H-gla-oh
Title | Journal |
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Computational prediction and analysis of protein γ-carboxylation sites based on a random forest method. | Molecular bioSystems 20121101 |
Patterns of periodic holes created by increased cell motility. | Interface focus 20120806 |
Decreased sensory responses in osteocalcin null mutant mice imply neuropeptide function. | Cellular and molecular neurobiology 20120701 |
Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. | The Journal of biological chemistry 20120608 |
Effect of anticoagulation with citrate versus heparin on the adsorption of coagulation factors to blood purification resins with different charge. | Biomacromolecules 20120213 |
Evidence of associations between feto-maternal vitamin D status, cord parathyroid hormone and bone-specific alkaline phosphatase, and newborn whole body bone mineral content. | Nutrients 20120201 |
Correlation between posttranslational modification and intrinsic disorder in protein. | Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 20120101 |
Regulatory mechanisms in bone following mechanical loading. | Gene regulation and systems biology 20120101 |
Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats. | Nutrition & metabolism 20120101 |
Antioxidant properties of polysaccharide from the brown seaweed Sargassum graminifolium (Turn.), and its effects on calcium oxalate crystallization. | Marine drugs 20120101 |
Enhancing osteoconduction of PLLA-based nanocomposite scaffolds for bone regeneration using different biomimetic signals to MSCs. | International journal of molecular sciences 20120101 |
Vitamin K: the effect on health beyond coagulation - an overview. | Food & nutrition research 20120101 |
Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells. | PloS one 20120101 |
The end-organ impairment in liver cirrhosis: appointments for critical care. | Critical care research and practice 20120101 |
Carboxylator: incorporating solvent-accessible surface area for identifying protein carboxylation sites. | Journal of computer-aided molecular design 20111001 |
Molecular modulation of osteocalcin and its relevance in diabetes (Review). | International journal of molecular medicine 20110901 |
Ucmaa (Grp-2) is required for zebrafish skeletal development. Evidence for a functional role of its glutamate γ-carboxylation. | Matrix biology : journal of the International Society for Matrix Biology 20110901 |
Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities. | Growth factors (Chur, Switzerland) 20110801 |
Osteocalcin is a stress-responsive neuropeptide. | Endocrine regulations 20110401 |
Association between atherosclerosis and osteoporosis, the role of vitamin D. | Archives of medical science : AMS 20110401 |
Vitamin K, osteoporosis and degenerative diseases of ageing. | Menopause international 20110301 |
Extraskeletal osteosarcoma with pulmonary metastasis in a female f344 rat. | Journal of toxicologic pathology 20110301 |
The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. | The Journal of biological chemistry 20110218 |
Interaction of prothrombin with a phospholipid surface: evidence for a membrane-induced conformational change. | Molecular and cellular biochemistry 20110201 |
Ca 2+-induced self-assembly in designed peptides with optimally spaced gamma-carboxyglutamic acid residues. | Journal of inorganic biochemistry 20110101 |
Approaching biomarkers of membranous nephropathy from a murine model to human disease. | Journal of biomedicine & biotechnology 20110101 |
Osteogenic predifferentiation of human bone marrow-derived stem cells by short-term mechanical stimulation. | The open orthopaedics journal 20110101 |
Effect of long-term oral anticoagulant therapy on bone mineral density and bone turnover markers: a prospective 12 month study. | Bratislavske lekarske listy 20110101 |
STAT6 expression in glioblastoma promotes invasive growth. | BMC cancer 20110101 |
Protein C mutation (A267T) results in ER retention and unfolded protein response activation. | PloS one 20110101 |
Expression of recombinant human coagulation factor VII by the Lizard Leishmania expression system. | Journal of biomedicine & biotechnology 20110101 |
A mutation in the UBIAD1 gene in a Han Chinese family with Schnyder corneal dystrophy. | Molecular vision 20110101 |
Gene-drug interaction in stroke. | Stroke research and treatment 20110101 |
Characterization of γ-carboxylated tryptic peptides by collision-induced dissociation and electron transfer dissociation mass spectrometry. | European journal of mass spectrometry (Chichester, England) 20110101 |
Investigation and identification of protein γ-glutamyl carboxylation sites. | BMC bioinformatics 20110101 |
Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation. | The Journal of nutritional biochemistry 20101101 |
Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice. | Calcified tissue international 20101001 |
Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo. | Arteriosclerosis, thrombosis, and vascular biology 20101001 |
Vitamin K-dependent gamma-glutamylcarboxylase in Atlantic salmon (Salmo salar L.). | Fish physiology and biochemistry 20100901 |
Exploring the role of the phospholipid ligand in endothelial protein C receptor: a molecular dynamics study. | Proteins 20100901 |
Investigating clearance mechanisms for recombinant activated factor VII in a perfused liver model. | Thrombosis and haemostasis 20100801 |
Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: a fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthritic chondrocytes. | Osteoarthritis and cartilage 20100801 |
Characterization of conantokin Rl-A: molecular phylogeny as structure/function study. | Journal of peptide science : an official publication of the European Peptide Society 20100801 |
The effects of enamel matrix derivative on the proliferation and differentiation of human mesenchymal stem cells. | Clinical oral implants research 20100701 |
Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg (2+)-con-T[K7gamma] complex. | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100601 |
Targeting adenoviruses with factor x-single-chain antibody fusion proteins. | Human gene therapy 20100601 |
The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. | The Journal of clinical investigation 20100601 |
A novel splice site mutation in intron C of PROS1 leads to markedly reduced mutant mRNA level, absence of thrombin-sensitive region, and impaired secretion and cofactor activity of mutant protein S. | Thrombosis research 20100501 |
Recent estimates of the structure of the factor VIIa (FVIIa)/tissue factor (TF) and factor Xa (FXa) ternary complex. | Thrombosis research 20100401 |
Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein. | Cardiovascular research 20100301 |
Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures. | Calcified tissue international 20100301 |
An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase. | The Journal of biological chemistry 20100219 |
Identification of four alternatively spliced transcripts of the Ucma/GRP gene, encoding a new Gla-containing protein. | Experimental cell research 20100115 |
Undercarboxylated osteocalcin is a biomarker of carotid calcification in patients with essential hypertension. | Kidney & blood pressure research 20100101 |
Critical evaluation of gamma-irradiated serum used as feeder in the culture and demonstration of putative nanobacteria and calcifying nanoparticles. | PloS one 20100101 |
Skeletal site-related variation in human trabecular bone transcriptome and signaling. | PloS one 20100101 |
Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans. | Disease markers 20100101 |
Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport. | BMC cell biology 20100101 |
Carbonic anhydrase I is recognized by an SOD1 antibody upon biotinylation of human spinal cord extracts. | International journal of molecular sciences 20100101 |
VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey. | PloS one 20100101 |
GAS6 enhances repair following cuprizone-induced demyelination. | PloS one 20100101 |
Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms. | American journal of physiology. Cell physiology 20091201 |
Use of a bacterially expressed human factor IX light chain to develop polyclonal antibody anti-hFIX. | Applied biochemistry and biotechnology 20091101 |
Vitamin K in parenteral nutrition. | Gastroenterology 20091101 |
Metal-binding affinity and selectivity of nonstandard natural amino acid residues from DFT/CDM calculations. | The journal of physical chemistry. B 20090827 |
Direct analysis reveals an absence of gamma-carboxyglutamic acid in cancer procoagulant from human tissues. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20090701 |
Phylogenetic analysis of ALAD and MGP genes related to lead toxicity. | Toxicology and industrial health 20090701 |
Membrane-dependent interaction of factor Xa and prothrombin with factor Va in the prothrombinase complex. | Biochemistry 20090609 |
From the Gla domain to a novel small-molecule detector of apoptosis. | Cell research 20090501 |
Non-strict strand orientation of the Ca2+-induced dimerization of a conantokin peptide variant with sequence-shifted gamma-carboxyglutamate residues. | Peptides 20090501 |
The mineral phase of calcified cartilage: its molecular structure and interface with the organic matrix. | Biophysical journal 20090422 |
Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K-dependent and warfarin-sensitive secretion. | Blood 20090416 |
Structural characterization of five post-translationally modified isomorphs of a novel putative delta-conotoxin from the vermivorous snail Conus delessertii from the Mexican Caribbean Sea. | Peptides 20090301 |
Polymorphisms in MGP gene and their association with lead toxicity. | Toxicology mechanisms and methods 20090301 |
Platelet factor 4 impairs the anticoagulant activity of activated protein C. | The Journal of biological chemistry 20090227 |
Vitamin K, an update for the paediatrician. | European journal of pediatrics 20090201 |
Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients. | Thrombosis and haemostasis 20090201 |
Regulation of pituitary gene expression by adrenalectomy. | Obesity (Silver Spring, Md.) 20090101 |
Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay. | Molecular vision 20090101 |
BMP-13 emerges as a potential inhibitor of bone formation. | International journal of biological sciences 20090101 |
Characterization of porcine factor VII, X and comparison with human factor VII, X. | Blood cells, molecules & diseases 20090101 |
Characterization of granulations of calcium and apatite in serum as pleomorphic mineralo-protein complexes and as precursors of putative nanobacteria. | PloS one 20090101 |
Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis. | Vascular health and risk management 20090101 |
Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain. | Therapeutics and clinical risk management 20090101 |
Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma. | BMC cancer 20090101 |
Parallel changes in gene expression in peripheral blood mononuclear cells and the brain after maternal separation in the mouse. | BMC research notes 20090101 |
Microstructure and mineral composition of dystrophic calcification associated with the idiopathic inflammatory myopathies. | Arthritis research & therapy 20090101 |
Endothelial cells influence the osteogenic potential of bone marrow stromal cells. | Biomedical engineering online 20090101 |
Fetuin-A/albumin-mineral complexes resembling serum calcium granules and putative nanobacteria: demonstration of a dual inhibition-seeding concept. | PloS one 20090101 |
Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. | The Journal of biological chemistry 20081226 |
The PT1-Ca2+ Gla domain binds to a membrane through two dipalmitoylphosphatidylserines. A computational study. | Biochemistry 20081216 |
Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine. | Biochemical and biophysical research communications 20081107 |
Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial. | PLoS medicine 20081001 |
Noninvasive markers of oxidative DNA stress, RNA degradation and protein degradation are differentially correlated with resting metabolic rate and energy intake in children and adolescents. | Pediatric research 20080901 |
Conantokin-P, an unusual conantokin with a long disulfide loop. | Toxicon : official journal of the International Society on Toxinology 20080801 |
Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z. | The Journal of biological chemistry 20080718 |
Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins. | Toxicon : official journal of the International Society on Toxinology 20080701 |
Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells. | The Journal of biological chemistry 20080627 |
Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification. | Circulation research 20080509 |
Proline and gamma-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4. | Circulation research 20080509 |
Vitamin K intake and atherosclerosis. | Current opinion in lipidology 20080201 |
Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks. | Peptides 20080201 |
Vascular calcification and uremia: what do we know? | American journal of nephrology 20080101 |
Molecular characterization of spontaneous mesenchymal stem cell transformation. | PloS one 20080101 |
Detection of a gamma-carboxy-glutamate as novel post-translational modification of human transthyretin. | Protein and peptide letters 20080101 |
Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. | Thrombosis research 20080101 |
gamma-Glutamate and beta-hydroxyaspartate in proteins. | Methods in molecular biology (Clifton, N.J.) 20080101 |
The vitamin K cycle. | Vitamins and hormones 20080101 |
Vitamin K-dependent gamma-glutamylcarboxylation: an ancient posttranslational modification. | Vitamins and hormones 20080101 |
Vitamin K and bone health in adult humans. | Vitamins and hormones 20080101 |
The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification. | Journal of vascular research 20080101 |
Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women. | Journal of bone and mineral metabolism 20080101 |
Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53. | Proteome science 20080101 |
Production of metal ion-dependent monoclonal antibodies against peptides in bovine prothrombin fragment 1. | Human antibodies 20080101 |
Characterization of 11p14-p12 deletion in WAGR syndrome by array CGH for identifying genes contributing to mental retardation and autism. | Cytogenetic and genome research 20080101 |
Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. | The Journal of biological chemistry 20071221 |
The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells. | Blood 20071201 |
Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification. | Journal of thrombosis and haemostasis : JTH 20071201 |
Effect of carboxyl-group of D-glutamic acid or gamma-carboxy-D-glutamic acid as N-terminal amino acid of (111)in-diethylenetriaminepentaacetic acid-octreotide on accumulation of radioactivity in kidney. | Biological & pharmaceutical bulletin 20071101 |
[Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function]. | Clinical calcium 20071101 |
Regulation of matrix Gla protein by parathyroid hormone in MC3T3-E1 osteoblast-like cells involves protein kinase A and extracellular signal-regulated kinase pathways. | Journal of cellular biochemistry 20071001 |
Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients. | Laboratory investigation; a journal of technical methods and pathology 20071001 |
[Gas-6 and protein S: vitamin K-dependent factors and ligands for the TAM tyrosine kinase receptors family]. | Medecine sciences : M/S 20071001 |
Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity. | Journal of thrombosis and haemostasis : JTH 20070901 |
Quantum chemical study of the mechanism of action of vitamin K carboxylase (VKC). IV. Intermediates and transition states. | The journal of physical chemistry. A 20070809 |
Snake-venom-derived Factor IX-binding protein specifically blocks the gamma-carboxyglutamic acid-rich-domain-mediated membrane binding of human Factors IX and X. | The Biochemical journal 20070715 |
Vitamin K: the coagulation vitamin that became omnipotent. | Thrombosis and haemostasis 20070701 |
Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase. | Blood 20070615 |
A vasopressin/oxytocin-related conopeptide with gamma-carboxyglutamate at position 8. | The Biochemical journal 20070615 |
Enhancement effects of vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) on intestinal alkaline phosphatase activity in rats. | Journal of nutritional science and vitaminology 20070601 |
Substitution of the Gla domain in factor X with that of protein C impairs its interaction with factor VIIa/tissue factor: lack of comparable effect by similar substitution in factor IX. | The Journal of biological chemistry 20070525 |
Association free energy of dipalmitoylphosphatidylserines in a mixed dipalmitoylphosphatidylcholine membrane. | Biophysical journal 20070501 |
Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives. | The Journal of biological chemistry 20070427 |
Hydroxyapatite surface-induced peptide folding. | Journal of the American Chemical Society 20070425 |
Preferential localization of recombinant factor VIIa to platelets activated with a combination of thrombin and a glycoprotein VI receptor agonist. | Journal of thrombosis and haemostasis : JTH 20070401 |
Association of warfarin dose with genes involved in its action and metabolism. | Human genetics 20070301 |
[Advances in study of structures and functions of conantokins]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070301 |
The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif. | Journal of the American Chemical Society 20070214 |
Warfarin-induced vasculopathy. | Journal of thrombosis and thrombolysis 20070201 |
Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women. | The British journal of nutrition 20070201 |
Full-length cDNA cloning and protein three-dimensional structure modeling of porcine prothrombin. | Blood cells, molecules & diseases 20070101 |
A distinct epigenetic signature at targets of a leukemia protein. | BMC genomics 20070101 |
The vascular biology of calcification. | Seminars in dialysis 20070101 |
Simultaneous generation of aptamers to multiple gamma-carboxyglutamic acid proteins from a focused aptamer library using DeSELEX and convergent selection. | Oligonucleotides 20070101 |
Growth arrest-specific protein 6 (GAS6) and the protein C pathway. | Critical care (London, England) 20070101 |
Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate. | BMC cancer 20070101 |
Role of vitamin K on biochemical markers, bone mineral density, and fracture risk. | Journal of endocrinological investigation 20070101 |
Single nucleotide polymorphisms in bone turnover-related genes in Koreans: ethnic differences in linkage disequilibrium and haplotype. | BMC medical genetics 20070101 |
BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion. | Molecular cancer 20070101 |
The immune response is involved in atherosclerotic plaque calcification: could the RANKL/RANK/OPG system be a marker of plaque instability? | Clinical & developmental immunology 20070101 |
From gamma-carboxy-glutamate to protein C. | Journal of thrombosis and haemostasis : JTH 20061201 |
Molecular dynamics calculations of wild type vs. mutant protein C: relationship between binding affinity to endothelial cell protein C receptor and hereditary disease. | Journal of biomolecular structure & dynamics 20061201 |
Vascular calcification: pathobiological mechanisms and clinical implications. | Circulation research 20061110 |
Expression of osteonectin and matrix Gla protein in scleroderma patients with and without calcinosis. | Rheumatology (Oxford, England) 20061101 |
A single gamma-carboxyglutamic acid residue in a novel cysteine-rich secretory protein without propeptide. | Biochemistry 20061024 |
Design and concise synthesis of fully protected analogues of l-gamma-carboxyglutamic acid. | The Journal of organic chemistry 20060915 |
[Protective effects of vitamin K against osteoporosis and its pleiotropic actions]. | Clinical calcium 20060901 |
High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa. | The Journal of biological chemistry 20060825 |
The first gamma-carboxyglutamate-containing neuropeptide. | Neurochemistry international 20060801 |
Isoelectric points and post-translational modifications of connexin26 and connexin32. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060601 |
Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile. | The FEBS journal 20060601 |
Screening for post-translational modifications in conotoxins using liquid chromatography/mass spectrometry: an important component of conotoxin discovery. | Toxicon : official journal of the International Society on Toxinology 20060501 |
Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat. | Bioscience, biotechnology, and biochemistry 20060401 |
Comprehensive analysis of the renal transcriptional response to acute uranyl nitrate exposure. | BMC genomics 20060101 |
Decreased inhibitory activity of prothrombin to calcium oxalate crystallization by specific chemical modification of its gamma-carboxyglutamic acid residues. | Urology 20060101 |
Osteocalcin and bone-specific alkaline phosphatase in sickle cell haemoglobinopathies. | Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria 20060101 |
Sequential coagulation factor VIIa domain binding to tissue factor. | Biochemical and biophysical research communications 20051202 |
The role of gamma-carboxylation in the anti-apoptotic function of gas6. | Journal of thrombosis and haemostasis : JTH 20051201 |
Protein C Sapporo (protein C Glu 25 --> Lys): a heterozygous missense mutation in the Gla domain provides new insight into the interaction between protein C and endothelial protein C receptor. | Thrombosis and haemostasis 20051101 |
Identification of genes differentially expressed in wild type and Purkinje cell degeneration mice. | Molecules and cells 20051031 |
Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties. | Biochemistry 20050920 |
Dexamethasone and basic-fibroblast growth factor regulate markers of mineralization in cementoblasts in vitro. | Journal of periodontology 20050901 |
Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification. | Arteriosclerosis, thrombosis, and vascular biology 20050801 |
Vitamin K in the treatment and prevention of osteoporosis and arterial calcification. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050801 |
Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. | The Journal of biological chemistry 20050722 |
Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation. | Biochemistry 20050628 |
Anabolic actions of PTH (1-34): use of a novel tissue engineering model to investigate temporal effects on bone. | Bone 20050601 |
Matrix gamma-carboxyglutamic acid protein (MGP) G-7A and T-138C gene polymorphisms in Indian (Mayo and Teenek) and Mestizo populations from Mexico. | Human biology 20050601 |
[Molecular mechanisms of vitamin K action in the bone homeostasis]. | Clinical calcium 20050501 |
Engineering of a recombinant vitamin K-dependent gamma-carboxylation system with enhanced gamma-carboxyglutamic acid forming capacity: evidence for a functional CXXC redox center in the system. | The Journal of biological chemistry 20050318 |
Rapid fabrication of keratin-hydroxyapatite hybrid sponges toward osteoblast cultivation and differentiation. | Biomaterials 20050101 |
The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding. | Blood 20050101 |
Effects of urinary prothrombin fragment 1 in the formation of calcium oxalate calculus. | The Journal of urology 20050101 |
Putative gamma-conotoxins in vermivorous cone snails: the case of Conus delessertii. | Peptides 20050101 |
Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate. | Cardiovascular diabetology 20050101 |
Osteo-Promoter Database (OPD) -- promoter analysis in skeletal cells. | BMC genomics 20050101 |
Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension. | Respiratory research 20050101 |
Structure-function relationships of C-type lectin-related proteins. | Pathophysiology of haemostasis and thrombosis 20050101 |
Chemical modification of cysteine residues is a misleading indicator of their status as active site residues in the vitamin K-dependent gamma-glutamyl carboxylation reaction. | The Journal of biological chemistry 20041224 |
Conantokins: peptide antagonists of NMDA receptors. | Current medicinal chemistry 20041201 |
Total chemical synthesis and NMR characterization of the glycopeptide tx5a, a heavily post-translationally modified conotoxin, reveals that the glycan structure is alpha-D-Gal-(1-->3)-alpha-D-GalNAc. | European journal of biochemistry 20041201 |
Oral anticoagulant treatment: friend or foe in cardiovascular disease? | Blood 20041115 |
Identification of residues Asn89, Ile90, and Val107 of the factor IXa second epidermal growth factor domain that are essential for the assembly of the factor X-activating complex on activated platelets. | The Journal of biological chemistry 20041105 |
A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide. | Biochemistry 20041019 |
Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin. | The Journal of biological chemistry 20041008 |
[Serum osteoprotegrin and serum bone gamma-carboxyglutamine acid-containing protein are correlated with bone mineral density in normal women]. | Zhonghua yi xue za zhi 20041002 |
Multiple 6-bromotryptophan residues in a sleep-inducing peptide. | Biochemistry 20040928 |
The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. | The Journal of biological chemistry 20040730 |
The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M. | The Journal of biological chemistry 20040730 |
Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern. | Biochemical and biophysical research communications 20040709 |
Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts. | Biochemical and biophysical research communications 20040702 |
Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin. | Journal of thrombosis and haemostasis : JTH 20040701 |
Matrix GLA protein modulates branching morphogenesis in fetal rat lung. | American journal of physiology. Lung cellular and molecular physiology 20040601 |
Platelet factor 4 modulation of the thrombomodulin-protein C system. | Critical care medicine 20040501 |
Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry. | Journal of mass spectrometry : JMS 20040501 |
Kinetics of factor Xa inhibition by recombinant tick anticoagulant peptide: both active site and exosite interactions are required for a slow- and tight-binding inhibition mechanism. | Biochemistry 20040330 |
Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels. | Bone 20040301 |
Binding of the factor IX gamma-carboxyglutamic acid domain to the vitamin K-dependent gamma-glutamyl carboxylase active site induces an allosteric effect that may ensure processive carboxylation and regulate the release of carboxylated product. | The Journal of biological chemistry 20040220 |
A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues. | Journal of molecular biology 20040220 |
[Effect of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis]. | Zhonghua yi xue za zhi 20040217 |
Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. | Thrombosis and haemostasis 20040201 |
Use of snake venom inhibitors in studies of the function and tertiary structure of coagulation factors. | International journal of hematology 20040201 |
Effects of vitamin K2 on osteoporosis. | Current pharmaceutical design 20040101 |
The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis. | Proteins 20031115 |
Determination of disulfide bond assignment of human vitamin K-dependent gamma-glutamyl carboxylase by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. | The Journal of biological chemistry 20031114 |
[Study on association of polymorphism of MGP(T-138C) gene and blood lead level in children]. | Wei sheng yan jiu = Journal of hygiene research 20031101 |
Vitamin K and bone health. | The Proceedings of the Nutrition Society 20031101 |
Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain. | Biochemical and biophysical research communications 20031017 |
Glucocorticoid effects on vitamin K-dependent carboxylase activity and matrix Gla protein expression in rat lung. | American journal of physiology. Lung cellular and molecular physiology 20030901 |
Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. | Nature structural biology 20030901 |
The Gla domain of factor IXa binds to factor VIIIa in the tenase complex. | The Journal of biological chemistry 20030815 |
The extended interactions and Gla domain of blood coagulation factor Xa. | Biochemistry 20030708 |
Intracrystalline proteins and urolithiasis: a synchrotron X-ray diffraction study of calcium oxalate monohydrate. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030701 |
Crystal structure of Mg2+- and Ca2+-bound Gla domain of factor IX complexed with binding protein. | The Journal of biological chemistry 20030627 |
Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein. | British journal of cancer 20030616 |
Direct binding properties of conantokins to native N-methyl-d-aspartate receptors. | The journal of peptide research : official journal of the American Peptide Society 20030601 |
Site-directed fluorescence probing to dissect the calcium-dependent association between soluble tissue factor and factor VIIa domains. | Biochimica et biophysica acta 20030530 |
Role of the Gla and first epidermal growth factor-like domains of factor X in the prothrombinase and tissue factor-factor VIIa complexes. | The Journal of biological chemistry 20030321 |
Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding. | Blood 20030315 |
The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa. | The Journal of biological chemistry 20030307 |
Mutagenesis of the gamma-carboxyglutamic acid domain of human factor VII to generate maximum enhancement of the membrane contact site. | The Journal of biological chemistry 20030307 |
Deletion or replacement of the second EGF-like domain of protein S results in loss of APC cofactor activity. | Blood 20030215 |
Cloning and expression of rat coagulation factor VII. | Thrombosis research 20030215 |
Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. | The Journal of biological chemistry 20030131 |
Identification of a gene encoding a typical gamma-carboxyglutamic acid domain in the tunicate Halocynthia roretzi. | Journal of thrombosis and haemostasis : JTH 20030101 |
Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile. | European journal of biochemistry 20021201 |
Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif. | The Journal of biological chemistry 20021108 |
Chronic disseminated intravascular coagulation and childhood-onset skin necrosis resulting from homozygosity for a protein C Gla domain mutation, Arg15Trp. | Journal of pediatric hematology/oncology 20021101 |
Gas6 binding to photoreceptor outer segments requires gamma-carboxyglutamic acid (Gla) and Ca(2+) and is required for OS phagocytosis by RPE cells in vitro. | Experimental eye research 20021001 |
Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells. | Journal of immunology (Baltimore, Md. : 1950) 20020901 |
High-performance liquid chromatography--mass spectrometry and electron-capture dissociation tandem mass spectrometry of osteocalcin. Determination of gamma-carboxyglutamic acid residues. | Journal of chromatography. A 20020712 |
Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo. | Blood 20020701 |
Growth characteristics, angiotensin II generation, and microarray-determined gene expression in vascular smooth muscle cells from young spontaneously hypertensive rats. | Journal of hypertension 20020701 |
Characteristics and composition of the vitamin K-dependent gamma-glutamyl carboxylase-binding domain on osteocalcin. | The Biochemical journal 20020515 |
gamma-Carboxyglutamic acid content of hepatocellular carcinoma-associated des-gamma-carboxy prothrombin. | Biochimica et biophysica acta 20020424 |
Detection of vitamin K-dependent proteins in venoms with a monoclonal antibody specific for gamma-carboxyglutamic acid. | Toxicon : official journal of the International Society on Toxinology 20020401 |
Effect of prothrombin and its activation fragments on calcium oxalate crystal growth and aggregation in undiluted human urine in vitro: relationship between protein structure and inhibitory activity. | Clinical science (London, England : 1979) 20020401 |
Structure and dynamics of zymogen human blood coagulation factor X. | Biophysical journal 20020301 |
A human antibody that inhibits factor IX/IXa function potently inhibits arterial thrombosis without increasing bleeding. | Arteriosclerosis, thrombosis, and vascular biology 20020301 |
Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated rats. | The Journal of biological chemistry 20020208 |
Localization of phosphatidylserine binding sites to structural domains of factor Xa. | The Journal of biological chemistry 20020118 |
Ca2+ binding to proteins containing gamma-carboxyglutamic acid residues. | Methods in molecular biology (Clifton, N.J.) 20020101 |
Effects of skeletal loading on bone mass and compensation mechanism in bone: a new insight into the 'mechanostat' theory. | Journal of bone and mineral metabolism 20020101 |
Identification of extrinsic blood coagulation pathway inhibitors from the tick Ornithodoros savignyi (Acari: Argasidae). | Experimental parasitology 20020101 |
Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain. | The Biochemical journal 20011201 |
Fourier-transform infrared spectroscopic study of Ca2+-binding to osteocalcin. | Calcified tissue international 20011201 |
A novel fluorescence assay to study propeptide interaction with gamma-glutamyl carboxylase. | Biochemistry 20011002 |
Matrix gamma-carboxyglutamic acid protein is a key regulator of PTH-mediated inhibition of mineralization in MC3T3-E1 osteoblast-like cells. | Endocrinology 20011001 |
Spin and fluorescent probing of the binding interface between tissue factor and factor VIIa at multiple sites. | Biophysical journal 20011001 |
An anti-EGF monoclonal antibody that detects intramolecular communication in factor IX. | Biochemical and biophysical research communications 20010907 |
Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B. | Blood 20010901 |
Structure-function relationships of the NMDA receptor antagonist conantokin peptides. | Current drug targets 20010901 |
A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels. | The Journal of biological chemistry 20010831 |
A comparative study of the adsorption of amino acids on to calcium minerals found in renal calculi. | Clinical science (London, England : 1979) 20010801 |
Expression and localization of MGP in rat tooth cementum. | Archives of oral biology 20010701 |
The omega-loop region of the human prothrombin gamma-carboxyglutamic acid domain penetrates anionic phospholipid membranes. | The Journal of biological chemistry 20010629 |
Functional preference of the constituent amino acid residues in a phage-library-based nonphosphorylated inhibitor of the Grb2-SH2 domain. | The journal of peptide research : official journal of the American Peptide Society 20010601 |
Induction of acquired factor IX inhibitors in cynomolgus monkey (Macaca fascicularis): a new primate model of hemophilia B. | Thrombosis research 20010515 |
Synthesis of gamma-carboxylated polypeptides by alpha-cells of the pancreatic islets. | Biochemical and biophysical research communications 20010504 |
Amino acid determinants for NMDA receptor inhibition by conantokin-T. | Journal of neurochemistry 20010501 |
Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy. | Obstetrics and gynecology 20010501 |
Total chemical synthesis of human matrix Gla protein. | Protein science : a publication of the Protein Society 20010401 |
On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila. | The Journal of biological chemistry 20010316 |
Sequence requirements for the N-methyl-D-aspartate receptor antagonist activity of conantokin-R. | The Journal of biological chemistry 20010309 |
Posttranslational modifications of recombinant myotube-synthesized human factor IX. | Blood 20010101 |
Novel vitamin K-dependent pathways regulating cell survival. | Apoptosis : an international journal on programmed cell death 20010101 |
1,25-Dihydroxyvitamin D3 promotes vitamin K2 metabolism in human osteoblasts. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20010101 |
Articular cartilage and changes in arthritis: noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage. | Arthritis research 20010101 |
Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. | Neuropharmacology 19980801 |
Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state. | Proceedings of the National Academy of Sciences of the United States of America 19970819 |
Carboxyl-terminal proteolytic processing of matrix Gla protein. | The Journal of biological chemistry 19911105 |
Synthesis of a gamma-carboxyglutamic acid containing heptapeptide corresponding to bovine prothrombin residues 17-23. | International journal of peptide and protein research 19861201 |
Gamma-carboxyglutamate in a neuroactive toxin. | The Journal of biological chemistry 19841210 |
Vitamin K dependent carboxylation: synthesis and biological properties of tetrazolyl analogues of pentapeptidic substrates. | Journal of medicinal chemistry 19840901 |
Vitamin K dependent carboxylation of glutamate residues to gamma-carboxyglutamate in microsomes from spleen and testes: comparison with liver, lung, and kidney. | Biochemistry 19830301 |
Vitamin K-dependent carboxylase: synthesis of an inhibitor of the glutamyl binding site. | FEBS letters 19830207 |
Mechanism of action of vitamin K: synthesis of gamma-carboxyglutamic acid. | CRC critical reviews in biochemistry 19800101 |