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DESIPRAMINE

CAS No.:
50-47-5
Catalog Number:
AG00DELK
Molecular Formula:
C18H22N2
Molecular Weight:
266.3807
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Purity
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Product Description
Catalog Number:
AG00DELK
Chemical Name:
DESIPRAMINE
CAS Number:
50-47-5
Molecular Formula:
C18H22N2
Molecular Weight:
266.3807
MDL Number:
MFCD00242884
IUPAC Name:
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
InChI:
InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
InChI Key:
HCYAFALTSJYZDH-UHFFFAOYSA-N
SMILES:
CNCCCN1c2ccccc2CCc2c1cccc2
EC Number:
200-040-0
UNII:
TG537D343B
Properties
Complexity:
267  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
266.178g/mol
Formal Charge:
0
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
266.388g/mol
Monoisotopic Mass:
266.178g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
15.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.9  
Literature
Title Journal
New therapeutic approaches and novel alternatives for organophosphate toxicity. Toxicology letters 20180701
Application of a nonradioactive assay for high throughput screening for inhibition of thyroid hormone uptake via the transmembrane transporter MCT8. Toxicology in vitro : an international journal published in association with BIBRA 20170401
Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates. Archives of toxicology 20170301
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition. Clinical pharmacology and therapeutics 20161101
Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway. The Journal of biological chemistry 20140808
Selective inhibition of hepatitis C virus infection by hydroxyzine and benztropine. Antimicrobial agents and chemotherapy 20140601
Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicological sciences : an official journal of the Society of Toxicology 20131201
Inhibition of 2,4-dinitrofluorobenzene-induced contact hypersensitivity reaction by antidepressant drugs. Pharmacological reports : PR 20130101
Analysis of region-specific changes in gene expression upon treatment with citalopram and desipramine reveals temporal dynamics in response to antidepressant drugs at the transcriptome level. Psychopharmacology 20121001
The effects of isolated and enriched housing conditions on baseline and drug-induced behavioural responses in the male rat. Behavioural brain research 20121001
Determination of desipramine in biological samples using liquid-liquid-liquid microextraction combined with in-syringe derivatization, gas chromatography, and nitrogen/phosphorus detection. Journal of separation science 20121001
A reconstructed human epidermal keratinization culture model to characterize ceramide metabolism in the stratum corneum. Archives of dermatological research 20120901
'Pre-cebo': an unrecognized issue in the interpretation of adequate relief during irritable bowel syndrome drug trials. Journal of clinical gastroenterology 20120901
Comparative evaluation of the effect of tricyclic antidepressants on inducible nitric oxide synthase expression in neuropathic pain model. Nitric oxide : biology and chemistry 20120815
Adrenergic stimulation-released 5-HT stored in adrenergic nerves inhibits CGRPergic nerve-mediated vasodilatation in rat mesenteric resistance arteries. British journal of pharmacology 20120801
Effect of long-term caffeine administration on depressive-like behavior in rats exposed to chronic unpredictable stress. Behavioural pharmacology 20120801
Depressive and cardiovascular disease comorbidity in a rat model of social stress: a putative role for corticotropin-releasing factor. Psychopharmacology 20120701
Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120701
Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice. Journal of neural transmission (Vienna, Austria : 1996) 20120601
Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats. British journal of pharmacology 20120601
Sex differences in baseline and drug-induced behavioural responses in classical behavioural tests. Progress in neuro-psychopharmacology & biological psychiatry 20120601
Noradrenergic antidepressant responses to desipramine in vivo are reciprocally regulated by arrestin3 and spinophilin. Neuropharmacology 20120601
Effect of early life housing manipulation on baseline and drug-induced behavioural responses on neurochemistry in the male rat. Progress in neuro-psychopharmacology & biological psychiatry 20120601
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry 20120524
Thiamine is a substrate of organic cation transporters in Caco-2 cells. European journal of pharmacology 20120505
The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain. Psychopharmacology 20120501
Comparison of ΔFosB immunoreactivity induced by vagal nerve stimulation with that caused by pharmacologically diverse antidepressants. The Journal of pharmacology and experimental therapeutics 20120501
In vitro-to-in vivo predictions of drug-drug interactions involving multiple reversible inhibitors. Expert opinion on drug metabolism & toxicology 20120401
Desipramine selectively potentiates norepinephrine-elicited ERK1/2 activation through the α2A adrenergic receptor. Biochemical and biophysical research communications 20120330
The effects of nigrostriatal dopamine depletion on the thalamic parafascicular nucleus. Brain research 20120329
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Bioorganic & medicinal chemistry letters 20120315
Morris water maze performance deficit produced by intermittent swim stress is partially mediated by norepinephrine. Pharmacology, biochemistry, and behavior 20120301
Reversed chloroquine molecules as a strategy to overcome resistance in malaria. Current topics in medicinal chemistry 20120301
Difficulties in dopamine transporter radioligand PET analysis: the example of LBT-999 using [18F] and [11C] labelling Part I: PET studies. Nuclear medicine and biology 20120201
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation. European journal of medicinal chemistry 20120201
On the improvement of inhibitory response control and visuospatial attention by indirect and direct adrenoceptor agonists. Psychopharmacology 20120101
Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology 20120101
Platinum anticancer agents and antidepressants: desipramine enhances platinum-based cytotoxicity in human colon cancer cells. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20120101
Effects of noradrenergic denervation on L-DOPA-induced dyskinesia and its treatment by α- and β-adrenergic receptor antagonists in hemiparkinsonian rats. Pharmacology, biochemistry, and behavior 20120101
Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. European journal of medicinal chemistry 20120101
Reactive metabolites of desipramine and clomipramine: The kinetics of formation and reactivity with DNA. Bioorganic & medicinal chemistry 20120101
Neuroimmune endocrine effects of antidepressants. Neuropsychiatric disease and treatment 20120101
Accumulation of an antidepressant in vesiculogenic membranes of yeast cells triggers autophagy. PloS one 20120101
Primum non nocere: an evolutionary analysis of whether antidepressants do more harm than good. Frontiers in psychology 20120101
Desipramine inhibits histamine H1 receptor-induced Ca2+ signaling in rat hypothalamic cells. PloS one 20120101
Vagal nerve stimulation rapidly activates brain-derived neurotrophic factor receptor TrkB in rat brain. PloS one 20120101
High dose methylphenidate treatment in adult attention deficit hyperactivity disorder: a case report. Journal of medical case reports 20120101
Neonatal serotonin (5-HT) depletion does not affect spatial learning and memory in rats. Pharmacological reports : PR 20120101
Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats. Evidence-based complementary and alternative medicine : eCAM 20120101
Milnacipran inhibits glutamatergic N-methyl-D-aspartate receptor activity in spinal dorsal horn neurons. Molecular pain 20120101
Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction. Pharmacological reports : PR 20120101
Desipramine pretreatment improves sympathetic remodeling and ventricular fibrillation threshold after myocardial ischemia. Journal of biomedicine & biotechnology 20120101
Stimulatory effect of antidepressant drug pretreatment on progression of B16F10 melanoma in high-active male and female C57BL/6J mice. Journal of neuroimmunology 20111215
Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice. Biological psychiatry 20111201
Case scenario: opioid association with serotonin syndrome: implications to the practitioners. Anesthesiology 20111201
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Regulation of CCL2/MCP-1 production in astrocytes by desipramine and atomoxetine: involvement of α2 adrenergic receptors. Brain research bulletin 20111125
Serotonergic and noradrenergic pathways are required for the anxiolytic-like and antidepressant-like behavioral effects of repeated vagal nerve stimulation in rats. Biological psychiatry 20111115
Antidepressants elevate GDNF expression and release from C₆ glioma cells in a β-arrestin1-dependent, CREB interactive pathway. The international journal of neuropsychopharmacology 20111101
The antidepressant desipramine is an arrestin-biased ligand at the α(2A)-adrenergic receptor driving receptor down-regulation in vitro and in vivo. The Journal of biological chemistry 20111014
Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152). Journal of medicinal chemistry 20111013
The triple reuptake inhibitor DOV216,303 exhibits limited antidepressant-like properties in the differential reinforcement of low-rate 72-second responding assay, likely due to dopamine reuptake inhibition. Journal of psychopharmacology (Oxford, England) 20111001
Chronic desipramine treatment alters tyrosine hydroxylase but not norepinephrine transporter immunoreactivity in norepinephrine axons in the rat prefrontal cortex. The international journal of neuropsychopharmacology 20111001
Desipramine treatment has minimal effects on the brain accumulation of glucocorticoids in P-gp-deficient and wild-type mice. Psychoneuroendocrinology 20111001
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors. European journal of medicinal chemistry 20111001
Long-term ovariectomy modulates the antidepressant-like action of estrogens, but not of antidepressants. Journal of psychopharmacology (Oxford, England) 20111001
Impact of chronic cyanosis and reoxygenation on the microheterogeneity of the myocardial blood flow: digital radiographic study in neonatal rats. General thoracic and cardiovascular surgery 20111001
Rapid target-specific remodeling of fast-spiking inhibitory circuits after loss of dopamine. Neuron 20110908
The disruption of central CO2 chemosensitivity in a mouse model of Rett syndrome. American journal of physiology. Cell physiology 20110901
Stress modulation of cognitive and affective processes. Stress (Amsterdam, Netherlands) 20110901
Ontogenetic serotoninergic lesioning alters histaminergic activity in rats in adulthood. Neurotoxicity research 20110801
Behavioural effects of antidepressants are dependent and independent on the integrity of the dentate gyrus. The international journal of neuropsychopharmacology 20110801
Predictive validity of a non-induced mouse model of compulsive-like behavior. Behavioural brain research 20110801
Development of a highly sensitive cytotoxicity assay system for CYP3A4-mediated metabolic activation. Drug metabolism and disposition: the biological fate of chemicals 20110801
Selective serotonin reuptake inhibitors attenuate the antigen presentation from dendritic cells to effector T lymphocytes. FEMS immunology and medical microbiology 20110801
Citalopram versus desipramine in treatment resistant depression: effect of continuation or switching strategies: a randomized open study. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20110801
Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases. The Journal of clinical investigation 20110801
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry 20110714
Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus. Brain research 20110705
Adoptive transfer of macrophage from mice with depression-like behavior enhances susceptibility to colitis. Inflammatory bowel diseases 20110701
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research 20110701
Lipid raft-dependent activation of dual oxidase 1/H2O2/NF-κB pathway in bronchial epithelial cells. American journal of physiology. Cell physiology 20110701
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals 20110701
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. European journal of medicinal chemistry 20110601
Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110601
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry 20110413
Antidepressant-like action of intracerebral 6-fluoronorepinephrine, a selective full α-adrenoceptor agonist. The international journal of neuropsychopharmacology 20110401
Electrospray ionization-ion mobility spectrometry as a detection system for three-phase hollow fiber microextraction technique and simultaneous determination of trimipramine and desipramine in urine and plasma samples. Analytical and bioanalytical chemistry 20110401
Long-term body weight outcomes of antidepressant-environment interactions. Molecular psychiatry 20110301
Treatment of depressive symptoms in Parkinson's disease. European journal of neurology 20110301
Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorganic & medicinal chemistry letters 20110301
Automated experimental system capturing three behavioral components during murine forced swim test. Life sciences 20110227
Pharmacologic treatment of depression in multiple sclerosis. The Cochrane database of systematic reviews 20110216
Slow and incomplete sympathetic reinnervation of rat tail artery restores the amplitude of nerve-evoked contractions provided a perivascular plexus is present. American journal of physiology. Heart and circulatory physiology 20110201
The effects of antidepressants on mitochondrial function in a model cell system and isolated mitochondria. Neurochemical research 20110201
Effects of atomoxetine, desipramine, d-amphetamine and methylphenidate on impulsivity in juvenile rats, measured in a T-maze procedure. Neuroscience letters 20110201
5,7,3'-Trihydroxy-3,4'-dimethoxyflavone inhibits the tubulin polymerization and activates the sphingomyelin pathway. Molecular carcinogenesis 20110201
PET of (R)-11C-rolipram binding to phosphodiesterase-4 is reproducible and sensitive to increased norepinephrine in the rat heart. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20110201
[The delayed sensitization of CRH response developed after chronic variable stress on the acoustic startle reflex]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20110201
Insulin modulates cocaine-sensitive monoamine transporter function and impulsive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110126
Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants. Biochemical and biophysical research communications 20110107
Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway. Journal of neuro-oncology 20110101
Long-lasting cognitive deficit induced by stress is alleviated by acute administration of antidepressants. Psychoneuroendocrinology 20110101
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors. Bioorganic & medicinal chemistry 20110101
Propionibacterium acnes CAMP factor and host acid sphingomyelinase contribute to bacterial virulence: potential targets for inflammatory acne treatment. PloS one 20110101
Role of Striatum in the Pause and Burst Generation in the Globus Pallidus of 6-OHDA-Treated Rats. Frontiers in systems neuroscience 20110101
Narcolepsy: a review. Neuropsychiatric disease and treatment 20110101
Effects of Hypericum perforatum extract on rat irritable bowel syndrome. Pharmacognosy magazine 20110101
Identification of bilateral changes in TID1 expression in the 6-OHDA rat model of Parkinson's disease. PloS one 20110101
Lithium monotherapy increases ACTH and cortisol response in the DEX/CRH test in unipolar depressed subjects. A study with 30 treatment-naive patients. PloS one 20110101
Neonatal serotonin (5-HT) depletion does not disrupt prepulse inhibition of the startle response in rats. Pharmacological reports : PR 20110101
Reversal of myo-inositol metabolic level in the left dorsolateral prefrontal cortex of rats exposed to forced swimming test following desipramine treatment: an in vivo localized (1)H-MRS study at 4.7 T. Magnetic resonance imaging 20101201
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals 20101201
Astrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism. Journal of neurophysiology 20101201
Inhibition of norepinephrine reuptake and size of myocardial infarction during focal ischemia and after preconditioning. Bulletin of experimental biology and medicine 20101201
Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain. Journal of medicinal chemistry 20101111
Rigid analogues of the α2-adrenergic blocker atipamezole: small changes, big consequences. Journal of medicinal chemistry 20101014
Forced swim test behavior in postpartum rats. Pharmacology, biochemistry, and behavior 20101001
Involvement of threonine 258 and serine 259 motif in amphetamine-induced norepinephrine transporter endocytosis. Journal of neurochemistry 20101001
Protective effect of desipramine, venlafaxine and trazodone against experimental animal model of transient global ischemia: possible involvement of NO-cGMP pathway. Brain research 20100924
gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression. Biological psychiatry 20100915
Effects of antidepressants on the performance in the forced swim test of two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions. Psychopharmacology 20100901
Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the alpha2-adrenergic receptor: implications for antidepressant drug mechanism of action. European journal of cell biology 20100901
Intermittent and continuous swim stress-induced behavioral depression: sensitivity to norepinephrine- and serotonin-selective antidepressants. Psychopharmacology 20100901
Beneficial effects of desipramine on cognitive function of chronically stressed rats are mediated by alpha1-adrenergic receptors in medial prefrontal cortex. Progress in neuro-psychopharmacology & biological psychiatry 20100816
Desipramine attenuates forced swim test-induced behavioral and neurochemical alterations in mice: an in vivo(1)H-MRS study at 9.4T. Brain research 20100812
In vivo voltammetric monitoring of catecholamine release in subterritories of the nucleus accumbens shell. Neuroscience 20100811
HPC-1/syntaxin 1A gene knockout mice show abnormal behavior possibly related to a disruption in 5-HTergic systems. The European journal of neuroscience 20100701
The tricyclic antidepressant desipramine inhibits T3 import into primary neurons. Neuroscience letters 20100630
Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231). Journal of medicinal chemistry 20100610
Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem. Drug metabolism and disposition: the biological fate of chemicals 20100601
Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100601
Antidepressant-like or anxiolytic-like actions of topiramate alone or co-administered with intra-lateral septal infusions of neuropeptide Y in male Wistar rats. Peptides 20100601
Effects of single and simultaneous lesions of serotonergic and noradrenergic pathways on open-space and bright-space anxiety-like behavior in two animal models. Behavioural brain research 20100501
Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors. Bioorganic & medicinal chemistry letters 20100501
Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine. Biochemical and biophysical research communications 20100409
Psychotropic drugs have contrasting skeletal effects that are independent of their effects on physical activity levels. Bone 20100401
Vulnerability of peripheral catecholaminergic neurons to MPTP is not regulated by alpha-synuclein. Neurobiology of disease 20100401
Regulation of MCP-1 production in brain by stress and noradrenaline-modulating drugs. Journal of neurochemistry 20100401
1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors. Journal of medicinal chemistry 20100311
Treatment of resistant depression in patients with cancer with low doses of ketamine and desipramine. Journal of palliative medicine 20100301
Nerve growth factor (NGF) has novel antidepressant-like properties in rats. Pharmacology, biochemistry, and behavior 20100201
Dynamic monitoring of NET activity in mature murine sympathetic terminals using a fluorescent substrate. British journal of pharmacology 20100201
[Uptake1 inibition in reperfusion: noradrenalin dynamic and myocardiola infraction size]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20100201
Effects of extracellular pH reductions on [(3)H]D-aspartate and [(3)H]noradrenaline release by presynaptic nerve terminals isolated from rat cerebral cortex. Journal of neural transmission (Vienna, Austria : 1996) 20100101
Transient supersensitivity to alpha-adrenoceptor agonists, and distinct hyper-reactivity to vasopressin and angiotensin II after denervation of rat tail artery. British journal of pharmacology 20100101
Psychopharmacological neuroprotection in neurodegenerative disease: assessing the preclinical data. The Journal of neuropsychiatry and clinical neurosciences 20100101
Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Pharmacological interventions for antisocial personality disorder. The Cochrane database of systematic reviews 20100101
Tetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease. Neuropsychiatric disease and treatment 20100101
A new strategy for antidepressant prescription. Frontiers in neuroscience 20100101
Antidepressant/anxiolytic and anti-nociceptive effects of novel 2-substituted 1,4-benzodiazepine-2-ones. Scientia pharmaceutica 20100101
Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers. Neuro endocrinology letters 20100101
IFN-gamma reduction by tricyclic antidepressants. International journal of psychiatry in medicine 20100101
Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder. International journal of tryptophan research : IJTR 20100101
Desipramine induced changes in the norepinephrine transporter, alpha- and gamma-synuclein in the hippocampus, amygdala and striatum. Neuroscience letters 20091225
In vivo voltammetric monitoring of norepinephrine release in the rat ventral bed nucleus of the stria terminalis and anteroventral thalamic nucleus. The European journal of neuroscience 20091203
The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. Neurochemistry international 20091201
Desipramine inhibits the growth of a mouse skin squamous cell carcinoma cell line and affects glucocorticoid receptor-mediated transcription. Molecular carcinogenesis 20091201
Effect of acute and repeated treatment with desipramine or methylphenidate on serial reversal learning in rats. Neuropharmacology 20091201
Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury. Pain 20091201
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. Journal of medicinal chemistry 20091126
Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles. Bioorganic & medicinal chemistry 20091115
Inhibitory effect of antidepressants on the NMDA-evoked [(3)H]noradrenaline release from rat hippocampal slices. Neurochemistry international 20091101
MPTP-induced neuroblast apoptosis in the subventricular zone is not regulated by dopamine or other monoamine transporters. Neurotoxicology 20091101
Tricyclic antidepressant toxicity treated with massive sodium bicarbonate. The American journal of emergency medicine 20091101
Comparison of fused-core and conventional particle size columns by LC-MS/MS and UV: application to pharmacokinetic study. Journal of pharmaceutical and biomedical analysis 20091015
Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters. Journal of medicinal chemistry 20091008
Prefrontal cortical D1 dopamine receptors modulate subcortical D2 dopamine receptor-mediated stress responsiveness. The international journal of neuropsychopharmacology 20091001
Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors. Bioorganic & medicinal chemistry letters 20091001
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry 20091001
1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors. Journal of medicinal chemistry 20090924
Desipramine induces disorder in cholesterol-rich membranes: implications for viral trafficking. Physical biology 20090910
Early prediction of the effectiveness of antidepressants: inputs from an animal model. Journal of molecular neuroscience : MN 20090901
Cooperative opioid and serotonergic mechanisms generate superior antidepressant-like effects in a mice model of depression. The international journal of neuropsychopharmacology 20090901
Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols. Bioorganic & medicinal chemistry letters 20090901
Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: stress and depression. Dialogues in clinical neuroscience 20090901
Behavioral effects of four antidepressants on an ischemic rat model of emotional disturbances. Behavioural brain research 20090812
Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission. Physiology & behavior 20090804
Treatment with escitalopram but not desipramine decreases escape latency times in a learned helplessness model using juvenile rats. Psychopharmacology 20090801
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. Journal of medicinal chemistry 20090723
Disposition of desipramine, a sensitive cytochrome P450 2D6 substrate, when coadministered with intravenous temsirolimus. Cancer chemotherapy and pharmacology 20090701
Behavioral sensitization to cocaine: cooperation between glucocorticoids and epinephrine. Psychopharmacology 20090701
Effects of the histone deacetylase inhibitor sodium butyrate in models of depression and anxiety. Neuropharmacology 20090701
Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line. Neuroscience research 20090701
Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors. European journal of medicinal chemistry 20090601
Toluene has antidepressant-like actions in two animal models used for the screening of antidepressant drugs. Psychopharmacology 20090601
Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of chronic antidepressant treatments. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090601
Reactivation of inflammatory bowel disease in a mouse model of depression. Gastroenterology 20090601
Jugular venous overflow of noradrenaline from the brain: a neurochemical indicator of cerebrovascular sympathetic nerve activity in humans. The Journal of physiology 20090601
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. Journal of medicinal chemistry 20090514
Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090501
Strategies for a reliable biostatistical analysis of differentially expressed spots from two-dimensional electrophoresis gels. Journal of proteome research 20090501
3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors. Bioorganic & medicinal chemistry letters 20090501
Melatonin reduces induction of Bax, caspase and cell death in methamphetamine-treated human neuroblastoma SH-SY5Y cultured cells. Journal of pineal research 20090501
Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Archives of general psychiatry 20090501
Specificity of direct transition from wake to REM sleep in orexin/ataxin-3 transgenic narcoleptic mice. Experimental neurology 20090501
Time-dependent alterations of peripheral immune parameters after nigrostriatal dopamine depletion in a rat model of Parkinson's disease. Brain, behavior, and immunity 20090501
Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090401
Uptake of mIBG and catecholamines in noradrenaline- and organic cation transporter-expressing cells: potential use of corticosterone for a preferred uptake in neuroblastoma- and pheochromocytoma cells. Nuclear medicine and biology 20090401
Will tricyclic antidepressants make a comeback for depressed Parkinson disease patients? Neurology 20090310
Antidepressants influence somatostatin levels and receptor pharmacology in brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090301
Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090301
Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090301
Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. Clinical and experimental pharmacology & physiology 20090301
Remodeling of hippocampal spine synapses in the rat learned helplessness model of depression. Biological psychiatry 20090301
Possible role of norepinephrine in cocaine-induced conditioned taste aversions. Pharmacology, biochemistry, and behavior 20090301
Beta2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic pain. Neurobiology of disease 20090301
Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue. Molecular pharmacology 20090301
Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats. Canadian journal of physiology and pharmacology 20090301
The effects of desvenlafaxine and paroxetine on the pharmacokinetics of the cytochrome P450 2D6 substrate desipramine in healthy adults. Journal of clinical pharmacology 20090201
Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations. Fundamental & clinical pharmacology 20090201
Antidepressants in the treatment of adult attention-deficit hyperactivity disorder: a systematic review. Advances in therapy 20090201
Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats. Behavioural brain research 20090130
Pharmacotherapy and psychotherapy for body dysmorphic disorder. The Cochrane database of systematic reviews 20090121
Protection against cell death and sustained tyrosine hydroxylase phosphorylation in hydrogen peroxide- and MPP-treated human neuroblastoma cells with melatonin. Journal of pineal research 20090101
Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys. Psychopharmacology 20090101
Antidepressants alleviate the impact of reinforcer downshift. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090101
Expression and functional characterization of choline transporter in human keratinocytes. Journal of pharmacological sciences 20090101
Serotoninergic and non-serotoninergic effects of two tricyclic antidepressants on visceral nociception in a rat model. Scandinavian journal of gastroenterology 20090101
Time course and dose response of alpha tocopherol on oxidative stress in haemodialysis patients. BMC nephrology 20090101
Tetrabenazine as anti-chorea therapy in Huntington disease: an open-label continuation study. Huntington Study Group/TETRA-HD Investigators. BMC neurology 20090101
Alcohol reverses depressive and pronociceptive effects of chronic stress in mice with enhanced activity of the opioid system. Acta neurobiologiae experimentalis 20090101
Age-dependent stimulatory effect of desipramine and fluoxetine pretreatment on metastasis formation by B16F10 melanoma in male C57BL/6 mice. Pharmacological reports : PR 20090101
Potentiation of the antidepressant-like effect of desipramine or reboxetine by metyrapone in the forced swimming test in rats. Pharmacological reports : PR 20090101
Spectroscopic and electrochemical analysis of psychotropic drugs. Indian journal of pharmaceutical sciences 20090101
Comparison of the behavioural pharmacology of the Lister-Hooded with 2 commonly utilised albino rat strains. Progress in neuro-psychopharmacology & biological psychiatry 20081212
Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081201
Chronic antidepressant treatments increase basic fibroblast growth factor and fibroblast growth factor-binding protein in neurons. Neuropharmacology 20081201
The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. The Journal of pharmacology and experimental therapeutics 20081201
Do desipramine [10,11-dihydro-5-[3-(methylamino) propyl]-5H-dibenz[b,f]azepine monohydrochloride] and fluoxetine [N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine] ameliorate the extent of colonic damage induced by acetic acid in rats? The Journal of pharmacology and experimental therapeutics 20081201
Reduction in the latency of action of antidepressants by 17 beta-estradiol in the forced swimming test. Psychopharmacology 20081201
An assessment of drug-drug interactions: the effect of desvenlafaxine and duloxetine on the pharmacokinetics of the CYP2D6 probe desipramine in healthy subjects. Drug metabolism and disposition: the biological fate of chemicals 20081201
Striatal 5-HT1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat. Neuropharmacology 20081201
Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors. Bioorganic & medicinal chemistry letters 20081201
Reinforcement magnitude modulation of rate-dependent effects of fluvoxamine and desipramine in the rat. Behavioural pharmacology 20081201
Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey. Behavioural brain research 20081103
Differential effects of chronic antidepressant treatment on shuttle box escape deficits induced by uncontrollable stress. Psychopharmacology 20081101
Desipramine blocks alcohol-induced anxiety- and depressive-like behaviors in two rat strains. Pharmacology, biochemistry, and behavior 20081101
Evaluation of the repeated open-space swim model of depression in the mouse. Pharmacology, biochemistry, and behavior 20081101
Effect of desvenlafaxine on the cytochrome P450 2D6 enzyme system. Journal of psychiatric practice 20081101
Possible role of citalopram and desipramine against sleep deprivation-induced anxiety like-behavior alterations and oxidative damage in mice. Indian journal of experimental biology 20081101
Antidepressant-like effects of echo-planar magnetic resonance imaging in mice determined using the forced swimming test. Brain research 20081021
Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission. European journal of pharmacology 20081010
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry 20081009
Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stress. Neuropharmacology 20081001
Desipramine or glutamate antagonists synergized the antidepressant-like actions of intra-nucleus accumbens infusions of minocycline in male Wistar rats. Progress in neuro-psychopharmacology & biological psychiatry 20081001
Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors. Bioorganic & medicinal chemistry letters 20080915
Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex. Neuroscience letters 20080912
Mouse strain differences in immobility and sensitivity to fluvoxamine and desipramine in the forced swimming test: analysis of serotonin and noradrenaline transporter binding. European journal of pharmacology 20080911
Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches. Behavioural pharmacology 20080901
Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions. Behavioural pharmacology 20080901
Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy. The European journal of neuroscience 20080901
Assessing the neuronal serotonergic target-based antidepressant stratagem: impact of in vivo interaction studies and knockout models. Current neuropharmacology 20080901
Desipramine-induced apoptosis in human PC3 prostate cancer cells: activation of JNK kinase and caspase-3 pathways and a protective role of [Ca2+]i elevation. Toxicology 20080819
Antidepressant treatments regulate matrix metalloproteinases-2 and -9 (MMP-2/MMP-9) and tissue inhibitors of the metalloproteinases (TIMPS 1-4) in the adult rat hippocampus. Synapse (New York, N.Y.) 20080801
Reuptake of L-DOPA-derived extracellular DA in the striatum of a rodent model of Parkinson's disease via norepinephrine transporter. Synapse (New York, N.Y.) 20080801
Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests. Neuropeptides 20080801
D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action. European journal of pharmacology 20080728
Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI). Bioorganic & medicinal chemistry letters 20080715
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. Journal of medicinal chemistry 20080710
Toward prediction of alkane/water partition coefficients. Journal of medicinal chemistry 20080710
Enhanced norepinephrine output during long-term desipramine treatment: a possible role for the extraneuronal monoamine transporter (SLC22A3). Journal of psychiatric research 20080701
An in vitro mechanistic study to elucidate the desipramine/bupropion clinical drug-drug interaction. Drug metabolism and disposition: the biological fate of chemicals 20080701
Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala. Journal of chemical neuroanatomy 20080701
Pharmacokinetic and pharmacodynamic studies of drug interaction following oral administration of imipramine and sodium alginate in rats. Naunyn-Schmiedeberg's archives of pharmacology 20080701
In vivo PET imaging of cardiac presynaptic sympathoneuronal mechanisms in the rat. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080701
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry 20080612
Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression. The Journal of clinical investigation 20080602
Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice. The pharmacogenomics journal 20080601
Inter-individual differences in novelty-seeking behavior in rats predict differential responses to desipramine in the forced swim test. Psychopharmacology 20080601
The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat. Psychopharmacology 20080601
Lack of persistent effects of ketamine in rodent models of depression. Psychopharmacology 20080601
Cardiac sympathetic hypo-innervation in familial dysautonomia. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20080601
Synergistic effects of stress and omega-3 fatty acid deprivation on emotional response and brain lipid composition in adult rats. Prostaglandins, leukotrienes, and essential fatty acids 20080601
Narcolepsy: current treatment options and future approaches. Neuropsychiatric disease and treatment 20080601
Cholecystokinin antagonists (part 1): Antinociceptive, anxiolytic and antidepressant effects of N-(5-methyl-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazol-4-yl)-N'-phenylureas and carboxamides. Drug discoveries & therapeutics 20080601
Increased dopaminergic signaling impairs aversive olfactory memory retention in Drosophila. Biochemical and biophysical research communications 20080523
Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain research 20080523
Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model. Brain research 20080507
Determination of fluoxetine in plasma by gas chromatography-mass spectrometry using stir bar sorptive extraction. Analytica chimica acta 20080505
The role of the arginine vasopressin Avp1b receptor in the acute neuroendocrine action of antidepressants. Psychoneuroendocrinology 20080501
Abuse liability assessment of atomoxetine in a drug-abusing population. Drug and alcohol dependence 20080501
Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled study. Movement disorders : official journal of the Movement Disorder Society 20080430
The role of NMDA receptor antagonists in nicotine tolerance, sensitization, and physical dependence: a preclinical review. Yonsei medical journal 20080430
Clinical practice. Irritable bowel syndrome. The New England journal of medicine 20080417
Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression. Psychopharmacology 20080401
Efficacy of imipramine in psychotic versus nonpsychotic depression. Journal of clinical psychopharmacology 20080401
Biphasic effects of Morus alba leaves green tea extract on mice in chronic forced swimming model. Phytotherapy research : PTR 20080401
Identification of antidepressant drug leads through the evaluation of marine natural products with neuropsychiatric pharmacophores. Pharmacology, biochemistry, and behavior 20080301
VTA dopamine neuron bursting is altered in an animal model of depression and corrected by desipramine. Journal of molecular neuroscience : MN 20080301
MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor. Journal of psychopharmacology (Oxford, England) 20080301
Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder. Progress in neuro-psychopharmacology & biological psychiatry 20080215
Increased water temperature renders single-housed C57BL/6J mice susceptible to antidepressant treatment in the forced swim test. Behavioural brain research 20080211
An anti-immobility effect of exogenous corticosterone in mice. European journal of pharmacology 20080202
In vitro biotransformation of amitriptyline and imipramine with rat hepatic S9 fraction: evaluation of the toxicity with Spirotox and Thamnotoxkit F Tests. Archives of environmental contamination and toxicology 20080201
The differential regulation of BDNF and TrkB levels in juvenile rats after four days of escitalopram and desipramine treatment. Neuropharmacology 20080201
Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin. Journal of clinical pharmacology 20080201
Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models. Behavioural pharmacology 20080201
Reinforcement magnitude modulates the rate-dependent effects of fluvoxamine and desipramine on fixed-interval responding in the pigeon. Behavioural pharmacology 20080201
Comparison of the effects of desmethylimipramine on behavior in the forced swim test in peripubertal and adult rats. Behavioural pharmacology 20080201
Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart. Nuclear medicine and biology 20080201
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry 20080124
Tyrosine depletion lowers dopamine synthesis and desipramine-induced prefrontal cortex catecholamine levels. Brain research 20080123
Photophysics and photochemistry of imipramine, desimipramine, and clomipramine in several solvents: a fluorescence, 266 nm laser flash, and theoretical study. The journal of physical chemistry. B 20080110
Platelet imidazoline receptors as state marker of depressive symptomatology. Journal of psychiatric research 20080101
A novel approach for predicting antidepressant-induced sexual dysfunction in rats. Psychopharmacology 20080101
Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model. Respiratory physiology & neurobiology 20080101
Estrogens participate in the antidepressant-like effect of desipramine and fluoxetine in male rats. Pharmacology, biochemistry, and behavior 20080101
Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice. Psychoneuroendocrinology 20080101
Down-regulation of norepinephrine transporter expression on membrane surface induced by chronic administration of desipramine and the antagonism by co-administration of local anesthetics in mice. Neurochemistry international 20080101
Desipramine induces apoptotic cell death through nonmitochondrial and mitochondrial pathways in different types of human colon carcinoma cells. Pharmacology 20080101
Automated classification of the behavior of rats in the forced swimming test with support vector machines. Neural networks : the official journal of the International Neural Network Society 20080101
Involvement of ROS/ASMase/JNK signalling pathway in inhibiting UVA-induced apoptosis of HaCaT cells by polypeptide from Chlamys farreri. Free radical research 20080101
Histamine uptake into human vascular endothelial cells and influence of three different antidepressant drugs. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080101
Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease. Journal of neuroinflammation 20080101
The role of the entorhinal cortex in extinction: influences of aging. Neural plasticity 20080101
Time-dependent biphasic modulation of human BDNF by antidepressants in neuroblastoma cells. BMC neuroscience 20080101
Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration. BMC pharmacology 20080101
A novel approach to the prediction of drug-drug interactions in humans based on the serum incubation method. Drug metabolism and pharmacokinetics 20080101
Community-based randomised controlled trial evaluating falls and osteoporosis risk management strategies. Trials 20080101
A cost-utility comparison of four first-line medications in painful diabetic neuropathy. PharmacoEconomics 20080101
[Two cases of suspected Munchausen by proxy syndrome: the importance of forensic toxicological analyses in handling suspicions and producing evidence]. Archiv fur Kriminologie 20080101
Pharmacological properties of the active metabolites of the antidepressants desipramine and citalopram. European journal of pharmacology 20071208
The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20071201
Direct inhibitory effect of fluoxetine on N-methyl-D-aspartate receptors in the central nervous system. Biological psychiatry 20071201
Blockade of autoreceptor-mediated inhibition of norepinephrine release by atipamezole is maintained after chronic reuptake inhibition. The international journal of neuropsychopharmacology 20071201
Potential antidepressants: pharmacology of 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in rodent behavioural models. Die Pharmazie 20071201
[Multivariate study of the Open Field Drink Test using undernourished rats and desipramine as an antipanic drug]. Investigacion clinica 20071201
An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature 20071122
The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants. Psychopharmacology 20071101
Antidepressant-like effect of tramadol in the unpredictable chronic mild stress procedure: possible involvement of the noradrenergic system. Behavioural pharmacology 20071101
Analysis of tricyclic antidepressant drugs in plasma by means of solid-phase microextraction-liquid chromatography-mass spectrometry. Journal of mass spectrometry : JMS 20071001
[Pharmacological treatment of Rett syndrome improves breathing and survival in a mouse model]. Medecine sciences : M/S 20071001
Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague-Dawley rats. Biological psychiatry 20070915
LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science (New York, N.Y.) 20070907
Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons. Psychopharmacology 20070901
[(3)H] citalopram binding to serotonin transporter sites in minnow brains. Basic & clinical pharmacology & toxicology 20070901
Dopamine and depression. Archives of general psychiatry 20070901
Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test. Biological & pharmaceutical bulletin 20070901
The effect of beta-cyclodextrin on liquid chromatography/electrospray-mass spectrometry analysis of hydrophobic drug molecules. Journal of chromatography. A 20070817
Reduced evoked fos expression in activity-related brain regions in animal models of behavioral depression. Progress in neuro-psychopharmacology & biological psychiatry 20070815
The effects of serotoninergic, noradrenergic, cholinergic and dopaminergic drugs on vigilance states in MPTP-treated mice. Brain research 20070803
Interstitial norepinephrine concentrations in skeletal muscle of ischemic heart failure. American journal of physiology. Heart and circulatory physiology 20070801
A cost-effectiveness comparison of desipramine, gabapentin, and pregabalin for treating postherpetic neuralgia. Journal of the American Geriatrics Society 20070801
cAMP response element-binding protein deficiency allows for increased neurogenesis and a rapid onset of antidepressant response. The Journal of neuroscience : the official journal of the Society for Neuroscience 20070718
Attenuation of estrous cycle-dependent marble burying in female rats by acute treatment with progesterone and antidepressants. Psychoneuroendocrinology 20070701
Brain Na+, K+-ATPase isoforms: different hypothalamus and mesencephalon response to acute desipramine treatment. Life sciences 20070627
The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system. Biochemical pharmacology 20070615
chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model. The Journal of biological chemistry 20070615
Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test. Psychopharmacology 20070601
Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. The Journal of pharmacology and experimental therapeutics 20070601
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry 20070601
Cardiac epinephrine synthesis and ischemia-induced myocardial epinephrine release. Cardiovascular research 20070601
Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma. The FEBS journal 20070601
Chronic treatment with desipramine improves cognitive performance of rats in an attentional set-shifting test. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070501
Extinction-induced 'despair' in the water maze, exploratory behavior and fear: effects of chronic antidepressant treatment. Neurobiology of learning and memory 20070501
Reduction of high-affinity beta2-adrenergic receptor binding by hyperforin and hyperoside on rat C6 glioblastoma cells measured by fluorescence correlation spectroscopy. Biochemistry 20070501
Desipramine activated Bcl-2 expression and inhibited lipopolysaccharide-induced apoptosis in hippocampus-derived adult neural stem cells. Journal of pharmacological sciences 20070501
Coadministration of nefazodone and desipramine: a pharmacokinetic interaction study. JPMA. The Journal of the Pakistan Medical Association 20070501
Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. The Journal of pharmacology and experimental therapeutics 20070401
Desipramine-induced Ca2+ movement and cytotoxicity in PC3 human prostate cancer cells. Toxicology in vitro : an international journal published in association with BIBRA 20070401
Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. Journal of clinical psychopharmacology 20070401
Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome. The European journal of neuroscience 20070401
Noradrenergic facilitation of shock-probe defensive burying in lateral septum of rats, and modulation by chronic treatment with desipramine. Progress in neuro-psychopharmacology & biological psychiatry 20070330
Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter. The Journal of biological chemistry 20070323
Abnormal involuntary movements (AIMs) following pulsatile dopaminergic stimulation: severe deterioration and morphological correlates following the loss of locus coeruleus neurons. Brain research 20070302
Sympathetic and hyperthermic reactions by orexin A: role of cerebral catecholaminergic neurons. Regulatory peptides 20070301
Pharmacological characterization of the beta-adrenoceptor that mediates the relaxant response to noradrenaline in guinea-pig tracheal smooth muscle. Naunyn-Schmiedeberg's archives of pharmacology 20070301
Calcineurin (protein phosphatase 2B) is involved in the mechanisms of action of antidepressants. Neuroscience 20070223
Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs. Biochemical and biophysical research communications 20070216
Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death. Cancer research 20070215
Pharmacokinetics of desipramine HCl when administered with cinacalcet HCl. European journal of clinical pharmacology 20070201
Effects of different doses of venlafaxine on serotonin and norepinephrine reuptake in healthy volunteers. The international journal of neuropsychopharmacology 20070201
Effect of antidepressant drugs on 6-OHDA-treated mice in the FST. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070201
The role of noradrenergic tone in the dorsal raphe nucleus of the mouse in the acute behavioral effects of antidepressant drugs. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070201
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior. Psychopharmacology 20070201
Suicidality scores during double-blind fluoxetine and desipramine treatment in Mexican Americans. Journal of clinical psychopharmacology 20070201
Disruption of noradrenergic transmission and the behavioural response to a novel environment in NK1R-/- mice. The European journal of neuroscience 20070201
Effects of acute fluoxetine, paroxetine and desipramine on rats tested on the elevated plus-maze. Behavioural brain research 20070125
Enhancement of the anti-immobility action of antidepressants by a selective 5-HT7 receptor antagonist in the forced swimming test in mice. European journal of pharmacology 20070119
Effect of chronic administration of duloxetine on serotonin and norepinephrine transporter binding sites in rat brain. Biological psychiatry 20070115
Synthesis of 11C-labelled (R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET. Bioorganic & medicinal chemistry 20070115
Antidepressant-induced undesirable weight gain: prevention with rimonabant without interference with behavioral effectiveness. European journal of pharmacology 20070112
Vulnerability for apoptosis in the limbic system after myocardial infarction in rats: a possible model for human postinfarct major depression. Journal of psychiatry & neuroscience : JPN 20070101
Anti-inflammatory properties of desipramine and fluoxetine. Respiratory research 20070101
CRE/CREB-driven up-regulation of gene expression by chronic social stress in CRE-luciferase transgenic mice: reversal by antidepressant treatment. PloS one 20070101
A possible role for the endocannabinoid system in the neurobiology of depression. Clinical practice and epidemiology in mental health : CP & EMH 20070101
Effect of citalopram in the modified forced swim test in rats. Pharmacological reports : PR 20070101
Nocturnal enuresis. BMJ clinical evidence 20070101
Functional interaction between alpha2-adrenoceptors, mu- and kappa-opioid receptors in the guinea pig myenteric plexus: effect of chronic desipramine treatment. European journal of pharmacology 20061228
Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20061201
The mechanism of activity-dependent sodium channel inhibition by the antidepressants fluoxetine and desipramine. Molecular pharmacology 20061201
Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition. Neuropharmacology 20061201
Delayed effects of antidepressant drugs in rats. Behavioural pharmacology 20061201
Resolving the onset of antidepressants' clinical actions: critical for clinical practice and new drug development. Journal of clinical psychopharmacology 20061201
Involvement of sphingolipids in apoptin-induced cell killing. Molecular therapy : the journal of the American Society of Gene Therapy 20061101
Desipramine prevents the sustained increase in corticotropin-releasing hormone-like immunoreactivity induced by repeated immobilization stress in the rat central extended amygdala. Journal of neuroscience research 20061101
Inhibition of nonexocytotic norepinephrine release by desipramine reduces myocardial infarction size. Canadian journal of physiology and pharmacology 20061101
Antidepressant treatment reduces Fos-like immunoreactivity induced by swim stress in different columns of the periaqueductal gray matter. Brain research bulletin 20061016
The effects of alpha1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum. Annals of tropical medicine and parasitology 20061001
Ang II and Ang III modulate PTZ seizure threshold in non-stressed and stressed mice: possible involvement of noradrenergic mechanism. Neuropeptides 20061001
Effects of pregnanolone in rats discriminating cocaine. Pharmacology, biochemistry, and behavior 20061001
The comparison of immobility time in experimental rat swimming models. Life sciences 20060927
Antidepressant-like activity of selective serotonin reuptake inhibitors combined with a NK1 receptor antagonist in the mouse forced swimming test. Behavioural brain research 20060925
Inhibition of N-methyl-D-aspartate receptor function appears to be one of the common actions for antidepressants. Journal of psychopharmacology (Oxford, England) 20060901
Optimization of solid-phase microextraction procedures for the determination of tricyclic antidepressants and anticonvulsants in plasma samples by liquid chromatography. Analytical and bioanalytical chemistry 20060901
Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells. Journal of neurochemistry 20060901
Desipramine inhibits Na+/H+ exchanger in human submandibular cells. Journal of dental research 20060901
Pharmacological and genetic influences on hole-board behaviors in mice. Pharmacology, biochemistry, and behavior 20060901
Antidepressant principles of the roots of Polygala tenuifolia. Journal of natural products 20060901
Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats. Progress in neuro-psychopharmacology & biological psychiatry 20060830
Biphasic change in BDNF gene expression following antidepressant drug treatment explained by differential transcript regulation. Brain research 20060823
New insights on the use of desipramine as an inhibitor for acid ceramidase. FEBS letters 20060821
Effects of acute and subchronic treatments with fluoxetine and desipramine on the memory of fear in moderate and high-intensity contextual conditioning. European journal of pharmacology 20060807
Nigrostriatal damage with 6-OHDA: validation of routinely applied procedures. Annals of the New York Academy of Sciences 20060801
Characterization of cytotoxic actions of tricyclic antidepressants on human HT29 colon carcinoma cells. European journal of pharmacology 20060710
Critical involvement of dopaminergic neurotransmission in impulsive decision making. Biological psychiatry 20060701
Behavioral disinhibition requires dopamine receptor activation. Psychopharmacology 20060701
Monoamine uptake inhibitors block alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation. American journal of physiology. Heart and circulatory physiology 20060701
Brugada electrocardiographic pattern due to tricyclic antidepressant overdose. Journal of electrocardiology 20060701
Differential alpha-mediated inhibition of dopamine and noradrenaline release in the parietal and occipital cortex following noradrenaline transporter blockade. Journal of neurochemistry 20060701
Hippocampal cell proliferation regulation by repeated stress and antidepressants. Neuroreport 20060626
Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics. Brain research 20060622
Frequency of high-risk use of QT-prolonging medications. Pharmacoepidemiology and drug safety 20060601
Pharmacological treatment of attention-deficit/hyperactivity disorder in adults. Expert opinion on investigational drugs 20060601
[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations]. No to shinkei = Brain and nerve 20060601
Post-stress facilitation of serotonergic, but not noradrenergic, neurotransmission in the dorsal hippocampus prevents learned helplessness development in rats. Brain research 20060504
Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK/AP-1 pathway. International journal of molecular medicine 20060501
The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress. Journal of neuroimmunology 20060401
Rates of in vivo methylation of desipramine and nortriptyline. Pharmacotherapy 20060401
The involvement of endogenous opioid mechanisms in the antinociceptive effects induced by antidepressant drugs, desipramine and trimipramine. Pharmacology, biochemistry, and behavior 20060401
A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biological psychiatry 20060301
Cardiac sympathetic neuroprotective effect of desipramine in tachycardia-induced cardiomyopathy. American journal of physiology. Heart and circulatory physiology 20060301
Effects of venlafaxine and desipramine on heroin-induced conditioned place preference in the rat. Addiction biology 20060301
Social isolation alters the effect of desipramine in the rat forced swimming test. Behavioural brain research 20060227
Chronic antidepressant treatment modulates the release of somatostatin in the rat nucleus accumbens. Neuroscience letters 20060227
Saw palmetto is an indirectly acting sympathomimetic in the rat-isolated prostate gland. The Prostate 20060201
G protein-activated inwardly rectifying K+ channel inhibition and rescue of weaver mouse motor functions by antidepressants. Neuroscience research 20060201
Response to SSRI-induced enuresis: a case report. Journal of clinical psychopharmacology 20060201
Nonstimulant medications for the treatment of ADHD. Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc 20060201
Prediction of drug-drug interactions for AUCoral of high clearance drug from in vitro data: utilization of a microtiter plate assay and a dispersion model. Current drug metabolism 20060201
Dopamine efflux in the rat striatum evoked by electrical stimulation of the subthalamic nucleus: potential mechanism of action in Parkinson's disease. The European journal of neuroscience 20060201
A double-blind, multicenter, parallel-group study of paroxetine, desipramine, or placebo in breast cancer patients (stages I, II, III, and IV) with major depression. The Journal of clinical psychiatry 20060201
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. The Journal of neuroscience : the official journal of the Society for Neuroscience 20060111
Enhanced neurally evoked responses and inhibition of norepinephrine reuptake in rat mesenteric arteries after spinal transection. American journal of physiology. Heart and circulatory physiology 20060101
Evidence that serotonin reuptake modulators increase the density of serotonin innervation in the forebrain. Journal of neurochemistry 20060101
Desipramine attenuates working memory impairments induced by partial loss of catecholamines in the rat medial prefrontal cortex. Psychopharmacology 20060101
Synthesis and positron emission tomography evaluation of three norepinephrine transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20060101
Excess fatality from desipramine in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry 20060101
Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone. Neuroscience 20060101
Effect of MPEP treatment on brain-derived neurotrophic factor gene expression. Pharmacological reports : PR 20060101
Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20051201
Sequential changes in BDNF mRNA expression and synaptic levels of AMPA receptor subunits in rat hippocampus after chronic antidepressant treatment. Neuropharmacology 20051201
The human norepinephrine transporter in combination with 11C-m-hydroxyephedrine as a reporter gene/reporter probe for PET of gene therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20051201
Effect of low-dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers. Clinical pharmacology and therapeutics 20051201
Antidepressants and prolonged stress in rats modulate CAM-L1, laminin, and pCREB, implicated in neuronal plasticity. Neurobiology of disease 20051101
Desipramine treatment of cocaine-dependent patients with depression: a placebo-controlled trial. Drug and alcohol dependence 20051101
Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Molecular pharmacology 20051101
Selective cortical VGLUT1 increase as a marker for antidepressant activity. Neuropharmacology 20051101
Effect of prolonged exposure to milnacipran on norepinephrine transporter in cultured bovine adrenal medullary cells. Biochemical pharmacology 20051101
Fluvoxamine and desipramine on fixed-ratio responding: effects of reinforcement magnitude. Behavioural pharmacology 20051101
Chronic administration of the delta opioid receptor agonist (+)BW373U86 and antidepressants on behavior in the forced swim test and BDNF mRNA expression in rats. Psychopharmacology 20051101
Cardiac and extracardiac sympathetic denervation in Parkinson's disease with orthostatic hypotension and in pure autonomic failure. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20051101
Treatment response in antidepressant-naïve postherpetic neuralgia patients: double-blind, randomized trial. The journal of pain : official journal of the American Pain Society 20051101
Antidepressants and REM sleep in Wistar-Kyoto and Sprague-Dawley rats. European journal of pharmacology 20051017
A selective test for antidepressant treatments using rats bred for stress-induced reduction of motor activity in the swim test. Psychopharmacology 20051001
Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051001
Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[18F]FMeNER-D2. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20051001
Effects of zotepine and olanzapine on noradrenaline transporter in cultured bovine adrenal medullary cells. Human psychopharmacology 20051001
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism 20051001
Antidepressants differentially affect expression of complexin I and II RNA in rat hippocampus. Psychopharmacology 20050901
The effects of desmethylimipramine on cyclic AMP-stimulated gene transcription in a model cell system. Biochemical pharmacology 20050901
Tyrosine administration does not affect desipramine-induced dopamine levels as measured in vivo in prefrontal cortex. Brain research 20050830
Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment. Journal of neurochemistry 20050801
Cocaine-induced modulation of long-term potentiation in the CA1 region of rat hippocampus. Neuropharmacology 20050801
Ethanol-induced changes in the content of triglycerides, ceramides, and glucosylceramides in cultured neurons. Alcoholism, clinical and experimental research 20050801
Deliberate misuse of tricyclic antidepressants by intravenous drug users--case studies and report. Scottish medical journal 20050801
An index of local sensitivity to nonignorable drop-out in longitudinal modelling. Statistics in medicine 20050730
Linking tricyclic antidepressants to ionotropic glutamate receptors. Biochemical and biophysical research communications 20050729
Effect of desipramine on Ca2+ levels and growth in renal tubular cells. Cellular signalling 20050701
Antidepressant action of agomelatine (S 20098) in a transgenic mouse model. Progress in neuro-psychopharmacology & biological psychiatry 20050701
Therapeutic monitoring of imipramine and desipramine by micellar liquid chromatography with direct injection and electrochemical detection. Biomedical chromatography : BMC 20050601
Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. Journal of hepatology 20050601
Regulation of activin mRNA and Smad2 phosphorylation by antidepressant treatment in the rat brain: effects in behavioral models. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050518
Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants. Bioorganic & medicinal chemistry letters 20050516
Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology. Biological psychiatry 20050515
Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol. European journal of pharmacology 20050509
Behavioral responses during the forced swim test are not affected by anti-inflammatory agents or acute illness induced by lipopolysaccharide. Behavioural brain research 20050507
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry 20050505
Aging and cardiac responses to epinephrine in humans: role of neuronal uptake. American journal of physiology. Heart and circulatory physiology 20050501
Brugada syndrome precipitated by a tricyclic antidepressant. Heart (British Cardiac Society) 20050501
Norepinephrine transporter function and desipramine: residual drug effects versus short-term regulation. Journal of neuroscience methods 20050430
Variability of the mesolimbic neuronal activity in a rat model of depression. Neuroreport 20050404
Evaluation of the reinforcing effects of monoamine reuptake inhibitors under a concurrent schedule of food and i.v. drug delivery in rhesus monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050401
Reboxetine for the treatment of patients with Cocaine Dependence Disorder. Human psychopharmacology 20050401
Different effects of desipramine on bufuralol 1''-hydroxylation by rat and human CYP2D enzymes. Biological & pharmaceutical bulletin 20050401
Cognitive therapy vs medications in the treatment of moderate to severe depression. Archives of general psychiatry 20050401
A comparison of neurokinin 1 receptor knock-out (NK1-/-) and wildtype mice: exploratory behaviour and extracellular noradrenaline concentration in the cerebral cortex of anaesthetised subjects. Neuropharmacology 20050401
Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats. Biological psychiatry 20050315
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer research 20050315
Obesity among outpatients with major depressive disorder. The international journal of neuropsychopharmacology 20050301
Phenotypic assessment of galanin overexpressing and galanin receptor R1 knockout mice in the tail suspension test for depression-related behavior. Psychopharmacology 20050301
The safety of non-stimulant agents for the treatment of attention-deficit hyperactivity disorder. Expert opinion on drug safety 20050301
Protection of LLC-PK1 cells against hydrogen peroxide-induced cell death by modulation of ceramide level. Archives of pharmacal research 20050301
Effects of desipramine treatment on tyrosine hydroxylase gene expression in cultured neuroblastoma cells and rat brain tissue. Brain research. Molecular brain research 20050218
Comparative effects of duloxetine and desipramine on sleep EEG in healthy subjects. Psychopharmacology 20050201
Effects of acute treatment with antidepressant drugs on sensorimotor gating deficits in rats. Psychopharmacology 20050201
Effects of repeated cocaine on the release and clearance of dopamine within the rat medial prefrontal cortex. Synapse (New York, N.Y.) 20050201
Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder. The Journal of clinical psychiatry 20050201
Quantitative in vitro phosphor imaging using [3H] and [18F] radioligands: the effects of chronic desipramine treatment on serotonin 5-HT2 receptors. Journal of neuroscience methods 20050130
GABAB receptor antagonist-mediated antidepressant-like behavior is serotonin-dependent. The Journal of pharmacology and experimental therapeutics 20050101
Antidepressants attenuate both the enhanced ethanol intake and ethanol-induced anxiolytic effects in diazepam withdrawn rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050101
Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment. Neuropharmacology 20050101
Amygdala-dependent mechanisms underlying memory retrieval of conditioned taste aversion. Chemical senses 20050101
Chronic treatment with clomipramine and desipramine induces deficit in long-term visuo-spatial memory of rats. The International journal of neuroscience 20050101
Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response. The American journal on addictions 20050101
An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-alpha production culminating in increases in noradrenergic neurotransmission. Neuroscience 20050101
Effect of long-lasting serotonin depletion on environmental enrichment-induced neurogenesis in adult rat hippocampus and spatial learning. Neuroscience 20050101
Effects of desipramine and escitalopram on postprandial symptoms induced by the nutrient drink test in healthy volunteers: a randomized, double-blind, placebo-controlled study. Digestion 20050101
Voltammetric assessment of dopamine clearance in the absence of the dopamine transporter: no contribution of other transporters in core or shell of nucleus accumbens. Journal of neuroscience methods 20041230
Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans. Molecular psychiatry 20041201
Chronic treatment with desipramine and fluoxetine modulate BDNF, CaMKKalpha and CaMKKbeta mRNA levels in the hippocampus of transgenic mice expressing antisense RNA against the glucocorticoid receptor. Neuropharmacology 20041201
5,7-dihydroxytryptamine lesions of the dorsal and median raphe nuclei interfere with lithium-induced conditioned gaping, but not conditioned taste avoidance, in rats. Behavioral neuroscience 20041201
Effects of chronic stress on methamphetamine-induced dopamine depletions in the striatum. Annals of the New York Academy of Sciences 20041201
Depressive symptoms and alcohol consumption among nonalcoholic depression patients treated with desipramine. Canadian journal of psychiatry. Revue canadienne de psychiatrie 20041201
Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance. Drug metabolism and disposition: the biological fate of chemicals 20041101
Autoreceptor-mediated inhibition of norepinephrine release in rat medial prefrontal cortex is maintained after chronic desipramine treatment. Journal of neurochemistry 20041101
Beta-arrestin-1 levels: reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain. The American journal of psychiatry 20041101
Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron 20041028
Antidepressants activate CaMKII in neuron cell body by Thr286 phosphorylation. Neuroreport 20041025
The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels. Brain research 20041022
Effect of antidepressants on GABA(B) receptor function and subunit expression in rat hippocampus. Biochemical pharmacology 20041015
Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20041001
Psychosocial functioning during the treatment of major depressive disorder with fluoxetine. Journal of clinical psychopharmacology 20041001
Excess fatality from desipramine and dosage recommendations. Therapeutic drug monitoring 20041001
Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice. European journal of pharmacology 20040919
Evaluation of the reinforcing effects of atomoxetine in monkeys: comparison to methylphenidate and desipramine. Drug and alcohol dependence 20040906
Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression. Psychopharmacology 20040901
Brain-derived tumor necrosis factor-alpha and its involvement in noradrenergic neuron functioning involved in the mechanism of action of an antidepressant. The Journal of pharmacology and experimental therapeutics 20040901
Chronic antidepressant treatment causes a selective reduction of mu-opioid receptor binding and functional coupling to G Proteins in the amygdala of fawn-hooded rats. The Journal of pharmacology and experimental therapeutics 20040901
Reduction of vascular noradrenaline sensitivity by AT1 antagonists depends on functional sympathetic innervation. Hypertension (Dallas, Tex. : 1979) 20040901
Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide. Journal of the National Cancer Institute 20040901
Antidepressant-like effect of tramadol and its enantiomers in reserpinized mice: comparative study with desipramine, fluvoxamine, venlafaxine and opiates. Journal of psychopharmacology (Oxford, England) 20040901
Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression. European journal of pharmacology 20040816
The cytoprotective effect of inulin-type hexasaccharide extracted from Morinda officinalis on PC12 cells against the lesion induced by corticosterone. Life sciences 20040813
27-Hydroxycholesterol inhibits neutral sphingomyelinase in cultured human endothelial cells. Life sciences 20040813
Ceramide triggers Weibel-Palade body exocytosis. Circulation research 20040806
Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. British journal of pharmacology 20040801
The induction of splenic suppressor T cells through an immune-privileged site requires an intact sympathetic nervous system. Journal of neuroimmunology 20040801
Testosterone-dependent antidepressant-like effect of noradrenergic but not of serotonergic drugs. Pharmacology, biochemistry, and behavior 20040801
Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression. The Journal of clinical psychiatry 20040801
Modulating sensorimotor gating in healthy volunteers: the effects of desipramine and haloperidol. Psychiatry research 20040715
Differential interactions of desipramine with amphetamine and methamphetamine: evidence that amphetamine releases dopamine from noradrenergic neurons in the medial prefrontal cortex. Neurochemical research 20040701
Microautoradiography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors. Nuclear medicine and biology 20040701
Effects of neuronal norepinephrine uptake blockade on baroreflex neural and peripheral arc transfer characteristics. American journal of physiology. Regulatory, integrative and comparative physiology 20040601
Total sleep deprivation decreases immobility in the forced-swim test. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040601
Clinical implications of genetic polymorphism of CYP2D6 in Mexican Americans. Annals of internal medicine 20040601
Neuropharmacological treatment of refractory idiopathic thrombocytopenic purpura: roles of circulating catecholamines and serotonin. Thrombosis and haemostasis 20040601
Involvement of ceramide in the mechanism of Cr(VI)-induced apoptosis of CHO cells. Free radical research 20040601
Cellular consequences of stress and depression. Dialogues in clinical neuroscience 20040601
Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors. Proceedings of the National Academy of Sciences of the United States of America 20040525
Probing the mechanism of drug/lipid membrane interactions using Biacore. Analytical biochemistry 20040515
Serotonin reuptake inhibitors do not prevent 5,7-dihydroxytryptamine-induced depletion of serotonin in rat brain. Brain research 20040508
Comparative study of the effects of desipramine and reboxetine on locus coeruleus neurons in rat brain slices. Neuropharmacology 20040501
NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase. Journal of cellular physiology 20040501
Role of ceramide in ischemic preconditioning. Journal of the American College of Surgeons 20040501
PAMPA--a drug absorption in vitro model 8. Apparent filter porosity and the unstirred water layer. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040501
Toward a rapidly acting antidepressant: the normetanephrine and extraneuronal monoamine transporter (uptake 2) hypothesis. The American journal of psychiatry 20040501
'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam. Behavioural pharmacology 20040501
Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chemico-biological interactions 20040415
The delta-opioid receptor agonist (+)BW373U86 regulates BDNF mRNA expression in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040401
Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain. The European journal of neuroscience 20040401
[Effects of neurotensin microinjected into ventral tegmental area on spontaneous motor activity in neonatal 6-hydroxydopamine-treated rats]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20040401
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications 20040319
Enzymatic tissue digestion as an alternative sample preparation approach for quantitative analysis using liquid chromatography-tandem mass spectrometry. Analytical chemistry 20040315
Mirtazapine-induced corelease of dopamine and noradrenaline from noradrenergic neurons in the medial prefrontal and occipital cortex. European journal of pharmacology 20040308
Effect of combined administration of 5-HT1A or 5-HT1B/1D receptor antagonists and antidepressants in the forced swimming test. European journal of pharmacology 20040308
Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040301
Role of histamine H3 receptors during ischemia/reperfusion in isolated rat hearts. Journal of cardiovascular pharmacology 20040301
Different prejunctional and postjunctional responses to angiotensin II and AT1-receptor inhibition: influence of maturation. Journal of cardiovascular pharmacology 20040301
Inducible cAMP early repressor regulates corticosterone suppression after tricyclic antidepressant treatment. The Journal of neuroscience : the official journal of the Society for Neuroscience 20040225
Relationship between the antinociceptive response to desipramine and changes in GABAB receptor function and subunit expression in the dorsal horn of the rat spinal cord. Biochemical pharmacology 20040215
Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine. FEBS letters 20040213
Sympathetic augmentation in hypertension: role of nerve firing, norepinephrine reuptake, and Angiotensin neuromodulation. Hypertension (Dallas, Tex. : 1979) 20040201
Effect of the novel anxiolytic drug deramciclane on cytochrome P(450) 2D6 activity as measured by desipramine pharmacokinetics. European journal of clinical pharmacology 20040201
Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study. Biological psychiatry 20040201
Regulation of the norepinephrine transporter by chronic administration of antidepressants. Biological psychiatry 20040201
Effects of antidepressants on the conformation of phospholipid headgroups studied by solid-state NMR. Magnetic resonance in chemistry : MRC 20040201
Antidepressant-like effect of nicotinamide adenine dinucleotide in the forced swim test in rats. Pharmacology, biochemistry, and behavior 20040201
Noradrenaline transporter blockers raise extracellular dopamine in medial prefrontal but not parietal and occipital cortex: differences with mianserin and clozapine. Journal of neurochemistry 20040201
Alpha-tocopherol influences the lipid membrane affinity of desipramine in a pH-dependent manner. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040201
Ethnic differences in substance abuse treatment retention, compliance, and outcome from two clinical trials. Psychiatric services (Washington, D.C.) 20040201
The persistent membrane retention of desipramine causes lasting inhibition of norepinephrine transporter function. Neurochemical research 20040201
Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell 20040109
Dopamine in the medial prefrontal cortex controls genotype-dependent effects of amphetamine on mesoaccumbens dopamine release and locomotion. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040101
Modification by dopaminergic drugs of choice behavior under concurrent schedules of intravenous saline and food delivery in monkeys. The Journal of pharmacology and experimental therapeutics 20040101
The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression. Progress in neuro-psychopharmacology & biological psychiatry 20040101
Potential and practical adrenomedullary PET radiopharmaceuticals as an alternative to m-iodobenzylguanidine: m-(omega-[18F]fluoroalkyl)benzylguanidines. Bioconjugate chemistry 20040101
Depression predicts higher rates of heroin use on desipramine with buprenorphine than with methadone. The American journal on addictions 20040101
Influence of antidepressant drugs on macrophage cytotoxic activity in rats. Polish journal of pharmacology 20040101
Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo. Synapse (New York, N.Y.) 20031215
Cortical alpha-adrenoceptor downregulation by tricyclic antidepressants in the rat brain. Neurochemistry international 20031201
Effects of desipramine on regional serotonin synthesis in the rat brain: acute and chronic autoradiographic studies. Neurochemistry international 20031201
Advances in the management of irritable bowel syndrome. Current gastroenterology reports 20031201
Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day. Acta psychiatrica Scandinavica 20031201
Effect of the antidepressant desipramine on cytosolic Ca(2+) movement and proliferation in human osteosarcoma cells. Pharmacology 20031201
In vivo monitoring of norepinephrine and its metabolites in skeletal muscle. Neurochemistry international 20031101
Role of brain dopaminergic system in the adrenomedullin-induced diuresis and natriuresis. Pharmacological research 20031101
Selectively bred Wistar-Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants. Molecular psychiatry 20031101
Synthesis and pharmacological evaluation of (Z)-9-(heteroarylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes: thiophene analogues as potent norepinephrine transporter inhibitors. Bioorganic & medicinal chemistry letters 20031020
Effects of methylphenidate, desipramine, and L-dopa on attention and inhibition in children with Attention Deficit Hyperactivity Disorder. Behavioural brain research 20031017
chi-Conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter. The Journal of biological chemistry 20031010
Antidepressant-induced increase in high-affinity rolipram binding sites in rat brain: dependence on noradrenergic and serotonergic function. The Journal of pharmacology and experimental therapeutics 20031001
Functional reactivity of central cholinergic systems following desipramine treatments and sleep deprivation. Naunyn-Schmiedeberg's archives of pharmacology 20031001
A new norepinephrine transporter imaging agent for cardiac sympathetic nervous function imaging: radioiodinated (R)-N-methyl-3-(2-iodophenoxy)-3-phenylpropanamine. Nuclear medicine and biology 20031001
Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors. British journal of pharmacology 20031001
Enhanced noradrenergic transmission in the spontaneously hypertensive rat anococcygeus muscle. British journal of pharmacology 20031001
Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biological psychiatry 20031001
Cytoprotective effect is one of common action pathways for antidepressants. Acta pharmacologica Sinica 20031001
Mechanism-based inhibition of CYP activities in rat liver by fluoxetine and structurally similar alkylamines. Xenobiotica; the fate of foreign compounds in biological systems 20031001
Phenylephrine induces endogenous noradrenaline release in the rat vas deferens through nitric oxide synthase pathway. Pharmacology & toxicology 20031001
Effects of reboxetine on sympathetic neuroeffector transmission in rabbit carotid artery. The Journal of pharmacology and experimental therapeutics 20030901
Duloxetine increases serotonin and norepinephrine availability in healthy subjects: a double-blind, controlled study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030901
Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice. Biological psychiatry 20030901
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters 20030818
Antidepressant-like effects in various mice strains in the tail suspension test. Behavioural brain research 20030814
Intraaccumbens dopaminergic lesion suppresses desipramine effects in the forced swim test but not in the neuronal activity of lateral septal nucleus. Progress in neuro-psychopharmacology & biological psychiatry 20030801
Comorbid major depressive disorder as a prognostic factor in cocaine-abusing buprenorphine-maintained patients treated with desipramine and contingency management. The American journal of drug and alcohol abuse 20030801
Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. Journal of neurochemistry 20030701
The effects of antidepressant treatment on serotonergic and dopaminergic systems in Fawn-Hooded rats: a quantitative autoradiography study. Brain research 20030620
Regional brain metabolic correlates of alpha-methylparatyrosine-induced depressive symptoms: implications for the neural circuitry of depression. JAMA 20030618
Inhibition of the norepinephrine transporter function in cultured bovine adrenal medullary cells by bisphenol A. Biochemical pharmacology 20030615
Desipramine and contingency management for cocaine and opiate dependence in buprenorphine maintained patients. Drug and alcohol dependence 20030605
Effects of 5-HT(6) receptor blockade on the neurochemical outcome of antidepressant treatment in the frontal cortex of the rat. Journal of neural transmission (Vienna, Austria : 1996) 20030601
Tail-swing behavior: a novel animal model for anxiety. Methods and findings in experimental and clinical pharmacology 20030601
Analysis of the effect of (-)-BPAP, a selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain. Life sciences 20030509
Desipramine attenuates loss of cardiac sympathetic neurotransmitters produced by congestive heart failure and NE infusion. American journal of physiology. Heart and circulatory physiology 20030501
Impact of maternal deprivation on brain corticotropin-releasing hormone circuits: prevention of CRH receptor-2 mRNA changes by desipramine treatment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030501
Effects of reducing contingency management values on heroin and cocaine use for buprenorphine- and desipramine-treated patients. Addiction (Abingdon, England) 20030501
Effects of selective serotonin reuptake inhibitors on immobility time in the tail suspension test in streptozotocin-induced diabetic mice. Pharmacology, biochemistry, and behavior 20030501
Updates on attention deficit hyperactivity disorder, child abuse and neglect, and sudden infant death syndrome. Current opinion in pediatrics 20030401
Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine. Placenta 20030401
1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3. Journal of neurochemistry 20030401
Sympathetic nerve destruction in spleen in murine AIDS. Brain, behavior, and immunity 20030401
Regulation of GAP-43 expression by chronic desipramine treatment in rat cultured hippocampal cells. Biological psychiatry 20030315
Binding and transport in norepinephrine transporters. Real-time, spatially resolved analysis in single cells using a fluorescent substrate. The Journal of biological chemistry 20030314
Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography. Journal of medicinal chemistry 20030313
Age differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorder. Psychopharmacology 20030301
Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers. Clinical pharmacology and therapeutics 20030301
Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics. Brain research 20030221
Serotonin depletion in rat hippocampus attenuates L-NAME-induced spatial learning deficits. Brain research 20030214
Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats. Psychopharmacology 20030201
Differential effects of K(ATP) channel blockers on [(3)H]-noradrenaline overflow after short- and long-term exposure to (+)-oxaprotiline or desipramine. Naunyn-Schmiedeberg's archives of pharmacology 20030201
Antidepressant-induced switch of beta 1-adrenoceptor trafficking as a mechanism for drug action. The Journal of biological chemistry 20030110
Inhibition of the oligosaccharides extracted from Morinda officinalis, a Chinese traditional herbal medicine, on the corticosterone induced apoptosis in PC12 cells. Life sciences 20030110
Baseline prolactin and L-tryptophan availability predict response to antidepressant treatment in major depression. Psychopharmacology 20030101
Comparison of desipramine or carbamazepine to placebo for crack cocaine-dependent patients. The American journal on addictions 20030101
Prescribing cyclic antidepressants for vitiligo patients: which agents are superior, which are not? Psychotherapy and psychosomatics 20030101
Antidepressant drug treatment induces Arc gene expression in the rat brain. Neuroscience 20030101
[Attention deficit/hyperactivity disorder]. Ryoikibetsu shokogun shirizu 20030101
Prediction of treatment outcome by baseline urine cocaine results and self-reported cocaine use for cocaine and opioid dependence. The American journal of drug and alcohol abuse 20030101
Effects of combined treatment with imipramine and metyrapone in the forced swimming test in rats. Behavioral and pharmacokinetic studies. Polish journal of pharmacology 20030101
Effects of classic and newer antidepressants on the oxidation pathways of caffeine in rat liver. In vitro study. Polish journal of pharmacology 20030101
Treatment-related adverse events and outcome in a clinical trial of fluoxetine for major depressive disorder. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20030101
Autonomic control after blockade of the norepinephrine transporter: a model of orthostatic intolerance. Journal of applied physiology (Bethesda, Md. : 1985) 20021201
Alphaxalone, a neurosteroid anesthetic, inhibits norepinephrine transporter function in cultured bovine adrenal medullary cells. Anesthesia and analgesia 20021201
The role of the conserved GXXXRXG motif in the expression and function of the human norepinephrine transporter. Brain research. Molecular brain research 20021201
Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study. Journal of psychopharmacology (Oxford, England) 20021201
Chronic antidepressant treatment increases the membrane expression of AMPA receptors in rat hippocampus. Neuropharmacology 20021201
Acute treatment with the cyclic antidepressant desipramine, but not fluoxetine, increases membrane-associated G protein-coupled receptor kinases 2/3 in rat brain. Neuropharmacology 20021201
Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC beta 1 isozyme in rat brain. Neuropharmacology 20021201
[Effect of local and systemic desipramine administration on extracellular noradrenaline in the myocardium of rats]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20021201
In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments may produce greater effects than selective drugs. Behavioural brain research 20021115
Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate? Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021101
Differential pre- and postsynaptic effects of desipramine on cardiac sympathetic nerve terminals in RHF. American journal of physiology. Heart and circulatory physiology 20021101
Genotype- and experience-dependent susceptibility to depressive-like responses in the forced-swimming test. Psychopharmacology 20021101
Effect of terbinafine on the pharmacokinetics and pharmacodynamics of desipramine in healthy volunteers identified as cytochrome P450 2D6 (CYP2D6) extensive metabolizers. Journal of clinical pharmacology 20021101
Age-dependent changes of cardiac neuronal noradrenaline reuptake transporter (uptake1) in the human heart. Journal of the American College of Cardiology 20021016
Relationship between alpha(1)-adrenergic receptor-induced contraction and extracellular signal-regulated kinase activation in the bovine inferior alveolar artery. The Journal of pharmacology and experimental therapeutics 20021001
The effect of chronic oral desipramine on capsaicin-induced allodynia and hyperalgesia: a double-blinded, placebo-controlled, crossover study. Anesthesia and analgesia 20021001
Allopregnanolone levels and symptom improvement in severe premenstrual syndrome. Journal of clinical psychopharmacology 20021001
Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine. The American journal of psychiatry 20021001
The treatment of depression in patients maintained on dialysis. Journal of psychosomatic research 20021001
Caspase 3 gene expression and [Ca2+]i homeostasis underlying desipramine-induced C6 glioma cell apoptosis. Acta pharmacologica Sinica 20020901
Interaction of stress and noradrenergic drugs in the control of picrotoxin-induced seizures. Epilepsy research 20020901
[Effects of antidepressants on the expression of rat brain dopamine receptors]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science 20020901
Enhanced antidepressant effect of sigma(1) (sigma(1)) receptor agonists in beta(25-35)-amyloid peptide-treated mice. Behavioural brain research 20020821
Regulation of norepinephrine transporter abundance by catecholamines and desipramine in vivo. Brain research 20020816
The SSRIs drug Fluoxetine, but not the noradrenergic tricyclic drug Desipramine, improves memory performance during acute major depression. Brain research bulletin 20020815
Epinephrine in the heart: uptake and release, but no facilitation of norepinephrine release. Circulation 20020813
Noradrenergic and serotonergic neuroendocrine responses in prepubertal, peripubertal, and postpubertal rats pretreated with desipramine and sertraline. Journal of the American Academy of Child and Adolescent Psychiatry 20020801
Double-blind study of high-dose fluoxetine versus lithium or desipramine augmentation of fluoxetine in partial responders and nonresponders to fluoxetine. Journal of clinical psychopharmacology 20020801
Tricyclic antidepressants and the Brugada syndrome: an example of Brugada waves appearing after the administration of desipramine. Clinical cardiology 20020801
The antidepressant-like effect induced by the sigma(1) (sigma(1)) receptor agonist igmesine involves modulation of intracellular calcium mobilization. Psychopharmacology 20020801
Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. Prescrire international 20020801
Inhibition of SK3 channels in the TE671 human medulloblastoma cell line by desipramine and imipramine. European journal of pharmacology 20020719
Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction. Free radical biology & medicine 20020715
Effects of desipramine treatment on norepinephrine transporter gene expression in the cultured SK-N-BE(2)M17 cells and rat brain tissue. Journal of neurochemistry 20020701
Sister chromatid exchanges produced by imipramine and desipramine in mouse bone marrow cells treated in vivo. Toxicology letters 20020614
Antidepressant-like effects of cytidine in the forced swim test in rats. Biological psychiatry 20020601
Inhibition of transport function and desipramine binding at the human noradrenaline transporter by N-ethylmaleimide and protection by substrate analogs. Naunyn-Schmiedeberg's archives of pharmacology 20020601
Nicotinic acetylcholine receptor regulation of spinal norepinephrine release. Anesthesiology 20020601
Reproductive hormonal treatments for mood disorders in women. Dialogues in clinical neuroscience 20020601
Gonadal steroids, brain, and behavior: role of context. Dialogues in clinical neuroscience 20020601
Modulatory effects of ketamine on catecholamine efflux from in vivo cardiac sympathetic nerve endings in cats. Neuroscience letters 20020524
Effects of catecholamine uptake blockers in the caudate-putamen and subregions of the medial prefrontal cortex of the rat. Brain research 20020517
Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020515
Imipramine hydrochloride and desipramine hydrochloride as new reagents for detection of microamounts of blood in urine. Journal of pharmaceutical and biomedical analysis 20020515
Characterization of nicotinic agonist-induced [(3)H]dopamine release from synaptosomes prepared from four mouse brain regions. The Journal of pharmacology and experimental therapeutics 20020501
Orthostatic hypotension from sympathetic denervation in Parkinson's disease. Neurology 20020423
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020415
Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, NF-kappa B and extracellular signal-regulated protein kinase activation. Biochemical pharmacology 20020415
Antidepressant reversal of interferon-alpha-induced anhedonia. Physiology & behavior 20020415
Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model. European journal of pharmacology 20020405
Tramadol inhibits norepinephrine transporter function at desipramine-binding sites in cultured bovine adrenal medullary cells. Anesthesia and analgesia 20020401
Desipramine antagonized corticosterone-induced apoptosis in cultured PC12 cells. Acta pharmacologica Sinica 20020401
Sympathetic nervous system plays a major role in acute cold/restraint stress inhibition of host resistance to Listeria monocytogenes. Journal of neuroimmunology 20020401
Functional significance of a highly conserved glutamate residue of the human noradrenaline transporter. Journal of neurochemistry 20020401
Chronic behavioral disorders of human REM sleep: a new category of parasomnia. 1986 [classical article]. Sleep 20020315
The effect of lofepramine and other related agents on the motility of Tetrahymena pyriformis. Toxicology letters 20020310
Desipramine toxicity with terbinafine. The American journal of psychiatry 20020301
Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter. Pharmacogenetics 20020301
Leustroducsin B activates nuclear factor-kappaB via the acidic sphingomyelinase pathway in human bone marrow-derived stromal cell line KM-102. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20020301
Monoamine neurotoxins-induced apoptosis in lymphocytes by a common oxidative stress mechanism: involvement of hydrogen peroxide (H(2)O(2)), caspase-3, and nuclear factor kappa-B (NF-kappaB), p53, c-Jun transcription factors. Biochemical pharmacology 20020215
Significant reduction of 125 I-meta-iodobenzylguanidine accumulation directly caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine, a toxic agent for inducing experimental Parkinson's disease. Nuclear medicine communications 20020201
Brain 5-HT receptor system in the stressed infant rat: implications for vulnerability to substance abuse. Psychoneuroendocrinology 20020101
Noradrenergic antidepressants: does chronic treatment increase or decrease nuclear CREB-P? Journal of neural transmission (Vienna, Austria : 1996) 20020101
Falsely elevated imipramine levels in a patient taking quetiapine. Journal of the American Academy of Child and Adolescent Psychiatry 20020101
Influence of ACTH on the effects of imipramine, desipramine and lithium on duration of immobility of rats in the forced swim test. Pharmacology, biochemistry, and behavior 20020101
Norepinephrine metabolism in neuron: dissociation between 3,4-dihydroxyphenylglycol and 3,4-dihydroxymandelic acid pathways. Acta pharmacologica Sinica 20020101
Seed finding in golden hamsters: a potential animal model for screening anxiolytic drugs. Neuropsychobiology 20020101
Utility of crossover designs in clinical trials: efficacy of desipramine vs. placebo in opioid-dependent cocaine abusers. The American journal on addictions 20020101
Treatment-resistant depression and Axis II comorbidity. Psychotherapy and psychosomatics 20020101
Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats. Amino acids 20020101
A 3D QSAR pharmacophore model and quantum chemical structure--activity analysis of chloroquine(CQ)-resistance reversal. Journal of chemical information and computer sciences 20020101
Impact of criteria-based diagnosis of burning mouth syndrome on treatment outcome. Journal of orofacial pain 20020101
Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology. Brain research. Molecular brain research 20011216
Hyperactive phosphoinositide signaling pathway in platelets of depressed patients: effect of desipramine treatment. Psychiatry research 20011215
Tricyclic antidepressants directly depress human myocardial mechanical function independent of effects on the conduction system. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20011201
Cerebral blood flow in obsessive-compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders. Psychiatry research 20011130
A new class of antiarrhythmic-defibrillatory agents. Bioorganic & medicinal chemistry letters 20011119
Microheterogeneity of myocardial blood flow. Basic research in cardiology 20011101
Increased neuronal activity in locus coeruleus from adult rats undernourished at perinatal age: its reversal by desipramine. Life sciences 20011012
Concurrent use of oral contraceptives with antidepressants for premenstrual syndromes. Journal of clinical psychopharmacology 20011001
Facilitation of Ca2+ store-dependent noradrenaline release after an N-methyl-D-aspartate receptor antagonist in the rat supraoptic nucleus. Journal of neuroendocrinology 20011001
Sample preparation with fiber-in-tube solid-phase microextraction for capillary electrophoretic separation of tricyclic antidepressant drugs in human urine. Electrophoresis 20011001
Lipopolysaccharide-mediated immobility in mice: reversal by cyclooxygenase enzyme inhibitors. Methods and findings in experimental and clinical pharmacology 20011001
Differential time-course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors. Synapse (New York, N.Y.) 20010915
Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. American journal of physiology. Renal physiology 20010901
Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice. The Journal of pharmacology and experimental therapeutics 20010901
Noradrenergic modulation of serotonin release in rat dorsal and median raphé nuclei via alpha(1) and alpha(2A) adrenoceptors. Neuropharmacology 20010901
Ischemic preconditioning attenuates cardiac sympathetic nerve injury via ATP-sensitive potassium channels during myocardial ischemia. Circulation 20010828
Acute and chronic effects of desipramine and clorgyline on alpha(2)-adrenoceptors regulating noradrenergic transmission in the rat brain: a dual-probe microdialysis study. British journal of pharmacology 20010801
Chronic desipramine treatment selectively potentiates somatostatin-induced dopamine release in the nucleus accumbens. The European journal of neuroscience 20010801
A morpholinocatechol compound (UK42620) with clonidine- and tyramine-like actions. Journal of autonomic pharmacology 20010801
A possible indirect sympathomimetic action of metformin in the arterial vessel wall of spontanously hypertensive rats. Life sciences 20010720
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry 20010719
Prejunctional actions of methylenedioxymethamphetamine in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice. European journal of pharmacology 20010706
Antidepressant-like actions of pregnancy, and progesterone in Wistar rats forced to swim. Psychoneuroendocrinology 20010701
Cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010701
Involvement of GABAergic systems in manifestation of pharmacological activity of desipramine. Japanese journal of pharmacology 20010701
Regional alterations of myocardial norepinephrine transporter density in streptozotocin-induced diabetic rats: implications for heterogeneous cardiac accumulation of MIBG in diabetes. European journal of nuclear medicine 20010701
St. John's wort extract Ze 117 (Hypericum perforatum) inhibits norepinephrine and serotonin uptake into rat brain slices and reduces 3-adrenoceptor numbers on cultured rat brain cells. Pharmacopsychiatry 20010701
Effects of Hypericum perforatum (St. John's wort) on passive avoidance in the rat: evaluation of potential neurochemical mechanisms underlying its antidepressant activity. Pharmacopsychiatry 20010701
Effects of nociceptin on cardiac norepinephrine and acetylcholine release evoked by ouabain. Brain research 20010615
Transcranial magnetic stimulation and antidepressive drugs share similar cellular effects in rat hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010601
Chronic treatment of C6 glioma cells with antidepressant drugs results in a redistribution of Gsalpha. Molecular pharmacology 20010601
Relative bioavailability of imipramine (Tofranil) coated tablets in healthy volunteers. International journal of clinical pharmacology and therapeutics 20010601
Association between depressive behavior and absence of serotonin-dopamine interaction in the nucleus accumbens. Psychopharmacology 20010601
Uptake of the dopaminergic neurotoxin, norsalsolinol, into PC12 cells via dopamine transporter. Archives of toxicology 20010601
Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine. Brain research 20010525
Long-term impairment of anterograde axonal transport along fiber projections originating in the rostral raphe nuclei after treatment with fenfluramine or methylenedioxymethamphetamine. Synapse (New York, N.Y.) 20010501
Antidepressant drug-induced alterations in neuron-localized tumor necrosis factor-alpha mRNA and alpha(2)-adrenergic receptor sensitivity. The Journal of pharmacology and experimental therapeutics 20010501
Activity of phenothiazines against antibiotic-resistant Mycobacterium tuberculosis: a review supporting further studies that may elucidate the potential use of thioridazine as anti-tuberculosis therapy. The Journal of antimicrobial chemotherapy 20010501
Dual phases of functional change in norepinephrine transporter in cultured bovine adrenal medullary cells by long-term treatment with clozapine. Journal of neurochemistry 20010501
Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice. Psychopharmacology 20010501
Lesion of the bulbospinal noradrenergic pathways blocks desipramine-induced inhibition of the C-fiber evoked nociceptive reflex in rats. Neuroscience letters 20010413
Involvement of noradrenaline transporters in S-nitrosocysteine-stimulated noradrenaline release from rat brain slices: existence of functional Na(+)-independent transporter activity. Neurochemistry international 20010401
Idazoxan and 8-OH-DPAT modify the behavioral effects induced by either NA, or 5-HT, or dual NA/5-HT reuptake inhibition in the rat forced swimming test. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010401
Chip-based quantitative capillary electrophoresis/mass spectrometry determination of drugs in human plasma. Analytical chemistry 20010401
Development of a depersonalization severity scale. Journal of traumatic stress 20010401
Determination of residues in the norepinephrine transporter that are critical for tricyclic antidepressant affinity. The Journal of biological chemistry 20010316
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. Journal of medicinal chemistry 20010315
Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. Bioorganic & medicinal chemistry letters 20010312
Repeated electroconvulsive stimulation, but not antidepressant drugs, induces mossy fibre sprouting in the rat hippocampus. Brain research 20010302
Low temperature prevents potentiation of norepinephrine release by phenylephrine. Neurochemistry international 20010301
Dialysate dihydroxyphenylglycol as a window for in situ axoplasmic norepinephrine disposition. Neurochemistry international 20010301
Determination of myocardial norepinephrine in freely moving rats using in vivo microdialysis sampling and liquid chromatography with dual-electrode amperometric detection. Journal of pharmaceutical and biomedical analysis 20010301
Modulation of MK-801-induced behaviour by noradrenergic agents in mice. Psychopharmacology 20010301
Comparison of noradrenergic and serotonergic antidepressants in reducing immobility time in the tail suspension test. Japanese journal of pharmacology 20010301
Effect of hypothyroidism on pathways for iodothyronine and tryptophan uptake into rat adipocytes. American journal of physiology. Endocrinology and metabolism 20010201
Release of amines from acidified stores following accumulation by Transport-P. British journal of pharmacology 20010201
Norepinephrine reuptake is impaired in skeletal muscle of hypertensive rats in vivo. Hypertension (Dallas, Tex. : 1979) 20010201
New reagents for detection of faecal occult blood. Journal of pharmaceutical and biomedical analysis 20010201
Localization and characterization of a short isoform of the corticotropin-releasing factor receptor type 2alpha (CRF(2)alpha-tr) in the rat brain. Biochemical and biophysical research communications 20010119
Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro. European journal of pharmacology 20010105
Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study. Neurochemistry international 20010101
Modifications in brain CaM kinase II after long-term treatment with desmethylimipramine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010101
Myocardial interstitial norepinephrine and dihydroxyphenylglycol levels during ischemia and reperfusion. Cardiovascular research 20010101
Chronic treatment with desipramine facilitates its effect on extracellular noradrenaline in the rat hippocampus: studies on the role of presynaptic alpha2-adrenoceptors. Naunyn-Schmiedeberg's archives of pharmacology 20010101
The effects of antidepressants on obstructed and unobstructed gait in healthy elderly people. The journals of gerontology. Series A, Biological sciences and medical sciences 20010101
Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder. BMC neuroscience 20010101
Antidepressants do not modulate estrogen receptor alpha-mediated gene expression. Journal of neural transmission (Vienna, Austria : 1996) 20010101
National Patterns of Medication Treatment for Depression, 1987 to 2001. Primary care companion to the Journal of clinical psychiatry 20010101
Clomipramine and related structures as inhibitors of the skeletal sarcoplasmic reticulum Ca2+ pump. Journal of bioenergetics and biomembranes 20000401
Venlafaxine treatment of cocaine abusers with depressive disorders. The American journal of drug and alcohol abuse 20000201
Antidepressant drugs appear to enhance cocaine-induced toxicity. Experimental and clinical psychopharmacology 20000201
Effect of tolcapone on the haemodynamic effects and tolerability of desipramine. European neurology 20000101
[Comparative study of hemodynamic effects of antidepressants (tetrindole and desipramine) during immobilization stress in hypertensive rats]. Eksperimental'naia i klinicheskaia farmakologiia 20000101
Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. The Journal of neuroscience : the official journal of the Society for Neuroscience 19991201
Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone. Archives of general psychiatry 19990901
The toxicity of 6-hydroxydopamine on PC12 and P19 cells. Brain research. Molecular brain research 19990521
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). The Journal of pharmacology and experimental therapeutics 19980701
The effect of antidepressants on rat aggressive behavior in the electric footshock and apomorphine-induced aggressiveness paradigms. Methods and findings in experimental and clinical pharmacology 19980501
Apomorphine-induced aggressiveness and [3H]citalopram binding after antidepressant treatment in rats. Pharmacology, biochemistry, and behavior 19980301
Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. The Journal of pharmacology and experimental therapeutics 19971201
Haloperidol-induced catalepsy: a model for screening antidepressants effective in treatment of depression with Parkinson's disease. Indian journal of experimental biology 19971201
Neuropathy associated with tricyclic antidepressants. International journal of geriatric psychiatry 19970801
Cloning and characterization of two human polyspecific organic cation transporters. DNA and cell biology 19970701
Withdrawal hypomania associated with paroxetine. Journal of clinical psychopharmacology 19970201
Probable nefazodone-induced mania in a patient with unreported bipolar disorder. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 19961201
Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat. Brain research 19961111
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience 19960401
Nitric oxide contributes to desipramine-induced hypotension in rats. Human & experimental toxicology 19960401
Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats. Journal of toxicology. Clinical toxicology 19960101
Reduction of desipramine cardiotoxicity and prolongation of survival in rats with the use of polyclonal drug-specific antibody Fab fragments. Annals of emergency medicine 19950901
Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene transcription. Molecular pharmacology 19950601
A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization. Archives of biochemistry and biophysics 19950601
Chronic antidepressant treatment down-regulates the induction of c-fos mRNA in response to acute stress in rat frontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 19950501
Blood dyscrasias with carbamazepine and valproate: a pharmacoepidemiological study of 2,228 patients at risk. The American journal of psychiatry 19950301
Beneficial effects of co-administration of catechol-O-methyltransferase inhibitors and L-dihydroxyphenylalanine in rat models of depression. European journal of pharmacology 19950214
Mixed mania: apparent induction by a tricyclic antidepressant in five consecutively treated patients with bipolar depression. Biological psychiatry 19950101
A double-blind trial of bupropion versus desipramine for bipolar depression. The Journal of clinical psychiatry 19940901
Severe imipramine-induced myoclonus in a patient with psychotic bipolar depression, catatonia, and schizencephaly. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 19940301
Characteristics of desipramine-refractory depression. The Journal of clinical psychiatry 19940101
The role of receptor binding in drug discovery. Journal of natural products 19930401
Amphetamine and antidepressant drug effects on GABA- and NMDA-related seizures. Brain research bulletin 19930101
Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: a case report. Clinical pharmacology and therapeutics 19930101
Potential mechanism of desipramine-related sudden death in children. Psychosomatics 19930101
Desipramine-induced oral-pharyngeal disturbances: stuttering and jaw myoclonus. Journal of clinical psychopharmacology 19921201
Bupropion-induced carbohydrate craving and weight gain. The American journal of psychiatry 19921001
Sudden self-harm while taking fluoxetine. The American journal of psychiatry 19920801
Increased pulse and blood pressure associated with desipramine treatment of bulimia nervosa. Journal of clinical psychopharmacology 19920601
Trazodone induction of migraine headache through mCPP. The American journal of psychiatry 19920501
Effect of IAP and chronic antidepressant administration on the 5HT1A receptor in rat cortical membranes. Progress in neuro-psychopharmacology & biological psychiatry 19920501
Oral contraceptives and panic disorder. The Journal of clinical psychiatry 19920501
Reversal of desipramine toxicity in rats using drug-specific antibody Fab' fragment: effects on hypotension and interaction with sodium bicarbonate. The Journal of pharmacology and experimental therapeutics 19920301
Control of depression with fluoxetine and antiseizure medication in a brain-injured patient. The American journal of psychiatry 19920201
Low dose desipramine treatment of cocaine-related panic attacks. The Journal of nervous and mental disease 19911201
Regulation of serotonin type 2 (5-HT2) and beta-adrenergic receptors in rat cerebral cortex following novel and classical antidepressant treatment. Journal of psychiatry & neuroscience : JPN 19911101
Repeated administration of desmethylimipramine blocks the reserpine-induced increase in tyrosine hydroxylase mRNA in locus coeruleus neurons of the rat. Brain research. Molecular brain research 19910701
Changes in convulsion susceptibility of lidocaine by alteration of brain catecholaminergic functions. Japanese journal of pharmacology 19910501
2-Hydroxydesipramine and desipramine plasma levels and electrocardiographic effects in depressed younger adults. Journal of clinical psychopharmacology 19910401
Symptoms of major depression: acute effect of withdrawing antidepressants. Acta psychiatrica Scandinavica 19910301
Low dose tricyclic tachycardia. Journal of the American Academy of Child and Adolescent Psychiatry 19910101
Pediatric cardiovascular effects of imipramine and desipramine. Journal of the American Academy of Child and Adolescent Psychiatry 19910101
Sudden death in children receiving Norpramin: a review of three reported cases and commentary. Journal of the American Academy of Child and Adolescent Psychiatry 19910101
Hyperprolactinemia and risk for relapse of cocaine abuse. Biological psychiatry 19901101
The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain 19900801
Serious adverse effects of combining fluoxetine and tricyclic antidepressants. The American journal of psychiatry 19900401
Desipramine relieves postherpetic neuralgia. Clinical pharmacology and therapeutics 19900301
Noradrenergic mechanisms appear not to be involved in cocaine-induced seizures and lethality. Life sciences 19900101
Protracted ventricular arrhythmias occurring after abrupt tricyclic antidepressant withdrawal. Psychosomatics 19900101
Ventricular tachycardia associated with desipramine and thioridazine. Psychosomatics 19900101
A double-blind placebo controlled study of desipramine in the treatment ADD: II. Serum drug levels and cardiovascular findings. Journal of the American Academy of Child and Adolescent Psychiatry 19891101
Hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite, desipramine. Journal of forensic sciences 19890701
Effects of chronic antidepressant and benzodiazepine treatment on corticotropin-releasing-factor receptors in rat brain and pituitary. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 19890301
Use of yohimbine to counteract nortriptyline-induced orthostatic hypotension. Journal of clinical psychopharmacology 19890201
Corticotropin-releasing factor: putative neurotransmitter in the noradrenergic nucleus locus ceruleus. Psychopharmacology bulletin 19890101
Treatment-emergent depression with antidepressants in panic disorder. Comprehensive psychiatry 19890101
Fluoxetine induces elevation of desipramine level and exacerbation of geriatric nonpsychotic depression. Journal of clinical psychopharmacology 19881201
Relapse to cocaine abuse after initiating desipramine treatment. JAMA 19881104
Episodic barrel rotations induced by intrastriatal injection of quinolinic acid in rats. Inhibition by anticonvulsants. Pharmacology, biochemistry, and behavior 19880901
Desipramine-induced conduction disorder. Postgraduate medicine 19880701
The jitteriness syndrome in panic disorder patients treated with antidepressants. The Journal of clinical psychiatry 19880301
Anorgasmia associated with desipramine. Canadian journal of psychiatry. Revue canadienne de psychiatrie 19880201
The effects of chronic antidepressant treatment in an animal model of anxiety. Psychopharmacology 19880101
Desipramine and testicular swelling in two patients. The Journal of clinical psychiatry 19880101
Transient mood elevation associated with antidepressant drug decrease. Canadian journal of psychiatry. Revue canadienne de psychiatrie 19871201
Increased adult behavioral 'despair' in rats neonatally exposed to desipramine or zimeldine: an animal model of depression? Pharmacology, biochemistry, and behavior 19871101
Response of tardive and L-dopa-induced dyskinesias to antidepressants. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 19871101
Possible toxic interaction between cyproheptadine and phenelzine. The American journal of psychiatry 19870901
A grand mal seizure associated with desipramine and haloperidol. Canadian journal of psychiatry. Revue canadienne de psychiatrie 19870801
Hypersensitivity reaction to desipramine. The Journal of allergy and clinical immunology 19870701
Testicular swelling associated with desipramine. The Journal of clinical psychiatry 19870601
Cardiac myonecrosis in hypertensive crisis associated with monoamine oxidase inhibitor therapy. The American journal of medicine 19870501
Imipramine and tinnitus. The Journal of clinical psychiatry 19870301
Occurrence of myoclonus in patients treated with cyclic antidepressants. Archives of general psychiatry 19870301
Effects of antihypertensive drugs on sympathetic vascular control in relation to neuropeptide Y. Journal of cardiovascular pharmacology 19870101
Noradrenergic involvement in catalepsy induced by delta 9-tetrahydrocannabinol. Neuropharmacology 19870101
[Torsade de pointes caused by tricyclic antidepressive agents. Description of a clinical case]. Giornale italiano di cardiologia 19861201
Nocturnal cataclysms with myoclonus: a new side effect of clomipramine. The American journal of psychiatry 19861101
Profound behavioral toxicity due to tricyclic antidepressants. The Journal of nervous and mental disease 19861001
Transient contralateral rotation following unilateral substantia nigra lesion reflects susceptibility of the nigrostriatal system to exhaustion by amphetamine. Life sciences 19860707
Painful postcoital testicular retraction linked with desipramine. The American journal of psychiatry 19860501
Speech blockage induced by maprotiline. The American journal of psychiatry 19860301
Mechanism of the tachycardia following systemic alpha-methyldopa administration in conscious rats. Journal of cardiovascular pharmacology 19860101
Central noradrenaline depletion antagonizes aspects of d-amphetamine-induced hyperactivity in the rat. Psychopharmacology 19860101
Behavioral depression following clonidine withdrawal: a new animal model of long-lasting depression? Psychopharmacology bulletin 19860101
Two cases of hypomania following the addition of L-tryptophan to a monoamine oxidase inhibitor. The American journal of psychiatry 19851201
Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats. Neuropharmacology 19851001
Desipramine-induced delirium at 'subtherapeutic' concentrations: a case report. Canadian journal of psychiatry. Revue canadienne de psychiatrie 19850801
Trazodone-induced mania following desipramine-induced mania in major depressive disorders. The American journal of psychiatry 19850301
Manic symptoms following addition of lithium to antidepressant treatment. Journal of clinical psychopharmacology 19841201
Identifying depression secondary to lithium-induced hypothyroidism. Psychosomatics 19841101
Use of desipramine in depressed inpatients. The Journal of clinical psychiatry 19841001
Treatment of outpatients with desipramine. The Journal of clinical psychiatry 19841001
Use of desipramine in the medically ill. The Journal of clinical psychiatry 19841001
Carbamazepine-induced tics. Developmental medicine and child neurology 19840801
Desipramine in the treatment of adolescents with attention deficit disorder. The American journal of psychiatry 19840701
Changes in amphetamine-induced anorexia and stereotypy during chronic treatment with antidepressant drugs. European journal of pharmacology 19840302
Antidepressant versus neuroleptic activities of sulpiride isomers on four animal models of depression. Psychopharmacology 19840101
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. Neuropsychobiology 19840101
Subjective complaints during desipramine treatment. Relative importance of plasma drug concentrations and the severity of depression. Archives of general psychiatry 19840101
Evidence for a selective brain noradrenergic involvement in the locomotor stimulant effects of amphetamine in the rat. Neuroscience letters 19831230
Desipramine in the treatment of hypersomnolence following abrupt cessation of cocaine use. The American journal of psychiatry 19831101
Anorgasmia associated with imipramine but not desipramine: case report. The Journal of clinical psychiatry 19830901
Desipramine-associated hepatitis. Journal of clinical psychopharmacology 19830801
Hypomania after desipramine withdrawal. The American journal of psychiatry 19830501
Desipramine-associated SIADH in an elderly woman: case report. The Journal of clinical psychiatry 19830401
Q-T prolongation and torsades de pointes ventricular tachycardia produced by the tetracyclic antidepressant agent maprotiline. The American journal of cardiology 19830301
Somatic symptoms in depression and antidepressants. The Journal of clinical psychiatry 19830101
Major adverse reactions during desipramine treatment: relationship to plasma drug concentrations, concomitant antipsychotic treatment, and patient characteristics. Archives of general psychiatry 19820901
Possible involvement of serotonergic neurons in the reduction of locomotor hyperactivity caused by amphetamine in neonatal rats depleted of brain dopamine. Brain research 19820722
(+/-)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 1. Synthesis and evaluation of (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine and analogues as potential antidepressant agents. Journal of medicinal chemistry 19820401
Sexual dysfunction and clomipramine. Canadian journal of psychiatry. Revue canadienne de psychiatrie 19820401
Pupil studies in depressed patients: an investigation of the mechanism of action of desipramine. The British journal of psychiatry : the journal of mental science 19820201
Variant ventricular tachycardia in desipramine toxicity. Southern medical journal 19811001
Inappropriate ADH secretion: the role of drug re-challenge. Psychosomatics 19800901
Hoarseness and tricyclic antidepressants. The American journal of psychiatry 19800501
Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities. Naunyn-Schmiedeberg's archives of pharmacology 19790901
Chronic treatment with antidepressant drugs: potentiation of apomorphine-induced aggressive behaviour in rats. Neuroscience letters 19790801
Rapid cycling in manic-depressives induced by tricyclic antidepressants. Archives of general psychiatry 19790501
High dose desipramine, plasma drug levels and clinical response. The Journal of clinical psychiatry 19790301
Inappropriate antidiuresis during desipramine therapy. Archives of internal medicine 19781101
Cardiovascular responses to mianserin hydrochloride: a comparison with tricyclic antidepressant drugs. British journal of clinical pharmacology 19780101
Clinical pharmacological studies of tandamine, a potential antidepressive drug. Psychopharmacology 19770323
Effects of viloxazine, an antidepressant agent, on biogenic amine uptake mechanisms and related activities. Canadian journal of physiology and pharmacology 19760801
On the anticataleptic action of cyproheptadine. Pharmacology, biochemistry, and behavior 19760801
Peripherally and centrally mediated bradycardiac effects of clonidine in anesthetized or spinal rats. The Tohoku journal of experimental medicine 19760701
Centrally mediated cardiovascular effects of intracisternal application of carbachol in anesthetized rats. Japanese journal of pharmacology 19760601
Ascending catecholamine pathways and amphetamine-induced locomotor activity: importance of dopamine and apparent non-involvement of norepinephrine. Brain research 19750815
Interaction between digoxin and tricyclic antidepressants in the rat. European journal of pharmacology 19720801
Inhibition of extrapyramidal side effects of haloperidol through the joint use of imipramine-type drugs. Psychosomatics 19720101
Tricyclic antidepressants and monoamine oxidase inhibitors. Archives of general psychiatry 19710601
Haloperidol-desipramine interaction in mice, rats and man. Chemico-biological interactions 19700801
[Mechanism of inversion by demethylimipramine of motor depression induced by tetrabenazine]. Farmakologiia i toksikologiia 19690101
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