Home Other Building Blocks METHOXYRESORUFIN

METHOXYRESORUFIN

CAS No.:
5725-89-3
Catalog Number:
AG00E981
Molecular Formula:
C13H9NO3
Molecular Weight:
227.2155
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
Product Description
Catalog Number:
AG00E981
Chemical Name:
METHOXYRESORUFIN
CAS Number:
5725-89-3
Molecular Formula:
C13H9NO3
Molecular Weight:
227.2155
MDL Number:
MFCD00037663
IUPAC Name:
7-methoxyphenoxazin-3-one
InChI:
InChI=1S/C13H9NO3/c1-16-9-3-5-11-13(7-9)17-12-6-8(15)2-4-10(12)14-11/h2-7H,1H3
InChI Key:
KNYYMGDYROYBRE-UHFFFAOYSA-N
SMILES:
COc1ccc2c(c1)oc1c(n2)ccc(=O)c1
Properties
Complexity:
436  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
227.058g/mol
Formal Charge:
0
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
227.219g/mol
Monoisotopic Mass:
227.058g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
47.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5  
Literature
Title Journal
Characterization of chicken cytochrome P450 1A4 and 1A5: inter-paralog comparisons of substrate preference and inhibitor selectivity. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20130501
Different profiles of hepatic alkoxyresorufin O-dealkylase activities in small rodents. Journal of applied toxicology : JAT 20121201
Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile. Journal of agricultural and food chemistry 20120606
Verapamil does not modify catalytic activity of CYP450 in rainbow trout after long-term exposure. Ecotoxicology and environmental safety 20120501
4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent. Archives of toxicology 20120201
Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives. International journal of molecular sciences 20120101
Differential inducing effect of benzo[a]pyrene on gene expression and enzyme activity of cytochromes P450 1A1 and 1A2 in Sprague-Dawley and Wistar rats. Drug metabolism and pharmacokinetics 20120101
Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110801
In vitro inhibition of porcine cytochrome P450 by 17β -estradiol and 17α-estradiol. Interdisciplinary toxicology 20110601
Computational approach to characterization of human liver drug-metabolizing enzymes. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20101009
Functional differences in the cytochrome P450 1 family enzymes from zebrafish (Danio rerio) using heterologously expressed proteins. Archives of biochemistry and biophysics 20101001
Biotransformation of PCBs in Arctic seabirds: characterization of phase I and II pathways at transcriptional, translational and activity levels. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20100601
Assessment of cytochrome P450 fluorometric substrates with rainbow trout and killifish exposed to dexamethasone, pregnenolone-16alpha-carbonitrile, rifampicin, and beta-naphthoflavone. Aquatic toxicology (Amsterdam, Netherlands) 20100510
Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables. Toxicology 20100209
The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine. Interdisciplinary toxicology 20090901
Hepatic P450 enzyme activity, tissue morphology and histology of mink (Mustela vison) exposed to polychlorinated dibenzofurans. Archives of environmental contamination and toxicology 20090801
Sequencing and characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of Mink (Mustela vison) to facilitate study of dioxin-like compounds. Toxicology and applied pharmacology 20090201
EROD and MROD as Markers of Cytochrome P450 1A Activities in Hepatic Microsomes from Entire and Castrated Male Pigs. Sensors (Basel, Switzerland) 20090101
Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201
Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2. Xenobiotica; the fate of foreign compounds in biological systems 20081201
Application of molecular modeling for prediction of substrate specificity in cytochrome P450 1A2 mutants. Drug metabolism and disposition: the biological fate of chemicals 20081101
Catalytic function of avian cytochrome P450 1A4 and 1A5 (CYP1A4 and CYP1A5) enzymes heterologously expressed using in vitro yeast system. Marine environmental research 20080701
Evidence that the anticarcinogenic effect of caffeic acid phenethyl ester in the resistant hepatocyte model involves modifications of cytochrome P450. Toxicological sciences : an official journal of the Society of Toxicology 20080701
A novel gender-related difference in the constitutive expression of hepatic cytochrome P4501A subfamily enzymes in Meishan pigs. Biochemical pharmacology 20080301
Purification of CYP2B-like protein from feral leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular, and immunological characterization. Journal of biochemical and molecular toxicology 20080101
Evaluation of the assumptions of an ontogeny model of rat hepatic cytochrome P450 activity. Drug metabolism and disposition: the biological fate of chemicals 20071201
Modulation of xenobiotic biotransformation system and hormonal responses in Atlantic salmon (Salmo salar) after exposure to tributyltin (TBT). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070401
Development of an on-line high performance liquid chromatography detection system for human cytochrome P450 1A2 inhibitors in extracts of natural products. Journal of chromatography. A 20070202
Effect of subacute oral doses of nivalenol on immune and metabolic defence systems in mice. Veterinary research 20070101
Species difference in the induction of hepatic CYP1A subfamily enzymes, especially CYP1A2, by 2-methoxy-4-nitroaniline among rats, mice, and guinea pigs. Archives of toxicology 20061101
Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts. Drug metabolism and disposition: the biological fate of chemicals 20060901
Methoxy-resorufin ether as an electrochemically active biological probe for cytochrome P450 O-demethylation. Bioelectrochemistry (Amsterdam, Netherlands) 20060101
A hepatocarcinogenic tryptophan-pyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cyp1a2 in male mice. Cancer science 20060101
Molecular cloning and expression of a novel cytochrome p450 from turkey liver with aflatoxin b1 oxidizing activity. Chemical research in toxicology 20060101
Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5. Biochemical pharmacology 20051115
Induction of rat hepatic cytochrome P-450 by ketamine and its toxicological implications. Journal of toxicology and environmental health. Part A 20050901
A novel class of cytochrome P450 reductase redox cyclers: cationic manganoporphyrins. Toxicological sciences : an official journal of the Society of Toxicology 20050501
Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals. Toxicological sciences : an official journal of the Society of Toxicology 20050401
The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation. Mutagenesis 20050301
Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats. The Journal of pharmacy and pharmacology 20050201
Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat. Mutagenesis 20050101
Effects of amitraz on cytochrome P450-dependent monooxygenases and estrogenic activity in MCF-7 human breast cancer cells and immature female rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20041101
The involvement of microsomal oxidases in pyrethroid resistance in Helicoverpa armigera from Asia. Insect biochemistry and molecular biology 20040801
Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes. The Journal of pharmacy and pharmacology 20040201
Inhibition of CYP 1A2-dependent MROD activity in rat liver microsomes: an explanation of the hepatic sequestration of a limited subset of halogenated aromatic hydrocarbons. Environmental toxicology 20030401
The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line. Placenta 20030101
Comparative expression of liver cytochrome P450-dependent monooxygenases in the horse and in other agricultural and laboratory species. Veterinary journal (London, England : 1997) 20030101
Molecular modeling of cytochrome P450 1A1: enzyme-substrate interactions and substrate binding affinities. Journal of biomolecular structure & dynamics 20021001
Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells. British journal of pharmacology 20020601
Effects elicited by toxaphene in the cynomolgus monkey (Macaca fascicularis): a pilot study. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20011201
Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010601
Effects of fumonisin B1 present in Fusarium moniliforme culture material on drug metabolising enzyme activities in ducks. Toxicology letters 20010519
Cytochrome P450 expression and related metabolism in human buccal mucosa. Carcinogenesis 20010301
[Effect of hypoxic stress on xenobiotic metabolism and activities of various isoforms of cytochrome P-450]. Eksperimental'naia i klinicheskaia farmakologiia 20010101
Properties