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Home Other Building Blocks 4-Hydroxytolbutamide

4-Hydroxytolbutamide

CAS No.:
5719-85-7
Catalog Number:
AG00E8VI
Molecular Formula:
C12H18N2O4S
Molecular Weight:
286.3473
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Product Description
Catalog Number:
AG00E8VI
Chemical Name:
4-Hydroxytolbutamide
CAS Number:
5719-85-7
Molecular Formula:
C12H18N2O4S
Molecular Weight:
286.3473
MDL Number:
MFCD00144466
IUPAC Name:
1-butyl-3-[4-(hydroxymethyl)phenyl]sulfonylurea
InChI:
InChI=1S/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)
InChI Key:
SJRHYONYKZIRPM-UHFFFAOYSA-N
SMILES:
CCCCNC(=O)NS(=O)(=O)c1ccc(cc1)CO
UNII:
52K8J94779
Properties
Complexity:
370  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
286.099g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
286.346g/mol
Monoisotopic Mass:
286.099g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
104A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.1  
Literature
Title Journal
Validated assays for human cytochrome P450 activities. Drug metabolism and disposition: the biological fate of chemicals 20040601
Cytochrome P450 2C9 phenotyping using low-dose tolbutamide. European journal of clinical pharmacology 20040501
Effect of albumin on phenytoin and tolbutamide metabolism in human liver microsomes: an impact more than protein binding. Drug metabolism and disposition: the biological fate of chemicals 20020601
Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers. Pharmacogenetics 20020301
Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans. Pharmacogenetics 20020301
Properties