PROPENTOFYLLINE
Title | Journal |
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Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. | PloS one 20130101 |
Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 days of morphine withdrawal. | Journal of neuroscience research 20120601 |
Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. | The journal of pain : official journal of the American Pain Society 20120601 |
Distinct time courses of microglial and astrocytic hyperactivation and the glial contribution to pain hypersensitivity in a facial cancer model. | Brain research 20120531 |
Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages. | Experimental neurology 20120401 |
Commentary on Landry et al.: 'Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages'. | Experimental neurology 20120401 |
Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia. | Neuro-oncology 20120201 |
Systematic review on the efficacy and safety of herbal medicines for vascular dementia. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states. | Molecular pain 20120101 |
Preincisional administration of intravenous or subcutaneous infiltration of low-dose ketamine suppresses postoperative pain after appendectomy. | Journal of pain research 20120101 |
Propentofylline targets TROY, a novel microglial signaling pathway. | PloS one 20120101 |
Treatment-resistant Schizophrenia: Evidence-based Strategies. | Mens sana monographs 20120101 |
Neuropathy-induced spinal GAP-43 expression is not a main player in the onset of mechanical pain hypersensitivity. | Journal of neurotrauma 20111201 |
Antiallodynic effects of propentofylline Elicited by interrupting spinal glial function in a rat model of bone cancer pain. | Journal of neuroscience research 20111101 |
Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats. | American journal of physiology. Gastrointestinal and liver physiology 20110901 |
Potent family-18 chitinase inhibitors: x-ray structures, affinities, and binding mechanisms. | The Journal of biological chemistry 20110708 |
Central glial activation mediates cancer-induced pain in a rat facial cancer model. | Neuroscience 20110428 |
The role of extracellular adenosine in chemical neurotransmission in the hippocampus and Basal Ganglia: pharmacological and clinical aspects. | Current topics in medicinal chemistry 20110401 |
Application of liquid chromatography-tandem mass spectrometry method for the simultaneous quantitative analysis of propentofylline and its chiral metabolite M1 in rats. | Biomedical chromatography : BMC 20110301 |
Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain. | Handbook of experimental pharmacology 20110101 |
A local anesthetic, ropivacaine, suppresses activated microglia via a nerve growth factor-dependent mechanism and astrocytes via a nerve growth factor-independent mechanism in neuropathic pain. | Molecular pain 20110101 |
A new drug design targeting the adenosinergic system for Huntington's disease. | PloS one 20110101 |
High-throughput assay for the identification of compounds regulating osteogenic differentiation of human mesenchymal stromal cells. | PloS one 20110101 |
Randomized, placebo controlled study of the effect of propentofylline on survival time and quality of life of cats with feline infectious peritonitis. | Journal of veterinary internal medicine 20110101 |
The contribution of spinal glial cells to chronic pain behaviour in the monosodium iodoacetate model of osteoarthritic pain. | Molecular pain 20110101 |
Pentoxifylline decreases allodynia and hyperalgesia in a rat model of neuropathic pain. | Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101 |
Activation of astrocytes in the spinal cord contributes to the development of bilateral allodynia after peripheral nerve injury in rats. | Brain research 20101202 |
Pharmacological shift of the ambiguous nitric oxide action from neurotoxicity to cyclic GMP-mediated protection. | Neurological research 20101101 |
Synergetic analgesia of propentofylline and electroacupuncture by interrupting spinal glial function in rats. | Neurochemical research 20101101 |
Dynamic regulation of spinal pro-inflammatory cytokine release in the rat in vivo following peripheral nerve injury. | Brain, behavior, and immunity 20100501 |
Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain. | Molecular pain 20100101 |
TNF-alpha and neuropathic pain--a review. | Journal of neuroinflammation 20100101 |
Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats. | Molecular pain 20100101 |
Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain. | PloS one 20100101 |
Use of propentofylline in feline bronchial disease: prospective, randomized, positive-controlled study. | Journal of the American Animal Hospital Association 20100101 |
Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus. | Molecular pain 20100101 |
Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel. | Journal of inflammation (London, England) 20100101 |
Post herpetic neuralgia, schwann cell activation and vitamin D. | Medical hypotheses 20091201 |
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors. | Bioorganic & medicinal chemistry letters 20091201 |
Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury. | Experimental neurology 20091101 |
Astrocyte activation and memory impairment in the repetitive febrile seizures model. | Epilepsy research 20091001 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
Release of adenosine and ATP during ischemia and epilepsy. | Current neuropharmacology 20090901 |
Adenosine neuromodulation and traumatic brain injury. | Current neuropharmacology 20090901 |
Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat. | Neuroscience 20090707 |
Natural non-trasgenic animal models for research in Alzheimer's disease. | Current Alzheimer research 20090401 |
Microbial transformation of hydroxy metabolites of 1-oxohexyl derivatives of theobromine by Cunninghamella echinulata NRRL 1384. | Letters in applied microbiology 20090101 |
Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately? | The open neurology journal 20090101 |
Effect of interleukin-1beta on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function. | Arthritis research & therapy 20090101 |
Disruption of glial function regulates the effects of electro-acupuncture at Tsusanli on gastric activity in rats. | The American journal of Chinese medicine 20090101 |
Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors. | Molecular pain 20090101 |
Vascular cognitive impairment. | Indian journal of psychiatry 20090101 |
Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures. | Journal of neurochemistry 20081001 |
Implication of activated astrocytes in the development of drug dependence: differences between methamphetamine and morphine. | Annals of the New York Academy of Sciences 20081001 |
Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat. | Pain 20080831 |
Present and prospective clinical therapeutic regimens for Alzheimer's disease. | Neuropsychiatric disease and treatment 20080801 |
Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection. | Neuroscience 20080409 |
A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia. | Progress in neuro-psychopharmacology & biological psychiatry 20080401 |
Modulation of microglia can attenuate neuropathic pain symptoms and enhance morphine effectiveness. | Pharmacological reports : PR 20080101 |
Progress update: Pharmacological treatment of Alzheimer's disease. | Neuropsychiatric disease and treatment 20071001 |
The role of ATP and adenosine in the brain under normoxic and ischemic conditions. | Purinergic signalling 20070901 |
Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. | The Journal of biological chemistry 20070720 |
Reprint of 'efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury' [Brain Behav. Immun. 21 (2007) 238-246]. | Brain, behavior, and immunity 20070701 |
Effects of interleukin-1beta on spinal cord nociceptive transmission in intact and propentofylline-treated rats. | The International journal of neuroscience 20070501 |
[Activation of astrocytes effects changes of substance P in cornu dorsal medullae spinalis in chronic prostatitis rats]. | Zhonghua nan ke xue = National journal of andrology 20070401 |
Chronic pain-induced astrocyte activation in the cingulate cortex with no change in neural or glial differentiation from neural stem cells in mice. | Neuroscience letters 20070319 |
P1 receptors and cytokine secretion. | Purinergic signalling 20070301 |
Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury. | Brain, behavior, and immunity 20070201 |
Behavioural and morphological evidence for the involvement of glial cell activation in delta opioid receptor function: implications for the development of opioid tolerance. | Molecular pain 20070101 |
p38 MAPK, microglial signaling, and neuropathic pain. | Molecular pain 20070101 |
Direct evidence of astrocytic modulation in the development of rewarding effects induced by drugs of abuse. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20061101 |
Induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: heterogeneity of the quiescent phenotype. | Glia 20060815 |
Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat. | Neuroscience letters 20060612 |
Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
mu-Opioid receptor internalization-dependent and -independent mechanisms of the development of tolerance to mu-opioid receptor agonists: Comparison between etorphine and morphine. | Neuroscience 20060101 |
Recent advances in basic neurosciences and brain disease: from synapses to behavior. | Molecular pain 20060101 |
Activation of p38 and p42/44 MAP kinase in neuropathic pain: involvement of VPAC2 and NK2 receptors and mediation by spinal glia. | Molecular and cellular neurosciences 20051201 |
Antianalgesia: stereoselective action of dextro-morphine over levo-morphine on glia in the mouse spinal cord. | The Journal of pharmacology and experimental therapeutics 20050901 |
Systemic administration of propentofylline does not attenuate morphine tolerance in non-injured rodents. | Neuroscience letters 20050826 |
Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade. | Purinergic signalling 20050601 |
Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576. | Neuropharmacology 20050101 |
Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines. | BMC pharmacology 20050101 |
Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. | Molecular pain 20050101 |
Treatment of vascular dementia: evidence from trials with non-cholinergic drugs. | Journal of the neurological sciences 20041115 |
Effect of propentofylline on hypoxic-ischaemic brain damage in newborn rat. | Chinese medical journal 20040801 |
The effects of local pentoxifylline and propentofylline treatment on formalin-induced pain and tumor necrosis factor-alpha messenger RNA levels in the inflamed tissue of the rat paw. | Anesthesia and analgesia 20040601 |
Pentoxyphylline and propentophylline are inhibitors of TNF-alpha release in monocytes activated by advanced glycation endproducts. | Journal of neural transmission (Vienna, Austria : 1996) 20040301 |
Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040201 |
Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. | The Cochrane database of systematic reviews 20040101 |
Propentofylline rapidly normalizes mitochondrial respiration in a gerbil low flow unilateral forebrain ischemia. | Neuroscience letters 20031002 |
Effect of PPF and ALCAR on the induction of NGF- and p75-mRNA and on APP processing in Tg2576 brain. | Neurochemistry international 20030801 |
Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines. | Pain 20030801 |
Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons. | European journal of pharmacology 20030105 |
Propentofylline for dementia. | The Cochrane database of systematic reviews 20030101 |
Beneficial effects of pentoxifylline and propentofylline on the warm ischemic injury of rat livers. | Transplantation proceedings 20021101 |
Propentofylline after focal cortical lesion in the rat: impact on functional recovery and basic fibroblast growth factor expression. | Neuroscience letters 20021018 |
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
Long-term potentiation protects rat hippocampal slices from the effects of acute hypoxia. | Brain research 20010713 |
Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. | The Journal of pharmacology and experimental therapeutics 20010601 |
Neuromodulatory effect of propentofylline on rat brain under acute and long-term hypoperfusion. | British journal of pharmacology 20010501 |
Drugs for treatment of Alzheimer's disease. | International journal of clinical practice 20010301 |
Effect of propentofylline on cerebral blood flow in a gerbil focal cerebral ischemia. | Journal of the neurological sciences 20010115 |
Microglial reaction in focal cerebral ischaemia induced by intra-carotid homologous clot injection. | Histology and histopathology 20010101 |
Clinical trials of propentofylline in vascular dementia. European/Canadian Propentofylline Study Group. | Alzheimer disease and associated disorders 19990101 |