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Oxatomide

CAS No.:
60607-34-3
Catalog Number:
AG00E8SY
Molecular Formula:
Molecular Weight:
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Purity
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Product Description
Catalog Number:
AG00E8SY
Chemical Name:
Oxatomide
CAS Number:
60607-34-3
MDL Number:
MFCD00211147
IUPAC Name:
3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one
InChI:
InChI=1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
InChI Key:
BAINIUMDFURPJM-UHFFFAOYSA-N
EC Number:
262-320-9
UNII:
J31IL9Z2EE
NSC Number:
309710
Properties
Complexity:
575  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
426.242g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
426.564g/mol
Monoisotopic Mass:
426.242g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
38.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.1  
Literature
Title Journal
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Pregnant with metastatic neuroendocrine tumour of the ovary: what now? Ecancermedicalscience 20120101
Inflammation and neurological adverse drugs reactions: a case of long lasting impaired consciousness after oxatomide administration in a patient with gastroenteritis. Italian journal of pediatrics 20120101
Molecular complexes of ketaconazole and oxatomide with p-chloranil: spectroscopic and spectrofluorimetric studies. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110901
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry 20110714
Innate signaling in otitis media: pathogenesis and recovery. Current allergy and asthma reports 20110201
Identification of clinically used drugs that activate pregnane X receptors. Drug metabolism and disposition: the biological fate of chemicals 20110101
Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. International archives of allergy and immunology 20110101
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. Healthcare informatics research 20101201
An integrative review of systematic reviews related to the management of breathlessness in respiratory illnesses. BMC pulmonary medicine 20100101
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology 20091001
Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast. Drugs 20090101
Determination of oxatomide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry. Biomedical chromatography : BMC 20080701
Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. Journal of pharmacological sciences 20080501
Inhibition of angiogenic factor production from murine mast cells by an antiallergic agent (epinastine hydrochloride) in vitro. Mediators of inflammation 20080101
CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20071101
A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20070301
Solvent effect on the charge transfer complex of oxatomide with 2,3-dichloro-5,6-dicyanobenzoquinone. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20061201
Effect of inhibitor of tumor necrosis factor-alpha and oxatomide on immune mediated otitis media. The Laryngoscope 20060901
Severe cholinergic urticaria successfully treated with scopolamine butylbromide in addition to antihistamines. Clinical and experimental dermatology 20060701
[Comparison of clinical efficacy and cost-quality of antihistamines in early treatment for Japanese cedar pollinosis]. Arerugi = [Allergy] 20060501
Antipruritic effect of the single oral administration of German chamomile flower extract and its combined effect with antiallergic agents in ddY mice. Journal of ethnopharmacology 20051003
Hydroxyzine and metabolites as a source of interference in carbamazepine particle-enhanced turbidimetric inhibition immunoassay (PETINIA). Therapeutic drug monitoring 20050801
Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants. Biological & pharmaceutical bulletin 20050201
Nimesulide-induced fixed drug eruption. Allergologia et immunopathologia 20050101
Identification of human p450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its inhibitory effect on enzyme activity. Biological & pharmaceutical bulletin 20040501
Cetirizine: a review of its use in allergic disorders. Drugs 20040101
The measurement of health-related quality of life (QOL) in paediatric clinical trials: a systematic review. Health and quality of life outcomes 20040101
West syndrome associated with administration of a histamine H1 antagonist, oxatomide. The Kurume medical journal 20040101
Dietary intake of the flower extracts of German chamomile (Matricaria recutita L.) inhibited compound 48/80-induced itch-scratch responses in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology 20031101
Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach. Journal of medicinal chemistry 20031009
Effects of fexofenadine and other antihistamines on components of the allergic response: adhesion molecules. The Journal of allergy and clinical immunology 20031001
[Development of nasal dosage form of oxatomide for rhinitis]. Arerugi = [Allergy] 20031001
Enhancement of allergic skin wheal responses in patients with atopic eczema/dermatitis syndrome by playing video games or by a frequently ringing mobile phone. European journal of clinical investigation 20030601
Evaluation of the effects of anti-pruritic drugs on scratch responses using histamine H1 receptor-deficient mice. European journal of pharmacology 20030530
The antiallergic drug oxatomide promotes human eosinophil apoptosis and suppresses IL-5-induced eosinophil survival. The Journal of allergy and clinical immunology 20030301
Pranlukast: a review of its use in the management of asthma. Drugs 20030101
Oxatomide for stable asthma in adults and children. The Cochrane database of systematic reviews 20030101
The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021201
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20020101
Drug eruption and liver injury caused by terfenadine and oxatomide. European journal of dermatology : EJD 20020101
High-performance liquid chromatographic determination of oxatomide and its metabolite and its application to pharmacokinetic study in rat plasma. Arzneimittel-Forschung 20020101
Pharmacokinetics of oxatomide in preterm infants. Drugs under experimental and clinical research 20020101
The role of central histaminergic neuron system as an anticonvulsive mechanism in developing brain. Brain & development 20011101
Circumvention of acquired resistance to doxorubicin in K562 human leukemia cells by oxatomide. Biological & pharmaceutical bulletin 20011001
Preclinical comparison of ebastine and other second generation H1-antihistamines. Pharmacology & toxicology 20011001
Oxatomide in the treatment of atopic dermatitis in breast-fed and very young infants. Minerva pediatrica 20010801
Double-blind multicenter study on the efficacy and tolerability of cetirizine compared with oxatomide in chronic idiopathic urticaria in preschool children. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010701
Change in tissue kallikrein level in nasal wash after the administration of oxatomide in patients with nasal allergy. American journal of rhinology 20010101
Effect of oxatomide, an antiallergic agent, on QT interval in dogs. Arzneimittel-Forschung 20010101
Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 19950201
Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clinical pharmacokinetics 19850101
Properties