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1,2-Dimethyl hydrazine

CAS No.:
540-73-8
Catalog Number:
AG00DVCU
Molecular Formula:
Molecular Weight:
Pack Size
Purity
Availability
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Quantity
  
Product Description
Catalog Number:
AG00DVCU
Chemical Name:
1,2-Dimethyl hydrazine
CAS Number:
540-73-8
MDL Number:
MFCD01741277
IUPAC Name:
1,2-dimethylhydrazine
InChI:
InChI=1S/C2H8N2/c1-3-4-2/h3-4H,1-2H3
InChI Key:
DIIIISSCIXVANO-UHFFFAOYSA-N
UNII:
IX068S9745
RTECS Number:
MV2625000
UN Number:
2382
Properties
Complexity:
6  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
60.069g/mol
Formal Charge:
0
Heavy Atom Count:
4  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
60.1g/mol
Monoisotopic Mass:
60.069g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
24.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.4  
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Inhibitory effect of bread crust antioxidant pronyl-lysine on two different categories of colonic premalignant lesions induced by 1,2-dimethylhydrazine. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20090801
Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate. International journal of cancer 20090801
Modulatory efficacy of hesperetin (citrus flavanone) on xenobiotic-metabolizing enzymes during 1,2-dimethylhydrazine-induced colon carcinogenesis. Chemico-biological interactions 20090715
Relative resistance of SGK1 knockout mice against chemical carcinogenesis. IUBMB life 20090701
Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis. Investigational new drugs 20090601
Peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of Embelin on colon carcinogenesis. Cancer research 20090601
Chemopreventive efficacy of pronyl-lysine on lipid peroxidation and antioxidant status in rat colon carcinogenesis. Fundamental & clinical pharmacology 20090601
IGFBP-2 overexpression reduces the appearance of dysplastic aberrant crypt foci and inhibits growth of adenomas in chemically induced colorectal carcinogenesis. International journal of cancer 20090501
Glycine- and proline-rich glycoprotein regulates the balance between cell proliferation and apoptosis for ACF formation in 1,2-dimethylhydrazine-treated A/J mice. Molecular and cellular biochemistry 20090501
Effect of Neem (Azadirchta indica) on serum glycoprotein contents of rats administered 1,2 dimethylhydrazine. Toxicology mechanisms and methods 20090501
[Role of peroxisome proliferators-activated receptor-gamma in the chemical prevention therapy of sulindac for precancerous lesions of rats]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20090418
Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation. Cancer science 20090401
Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis. Fundamental & clinical pharmacology 20090401
Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker. Journal of toxicologic pathology 20090301
Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis. Investigational new drugs 20090201
A therapeutic cancer vaccine targeting carcinoembryonic antigen in intestinal carcinomas. Human gene therapy 20090201
Modifying effects of morin on the development of aberrant crypt foci and bacterial enzymes in experimental colon cancer. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090201
Evaluation of a liver micronucleus assay with 12 chemicals using young rats (II): a study by the Collaborative Study Group for the Micronucleus Test/Japanese Environmental Mutagen Society-Mammalian Mutagenicity Study Group. Mutagenesis 20090101
Colorectal carcinogenesis: Review of human and experimental animal studies. Journal of carcinogenesis 20090101
The cyclooxygenase-2 inhibitor etoricoxib is a potent chemopreventive agent of colon carcinogenesis in the rat model. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20090101
Cyclophilin C-associated protein (CyCAP) knock-out mice spontaneously develop colonic mucosal hyperplasia and exaggerated tumorigenesis after treatment with carcinogen azoxymethane. BMC cancer 20090101
Effects of a probiotic soy product and physical exercise on formation of pre-neoplastic lesions in rat colons in a short-term model of carcinogenic. Journal of the International Society of Sports Nutrition 20090101
Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon. BMC gastroenterology 20090101
Influence of dietary resveratrol on early and late molecular markers of 1,2-dimethylhydrazine-induced colon carcinogenesis. Nutrition (Burbank, Los Angeles County, Calif.) 20090101
Effects of high-fat mixed-lipid diet and exercise on the antioxidant system in skeletal and cardiac muscles of rats with colon carcinoma. Pharmacological reports : PR 20090101
A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Molecular cancer 20090101
Membrane fluidity and surface changes during initiation of 1,2 dimethylhydrazine-induced colon carcinogenesis: protection by zinc. Oncology research 20090101
Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo. Molecular cancer 20090101
Chemopreventive response of diclofenac, a non-steroidal anti-inflammatory drug in experimental carcinogenesis. Nutricion hospitalaria 20090101
Role of zinc in modulating histo-architectural and biochemical alterations during dimethylhydrazine (DMH)-induced rat colon carcinogenesis. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20090101
Inhibitory effects of high temperature- and pressure-treated garlic on formation of 1,2-dimethylhydrazine-induced mucin-depleted foci and O(6)-methylguanine DNA adducts in the rat colorectum. Asian Pacific journal of cancer prevention : APJCP 20090101
Chemoprevention of 1,2-dimethylhydrazine-induced colon carcinogenesis by a non-steroidal anti-inflammatory drug, etoricoxib, in rats: inhibition of nuclear factor kappaB. Asian Pacific journal of cancer prevention : APJCP 20090101
Na(+)-stimulated Na+/H+ exchange and an unfavorable Ca2+ homeostasis initiate the cycloxygenase-2 inhibitors-induced apoptotic signals in colonic epithelial cells during the early stage of colon carcinogenesis. Oncology research 20090101
[Phospholipid content of plasma membranes and phospholipase C activity in epithelial cells of the large intestine in colitis-associated carcinogenesis in rats]. Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20090101
Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer management and research 20090101
Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon carcinogenesis. Investigational new drugs 20081201
Increased induction of apoptosis by Propionibacterium freudenreichii TL133 in colonic mucosal crypts of human microbiota-associated rats treated with 1,2-dimethylhydrazine. The British journal of nutrition 20081201
Deletion of MAG1 and MRE11 enhances the sensitivity of the Saccharomyces cerevisiae HUG1P-GFP promoter-reporter construct to genotoxicity. Biosensors & bioelectronics 20081201
Bone marrow microenvironment and tumor progression. Cancer microenvironment : official journal of the International Cancer Microenvironment Society 20081201
Effects of high-amylose maize starch and butyrylated high-amylose maize starch on azoxymethane-induced intestinal cancer in rats. Carcinogenesis 20081101
A 116-kDa phytoglycoprotein inhibits aberrant crypt foci formation through modulation of manganese superoxide dismutase, inducible nitric oxide synthase, cyclooxygenase-2, nuclear factor-kappa B, activator protein-1, and proliferating cell nuclear antigen in 1,2-dimethylhydrazine/dextran sodium sulfate-treated ICR mice. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20081101
Folic acid and sodium butyrate prevent tumorigenesis in a mouse model of colorectal cancer. Epigenetics 20081101
Long-term aerobic swimming training by rats reduces the number of aberrant crypt foci in 1,2-dimethylhydrazine-induced colon cancer. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20081101
Vanadium and 1, 25 (OH)2 vitamin D3 combination in inhibitions of 1,2, dimethylhydrazine-induced rat colon carcinogenesis. Biochimica et biophysica acta 20081001
Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study. The Journal of pharmacy and pharmacology 20081001
Role of oregano on bacterial enzymes in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis. Canadian journal of physiology and pharmacology 20081001
Role of cyclooxygenases in the stimulatory effect of carcinogen 1,2-dimethylhydrazine on stem cell survival in the intestinal epithelium and bone marrow. Bulletin of experimental biology and medicine 20081001
Cancer is a preventable disease that requires major lifestyle changes. Pharmaceutical research 20080901
No effects of olive oils with different phenolic content compared to corn oil on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. European journal of nutrition 20080901
Marine phosphatidylcholine suppresses 1,2-dimethylhydrazine-induced colon carcinogenesis in rats by inducing apoptosis. Nutrition research (New York, N.Y.) 20080901
Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells. Biologics : targets & therapy 20080901
Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesis model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080801
Contemporary approaches for modifying the mouse genome. Physiological genomics 20080801
Ursolic acid and oleanolic acid suppress preneoplastic lesions induced by 1,2-dimethylhydrazine in rat colon. Toxicologic pathology 20080601
Dose-dependent effect of oregano (Origanum vulgare L.) on lipid peroxidation and antioxidant status in 1,2-dimethylhydrazine-induced rat colon carcinogenesis. The Journal of pharmacy and pharmacology 20080601
Lack of chemoprevention of dietary Agaricus blazei against rat colonic aberrant crypt foci. Human & experimental toxicology 20080601
Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium. The British journal of nutrition 20080501
Possible carcinogenic risks of copper gluconate and their prevention by co-administered green tea catechins evaluated by a rat medium-term multi-organ carcinogenicity bioassay protocol. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080501
In-vivo evaluation in rats of colon-specific microspheres containing 5-fluorouracil. The Journal of pharmacy and pharmacology 20080501
The expression of low molecular weight protein tyrosine phosphatase is up-regulated in 1,2-dimethylhydrazine-induced colon tumours in rats. International journal of cancer 20080401
Modulatory activity of a Lactobacillus casei strain on 1,2-dimethylhydrazine-induced genotoxicity in rats. Environmental and molecular mutagenesis 20080401
Unsymmetrical DMH - an isomer of 1,2 DMH - is it potent to induce gastrointestinal carcinoma in rats? Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080401
A new medium-term rat colorectal bioassay applying neoplastic lesions as end points for detection of carcinogenesis modifiers effects with weak or controversial modifiers. Toxicologic pathology 20080401
Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis. Oncology reports 20080401
Obesity-related promotion of aberrant crypt foci in DMH-treated obese Zucker rats correlates with dyslipidemia rather than hyperinsulinemia. European journal of nutrition 20080401
Fructooligosaccharide and soy isoflavone suppress colonic aberrant crypt foci and cyclooxygenase-2 expression in dimethylhydrazine-treated rats. Journal of medicinal food 20080301
Anti-cancer effects of xanthones from pericarps of mangosteen. International journal of molecular sciences 20080301
Protective effects of vanadium against DMH-induced genotoxicity and carcinogenesis in rat colon: removal of O(6)-methylguanine DNA adducts, p53 expression, inducible nitric oxide synthase downregulation and apoptotic induction. Mutation research 20080227
Polymeric black tea polyphenols inhibit 1,2-dimethylhydrazine induced colorectal carcinogenesis by inhibiting cell proliferation via Wnt/beta-catenin pathway. Toxicology and applied pharmacology 20080215
Chemopreventive effect of plant originated glycoprotein on colitis-mediated colorectal cancer in A/J mice. Journal of biomedical science 20080101
K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine. International journal of cancer 20080101
Oral administration of a catalase-producing Lactococcus lactis can prevent a chemically induced colon cancer in mice. Journal of medical microbiology 20080101
Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. Journal of cellular and molecular medicine 20080101
Effect of nonsteroidal anti-inflammatory drugs and the procarcinogen 1,2-dimethylhydrazine on the antioxidant defense system. International journal of toxicology 20080101
Pituitary toxicity but lack of rat colon carcinogenicity of a DC-magnetic field in a medium-term bioassay. Asian Pacific journal of cancer prevention : APJCP 20080101
Antioxidative effects of nonsteroidal anti-inflammatory drugs during the initiation stages of experimental colon carcinogenesis in rats. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20080101
[Influence of dichlorodiphenyldichloroethylene on 1,2 dimethylhydrazine-induced androgen-dependent renal capsule angiosarcoma development]. Voprosy onkologii 20080101
[Colon carcinogenesis in rat vs. variable light]. Voprosy onkologii 20080101
Colonic perianastomotic carcinogenesis in an experimental model. BMC cancer 20080101
Recent advances in the investigation of curcuminoids. Chinese medicine 20080101
Voluntary exercise inhibits intestinal tumorigenesis in Apc(Min/+) mice and azoxymethane/dextran sulfate sodium-treated mice. BMC cancer 20080101
Lack of chemopreventive activity of Agaricus blazei mushroom on the development of 1,2-dimethylhydrazine-induced colonic aberrant crypt foci in rats. Nutrition and cancer 20080101
[Gas chromatographic determination of N,N-asymmetric dimethylhydrazine in different environmental objects]. Gigiena i sanitariia 20080101
Effect of non-steroidal anti-inflammatory drugs and the pro-carcinogen 1,2 dimethylhydrazine on the rat intestinal membrane structure and function. Nutricion hospitalaria 20080101
Dietary sphingomyelin inhibits colonic tumorigenesis with an up-regulation of alkaline sphingomyelinase expression in ICR mice. Anticancer research 20080101
Correspondence between flat aberrant crypt foci and mucin-depleted foci in rodent colon carcinogenesis. Anticancer research 20080101
The effect of etoricoxib, a cyclooxygenase-2-specific inhibitor, on the 1,2-dimethylhydrazine-administered rat intestinal membrane structure and function. Toxicology mechanisms and methods 20080101
Dose-response assessment of the anti-cancer efficacy of soy isoflavones in dimethylhydrazine-treated rats fed 6% fructooligosaccharide. Nutrition research and practice 20080101
Intrinsic resistance to apoptosis of colon epithelial cells is a potential determining factor in the susceptibility of the A/J mouse strain to dimethylhydrazine-induced colon tumorigenesis. Molecular carcinogenesis 20071201
Inhibitory effect of phytoglycoprotein on tumor necrosis factor-alpha and interleukin-6 at initiation stage of colon cancer in 1,2-dimethylhydrazine-treated ICR mice. Toxicology and applied pharmacology 20071201
Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer. Cancer research 20071115
Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/beta-catenin pathway and progression of early lesions in the rat. Carcinogenesis 20071101
Inhibitory effect of natural coumarin compounds, esculetin and esculin, on oxidative DNA damage and formation of aberrant crypt foci and tumors induced by 1,2-dimethylhydrazine in rat colons. Biological & pharmaceutical bulletin 20071101
Hydration behavior of alkyl amines and their corresponding protonated forms. 1. Ammonia and methylamine. The journal of physical chemistry. A 20071004
Significance of inflammation-associated regenerative mucosa characterized by Paneth cell metaplasia and beta-catenin accumulation for the onset of colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine. Carcinogenesis 20071001
Zinc mediated normalization of histoarchitecture and antioxidant status offers protection against initiation of experimental carcinogenesis. Molecular and cellular biochemistry 20071001
Insulin, leptin, and adiponectin receptors in colon: regulation relative to differing body adiposity independent of diet and in response to dimethylhydrazine. American journal of physiology. Gastrointestinal and liver physiology 20071001
Evaluation of nutritional availability and anti-tumor activity of selenium contained in selenium-enriched Kaiware radish sprouts. Bioscience, biotechnology, and biochemistry 20070901
Dimethylhydrazine model is not appropriate for evaluating effect of ethanol on colorectal cancer. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20070801
Evidence-based review versus points of view. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20070801
The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes. Carcinogenesis 20070701
Follow-up of tumor development in the colons of living rats and implications for chemoprevention trials: assessment of aspirin-difluoromethylornithine combination. International journal of oncology 20070701
Chemopreventive potential of zinc in experimentally induced colon carcinogenesis. Toxicology letters 20070615
Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). Journal of agricultural and food chemistry 20070613
Mucin-depleted foci are modulated by dietary treatments and show deregulation of proliferative activity in carcinogen-treated rodents. International journal of cancer 20070601
Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer. Oncology reports 20070601
[Mutagenic effect of the rocket fuel component asymmetric dimethylhydrazine on rats of various ages]. Genetika 20070601
Consumption of sericin suppresses colon oxidative stress and aberrant crypt foci in 1,2-dimethylhydrazine-treated rats by colon undigested sericin. Journal of nutritional science and vitaminology 20070601
Non-genomic action of resveratrol on androgen and oestrogen receptors in prostate cancer: modulation of the phosphoinositide 3-kinase pathway. British journal of cancer 20070521
Vitamin A and beta-carotene inhibitory effect during 1,2-dimethylhydrazine induced hepatocarcinogenesis potentiated by 5-azacytidine. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070401
Cytotoxic and antitumor activity of momilactone B from rice hulls. Journal of agricultural and food chemistry 20070307
A probiotic strain of Bacillus polyfermenticus reduces DMH induced precancerous lesions in F344 male rat. Biological & pharmaceutical bulletin 20070301
Fenugreek seeds modulate 1,2-dimethylhydrazine-induced hepatic oxidative stress during colon carcinogenesis. The Italian journal of biochemistry 20070301
Ferulic Acid: therapeutic potential through its antioxidant property. Journal of clinical biochemistry and nutrition 20070301
Cloudy apple juice is more effective than apple polyphenols and an apple juice derived cloud fraction in a rat model of colon carcinogenesis. Journal of agricultural and food chemistry 20070221
Application of ethyl chloroformate derivatization for gas chromatography-mass spectrometry based metabonomic profiling. Analytica chimica acta 20070205
Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansion. International immunopharmacology 20070201
Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis. International journal of oncology 20070201
Frequent mutation of Apc gene in rat colon tumors and mucin-depleted foci, preneoplastic lesions in experimental colon carcinogenesis. Cancer research 20070115
Protective role of luteolin in 1,2-dimethylhydrazine induced experimental colon carcinogenesis. Cell biochemistry and function 20070101
Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. Histology and histopathology 20070101
Long term administration of granulocyte-macrophage colony stimulating factor decreases development of 1-2 dimethylhydrazine-induced colon cancer in rats. Journal of surgical oncology 20070101
Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine. Journal of ethnobiology and ethnomedicine 20070101
Effect of running training on DMH-induced aberrant crypt foci in rat colon. Medicine and science in sports and exercise 20070101
Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. International journal of toxicology 20070101
Effect of 2-(carboxyphenyl) retinamide and genistein on the formation of early lesions in 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. Asian Pacific journal of cancer prevention : APJCP 20070101
Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate. BMC cancer 20070101
New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK. BMC genetics 20070101
Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract. International journal of toxicology 20070101
Chemopreventive effects of nonsteroidal anti-inflammatory drugs in the membrane lipid composition and fluidity parameters of the 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. Drug and chemical toxicology 20070101
Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers. Nutrition journal 20070101
Chemopreventive effects of nonsteroidal anti-inflammatory drugs on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. Toxicology mechanisms and methods 20070101
Total synthesis of (+)-rishirilide B: development and application of general processes for enantioselective oxidative dearomatization of resorcinol derivatives. Journal of the American Chemical Society 20061213
Dose dependent inhibitory effect of dietary caraway on 1,2-dimethylhydrazine induced colonic aberrant crypt foci and bacterial enzyme activity in rats. Investigational new drugs 20061101
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status. Mutation research 20061010
Effect of ginger on bacterial enzymes in 1,2-dimethylhydrazine induced experimental colon carcinogenesis. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20061001
Dietary resistant starch type 3 prevents tumor induction by 1,2-dimethylhydrazine and alters proliferation, apoptosis and dedifferentiation in rat colon. Carcinogenesis 20060901
The anti-obesity agent Orlistat is associated to increase in colonic preneoplastic markers in rats treated with a chemical carcinogen. Cancer letters 20060828
Susceptibility to colon carcinogenesis in C3H<-->C57BL/6 chimeric mice reflects both tissue microenvironment and genotype. Cancer letters 20060808
Effect of dietary caraway (Carum carvi L.) on aberrant crypt foci development, fecal steroids, and intestinal alkaline phosphatase activities in 1,2-dimethylhydrazine-induced colon carcinogenesis. Toxicology and applied pharmacology 20060801
Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis. Biochimica et biophysica acta 20060801
Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness. Carcinogenesis 20060801
Dose-response efficacy of caraway (Carum carvi L.) on tissue lipid peroxidation and antioxidant profile in rat colon carcinogenesis. The Journal of pharmacy and pharmacology 20060801
Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development. The British journal of nutrition 20060701
Lack of chemopreventive effects of ginger on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060601
Chronic colitis promotes tumor development. Oncology reports 20060601
Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine. International journal of cancer 20060515
Chemopreventive effect of trans-resveratrol--a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis. Carcinogenesis 20060501
Three-dimensional analysis of isolated hexosaminidase-altered aberrant crypts from colons of 1,2-dimethylhydrazine-treated rats. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20060301
Distribution of preneoplastic lesions and tumors, and beta-catenin gene mutations in colon carcinomas induced by 1,2-dimethylhydrazine plus dextran sulfate sodium. Journal of experimental & clinical cancer research : CR 20060301
A new medium-term rat colon bioassay applying neoplastic lesions as endpoints for detection of carcinogenesis modifiers-validation with known modifiers. Cancer letters 20060208
Lack of chemopreventive effects of alpha-eleostearic acid on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary and colon carcinogenesis in female Sprague-Dawley rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060201
Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats. Journal of carcinogenesis 20060101
Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in mice. BMC complementary and alternative medicine 20060101
Dietary trans-10, cis-12 and cis-9,trans-11 conjugated linoleic acids induce apoptosis in the colonic mucosa of rats treated with 1,2-dimethylhydrazine. Journal of medicinal food 20060101
PSC 833, an inhibitor of P-glycoprotein inhibits 1,2-dimethylhydrazine-induced colorectal carcinogenesis in male Fischer F344 rats. Anticancer research 20060101
Melatonin as antioxidant, geroprotector and anticarcinogen. Biochimica et biophysica acta 20060101
Prevention of 1,2-dimethylhydrazine-induced circulatory oxidative stress by bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione during colon carcinogenesis. Pharmacological reports : PR 20060101
Effects of VPS extract of Coriolus versicolor on cancer of the large intestine using a serial sacrifice technique. In vivo (Athens, Greece) 20060101
Histological response of peritoneal carcinomatosis after hyperthermic intraperitoneal chemoperfusion (HIPEC) in experimental investigations. BMC cancer 20060101
Effect of spices on lipid metabolism in 1,2-dimethylhydrazine-induced rat colon carcinogenesis. Journal of medicinal food 20060101
Inhibition of large intestinal cancers by celecoxib using a serial sacrifice technique. In vivo (Athens, Greece) 20060101
Greater development of 1,2-dimethylhydrazine-induced colon cancer in a rat model of type 2 diabetes mellitus. The Journal of international medical research 20060101
Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content. Nutrition and cancer 20060101
Amended final report on the safety assessment of Oryza Sativa (rice) Bran Oil, Oryza Sativa (rice) Germ Oil, Rice Bran Acid,Oryza Sativa (rice) Bran Wax, Hydrogenated Rice Bran Wax, Oryza Sativa (rice)Bran Extract, Oryza Sativa (rice) Extract, Oryza Sativa (rice) Germ Powder, Oryza Sativa (rice) Starch, Oryza Sativa (rice) Bran, Hydrolyzed Rice Bran Extract, Hydrolyzed Rice Bran Protein, Hydrolyzed Rice Extract, and Hydrolyzed Rice Protein. International journal of toxicology 20060101
IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment. Journal of carcinogenesis 20060101
Celecoxib and curcumin additively inhibit the growth of colorectal cancer in a rat model. Digestion 20060101
Hypolipidemic effect of ginger in 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis. Toxicology mechanisms and methods 20060101
Effect of oral Lactococcus lactis containing endostatin on 1, 2-dimethylhydrazine-induced colon tumor in rats. World journal of gastroenterology 20051214
Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. Mutation research 20051211
Modulation of radiation-induced disturbances of antioxidant defense systems by ginsan. Evidence-based complementary and alternative medicine : eCAM 20051201
Inhibitory effect of dietary monoglucosylceramide 1-O-beta-glucosyl-N-2'-hydroxyarachidoyl-4,8-sphingadienine on two different categories of colon preneoplastic lesions induced by 1,2-dimethylhydrazine in F344 rats. Cancer science 20051201
Novel sites of cytosolic glutathione peroxidase expression in colon. FEBS letters 20051107
A high-fat diet generates alterations in nuclear receptor expression: prevention by vitamin A and links with cyclooxygenase-2 and beta-catenin. International journal of cancer 20051010
Determination of hydrazine, monomethylhydrazine, 1,1-dimethylhydrazine, and 1,2-dimethylhydrazine by nonaqueous capillary electrophoresis with amperometric detection. Electrophoresis 20050901
Evaluation of the antitumor activity of interleukin-12 in an experimental murine model of colorectal cancer induced by 1,2 dimethyl-hydrazine (DMH). Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20050901
Cyclooxygenase-2 inhibition in colon experimental carcinogenesis. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20050901
Inositol hexaphosphate-induced enhancement of natural killer cell activity correlates with suppression of colon carcinogenesis in rats. World journal of gastroenterology 20050828
Targeting normal and neoplastic tissues in the rat jejunum and colon with boronated, cationic acrylamide copolymers. Journal of controlled release : official journal of the Controlled Release Society 20050818
Mucin-depleted foci have beta-catenin gene mutations, altered expression of its protein, and are dose- and time-dependent in the colon of 1,2-dimethylhydrazine-treated rats. International journal of cancer 20050810
Cloudy apple juice decreases DNA damage, hyperproliferation and aberrant crypt foci development in the distal colon of DMH-initiated rats. Carcinogenesis 20050801
Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazine-induced colon cancer. Clinica chimica acta; international journal of clinical chemistry 20050801
[Inhibitory effect of sodium butyrate on 1,2-dimethylhydrazine-induced tumorigenesis of colorectal cancer in mice]. Ai zheng = Aizheng = Chinese journal of cancer 20050801
The Cables gene on chromosome 18Q regulates colon cancer progression in vivo. Cancer biology & therapy 20050801
Effect of rofecoxib on colon chemical carcinogenesis at colonic anastomotic area in the rat. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20050601
Sulindac induces apoptosis and protects against colon carcinoma in mice. World journal of gastroenterology 20050514
Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen. The international journal of biochemistry & cell biology 20050501
Reduction of beta-glucuronidase and nitroreductase activity by yoghurt in a murine colon cancer model. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20050401
Grapefruit and oroblanco enhance hepatic detoxification enzymes in rats: possible role in protection against chemical carcinogenesis. Journal of agricultural and food chemistry 20050309
Effect of polyphenolic extracts from red wine and 4-OH-coumaric acid on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. European journal of nutrition 20050301
Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v) mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors. Laboratory investigation; a journal of technical methods and pathology 20050301
Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. Cancer science 20050201
Effect of ethanol consumption on colon cancer in an experimental model. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20050201
JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats. International journal of cancer 20050120
Modifying effect of propolis on dimethylhydrazine-induced DNA damage but not colonic aberrant crypt foci in rats. Environmental and molecular mutagenesis 20050101
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