(2S,3S)-3-Amino-2-hydroxy-4-phenylbutanoic acid
| Title | Journal |
|---|---|
| Investigation of α-phenylnorstatine and α-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibitors. | Bioorganic & medicinal chemistry 20110101 |
| Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. | Bioorganic & medicinal chemistry letters 20100815 |
| Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands. | Bioorganic & medicinal chemistry letters 20100201 |
| Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket. | Journal of medicinal chemistry 20091210 |
| Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. | Bioorganic & medicinal chemistry 20081201 |
| Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV. | Journal of medicinal chemistry 20080522 |
| Structure-activity relationships of novel HIV-1 protease inhibitors containing the 3-amino-2-chlorobenzoyl-allophenylnorstatine structure. | Bioorganic & medicinal chemistry 20080201 |
| Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties. | Bioorganic & medicinal chemistry letters 20070801 |
| Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. | Bioorganic & medicinal chemistry letters 20070601 |
| Computational analysis of plasmepsin IV bound to an allophenylnorstatine inhibitor. | FEBS letters 20061030 |
| Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor. | Acta crystallographica. Section D, Biological crystallography 20060301 |
| Remarkable diastereomeric rearrangement of an alpha-acyloxy beta-ketosulfide to an alpha-acyloxy thioester: a novel approach to the synthesis of optically active (2S,3S) beta-amino alpha-hydroxy acids. | The Journal of organic chemistry 20050902 |
| A novel dipeptide-based HIV protease inhibitor containing allophenylnorstatine. | Archiv der Pharmazie 20041101 |
| A phenylnorstatine inhibitor binding to HIV-1 protease: geometry, protonation, and subsite-pocket interactions analyzed at atomic resolution. | Journal of medicinal chemistry 20040408 |
| KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. | Bioorganic & medicinal chemistry letters 20040322 |
| Structure-activity and structure-metabolism relationships of HIV protease inhibitors containing the 3-hydroxy-2-methylbenzoyl-allophenylnorstatine structure. | Bioorganic & medicinal chemistry 20040102 |
| Inhibitors of the Plasmodium falciparum parasite aspartic protease plasmepsin II as potential antimalarial agents. | Current medicinal chemistry 20030601 |
| Receptor-independent 4D-QSAR analysis of a set of norstatine derived inhibitors of HIV-1 protease. | Journal of chemical information and computer sciences 20030101 |
| Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target. | Biochemistry 20020219 |
| Analysis of amide bond formation with an alpha-hydroxy-beta-amino acid derivative, 3-amino-2-hydroxy-4-phenylbutanoic acid, as an acyl component: byproduction of homobislactone. | The Journal of organic chemistry 20010810 |
| Structure-activity studies of FIV and HIV protease inhibitors containing allophenylnorstatine. | Bioorganic & medicinal chemistry 20010501 |
| Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine. | Journal of medicinal chemistry 19990520 |
| Structure-activity relationship of HIV-1 protease inhibitors containing AHPBA. Part III: Modification of P2 site. | Bioorganic & medicinal chemistry 19980501 |
| In vitro and ex vivo anti-human immunodeficiency virus (HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid. | Biological & pharmaceutical bulletin 19970201 |
| Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA--II. Modification of pyrrolidine ring at P1' proline. | Bioorganic & medicinal chemistry 19960801 |
| Design and synthesis of substrate-based peptidomimetic human immunodeficiency virus protease inhibitors containing the hydroxymethylcarbonyl isostere. | Biopolymers 19960101 |
| In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine. | Antimicrobial agents and chemotherapy 19930401 |
| KNI-102, a novel tripeptide HIV protease inhibitor containing allophenylnorstatine as a transition-state mimic. | Chemical & pharmaceutical bulletin 19911101 |
| Substrate analog inhibitors of HIV-1 protease containing phenylnorstatine as a transition state element. | Biochemical and biophysical research communications 19911015 |
| Rational design and synthesis of a novel class of active site-targeted HIV protease inhibitors containing a hydroxymethylcarbonyl isostere. Use of phenylnorstatine or allophenylnorstatine as a transition-state mimic. | Chemical & pharmaceutical bulletin 19910901 |