Home Other Building Blocks Asenapine

Asenapine

CAS No.:
65576-45-6
Catalog Number:
AG00E952
Molecular Formula:
C17H16ClNO
Molecular Weight:
285.7680
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥95%
1 week
United States
$119
- +
5mg
≥95%
1 week
United States
$244
- +
10mg
98%
1 week
United States
$257
- +
50mg
98%
1 week
United States
$890
- +
100mg
98%
1 week
United States
$1523
- +
Product Description
Catalog Number:
AG00E952
Chemical Name:
Asenapine
CAS Number:
65576-45-6
Molecular Formula:
C17H16ClNO
Molecular Weight:
285.7680
MDL Number:
MFCD09838016
IUPAC Name:
(2R,6R)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene
InChI:
InChI=1S/C17H16ClNO/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19/h2-8,14-15H,9-10H2,1H3/t14-,15-/m0/s1
InChI Key:
VSWBSWWIRNCQIJ-GJZGRUSLSA-N
SMILES:
Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C
EC Number:
265-829-4
Properties
Complexity:
363  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
285.092g/mol
Formal Charge:
0
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
285.771g/mol
Monoisotopic Mass:
285.092g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
12.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.8  
Literature
Title Journal
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease. Journal of medicinal chemistry 20140911
Newer antipsychotics and upcoming molecules for schizophrenia. European journal of clinical pharmacology 20130801
Asenapine for the treatment of manic and mixed episodes associated with bipolar I disorder: from clinical research to clinical practice. Expert opinion on pharmacotherapy 20130301
Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults. Expert review of clinical pharmacology 20130101
Development and validation of automated SPE-HPLC-MS/MS methods for the quantification of asenapine, a new antipsychotic agent, and its two major metabolites in human urine. Biomedical chromatography : BMC 20121201
New serotonin/dopamine antagonists for the treatment of schizophrenia: are we making real progress? Clinical schizophrenia & related psychoses 20121001
Pharmacological and clinical profile of recently approved second-generation antipsychotics: implications for treatment of schizophrenia in older patients. Drugs & aging 20121001
Iloperidone, asenapine and lurasidone: a primer on their current status. Expert opinion on pharmacotherapy 20120901
Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis. CNS drugs 20120901
Clinically important differences in the pharmacokinetics of the ten newer 'atypical' antipsychotics: Part 2. Metabolism and elimination. Journal of psychiatric practice 20120901
A systematic review of meta-analyses of the efficacy of oral atypical antipsychotics for the treatment of adult patients with schizophrenia. Expert opinion on pharmacotherapy 20120801
Involvement of 5-HT2A receptor and α2-adrenoceptor blockade in the asenapine-induced elevation of prefrontal cortical monoamine outflow. Synapse (New York, N.Y.) 20120701
Long-term efficacy and safety of asenapine or olanzapine in patients with schizophrenia or schizoaffective disorder: an extension study. Pharmacopsychiatry 20120701
Weight gain and glucose dysregulation with second-generation antipsychotics and antidepressants: a review for primary care physicians. Postgraduate medicine 20120701
▼Asenapine for bipolar I disorder? Drug and therapeutics bulletin 20120601
[Asenapine in bipolar disorder: efficacy, safety and place in clinical practice]. L'Encephale 20120601
Summary of the comparative effectiveness review on off-label use of atypical antipsychotics. Journal of managed care pharmacy : JMCP 20120601
Valproate reduces the glucuronidation of asenapine without affecting asenapine plasma concentrations. Journal of clinical pharmacology 20120501
Short-term safety and pharmacokinetic profile of asenapine in older patients with psychosis. International journal of geriatric psychiatry 20120501
Asenapine: a clinical review of a second-generation antipsychotic. Clinical therapeutics 20120501
Clinically important differences in the pharmacokinetics of the ten newer 'atypical' antipsychotics: part 1. Journal of psychiatric practice 20120501
Allergic reactions and sudden death with asenapine. The Journal of clinical psychiatry 20120501
Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration. Neuropharmacology 20120301
[Antipsychotic medications for bipolar I disorders. New atypical neuroleptic drug asenapine approved]. Der Nervenarzt 20120301
Interactions between antiepileptics and second-generation antipsychotics. Expert opinion on drug metabolism & toxicology 20120301
Quantification of asenapine and three metabolites in human plasma using liquid chromatography-tandem mass spectrometry with automated solid-phase extraction: application to a phase I clinical trial with asenapine in healthy male subjects. Biomedical chromatography : BMC 20120201
Asenapine as adjunctive treatment for acute mania associated with bipolar disorder: results of a 12-week core study and 40-week extension. Journal of clinical psychopharmacology 20120201
Asenapine versus olanzapine in people with persistent negative symptoms of schizophrenia. Journal of clinical psychopharmacology 20120201
The psychopharmacology of agitation: consensus statement of the american association for emergency psychiatry project Beta psychopharmacology workgroup. The western journal of emergency medicine 20120201
Asenapine: a synthesis of efficacy data in bipolar mania and schizophrenia. Clinical schizophrenia & related psychoses 20120101
The neuroprotective disease-modifying potential of psychotropics in Parkinson's disease. Parkinson's disease 20120101
Update on the role of antipsychotics in the treatment of Tourette syndrome. Neuropsychiatric disease and treatment 20120101
Critical appraisal of lurasidone in the management of schizophrenia. Neuropsychiatric disease and treatment 20120101
Atypical antipsychotic drugs, schizophrenia, and metabolic syndrome in non-Euro-American societies. Clinical neuropharmacology 20120101
Safety and tolerability of switching to asenapine from other antipsychotic agents: pooled results from two randomized multicenter trials in stable patients with persistent negative symptoms in schizophrenia. Neuropsychiatric disease and treatment 20120101
Stability-indicating liquid chromatographic method for the quantification of the new antipsychotic agent asenapine in bulk and in pharmaceutical formulation. Scientia pharmaceutica 20120101
Smoking and metabolism; asenapine; irreversible MAOIs. Psychosomatics 20120101
Asenapine: a review of acute and extension phase data in bipolar disorder. CNS neuroscience & therapeutics 20111201
System for disclosing hospitality should be transparent. BMJ (Clinical research ed.) 20111115
Long-Term Assessment of Asenapine vs. Olanzapine in Patients with Schizophrenia or Schizoaffective Disorder. Pharmacopsychiatry 20111101
Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. Lancet (London, England) 20111008
Attenuation of chronic mild stress-induced 'anhedonia' by asenapine is not associated with a 'hedonic' profile in intracranial self-stimulation. Journal of psychopharmacology (Oxford, England) 20111001
Biological perspectives: update on newer antipsychotic drugs: are they evidence based? Perspectives in psychiatric care 20111001
Asenapine: a new antipsychotic option. Journal of pharmacy practice 20111001
Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis. JAMA 20110928
Functional potencies of dopamine agonists and antagonists at human dopamine D₂ and D₃ receptors. European journal of pharmacology 20110901
Suicidal ideation associated with asenapine use: a report of 2 cases. Journal of clinical psychopharmacology 20110801
Asenapine pharmacokinetics in hepatic and renal impairment. Clinical pharmacokinetics 20110701
Unmet treatment needs in schizophrenia patients: is asenapine a potential therapeutic option? Expert review of neurotherapeutics 20110701
Asenapine for the treatment of stuttering: an analysis of three cases. The American journal of psychiatry 20110601
Asenapine improves phencyclidine-induced object recognition deficits in the rat: evidence for engagement of a dopamine D1 receptor mechanism. Psychopharmacology 20110401
Metabolism and excretion of asenapine in healthy male subjects. Drug metabolism and disposition: the biological fate of chemicals 20110401
Dual inhibition: a novel promising pharmacological approach for different disease conditions. The Journal of pharmacy and pharmacology 20110401
Update on newer antipsychotic drugs. Journal of psychosocial nursing and mental health services 20110401
Newer molecules in the treatment of schizophrenia: A clinical update. Indian journal of pharmacology 20110401
Dopamine D2 occupancy as a biomarker for antipsychotics: quantifying the relationship with efficacy and extrapyramidal symptoms. The AAPS journal 20110301
Asenapine: a review of its use in the management of mania in adults with bipolar I disorder. CNS drugs 20110301
A randomized placebo-controlled trial of asenapine for the prevention of relapse of schizophrenia after long-term treatment. The Journal of clinical psychiatry 20110301
Iloperidone, asenapine, and lurasidone: a brief overview of 3 new second-generation antipsychotics. Postgraduate medicine 20110301
The role of serotonin receptors in the action of atypical antipsychotic drugs. Current opinion in pharmacology 20110201
Efficacy of antimanic treatments: meta-analysis of randomized, controlled trials. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110101
Comparison of QTc data analysis methods recommended by the ICH E14 guidance and exposure-response analysis: case study of a thorough QT study of asenapine. Clinical pharmacology and therapeutics 20110101
Atypical antipsychotics: the two new arrivals. Issues in mental health nursing 20110101
Paliperidone ER and oral risperidone in patients with schizophrenia: a comparative database analysis. BMC psychiatry 20110101
Weight gain, obesity, and psychotropic prescribing. Journal of obesity 20110101
Class effect of pharmacotherapy in bipolar disorder: fact or misbelief? Annals of general psychiatry 20110101
The role of asenapine in the treatment of manic or mixed states associated with bipolar I disorder. Neuropsychiatric disease and treatment 20110101
Role of sublingual asenapine in treatment of schizophrenia. Neuropsychiatric disease and treatment 20110101
Effects of asenapine on depressive symptoms in patients with bipolar I disorder experiencing acute manic or mixed episodes: a post hoc analysis of two 3-week clinical trials. BMC psychiatry 20110101
Clinical potential of lurasidone in the management of schizophrenia. Therapeutics and clinical risk management 20110101
Review of the safety, efficacy, and side effect profile of asenapine in the treatment of bipolar 1 disorder. Patient preference and adherence 20110101
Clinical utility of the risperidone formulations in the management of schizophrenia. Neuropsychiatric disease and treatment 20110101
Asenapine: a clinical overview. The Journal of clinical psychiatry 20110101
Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the rat. Behavioural brain research 20101225
A review of new atypical antipsychotic launches in the United States. Psychiatry (Edgmont (Pa. : Township)) 20101201
Asenapine for long-term treatment of bipolar disorder: a double-blind 40-week extension study. Journal of affective disorders 20101101
Effects of asenapine on prefrontal N-methyl-D-aspartate receptor-mediated transmission: involvement of dopamine D1 receptors. Synapse (New York, N.Y.) 20101101
Adjunctive use of atypical antipsychotics for treatment-resistant generalized anxiety disorder. Pharmacotherapy 20100901
New antipsychotic drugs: how do their receptor-binding profiles compare? The Journal of clinical psychiatry 20100901
Evaluation of the clinical efficacy of asenapine in schizophrenia. Expert opinion on pharmacotherapy 20100801
Effect of absorption site on the pharmacokinetics of sublingual asenapine in healthy male subjects. Biopharmaceutics & drug disposition 20100701
Long-term assessment of Asenapine vs. Olanzapine in patients with schizophrenia or schizoaffective disorder. Pharmacopsychiatry 20100601
Pharmacology and efficacy of asenapine for manic and mixed states in adults with bipolar disorder. Expert review of neurotherapeutics 20100501
Repeated effects of asenapine on adrenergic and cholinergic muscarinic receptors. The international journal of neuropsychopharmacology 20100401
Asenapine in the treatment of acute mania in bipolar I disorder: a randomized, double-blind, placebo-controlled trial. Journal of affective disorders 20100401
Efficacy and safety of asenapine in a placebo- and haloperidol-controlled trial in patients with acute exacerbation of schizophrenia. Journal of clinical psychopharmacology 20100401
Asenapine induces differential regional effects on serotonin receptor subtypes. Journal of psychopharmacology (Oxford, England) 20100301
New drug information. Saphris. JAAPA : official journal of the American Academy of Physician Assistants 20100301
Asenapine (Saphris) sublingual tablets for schizophrenia and bipolar disorder. The Medical letter on drugs and therapeutics 20100208
New drugs: asenapine, iloperidone, and bepotastine besilate. Journal of the American Pharmacists Association : JAPhA 20100101
A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder. BMC systems biology 20100101
[The quest for the pharmacological treatment of schizophrenia: from conventional neuroleptics to atypical antipsychotics and beyond]. Vertex (Buenos Aires, Argentina) 20100101
Neuroleptic malignant syndrome after exposure to asenapine: a case report. Primary care companion to the Journal of clinical psychiatry 20100101
Asenapine, a new sublingual atypical antipsychotic. Journal of pharmacology & pharmacotherapeutics 20100101
Asenapine versus olanzapine in acute mania: a double-blind extension study. Bipolar disorders 20091201
Asenapine for schizophrenia and bipolar disorder: a review of the efficacy and safety profile for this newly approved sublingually absorbed second-generation antipsychotic. International journal of clinical practice 20091201
Asenapine maleate: a new drug for the treatment of schizophrenia and bipolar mania. Drugs of today (Barcelona, Spain : 1998) 20091201
Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacology 20091101
A 3-week, randomized, placebo-controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states. Bipolar disorders 20091101
Exposure-response analysis in patients with schizophrenia to assess the effect of asenapine on QTc prolongation. Journal of clinical pharmacology 20091101
Asenapine. Nature reviews. Drug discovery 20091101
Asenapine approved for treatment of schizophrenia, bipolar disorder. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090915
Asenapine. CNS drugs 20090901
Modeling and simulation of the time course of asenapine exposure response and dropout patterns in acute schizophrenia. Clinical pharmacology and therapeutics 20090701
Asenapine elevates cortical dopamine, noradrenaline and serotonin release. Evidence for activation of cortical and subcortical dopamine systems by different mechanisms. Psychopharmacology 20090601
Asenapine exerts distinctive regional effects on ionotropic glutamate receptor subtypes in rat brain. Synapse (New York, N.Y.) 20090501
Electrophysiological characterization of the effects of asenapine at 5-HT(1A), 5-HT(2A), alpha(2)-adrenergic and D(2) receptors in the rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090301
Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. Journal of psychopharmacology (Oxford, England) 20090101
Asenapine restores cognitive flexibility in rats with medial prefrontal cortex lesions. Psychopharmacology 20090101
Asenapine monotherapy in the acute treatment of both schizophrenia and bipolar I disorder. Neuropsychiatric disease and treatment 20090101
Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081101
Actions of novel agonists, antagonists and antipsychotic agents at recombinant rat 5-HT6 receptors: a comparative study of coupling to G alpha s. European journal of pharmacology 20080707
Acute and long-term treatment of mania. Dialogues in clinical neuroscience 20080601
Bipolar depression: trial-based insights to guide patient care. Dialogues in clinical neuroscience 20080601
American psychiatric association. P & T : a peer-reviewed journal for formulary management 20080601
Differential regional and dose-related effects of asenapine on dopamine receptor subtypes. Psychopharmacology 20080501
Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology 20080201
Efficacy and tolerability of asenapine in acute schizophrenia: a placebo- and risperidone-controlled trial. The Journal of clinical psychiatry 20071001
Drug-drug interactions associated with second-generation antipsychotics: considerations for clinicians and patients. Psychopharmacology bulletin 20070101
Asenapine in the treatment of negative symptoms of schizophrenia: clinical trial design and rationale. Psychopharmacology bulletin 20070101
Actions of ORG 5222 as a novel psychotropic agent. Pharmacology, biochemistry, and behavior 19900301
Properties