Home Sulfos methanesulfonic acid 4-{2-[(dimethylcarbamoyl)methoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate

methanesulfonic acid 4-{2-[(dimethylcarbamoyl)methoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate

CAS No.:
59721-29-8
Catalog Number:
AG00E8MK
Molecular Formula:
C21H26N4O8S
Molecular Weight:
494.5181
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
100mg
98%(HPLC)
In Stock USA
United States
$87
- +
250mg
98%
In Stock USA
United States
$94
- +
1g
98%
In Stock USA
United States
$188
- +
5g
98%
In Stock USA
United States
$532
- +
Product Description
Catalog Number:
AG00E8MK
Chemical Name:
methanesulfonic acid 4-{2-[(dimethylcarbamoyl)methoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate
CAS Number:
59721-29-8
Molecular Formula:
C21H26N4O8S
Molecular Weight:
494.5181
MDL Number:
MFCD00941410
IUPAC Name:
[4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate;methanesulfonic acid
InChI:
InChI=1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)
InChI Key:
FSEKIHNIDBATFG-UHFFFAOYSA-N
SMILES:
CS(=O)(=O)O.CN(C(=O)COC(=O)Cc1ccc(cc1)OC(=O)c1ccc(cc1)N=C(N)N)C
UNII:
451M50A1EQ
Properties
Complexity:
695  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
494.147g/mol
Formal Charge:
0
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
494.519g/mol
Monoisotopic Mass:
494.147g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
200A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Reduced sodium transport with nasal administration of the prostasin inhibitor camostat in subjects with cystic fibrosis. Chest 20130701
Effect of a serine protease inhibitor on the progression of chronic renal failure. American journal of physiology. Renal physiology 20121015
In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats. American journal of physiology. Renal physiology 20121001
An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. The Journal of clinical investigation 20120402
Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension. Clinical and experimental nephrology 20120201
Duodenal myotomy blocks reduction of meal size and prolongation of intermeal interval by cholecystokinin. Physiology & behavior 20120201
Oral delivery system for two-pulse colonic release of protein drugs and protease inhibitor/absorption enhancer compounds. Journal of pharmaceutical sciences 20110801
The short term satiety peptide cholecystokinin reduces meal size and prolongs intermeal interval. Peptides 20110601
ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Innate immunity 20110201
Regulator of calcineurin 1 controls growth plasticity of adult pancreas. Gastroenterology 20100801
Refractory chronic urticaria treated effectively with the protease inhibitors, nafamostat mesilate and camostat mesilate. Acta dermato-venereologica 20100701
Efficacy of camostat mesilate against dyspepsia associated with non-alcoholic mild pancreatic disease. Journal of gastroenterology 20100301
Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease. The Journal of pharmacology and experimental therapeutics 20090501
Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. Protein science : a publication of the Protein Society 20090501
Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. Journal of hypertension 20090101
Modelling of tumour--host coexistence In vitro in the presence of serine protease inhibitors. In vivo (Athens, Greece) 20090101
Activation of submucosal but not myenteric plexus of the gastrointestinal tract accompanies reduction of food intake by camostat. Regulatory peptides 20081009
CCK-induced pancreatic growth is not limited by mitogenic capacity in mice. American journal of physiology. Gastrointestinal and liver physiology 20080501
The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life sciences 20070501
Pancreatic diabetes in a follow-up survey of chronic pancreatitis in Japan. Journal of gastroenterology 20070401
Induction of early response genes in trypsin inhibitor-induced pancreatic growth. American journal of physiology. Gastrointestinal and liver physiology 20070201
The papilla of Vater just below the pylorus presenting as recurrent duodenal ulcer bleeding. Internal medicine (Tokyo, Japan) 20070101
[Effects of Chinese herbal medicines on spontaneous chronic pancreatitis in rats and the pathological relationships between formulas and syndromes]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20060701
Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice. The Journal of physiology 20060615
Properties of poly(lactic-co-glycolic acid) nanospheres containing protease inhibitors: camostat mesilate and nafamostat mesilate. International journal of pharmaceutics 20060511
Calcineurin-dependent and calcineurin-independent signal transduction pathways activated as part of pancreatic growth. Pancreas 20060401
Efficacy of camostat mesilate compared with famotidine for treatment of functional dyspepsia: is camostat mesilate effective? Journal of gastroenterology and hepatology 20060401
Camostat, an oral trypsin inhibitor, reduces pancreatic fibrosis induced by repeated administration of a superoxide dismutase inhibitor in rats. Journal of gastroenterology and hepatology 20050601
Water and enzyme secretion are tightly coupled in pancreatic secretion stimulated by food or CCK-58 but not by CCK-8. American journal of physiology. Gastrointestinal and liver physiology 20050501
Synthetic protease inhibitor camostat prevents and reverses dyslipidemia, insulin secretory defects, and histological abnormalities of the pancreas in genetically obese and diabetic rats. Metabolism: clinical and experimental 20050501
Preventive and therapeutic effects of the protease inhibitor camostat on pancreatic fibrosis and atrophy in CCK-1 receptor-deficient rats. Pancreas 20050101
Antimetastatic activity of a synthetic serine protease inhibitor, FOY-305 (Foypan). In vivo (Athens, Greece) 20050101
Tumor protein p53-induced nuclear protein 1 (TP53INP1) in spontaneous chronic pancreatitis in the WBN/Kob rat: drug effects on its expression in the pancreas. JOP : Journal of the pancreas 20040701
Calcineurin mediates pancreatic growth in protease inhibitor-treated mice. American journal of physiology. Gastrointestinal and liver physiology 20040501
[Autoimmune pancreatitis]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20040110
Circulating ethanol does not stimulate pancreatic secretion in conscious rats. Pancreas 20031101
CCK-58 is the only detectable endocrine form of cholecystokinin in rat. American journal of physiology. Gastrointestinal and liver physiology 20030801
Morphological relationship between intercalated duct and pancreatic islet in streptozotocin and/or camostat mesilate administrations in the chicken. Anatomia, histologia, embryologia 20030401
A possible defensive mechanism in the basal region of gastric mucosa and the healing of erosions. Clinical hemorheology and microcirculation 20030101
Different effects of oral administration of synthetic trypsin inhibitor on the pancreas between cholecystokinin-A receptor gene knockout mice and wild type mice. Japanese journal of pharmacology 20020701
Novel trial for the treatment of steroid dependency in minimal change disease: combined therapy of camostat mesilate and glycyrrhizin. Nephron 20020301
Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. Shock (Augusta, Ga.) 20020301
[Thoracic aortic aneurysm with chronic disseminated intravascular coagulation treated successfully with orally administered camostat mesilate, warfarin and aspirin]. [Rinsho ketsueki] The Japanese journal of clinical hematology 20020301
Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta. Gastroenterology 20010601
Effects of synthetic serine protease inhibitors on proliferation and collagen synthesis of human pancreatic periacinar fibroblast-like cells. Pancreas 20010401
Preparation and characterization of biodegradable or enteric-coated microspheres containing the protease inhibitor camostat. The Journal of pharmacy and pharmacology 20010201
Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves. Regulatory peptides 19990630
New orally active serine protease inhibitors. Journal of medicinal chemistry 19950707
Properties