7-HYDROXY METHOTREXATE
| Title | Journal |
|---|---|
| Simple and sensitive HPLC method for the fluorometric determination of methotrexate and its major metabolites in human plasma by post-column photochemical reaction. | Biomedical chromatography : BMC 20120101 |
| [Pharmacokinetic analysis of high-dose methotrexate treatments in children with hematologic malignancies]. | Orvosi hetilap 20111002 |
| The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determination. | Clinical laboratory 20110101 |
| High-dose methotrexate in children with acute lymphoblastic leukemia: 7-hydroxymethotrexate systemic exposure and urinary concentrations at the steady state correlate well with those of methotrexate. | Arzneimittel-Forschung 20100101 |
| Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo. | Molecular cancer therapeutics 20091201 |
| Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation. | Arthritis and rheumatism 20090801 |
| Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090501 |
| Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. | Biochemical pharmacology 20090415 |
| In vivo-in vitro relationship of methotrexate 7-hydroxylation by aldehyde oxidase in four different strain rats. | Drug metabolism and pharmacokinetics 20061201 |
| Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. | The Journal of pharmacology and experimental therapeutics 20060801 |
| Coadministration of lansoprazole and naproxen does not affect the pharmacokinetic profile of methotrexate in adult patients with rheumatoid arthritis. | Journal of clinical pharmacology 20051001 |
| Effects and interaction of 7-hydroxy methotrexate and methotrexate in leukaemic cells ex vivo measured by the thymidylate synthase inhibition assay. | Cancer chemotherapy and pharmacology 20050901 |
| Pharmacokinetic study of methotrexate following intra-articular injection of methotrexate loaded poly(L-lactic acid) microspheres in rabbits. | Journal of pharmaceutical sciences 20050601 |
| Interference of 7-hydroxymethotrexate with the determination of methotrexate in plasma samples from children with acute lymphoblastic leukemia employing routine clinical assays. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325 |
| Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy. | Blood 20041215 |
| Lumiracoxib does not affect methotrexate pharmacokinetics in rheumatoid arthritis patients. | The Annals of pharmacotherapy 20041001 |
| Combined oral cyclosporin and methotrexate therapy in patients with rheumatoid arthritis elevates methotrexate levels and reduces 7-hydroxymethotrexate levels when compared with methotrexate alone. | Rheumatology (Oxford, England) 20030801 |
| System approach to modeling metabolite formation from parent drug: a working example with methotrexate. | Methods and findings in experimental and clinical pharmacology 20021001 |
| Lack of pharmacokinetic interaction between rofecoxib and methotrexate in rheumatoid arthritis patients. | Journal of clinical pharmacology 20011001 |
| Separation of selected anticancer drugs using superheated water as the mobile phase. | Analytical chemistry 20010815 |
| No effect of phenobarbital pretreatment of rats on methotrexate pharmacokinetics in the isolated liver perfused in a single-pass way. | Pharmacology 20010201 |
| Acute hepatotoxicity after high-dose methotrexate administration to rats. | Pharmacology & toxicology 19910801 |