5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-8-[(1S)-1,2-dihydroxyethyl]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S,10S)-
Title | Journal |
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Metabolism of doxorubicin to the cardiotoxic metabolite doxorubicinol is increased in a mouse model of chronic glutathione deficiency: A potential role for carbonyl reductase 3. | Chemico-biological interactions 20150605 |
Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells. | Journal of nutritional science and vitaminology 20140101 |
The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium: insight to explain the cardiac safety of pixantrone in doxorubicin-treated patients. | The Journal of pharmacology and experimental therapeutics 20130201 |
Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4'-amino-3,5-dihydroxy-trans-stilbene. | Journal of nutritional science and vitaminology 20130101 |
Sex differences in improved efficacy of doxorubicin chemotherapy in Cbr1+/- mice. | Anti-cancer drugs 20120701 |
Selective determination of doxorubicin and doxorubicinol in rat plasma by HPLC with photosensitization reaction followed by chemiluminescence detection. | Talanta 20090415 |
Reduction of doxorubicin and oracin and induction of carbonyl reductase in human breast carcinoma MCF-7 cells. | Chemico-biological interactions 20081022 |
Evaluation of different calibrated spherical polyvinyl alcohol microspheres in transcatheter arterial chemoembolization: VX2 tumor model in rabbit liver. | Journal of vascular and interventional radiology : JVIR 20080701 |
Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro. | Drug metabolism and disposition: the biological fate of chemicals 20080601 |
Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin. | Drug metabolism and disposition: the biological fate of chemicals 20080501 |
The effect of flavonoid derivatives on doxorubicin transport and metabolism. | Bioorganic & medicinal chemistry 20080215 |
Quantification of pegylated liposomal doxorubicin and doxorubicinol in rat plasma by liquid chromatography/electrospray tandem mass spectroscopy: Application to preclinical pharmacokinetic studies. | Talanta 20080115 |
Mechanism of protection of moderately diet restricted rats against doxorubicin-induced acute cardiotoxicity. | Toxicology and applied pharmacology 20071115 |
Feasibility of simple chitosan sheet as drug delivery carrier. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061001 |
Paclitaxel and docetaxel stimulation of doxorubicinol formation in the human heart: implications for cardiotoxicity of doxorubicin-taxane chemotherapies. | The Journal of pharmacology and experimental therapeutics 20060701 |
Simultaneous liquid chromatographic determination of doxorubicin and its major metabolite doxorubicinol in parrot plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051105 |
Reduction of 13-deoxydoxorubicin and daunorubicinol anthraquinones by human carbonyl reductase. | Cardiovascular toxicology 20050101 |
The secondary alcohol and aglycone metabolites of doxorubicin alter metabolism of human erythrocytes. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20031201 |
Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1. | Cancer research 20031015 |
Pharmacokinetics of doxorubicin administered i.v. as Myocet (TLC D-99; liposome-encapsulated doxorubicin citrate) compared with conventional doxorubicin when given in combination with cyclophosphamide in patients with metastatic breast cancer. | Anti-cancer drugs 20030301 |
Effect of dexrazoxane on doxorubicin pharmacokinetics in young and old rats. | Cancer chemotherapy and pharmacology 20030201 |
Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy. | Cancer research 20011201 |
Effects of doxorubicinol on excitation--contraction coupling in guinea pig ventricular myocytes. | European journal of pharmacology 20010706 |
Human carbonyl reductase overexpression in the heart advances the development of doxorubicin-induced cardiotoxicity in transgenic mice. | Cancer research 20000915 |
The role of biotransformation in anthracycline-induced cardiotoxicity in mice. | The Journal of pharmacology and experimental therapeutics 19930901 |
[Possible role of adriamycinol in the cardiotoxicity induced by adriamycin in the rat]. | Giornale italiano di chemioterapia 19850101 |