of chemicals 20040601 |
| Direct interference of HIV protease inhibitors with pancreatic beta-cell function. | Naunyn-Schmiedeberg's archives of pharmacology 20040601 |
| Reversal of streptozotocin-induced hyperglycemia by transplantation of pseudoislets consisting of beta cells derived from ductal cells. | Endocrine journal 20040601 |
| Pharmacokinetic interactions of drugs with St John's wort. | Journal of psychopharmacology (Oxford, England) 20040601 |
| Cryopreserved rat, dog and monkey hepatocytes: measurement of drug metabolizing enzymes in suspensions and cultures. | Human & experimental toxicology 20040601 |
| Cytochrome P450 2C9 phenotyping using low-dose tolbutamide. | European journal of clinical pharmacology 20040501 |
| Beta-cell toxicity of ATP-sensitive K+ channel-blocking insulin secretagogues. | Biochemical pharmacology 20040501 |
| Endothelin-1 stimulates the translocation and upregulation of both glucose transporter and hexokinase in astrocytes: relationship with gap junctional communication. | Journal of neurochemistry 20040501 |
| Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance. | Drug metabolism and disposition: the biological fate of chemicals 20040501 |
| Interaction of dexloxiglumide, a cholecystokinin type-1 receptor antagonist, with human cytochromes P450. | Biopharmaceutics & drug disposition 20040501 |
| Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations. | Diabetes care 20040501 |
| Acute and long-term effects of nateglinide on insulin secretory pathways. | British journal of pharmacology 20040501 |
| Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(alpha)-dirhamnoside from Bauhinia forficata leaves. | Journal of natural products 20040501 |
| Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. | Xenobiotica; the fate of foreign compounds in biological systems 20040501 |
| Alteration of beta-cell constitutive NO synthase activity is involved in the abnormal insulin response to arginine in a new rat model of type 2 diabetes. | Molecular and cellular endocrinology 20040430 |
| Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. | The New England journal of medicine 20040429 |
| [3T3-L1 adipocytes reduces Kir6.2 channel expression in MIN6 insulin-secreting cells in vitro]. | Sheng li xue bao : [Acta physiologica Sinica] 20040425 |
| Fluorescence microscopy studies with a fluorescent glibenclamide derivative, a high-affinity blocker of pancreatic beta-cell ATP-sensitive K+ currents. | Biochemical pharmacology 20040415 |
| Inhibition of glucose-induced electrical activity in rat pancreatic beta-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents. | European journal of pharmacology 20040405 |
| Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation. | Life sciences 20040402 |
| A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic alpha-cell. | Cell calcium 20040401 |
| Effect of posaconazole on cytochrome P450 enzymes: a randomized, open-label, two-way crossover study. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040401 |
| Simultaneous determination of glipizide and rosiglitazone unbound drug concentrations in plasma by equilibrium dialysis and liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040305 |
| Evaluation of potential inductive effects of aprepitant on cytochrome P450 3A4 and 2C9 activity. | Journal of clinical pharmacology 20040301 |
| Phase I and II enzyme characterization of two sources of HepG2 cell lines. | Xenobiotica; the fate of foreign compounds in biological systems 20040301 |
| Systematic screening of potential beta-cell imaging agents. | Biochemical and biophysical research communications 20040220 |
| Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic beta-cells. | European journal of pharmacology 20040220 |
| Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. | Endocrinology 20040201 |
| Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. | The Journal of pharmacology and experimental therapeutics 20040201 |
| Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1. | British journal of clinical pharmacology 20040201 |
| Nutrients induce different Ca(2+) signals in cytosol and nucleus in pancreatic beta-cells. | Diabetes 20040201 |
| The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency. | The Journal of clinical endocrinology and metabolism 20040201 |
| Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism. | The Journal of clinical endocrinology and metabolism 20040201 |
| Beneficial effects of addition of oral spray insulin (Oralin) on insulin secretion and metabolic control in subjects with type 2 diabetes mellitus suboptimally controlled on oral hypoglycemic agents. | Diabetes technology & therapeutics 20040201 |
| Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6. | Cellular and molecular neurobiology 20040201 |
| Transepithelial permeation of tolbutamide across the human intestinal cell line, Caco-2. | Drug metabolism and pharmacokinetics 20040201 |
| Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride. | International journal of pharmaceutics 20040128 |
| Involvement of K+ channels and calcium-dependent pathways in the action of T3 on amino acid accumulation and membrane potential in Sertoli cells of immature rat testis. | Life sciences 20040123 |
| Modulation of the excitability of cholinergic basal forebrain neurones by KATP channels. | The Journal of physiology 20040115 |
| Is impairment of ischaemic preconditioning by sulfonylurea drugs clinically important? | Heart (British Cardiac Society) 20040101 |
| Regulation by sulfanylurea receptor type 1 of a non-selective cation channel involved in cytotoxic edema of reactive astrocytes. | Journal of neurosurgical anesthesiology 20040101 |
| Is acarbose equivalent to tolbutamide as first treatment for newly diagnosed type 2 diabetes in general practice? A randomised controlled trial. | Diabetes research and clinical practice 20040101 |
| Metabolic pathways that mediate inhibition of hypothalamic neurons by glucose. | Diabetes 20040101 |
| Early ionic and membrane potential changes caused by the pesticide rotenone in striatal cholinergic interneurons. | Experimental neurology 20040101 |
| Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulation. | The Journal of clinical endocrinology and metabolism 20040101 |
| The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. | Clinical pharmacology and therapeutics 20040101 |
| Dupuytren's disease in Bosnia and Herzegovina. An epidemiological study. | BMC musculoskeletal disorders 20040101 |
| The inhibitory effects of herbal components on CYP2C9 and CYP3A4 catalytic activities in human liver microsomes. | American journal of therapeutics 20040101 |
| A buffer temperature controlled perifusion system to study temperature dependence and kinetics of insulin secretion in MIN6 pseudoislets. | Journal of pharmacological and toxicological methods 20040101 |
| Chinese herbal medicines for type 2 diabetes mellitus. | The Cochrane database of systematic reviews 20040101 |
| The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1. | BMC pharmacology 20040101 |
| HLA DR phenotypic frequencies and genetic risk of Type 1 diabetes in west region of Algeria, Tlemcen. | BMC genetics 20040101 |
| Oral spray insulin in treatment of type 2 diabetes: a comparison of efficacy of the oral spray insulin (Oralin) with subcutaneous (SC) insulin injection, a proof of concept study. | Diabetes/metabolism research and reviews 20040101 |
| The UGDP controversy: thirty-four years of contentious ambiguity laid to rest. | Perspectives in biology and medicine 20040101 |
| Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies. | Rapid communications in mass spectrometry : RCM 20040101 |
| Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation. | BMC neuroscience 20040101 |
| Constitutive nitric oxide synthases in rat pancreatic islets: direct imaging of glucose-induced nitric oxide production in beta-cells. | Pflugers Archiv : European journal of physiology 20031201 |
| 'Open access' generic method for continuous determination of major human CYP450 probe substrates/metabolites and its application in drug metabolism studies. | Xenobiotica; the fate of foreign compounds in biological systems 20031201 |
| Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice. | Annals of the New York Academy of Sciences 20031201 |
| Clinical relevance of genetic polymorphisms in the human CYP2C9 gene. | European journal of clinical investigation 20031101 |
| Pharmacokinetics of tolbutamide after oral administration to rabbits with folate-induced renal failure. | Archives of pharmacal research 20031101 |
| Comparison of the Gordon-Taylor and Couchman-Karasz equations for prediction of the glass transition temperature of glass solutions of drug and polyvinylpyrrolidone prepared by melt extrusion. | Die Pharmazie 20031101 |
| Genetic cause of hyperglycaemia and response to treatment in diabetes. | Lancet (London, England) 20031018 |
| Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism. | Diabetes 20031001 |
| Analysis of synthetic anti-diabetic drugs in adulterated traditional Chinese medicines by high-performance capillary electrophoresis. | Journal of pharmaceutical and biomedical analysis 20030919 |
| Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030917 |
| Clinical and molecular characterization of a dominant form of congenital hyperinsulinism caused by a mutation in the high-affinity sulfonylurea receptor. | Diabetes 20030901 |
| ATP-sensitive potassium channels induced in liver cells after transfection with insulin cDNA and the GLUT 2 transporter regulate glucose-stimulated insulin secretion. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030901 |
| New aspects of neurotransmitter release and exocytosis: involvement of Ca2+/calmodulin-dependent phosphorylation of synapsin I in insulin exocytosis. | Journal of pharmacological sciences 20030901 |
| Evaluation of HOMA and QUICKI as measures of insulin sensitivity in prepubertal children. | Pediatric diabetes 20030901 |
| A novel approach to in situ characterization of pancreatic beta-cells. | Pflugers Archiv : European journal of physiology 20030801 |
| Inhaled insulin for the treatment of diabetes: projects and devices. | Expert opinion on pharmacotherapy 20030801 |
| The NO-cGMP-K+ channel pathway participates in the antinociceptive effect of diclofenac, but not of indomethacin. | Pharmacology, biochemistry, and behavior 20030801 |
| Hepatic delta9, delta6, and delta5 desaturations in non-insulin-dependent diabetes mellitus eSS rats. | Lipids 20030801 |
| No major difference in inhibitory susceptibility between CYP2C9.1 and CYP2C9.3. | European journal of clinical pharmacology 20030701 |
| Dimethyl disulfide exerts insecticidal neurotoxicity through mitochondrial dysfunction and activation of insect K(ATP) channels. | Journal of neurophysiology 20030701 |
| Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9. | Clinical pharmacology and therapeutics 20030701 |
| Effect of endothelin-1 on astrocytic protein content. | Glia 20030601 |
| Functional involvement of sulphonylurea receptor (SUR) type 1 and 2B in the activity of pig urethral ATP-sensitive K+ channels. | British journal of pharmacology 20030601 |
| Nesidioblastosis in adults: a challenging cause of organic hyperinsulinism. | European journal of clinical investigation 20030601 |
| Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2. | Xenobiotica; the fate of foreign compounds in biological systems 20030601 |
| Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. | The Biochemical journal 20030501 |
| Loperamide mobilizes intracellular Ca2+ stores in insulin-secreting HIT-T15 cells. | British journal of pharmacology 20030501 |
| Na+ channel inactivation: a comparative study between pancreatic islet beta-cells and adrenal chromaffin cells in rat. | The Journal of physiology 20030401 |
| Retention of transporter activities in cryopreserved, isolated rat hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20030401 |
| Glutamate-dependent inhibition of dopamine release in striatum is mediated by a new diffusible messenger, H2O2. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030401 |
| L-carnitine consecutively administered to patients on hemodialysis improves beta-cell response. | The International journal of artificial organs 20030401 |
| Rapid induction of insulin resistance in opioid mu-receptor knock-out mice. | Neuroscience letters 20030320 |
| Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity. | The Biochemical journal 20030315 |
| Implications of pharmacogenetics for individualizing drug treatment and for study design. | Journal of molecular medicine (Berlin, Germany) 20030301 |
| Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides. | The Journal of physiology 20030215 |
| A comparison of relative abundance, activity factor and inhibitory monoclonal antibody approaches in the characterization of human CYP enzymology. | British journal of clinical pharmacology 20030201 |
| Differential effects of K(ATP) channel blockers on [(3)H]-noradrenaline overflow after short- and long-term exposure to (+)-oxaprotiline or desipramine. | Naunyn-Schmiedeberg's archives of pharmacology 20030201 |
| Antihyperglycemic and hypoglycemic effect of Aporosa lindleyana in normal and alloxan induced diabetic rats. | Journal of ethnopharmacology 20030201 |
| Leptin fully suppresses acetylcholine-induced insulin secretion and is reversed by tolbutamide in isolated perfused chicken pancreas. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030201 |
| Calcium-dependent translocation of cytosolic phospholipase A2 in pancreatic beta-cells. | Biochemical and biophysical research communications 20030124 |
| Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. | Archives of biochemistry and biophysics 20030101 |
| High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20030101 |
| Possible involvement of potassium channels in peripheral antinociception induced by metamizol: lack of participation of ATP-sensitive K+ channels. | Pharmacology, biochemistry, and behavior 20030101 |
| Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans. | Journal of clinical pharmacology 20030101 |
| Differential selectivity of insulin secretagogues: mechanisms, clinical implications, and drug interactions. | Journal of diabetes and its complications 20030101 |
| Maternal-fetal transport of hypoglycaemic drugs. | Clinical pharmacokinetics 20030101 |
| Barriers to self-monitoring of blood glucose among adults with diabetes in an HMO: a cross sectional study. | BMC health services research 20030101 |
| Two distinct effects of cGMP on cytosolic Ca2+ concentration of rat pancreatic beta-cells. | Journal of pharmacological sciences 20030101 |
| The juice of fresh leaves of Catharanthus roseus Linn. reduces blood glucose in normal and alloxan diabetic rabbits. | BMC complementary and alternative medicine 20030101 |
| [A 50-year history of new drugs in Japan-the development and progress of anti-diabetic drugs and the epidemiological aspects of diabetes mellitus]. | Yakushigaku zasshi 20030101 |
| Study of the anti-hyperglycemic effect of anti-diabetic plants in rabbits with impaired glucose tolerance. | Proceedings of the Western Pharmacology Society 20030101 |
| Effect of ficus relegiosa on blood glucose and total lipid levels of normal and alloxan diabetic rabbits. | Journal of Ayub Medical College, Abbottabad : JAMC 20030101 |
| The relationship between oxidative metabolism and lipid peroxidation in rat liver microsomes. | Research communications in molecular pathology and pharmacology 20030101 |
| Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. | Drug metabolism and disposition: the biological fate of chemicals 20021201 |
| Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation. | The Journal of physiology 20021201 |
| Increase of insulin sensitivity in diabetic rats received die-huang-wan, a herbal mixture used in Chinese traditional medicine. | Acta pharmacologica Sinica 20021201 |
| Sulfonylurea stimulation of insulin secretion. | Diabetes 20021201 |
| Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas. | Diabetes 20021201 |
| Increased metabolizing activities of the tricarboxylic acid cycle and decreased drug metabolism in hepatocellular carcinoma. | Carcinogenesis 20021201 |
| How does glucose evoke electrical activity in the pancreatic beta-cell? | Diabetes & metabolism 20021201 |
| The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking. | European journal of biochemistry 20021101 |
| BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism. | The Journal of clinical endocrinology and metabolism 20021101 |
| Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C91 heterozygotes. | Clinical pharmacology and therapeutics 20021101 |
| Establishment of a transgenic cell line stably expressing human cytochrome P450 2C18 and identification of a CYP2C18 clone with exon 5 missing. | World journal of gastroenterology 20021015 |
| Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells. | The Journal of biological chemistry 20021004 |
| The molecular site of action of K(ATP) channel inhibitors determines their ability to inhibit iNOS-mediated relaxation in rat aorta. | Cardiovascular research 20021001 |
| Cell-type specific depression of neuronal excitability in rat hippocampus by activation of ATP-sensitive potassium channels. | European biophysics journal : EBJ 20021001 |
| Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism. | The Journal of clinical endocrinology and metabolism 20021001 |
| The peripheral antinociceptive effect of resveratrol is associated with activation of potassium channels. | Neuropharmacology 20021001 |
| Likelihood methods for measuring statistical evidence. | Statistics in medicine 20020915 |
| The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related. | The Journal of biological chemistry 20020906 |
| Glucose-sensing in glucagon-like peptide-1-secreting cells. | Diabetes 20020901 |
| Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1. | Diabetes 20020901 |
| Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase. | Laboratory investigation; a journal of technical methods and pathology 20020901 |
| Validated HPLC method for the determination of celecoxib in human serum and its application in a clinical pharmacokinetic study. | Die Pharmazie 20020901 |
| A novel simple method for the investigation of drug binding to the K(ATP) channel sulfonylurea receptor. | Analytical biochemistry 20020815 |
| Amino acid residues affecting the activities of human cytochrome P450 2C9 and 2C19. | Drug metabolism and disposition: the biological fate of chemicals 20020801 |
| [Acute insulin response to tolbutamide of pancreatic beta-cell]. | Nihon rinsho. Japanese journal of clinical medicine 20020801 |
| Effect of albumin and cytosol on enzyme kinetics of tolbutamide hydroxylation and on inhibition of CYP2C9 by gemfibrozil in human liver microsomes. | The Journal of pharmacology and experimental therapeutics 20020701 |
| Sulfonylurea receptor gene 16-3 polymorphism - association with sulfonylurea or insulin treatment in type 2 diabetic subjects. | Medical science monitor : international medical journal of experimental and clinical research 20020701 |
| [Development of simplified and rapid detection assay for genetic polymorphisms influencing drug response and its clinical applications]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20020701 |
| Neural control of the heart: developmental changes in ionic conductances in mammalian intrinsic cardiac neurons. | Autonomic neuroscience : basic & clinical 20020628 |
| Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by atmospheric pressure chemical ionization liquid chromatography-mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020615 |
| Effect of albumin on phenytoin and tolbutamide metabolism in human liver microsomes: an impact more than protein binding. | Drug metabolism and disposition: the biological fate of chemicals 20020601 |
| Hypoglycemic and hypotriglyceridemic effects of tolbutamide in triphenyltin chloride-induced diabetic rabbits. | Veterinary and human toxicology 20020601 |
| In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic microsomes. | American journal of veterinary research 20020601 |
| Desensitization of insulin secretion. | Biochemical pharmacology 20020601 |
| Effects of Kampo extracts on drug metabolism in rat liver microsomes: Rhei Rhizoma extract and Glycyrrhizae Radix extract inhibit drug oxidation. | Japanese journal of pharmacology 20020601 |
| Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by dipyrone. | European journal of pharmacology 20020524 |
| Functional expression of Kir 6.1/SUR1-K(ATP) channels in frog retinal Müller glial cells. | Glia 20020501 |
| Association of upregulated activity of K(ATP) channels with impaired insulin secretion in UCP1-expressing insulinoma cells. | The Journal of physiology 20020501 |
| Transient neonatal diabetes mellitus, type 4, type 1 diabetes mellitus, or MODY: which disease is it, anyway? | Journal of pediatric endocrinology & metabolism : JPEM 20020501 |
| Co-ordinated Ca(2+)-signalling within pancreatic islets: does beta-cell entrainment require a secreted messenger. | Cell calcium 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Cloning of cytochrome P-450 2C9 cDNA from human liver and its expression in CHL cells. | World journal of gastroenterology 20020415 |
| [High sensitivity to sulphonylurea treatment in 2 patients with maturity-onset diabetes of the young type 3]. | Nederlands tijdschrift voor geneeskunde 20020413 |
| Alterations of purine and pyrimidine nucleotide contents in rat corticoencephalic cell cultures following metabolic damage and treatment with openers and blockers of ATP-sensitive potassium channels. | Neurochemistry international 20020401 |
| Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels. | Nature neuroscience 20020401 |
| Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response. | Diabetes 20020401 |
| Pulsatile insulin release from islets isolated from three subjects with type 2 diabetes. | Diabetes 20020401 |
| Dopamine selectively reduces GABA(B) transmission onto dopaminergic neurones by an unconventional presynaptic action. | The Journal of physiology 20020401 |
| History of diabetes mellitus. | Saudi medical journal 20020401 |
| Enzyme and plasma protein induction by multiple oral administrations of phenobarbital at a therapeutic dosage regimen in dogs. | Journal of veterinary pharmacology and therapeutics 20020401 |
| Phototoxicity to diuretics and antidiabetics in the cultured keratinocyte cell line HaCaT: evaluation by clonogenic assay and single cell gel electrophoresis Comet assay). | Photodermatology, photoimmunology & photomedicine 20020401 |
| Leptin affects the electrical activity of neurones in the hypothalamic supraoptic nucleus. | Brain research bulletin 20020315 |
| Utility of rat liver slices to estimate hepatic clearance for application in physiologically based pharmacokinetic modeling: a study with tolbutamide, a compound with low extraction efficiency. | Drug metabolism and disposition: the biological fate of chemicals 20020301 |
| The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20020301 |
| CYP2C9 polymorphism: impact on tolbutamide pharmacokinetics and response. | Pharmacogenetics 20020301 |
| Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers. | Pharmacogenetics 20020301 |
| Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans. | Pharmacogenetics 20020301 |
| Characterisation of the effects of potassium channel modulating agents on mouse intestinal smooth muscle. | The Journal of pharmacy and pharmacology 20020301 |
| Pharmacological evidence for the activation of K(+) channels by diclofenac. | European journal of pharmacology 20020301 |
| Membrane potential dependent modulations of calcium oscillations in insulin-secreting INS-1 cells. | Cell calcium 20020301 |
| The effect of bergamottin on diazepam plasma levels and P450 enzymes in beagle dogs. | Drug metabolism and disposition: the biological fate of chemicals 20020201 |
| S2' substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B. | The Biochemical journal 20020201 |
| Triterpenes from Agarista mexicana as potential antidiabetic agents. | Phytotherapy research : PTR 20020201 |
| Novel properties of peptides derived from the sequence coded by exon 26A of human elastin. | The international journal of biochemistry & cell biology 20020201 |
| Overexpression of the Na/Ca exchanger shapes stimulus-induced cytosolic Ca(2+) oscillations in insulin-producing BRIN-BD11 cells. | Diabetes 20020201 |
| Feedback control of the ATP-sensitive K(+) current by cytosolic Ca(2+) contributes to oscillations of the membrane potential in pancreatic beta-cells. | Diabetes 20020201 |
| Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. | Pharmaceutical research 20020201 |
| Evidence that glucose-induced electrical activity in rat pancreatic beta-cells does not require KATP channel inhibition. | The Journal of membrane biology 20020201 |
| Mercuric chloride alters the membrane potential and intracellular calcium level in mouse pancreatic islet cells. | Journal of toxicology and environmental health. Part A 20020201 |
| Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes. | European journal of clinical pharmacology 20020201 |
| Inhibition of glucose-induced electrical activity by 4-hydroxytamoxifen in rat pancreatic beta-cells. | Cellular signalling 20020101 |
| A key role for beta-cell cytosolic phospholipase A(2) in the maintenance of insulin stores but not in the initiation of insulin secretion. | Diabetes 20020101 |
| Carriers of an inactivating beta-cell ATP-sensitive K(+) channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion. | Diabetes care 20020101 |
| ATP-independent anoxic activation of ATP-sensitive K+ channels in dorsal vagal neurons of juvenile mice in situ. | Neuroscience 20020101 |
| Tolbutamide alters glucose transport and metabolism in the embryonic mouse heart. | Teratology 20020101 |
| New trends in the development of oral antidiabetic drugs. | Current medicinal chemistry 20020101 |
| Chemical anoxia activates ATP-sensitive and blocks Ca(2+)-dependent K(+) channels in rat dorsal vagal neurons in situ. | Neuroscience 20020101 |
| The evolving role of oral insulin in the treatment of diabetes using a novel RapidMist System. | Diabetes/metabolism research and reviews 20020101 |
| Few cultured rat primary sensory neurons express a tolbutamide-sensitive K+ current. | Journal of cellular and molecular medicine 20020101 |
| Application of cDNA microarray technology to in vitro toxicology and the selection of genes for a real-time RT-PCR-based screen for oxidative stress in Hep-G2 cells. | Toxicologic pathology 20020101 |
| Fondaparinux sodium is not metabolised in mammalian liver fractions and does not inhibit cytochrome P450-mediated metabolism of concomitant drugs. | Clinical pharmacokinetics 20020101 |
| Trends in oral antihyperglycemic and insulin use in the Nova Scotia senior population (1993-1999). | The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20020101 |
| Role of the nitric oxide-cyclic GMP-K+ channel pathway in the antinociception induced by atrial natriuretic peptide (ANP) and diclofenac. | Proceedings of the Western Pharmacology Society 20020101 |
| Metabolic fate of pitavastatin (NK-104), a new inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase. Effects on drug-metabolizing systems in rats and humans. | Arzneimittel-Forschung 20020101 |
| Effect of garlic on cardiovascular disorders: a review. | Nutrition journal 20020101 |
| Pharmacokinetics of tolbutamide after oral administration in rabbits with folate-induced renal failure. | Research communications in molecular pathology and pharmacology 20020101 |
| Molecular cloning of monkey CYP2C43 cDNA and expression in yeast. | Drug metabolism and pharmacokinetics 20020101 |
| Effects of serum albumin and liver cytosol on CYP2C9- and CYP3A4-mediated drug metabolism. | Drug metabolism and pharmacokinetics 20020101 |
| Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. I. Secretory and morphological studies. | Biochemical pharmacology 20011215 |
| Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. II. Electrophysiological and fluorimetric studies. | Biochemical pharmacology 20011215 |
| Proliferation of C6 glioma cells is blunted by the increase in gap junction communication caused by tolbutamide. | FEBS letters 20011207 |
| Opioid receptor modulation of a metabolically sensitive ion channel in rat amygdala neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20011201 |
| Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats. | Diabetes 20011201 |
| Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin. | Pharmacogenetics 20011201 |
| The role of CYP2C9 genotype in the metabolism of diclofenac in vivo and in vitro. | European journal of clinical pharmacology 20011201 |
| The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide. | European journal of pharmacology 20011109 |
| Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19. | Drug metabolism and disposition: the biological fate of chemicals 20011101 |
| Application of the PKCYP-test to predict the amount of in vivo CYP2C11 using tolbutamide as a probe. | Biological & pharmaceutical bulletin 20011101 |
| In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9). | British journal of clinical pharmacology 20011101 |
| An aqueous extract of the green leafy vegetable Ipomoea aquatica is as effective as the oral hypoglycaemic drug tolbutamide in reducing the blood sugar levels of Wistar rats. | Phytotherapy research : PTR 20011101 |
| Effects of tolbutamide and N-benzoyl-D-phenylalanine (NBDP) on the regulation of [Ca2+]i oscillations in mouse pancreatic islets. | Biochemical pharmacology 20011001 |
| Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells. | Molecular pharmacology 20011001 |
| Insulin activates ATP-sensitive K(+) channels in pancreatic beta-cells through a phosphatidylinositol 3-kinase-dependent pathway. | Diabetes 20011001 |
| Fasting glucose insulin ratio: a useful measure of insulin resistance in girls with premature adrenarche. | The Journal of clinical endocrinology and metabolism 20011001 |
| Molecular modelling and 1H-NMR: ultimate tools for the investigation of tolbutamide: beta-cyclodextrin and tolbutamide: hydroxypropyl-beta-cyclodextrin complexes. | Chemical & pharmaceutical bulletin 20011001 |
| The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity. | Clinical pharmacology and therapeutics 20011001 |
| Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. | British journal of clinical pharmacology 20011001 |
| Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus. | Diabetologia 20011001 |
| Quantification of beta-cell function during IVGTT in Type II and non-diabetic subjects: assessment of insulin secretion by mathematical methods. | Diabetologia 20011001 |
| In vitro cytochrome P450-mediated hepatic activities for five substrates in specific pathogen free chickens. | Journal of veterinary pharmacology and therapeutics 20011001 |
| Mechanism-based inactivation of CYP2C11 by diclofenac. | Drug metabolism and disposition: the biological fate of chemicals 20010901 |
| Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. | The Journal of pharmacology and experimental therapeutics 20010901 |
| Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia. | Brain : a journal of neurology 20010901 |
| Dibutyryl-cyclic GMP induces peripheral antinociception via activation of ATP-sensitive K(+) channels in the rat PGE2-induced hyperalgesic paw. | British journal of pharmacology 20010901 |
| Effect of Cirsium pascuarense on blood glucose levels of normoglycaemic and alloxan-diabetic mice. | Phytotherapy research : PTR 20010901 |
| Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside. | Biological & pharmaceutical bulletin 20010901 |
| An ATP-sensitive K(+) conductance in dissociated neurones from adult rat intracardiac ganglia. | The Journal of physiology 20010801 |
| Sulfonylurea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression. | Pflugers Archiv : European journal of physiology 20010801 |
| The enhancement of glucose uptake caused by the collapse of gap junction communication is due to an increase in astrocyte proliferation. | Journal of neurochemistry 20010801 |
| Platelet-derived growth factor-BB: a survival factor for the retinal microvasculature during periods of metabolic compromise. | Current eye research 20010801 |
| Swelling-induced changes in cytosolic [Ca2++] in insulin-secreting cells: a role in regulatory volume decrease? | Molecular and cellular endocrinology 20010705 |
| In vivo effect of clarithromycin on multiple cytochrome P450s. | Drug metabolism and disposition: the biological fate of chemicals 20010701 |
| Longitudinal changes in body fat in African American and Caucasian children: influence of fasting insulin and insulin sensitivity. | The Journal of clinical endocrinology and metabolism 20010701 |
| Influence of the preparation method on the physicochemical properties of tolbutamide/cyclodextrin binary systems. | Drug development and industrial pharmacy 20010701 |
| The potential of small-scale fusion experiments and the Gordon-Taylor equation to predict the suitability of drug/polymer blends for melt extrusion. | Drug development and industrial pharmacy 20010701 |
| Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology. | Toxicology in vitro : an international journal published in association with BIBRA 20010601 |
| Tolbutamide stimulation of pancreatic beta-cells involves both cell recruitment and increase in the individual Ca(2+) response. | British journal of pharmacology 20010601 |
| Free radical-mediated tolbutamide desensitization of K+ATP channels in rat pancreatic beta-cells. | Endocrine journal 20010601 |
| A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4'-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6beta-hydroxylation. | Chemico-biological interactions 20010516 |
| Proteasomal activation mediates down-regulation of inositol 1,4,5-trisphosphate receptor and calcium mobilization in rat pancreatic islets. | Endocrinology 20010501 |
| Involvement of calmodulin in glucagon-like peptide 1(7-36) amide-induced inhibition of the ATP-sensitive K+ channel in mouse pancreatic beta-cells. | Experimental physiology 20010501 |
| Characterization of biotransformation enzyme activities in primary rat proximal tubular cells. | Chemico-biological interactions 20010416 |
| Isolation of the components of a complex mixture by means of column switching for their enhanced detection by mass spectrometry. | Journal of chromatography. A 20010413 |
| Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel. | British journal of pharmacology 20010401 |
| ION-pair liquid chromatography technique for the estimation of metformin in its multicomponent dosage forms. | Journal of pharmaceutical and biomedical analysis 20010401 |
| Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion? | Diabetes 20010401 |
| Changes in the dissolution of tolbutamide by a traditional Chinese medicine, Sho-saiko-to (Xiao Chaihu Tang). | Biological & pharmaceutical bulletin 20010401 |
| WY-14,643 and other agonists of the peroxisome proliferator-activated receptor reveal a new mode of action for salicylic acid in soybean disease resistance. | Planta 20010401 |
| Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine. | European journal of clinical pharmacology 20010401 |
| Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells. | Pflugers Archiv : European journal of physiology 20010401 |
| The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1. | Pflugers Archiv : European journal of physiology 20010401 |
| Effect of leptin on insulin, glugacon and somatostatin secretion in the perfused rat pancreas. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20010401 |
| Interaction of sulfonylurea-conjugated polymer with insulinoma cell line of MIN6 and its effect on insulin secretion. | Journal of biomedical materials research 20010401 |
| Effects of vitamins and common drugs on reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rat microsomes. | Archives of physiology and biochemistry 20010401 |
| Complexation with tolbutamide modifies the physicochemical and tableting properties of hydroxypropyl-beta-cyclodextrin. | International journal of pharmaceutics 20010314 |
| Variables in human liver microsome preparation: impact on the kinetics of l-alpha-acetylmethadol (LAAM) n-demethylation and dextromethorphan O-demethylation. | Drug metabolism and disposition: the biological fate of chemicals 20010301 |
| Interaction of stilbene disulphonates with cloned K(ATP) channels. | British journal of pharmacology 20010301 |
| Specific desensitization of sulfonylurea- but not imidazoline-induced insulin release after prolonged tolbutamide exposure. | Biochemical pharmacology 20010301 |
| Measurements of cytoplasmic Ca2+ in islet cell clusters show that glucose rapidly recruits beta-cells and gradually increases the individual cell response. | Diabetes 20010301 |
| Characterization of secretory and morphologic properties of primary cultured endocrine cells from porcine pancreata. | Pancreas 20010301 |
| Protein kinase C-dependent and -independent inhibition of Ca(2+) influx by phorbol ester in rat pancreatic beta-cells. | Cellular signalling 20010301 |
| Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes. | Diabetes care 20010301 |
| Characterization of glass solutions of poorly water-soluble drugs produced by melt extrusion with hydrophilic amorphous polymers. | The Journal of pharmacy and pharmacology 20010301 |
| Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline. | Xenobiotica; the fate of foreign compounds in biological systems 20010301 |
| Hypoglycemic effect of Hibiscus rosa sinensis L. leaf extract in glucose and streptozotocin induced hyperglycemic rats. | Indian journal of experimental biology 20010301 |
| Interindividual variations in levels and activities of cytochrome P-450 in liver microsomes of Chinese subjects. | Acta pharmacologica Sinica 20010301 |
| Activation of Na(+), K(+), Cl(-)-cotransport mediates intracellular Ca(2+) increase and apoptosis induced by Pinacidil in HepG2 human hepatoblastoma cells. | Biochemical and biophysical research communications 20010223 |
| The sulphonylurea glibenclamide inhibits multidrug resistance protein (MRP1) activity in human lung cancer cells. | British journal of pharmacology 20010201 |
| Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20010201 |
| Effects of sho-saiko-to (xiao chai hu tang), a Chinese traditional medicine, on the gastric function and absorption of tolbutamide in rats. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010201 |
| Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations. | Diabetes 20010201 |
| Hyperinsulinism of infancy: the regulated release of insulin by KATP channel-independent pathways. | Diabetes 20010201 |
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