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lucanthone

CAS No.:
479-50-5
Catalog Number:
AG00DJXZ
Molecular Formula:
C20H24N2OS
Molecular Weight:
340.4824
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
99%
1 week
United States
$1023
- +
5mg
99%
1 week
United States
$1973
- +
10mg
99%
1 week
United States
$3323
- +
20mg
99%
1 week
United States
$5807
- +
Product Description
Catalog Number:
AG00DJXZ
Chemical Name:
lucanthone
CAS Number:
479-50-5
Molecular Formula:
C20H24N2OS
Molecular Weight:
340.4824
MDL Number:
MFCD00866726
IUPAC Name:
1-[2-(diethylamino)ethylamino]-4-methylthioxanthen-9-one
InChI:
InChI=1S/C20H24N2OS/c1-4-22(5-2)13-12-21-16-11-10-14(3)20-18(16)19(23)15-8-6-7-9-17(15)24-20/h6-11,21H,4-5,12-13H2,1-3H3
InChI Key:
FBQPGGIHOFZRGH-UHFFFAOYSA-N
SMILES:
CCN(CCNc1ccc(c2c1c(=O)c1c(s2)cccc1)C)CC
EC Number:
207-532-4
UNII:
FC6D57000M
Properties
Complexity:
426  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
340.161g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
340.485g/mol
Monoisotopic Mass:
340.161g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
57.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4  
Literature
Title Journal
[2-Butyl-4-(4-tert-butyl-benz-yl)-1,2,4-triazol-3-yl-idene]chlorido[(1,2,5,6-η)-cyclo-octa-1,5-diene]iridium(I). Acta crystallographica. Section E, Structure reports online 20120201
[(1,2,5,6-η)-Cyclo-octa-1,5-diene]bis-(1-isopropyl-3-methyl-imidazolin-2-yl-idene)rhodium(I) tetra-fluorido-borate. Acta crystallographica. Section E, Structure reports online 20111201
3-(2,6-Dimethyl-anilino)imidazo[1,2-a]pyridin-1-ium perchlorate. Acta crystallographica. Section E, Structure reports online 20110501
N,N'-Bis(5-bromo-pyridin-2-yl)methane-diamine. Acta crystallographica. Section E, Structure reports online 20110401
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. The Journal of biological chemistry 20110225
4-(Piperidin-1-yl)-4H-benzo[b]tetra-zolo[1,5-d][1,4]diazepin-5(6H)-one. Acta crystallographica. Section E, Structure reports online 20110101
Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PloS one 20110101
Impact of Autophagy on Chemotherapy and Radiotherapy Mediated Tumor Cytotoxicity: 'To Live or not to Live'. Frontiers in oncology 20110101
[(1,2,5,6-η)-1,5-Cyclo-octa-diene](1-isopropyl-3-methyl-imidazolin-2-yl-idene)(triphenyl-phosphine)iridium(I) tetra-fluorido-borate dichloro-methane solvate. Acta crystallographica. Section E, Structure reports online 20100901
2-Propyl 3,3-dibromo-2-hydroxy-pyrrolidine-1-carboxyl-ate. Acta crystallographica. Section E, Structure reports online 20100301
2-Butyl-11-phenyl-5,10-dihydro-1H-benzo[e]imidazo[1,5-a][1,4]diazepine-1,3(2H)-dione. Acta crystallographica. Section E, Structure reports online 20100301
Radiation resistance in glioma cells determined by DNA damage repair activity of Ape1/Ref-1. Journal of radiation research 20100101
The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target. Molecular aspects of medicine 20070101
Clonogenicity of human leukemic cells protected from cell-lethal agents by heat shock protein 70. Cell stress & chaperones 20050301
Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone. Anticancer research 20040101
Design of small volume HX and triple-resonance probes for improved limits of detection in protein NMR experiments. Journal of magnetic resonance (San Diego, Calif. : 1997) 20030901
Abasic sites in DNA of HeLa cells induced by lucanthone. Cancer investigation 20020101
Accelerated regression of brain metastases in patients receiving whole brain radiation and the topoisomerase II inhibitor, lucanthone. International journal of radiation oncology, biology, physics 19990101
Properties