Evidence of associations between feto-maternal vitamin D status, cord parathyroid hormone and bone-specific alkaline phosphatase, and newborn whole body bone mineral content.

Nutrients 20120201

Correlation between posttranslational modification and intrinsic disorder in protein.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 20120101

Regulatory mechanisms in bone following mechanical loading.

Gene regulation and systems biology 20120101

Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats.

Nutrition & metabolism 20120101

Antioxidant properties of polysaccharide from the brown seaweed Sargassum graminifolium (Turn.), and its effects on calcium oxalate crystallization.

Marine drugs 20120101

Enhancing osteoconduction of PLLA-based nanocomposite scaffolds for bone regeneration using different biomimetic signals to MSCs.

International journal of molecular sciences 20120101

Vitamin K: the effect on health beyond coagulation - an overview.

Food & nutrition research 20120101

Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.

PloS one 20120101

The end-organ impairment in liver cirrhosis: appointments for critical care.

Critical care research and practice 20120101

Carboxylator: incorporating solvent-accessible surface area for identifying protein carboxylation sites.

Journal of computer-aided molecular design 20111001

Molecular modulation of osteocalcin and its relevance in diabetes (Review).

International journal of molecular medicine 20110901

Ucmaa (Grp-2) is required for zebrafish skeletal development. Evidence for a functional role of its glutamate γ-carboxylation.

Matrix biology : journal of the International Society for Matrix Biology 20110901

Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities.

Growth factors (Chur, Switzerland) 20110801

Osteocalcin is a stress-responsive neuropeptide.

Endocrine regulations 20110401

Association between atherosclerosis and osteoporosis, the role of vitamin D.

Archives of medical science : AMS 20110401

Vitamin K, osteoporosis and degenerative diseases of ageing.

Menopause international 20110301

Extraskeletal osteosarcoma with pulmonary metastasis in a female f344 rat.

Journal of toxicologic pathology 20110301

The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.

The Journal of biological chemistry 20110218

Interaction of prothrombin with a phospholipid surface: evidence for a membrane-induced conformational change.

Molecular and cellular biochemistry 20110201

Ca 2+-induced self-assembly in designed peptides with optimally spaced gamma-carboxyglutamic acid residues.

Journal of inorganic biochemistry 20110101

Approaching biomarkers of membranous nephropathy from a murine model to human disease.

Journal of biomedicine & biotechnology 20110101

Osteogenic predifferentiation of human bone marrow-derived stem cells by short-term mechanical stimulation.

The open orthopaedics journal 20110101

Effect of long-term oral anticoagulant therapy on bone mineral density and bone turnover markers: a prospective 12 month study.

Bratislavske lekarske listy 20110101

STAT6 expression in glioblastoma promotes invasive growth.

BMC cancer 20110101

Protein C mutation (A267T) results in ER retention and unfolded protein response activation.

PloS one 20110101

Expression of recombinant human coagulation factor VII by the Lizard Leishmania expression system.

Journal of biomedicine & biotechnology 20110101

A mutation in the UBIAD1 gene in a Han Chinese family with Schnyder corneal dystrophy.

Molecular vision 20110101

Gene-drug interaction in stroke.

Stroke research and treatment 20110101

Characterization of γ-carboxylated tryptic peptides by collision-induced dissociation and electron transfer dissociation mass spectrometry.

European journal of mass spectrometry (Chichester, England) 20110101

Investigation and identification of protein γ-glutamyl carboxylation sites.

BMC bioinformatics 20110101

Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation.

The Journal of nutritional biochemistry 20101101

Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice.

Calcified tissue international 20101001

Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo.

Arteriosclerosis, thrombosis, and vascular biology 20101001

Vitamin K-dependent gamma-glutamylcarboxylase in Atlantic salmon (Salmo salar L.).

Fish physiology and biochemistry 20100901

Exploring the role of the phospholipid ligand in endothelial protein C receptor: a molecular dynamics study.

Proteins 20100901

Investigating clearance mechanisms for recombinant activated factor VII in a perfused liver model.

Thrombosis and haemostasis 20100801

Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: a fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthritic chondrocytes.

Osteoarthritis and cartilage 20100801

Characterization of conantokin Rl-A: molecular phylogeny as structure/function study.

Journal of peptide science : an official publication of the European Peptide Society 20100801

The effects of enamel matrix derivative on the proliferation and differentiation of human mesenchymal stem cells.

Clinical oral implants research 20100701

Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg (2+)-con-T[K7gamma] complex.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100601

Targeting adenoviruses with factor x-single-chain antibody fusion proteins.

Human gene therapy 20100601

The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b.

The Journal of clinical investigation 20100601

A novel splice site mutation in intron C of PROS1 leads to markedly reduced mutant mRNA level, absence of thrombin-sensitive region, and impaired secretion and cofactor activity of mutant protein S.

Thrombosis research 20100501

Recent estimates of the structure of the factor VIIa (FVIIa)/tissue factor (TF) and factor Xa (FXa) ternary complex.

Thrombosis research 20100401

Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.

Cardiovascular research 20100301

Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures.

Calcified tissue international 20100301

An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase.

The Journal of biological chemistry 20100219

Identification of four alternatively spliced transcripts of the Ucma/GRP gene, encoding a new Gla-containing protein.

Experimental cell research 20100115

Undercarboxylated osteocalcin is a biomarker of carotid calcification in patients with essential hypertension.

Kidney & blood pressure research 20100101

Critical evaluation of gamma-irradiated serum used as feeder in the culture and demonstration of putative nanobacteria and calcifying nanoparticles.

PloS one 20100101

Skeletal site-related variation in human trabecular bone transcriptome and signaling.

PloS one 20100101

Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans.

Disease markers 20100101

Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport.

BMC cell biology 20100101

Carbonic anhydrase I is recognized by an SOD1 antibody upon biotinylation of human spinal cord extracts.

International journal of molecular sciences 20100101

VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey.

PloS one 20100101

GAS6 enhances repair following cuprizone-induced demyelination.

PloS one 20100101

Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms.

American journal of physiology. Cell physiology 20091201

Use of a bacterially expressed human factor IX light chain to develop polyclonal antibody anti-hFIX.

Applied biochemistry and biotechnology 20091101

Vitamin K in parenteral nutrition.

Gastroenterology 20091101

Metal-binding affinity and selectivity of nonstandard natural amino acid residues from DFT/CDM calculations.

The journal of physical chemistry. B 20090827

Direct analysis reveals an absence of gamma-carboxyglutamic acid in cancer procoagulant from human tissues.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20090701

Phylogenetic analysis of ALAD and MGP genes related to lead toxicity.

Toxicology and industrial health 20090701

Membrane-dependent interaction of factor Xa and prothrombin with factor Va in the prothrombinase complex.

Biochemistry 20090609

From the Gla domain to a novel small-molecule detector of apoptosis.

Cell research 20090501

Non-strict strand orientation of the Ca2+-induced dimerization of a conantokin peptide variant with sequence-shifted gamma-carboxyglutamate residues.

Peptides 20090501

The mineral phase of calcified cartilage: its molecular structure and interface with the organic matrix.

Biophysical journal 20090422

Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K-dependent and warfarin-sensitive secretion.

Blood 20090416

Structural characterization of five post-translationally modified isomorphs of a novel putative delta-conotoxin from the vermivorous snail Conus delessertii from the Mexican Caribbean Sea.

Peptides 20090301

Polymorphisms in MGP gene and their association with lead toxicity.

Toxicology mechanisms and methods 20090301

Platelet factor 4 impairs the anticoagulant activity of activated protein C.

The Journal of biological chemistry 20090227

Vitamin K, an update for the paediatrician.

European journal of pediatrics 20090201

Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients.

Thrombosis and haemostasis 20090201

Regulation of pituitary gene expression by adrenalectomy.

Obesity (Silver Spring, Md.) 20090101

Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay.

Molecular vision 20090101

BMP-13 emerges as a potential inhibitor of bone formation.

International journal of biological sciences 20090101

Characterization of porcine factor VII, X and comparison with human factor VII, X.

Blood cells, molecules & diseases 20090101

Characterization of granulations of calcium and apatite in serum as pleomorphic mineralo-protein complexes and as precursors of putative nanobacteria.

PloS one 20090101

Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis.

Vascular health and risk management 20090101

Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain.

Therapeutics and clinical risk management 20090101

Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma.

BMC cancer 20090101

Parallel changes in gene expression in peripheral blood mononuclear cells and the brain after maternal separation in the mouse.

BMC research notes 20090101

Microstructure and mineral composition of dystrophic calcification associated with the idiopathic inflammatory myopathies.

Arthritis research & therapy 20090101

Endothelial cells influence the osteogenic potential of bone marrow stromal cells.

Biomedical engineering online 20090101

Fetuin-A/albumin-mineral complexes resembling serum calcium granules and putative nanobacteria: demonstration of a dual inhibition-seeding concept.

PloS one 20090101

Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates.

The Journal of biological chemistry 20081226

The PT1-Ca2+ Gla domain binds to a membrane through two dipalmitoylphosphatidylserines. A computational study.

Biochemistry 20081216

Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine.

Biochemical and biophysical research communications 20081107

Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.

PLoS medicine 20081001

Noninvasive markers of oxidative DNA stress, RNA degradation and protein degradation are differentially correlated with resting metabolic rate and energy intake in children and adolescents.

Pediatric research 20080901

Conantokin-P, an unusual conantokin with a long disulfide loop.

Toxicon : official journal of the International Society on Toxinology 20080801

Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z.

The Journal of biological chemistry 20080718

Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins.

Toxicon : official journal of the International Society on Toxinology 20080701

Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells.

The Journal of biological chemistry 20080627

Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification.

Circulation research 20080509

Proline and gamma-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4.

Circulation research 20080509

Vitamin K intake and atherosclerosis.

Current opinion in lipidology 20080201

Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks.

Peptides 20080201

Vascular calcification and uremia: what do we know?

American journal of nephrology 20080101

Molecular characterization of spontaneous mesenchymal stem cell transformation.

PloS one 20080101

Detection of a gamma-carboxy-glutamate as novel post-translational modification of human transthyretin.

Protein and peptide letters 20080101

Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification.

Thrombosis research 20080101

gamma-Glutamate and beta-hydroxyaspartate in proteins.

Methods in molecular biology (Clifton, N.J.) 20080101

The vitamin K cycle.

Vitamins and hormones 20080101

Vitamin K-dependent gamma-glutamylcarboxylation: an ancient posttranslational modification.

Vitamins and hormones 20080101

Vitamin K and bone health in adult humans.

Vitamins and hormones 20080101

The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification.

Journal of vascular research 20080101

Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women.

Journal of bone and mineral metabolism 20080101

Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53.

Proteome science 20080101

Production of metal ion-dependent monoclonal antibodies against peptides in bovine prothrombin fragment 1.

Human antibodies 20080101

Characterization of 11p14-p12 deletion in WAGR syndrome by array CGH for identifying genes contributing to mental retardation and autism.

Cytogenetic and genome research 20080101

Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors.

The Journal of biological chemistry 20071221

The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells.

Blood 20071201

Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification.

Journal of thrombosis and haemostasis : JTH 20071201

Effect of carboxyl-group of D-glutamic acid or gamma-carboxy-D-glutamic acid as N-terminal amino acid of (111)in-diethylenetriaminepentaacetic acid-octreotide on accumulation of radioactivity in kidney.

Biological & pharmaceutical bulletin 20071101

[Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function].

Clinical calcium 20071101

Regulation of matrix Gla protein by parathyroid hormone in MC3T3-E1 osteoblast-like cells involves protein kinase A and extracellular signal-regulated kinase pathways.

Journal of cellular biochemistry 20071001

Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients.

Laboratory investigation; a journal of technical methods and pathology 20071001

[Gas-6 and protein S: vitamin K-dependent factors and ligands for the TAM tyrosine kinase receptors family].

Medecine sciences : M/S 20071001

Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity.

Journal of thrombosis and haemostasis : JTH 20070901

Quantum chemical study of the mechanism of action of vitamin K carboxylase (VKC). IV. Intermediates and transition states.

The journal of physical chemistry. A 20070809

Snake-venom-derived Factor IX-binding protein specifically blocks the gamma-carboxyglutamic acid-rich-domain-mediated membrane binding of human Factors IX and X.

The Biochemical journal 20070715

Vitamin K: the coagulation vitamin that became omnipotent.

Thrombosis and haemostasis 20070701

Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

Blood 20070615

A vasopressin/oxytocin-related conopeptide with gamma-carboxyglutamate at position 8.

The Biochemical journal 20070615

Enhancement effects of vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) on intestinal alkaline phosphatase activity in rats.

Journal of nutritional science and vitaminology 20070601

Substitution of the Gla domain in factor X with that of protein C impairs its interaction with factor VIIa/tissue factor: lack of comparable effect by similar substitution in factor IX.

The Journal of biological chemistry 20070525

Association free energy of dipalmitoylphosphatidylserines in a mixed dipalmitoylphosphatidylcholine membrane.

Biophysical journal 20070501

Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives.

The Journal of biological chemistry 20070427

Hydroxyapatite surface-induced peptide folding.

Journal of the American Chemical Society 20070425

Preferential localization of recombinant factor VIIa to platelets activated with a combination of thrombin and a glycoprotein VI receptor agonist.

Journal of thrombosis and haemostasis : JTH 20070401

Association of warfarin dose with genes involved in its action and metabolism.

Human genetics 20070301

[Advances in study of structures and functions of conantokins].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070301

The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif.

Journal of the American Chemical Society 20070214

Warfarin-induced vasculopathy.

Journal of thrombosis and thrombolysis 20070201

Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women.

The British journal of nutrition 20070201

Full-length cDNA cloning and protein three-dimensional structure modeling of porcine prothrombin.

Blood cells, molecules & diseases 20070101

A distinct epigenetic signature at targets of a leukemia protein.

BMC genomics 20070101

The vascular biology of calcification.

Seminars in dialysis 20070101

Simultaneous generation of aptamers to multiple gamma-carboxyglutamic acid proteins from a focused aptamer library using DeSELEX and convergent selection.

Oligonucleotides 20070101

Growth arrest-specific protein 6 (GAS6) and the protein C pathway.

Critical care (London, England) 20070101

Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate.

BMC cancer 20070101

Role of vitamin K on biochemical markers, bone mineral density, and fracture risk.

Journal of endocrinological investigation 20070101

Single nucleotide polymorphisms in bone turnover-related genes in Koreans: ethnic differences in linkage disequilibrium and haplotype.

BMC medical genetics 20070101

BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.

Molecular cancer 20070101

The immune response is involved in atherosclerotic plaque calcification: could the RANKL/RANK/OPG system be a marker of plaque instability?

Clinical & developmental immunology 20070101

From gamma-carboxy-glutamate to protein C.

Journal of thrombosis and haemostasis : JTH 20061201

Molecular dynamics calculations of wild type vs. mutant protein C: relationship between binding affinity to endothelial cell protein C receptor and hereditary disease.

Journal of biomolecular structure & dynamics 20061201

Vascular calcification: pathobiological mechanisms and clinical implications.

Circulation research 20061110

Expression of osteonectin and matrix Gla protein in scleroderma patients with and without calcinosis.

Rheumatology (Oxford, England) 20061101

A single gamma-carboxyglutamic acid residue in a novel cysteine-rich secretory protein without propeptide.

Biochemistry 20061024

Design and concise synthesis of fully protected analogues of l-gamma-carboxyglutamic acid.

The Journal of organic chemistry 20060915

[Protective effects of vitamin K against osteoporosis and its pleiotropic actions].

Clinical calcium 20060901

High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.

The Journal of biological chemistry 20060825

The first gamma-carboxyglutamate-containing neuropeptide.

Neurochemistry international 20060801

Isoelectric points and post-translational modifications of connexin26 and connexin32.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060601

Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile.

The FEBS journal 20060601

Screening for post-translational modifications in conotoxins using liquid chromatography/mass spectrometry: an important component of conotoxin discovery.

Toxicon : official journal of the International Society on Toxinology 20060501

Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat.

Bioscience, biotechnology, and biochemistry 20060401

Comprehensive analysis of the renal transcriptional response to acute uranyl nitrate exposure.

BMC genomics 20060101

Decreased inhibitory activity of prothrombin to calcium oxalate crystallization by specific chemical modification of its gamma-carboxyglutamic acid residues.

Urology 20060101

Osteocalcin and bone-specific alkaline phosphatase in sickle cell haemoglobinopathies.

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria 20060101

Sequential coagulation factor VIIa domain binding to tissue factor.

Biochemical and biophysical research communications 20051202

The role of gamma-carboxylation in the anti-apoptotic function of gas6.

Journal of thrombosis and haemostasis : JTH 20051201

Protein C Sapporo (protein C Glu 25 --> Lys): a heterozygous missense mutation in the Gla domain provides new insight into the interaction between protein C and endothelial protein C receptor.

Thrombosis and haemostasis 20051101

Identification of genes differentially expressed in wild type and Purkinje cell degeneration mice.

Molecules and cells 20051031

Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties.

Biochemistry 20050920

Dexamethasone and basic-fibroblast growth factor regulate markers of mineralization in cementoblasts in vitro.

Journal of periodontology 20050901

Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification.

Arteriosclerosis, thrombosis, and vascular biology 20050801

Vitamin K in the treatment and prevention of osteoporosis and arterial calcification.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050801

Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates.

The Journal of biological chemistry 20050722

Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation.

Biochemistry 20050628

Anabolic actions of PTH (1-34): use of a novel tissue engineering model to investigate temporal effects on bone.

Bone 20050601

Matrix gamma-carboxyglutamic acid protein (MGP) G-7A and T-138C gene polymorphisms in Indian (Mayo and Teenek) and Mestizo populations from Mexico.

Human biology 20050601

[Molecular mechanisms of vitamin K action in the bone homeostasis].

Clinical calcium 20050501

Engineering of a recombinant vitamin K-dependent gamma-carboxylation system with enhanced gamma-carboxyglutamic acid forming capacity: evidence for a functional CXXC redox center in the system.

The Journal of biological chemistry 20050318

Rapid fabrication of keratin-hydroxyapatite hybrid sponges toward osteoblast cultivation and differentiation.

Biomaterials 20050101

The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.

Blood 20050101

Effects of urinary prothrombin fragment 1 in the formation of calcium oxalate calculus.

The Journal of urology 20050101

Putative gamma-conotoxins in vermivorous cone snails: the case of Conus delessertii.

Peptides 20050101

Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate.

Cardiovascular diabetology 20050101

Osteo-Promoter Database (OPD) -- promoter analysis in skeletal cells.

BMC genomics 20050101

Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension.

Respiratory research 20050101

Structure-function relationships of C-type lectin-related proteins.

Pathophysiology of haemostasis and thrombosis 20050101

Chemical modification of cysteine residues is a misleading indicator of their status as active site residues in the vitamin K-dependent gamma-glutamyl carboxylation reaction.

The Journal of biological chemistry 20041224

Conantokins: peptide antagonists of NMDA receptors.

Current medicinal chemistry 20041201

Total chemical synthesis and NMR characterization of the glycopeptide tx5a, a heavily post-translationally modified conotoxin, reveals that the glycan structure is alpha-D-Gal-(1-->3)-alpha-D-GalNAc.

European journal of biochemistry 20041201

Oral anticoagulant treatment: friend or foe in cardiovascular disease?

Blood 20041115

Identification of residues Asn89, Ile90, and Val107 of the factor IXa second epidermal growth factor domain that are essential for the assembly of the factor X-activating complex on activated platelets.

The Journal of biological chemistry 20041105

A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide.

Biochemistry 20041019

Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin.

The Journal of biological chemistry 20041008

[Serum osteoprotegrin and serum bone gamma-carboxyglutamine acid-containing protein are correlated with bone mineral density in normal women].

Zhonghua yi xue za zhi 20041002

Multiple 6-bromotryptophan residues in a sleep-inducing peptide.

Biochemistry 20040928

The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus.

The Journal of biological chemistry 20040730

The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M.

The Journal of biological chemistry 20040730

Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern.

Biochemical and biophysical research communications 20040709

Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts.

Biochemical and biophysical research communications 20040702

Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin.

Journal of thrombosis and haemostasis : JTH 20040701

Matrix GLA protein modulates branching morphogenesis in fetal rat lung.

American journal of physiology. Lung cellular and molecular physiology 20040601

Platelet factor 4 modulation of the thrombomodulin-protein C system.

Critical care medicine 20040501

Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry.

Journal of mass spectrometry : JMS 20040501

Kinetics of factor Xa inhibition by recombinant tick anticoagulant peptide: both active site and exosite interactions are required for a slow- and tight-binding inhibition mechanism.

Biochemistry 20040330

Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels.

Bone 20040301

Binding of the factor IX gamma-carboxyglutamic acid domain to the vitamin K-dependent gamma-glutamyl carboxylase active site induces an allosteric effect that may ensure processive carboxylation and regulate the release of carboxylated product.

The Journal of biological chemistry 20040220

A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues.

Journal of molecular biology 20040220

[Effect of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis].

Zhonghua yi xue za zhi 20040217

Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study.

Thrombosis and haemostasis 20040201

Use of snake venom inhibitors in studies of the function and tertiary structure of coagulation factors.

International journal of hematology 20040201

Effects of vitamin K2 on osteoporosis.

Current pharmaceutical design 20040101

The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis.

Proteins 20031115

Determination of disulfide bond assignment of human vitamin K-dependent gamma-glutamyl carboxylase by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

The Journal of biological chemistry 20031114

[Study on association of polymorphism of MGP(T-138C) gene and blood lead level in children].

Wei sheng yan jiu = Journal of hygiene research 20031101

Vitamin K and bone health.

The Proceedings of the Nutrition Society 20031101

Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.

Biochemical and biophysical research communications 20031017

Glucocorticoid effects on vitamin K-dependent carboxylase activity and matrix Gla protein expression in rat lung.

American journal of physiology. Lung cellular and molecular physiology 20030901

Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.

Nature structural biology 20030901

The Gla domain of factor IXa binds to factor VIIIa in the tenase complex.

The Journal of biological chemistry 20030815

The extended interactions and Gla domain of blood coagulation factor Xa.

Biochemistry 20030708

Intracrystalline proteins and urolithiasis: a synchrotron X-ray diffraction study of calcium oxalate monohydrate.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030701

Crystal structure of Mg2+- and Ca2+-bound Gla domain of factor IX complexed with binding protein.

The Journal of biological chemistry 20030627

Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein.

British journal of cancer 20030616

Direct binding properties of conantokins to native N-methyl-d-aspartate receptors.

The journal of peptide research : official journal of the American Peptide Society 20030601

Site-directed fluorescence probing to dissect the calcium-dependent association between soluble tissue factor and factor VIIa domains.

Biochimica et biophysica acta 20030530

Role of the Gla and first epidermal growth factor-like domains of factor X in the prothrombinase and tissue factor-factor VIIa complexes.

The Journal of biological chemistry 20030321

Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding.

Blood 20030315

The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa.

The Journal of biological chemistry 20030307

Mutagenesis of the gamma-carboxyglutamic acid domain of human factor VII to generate maximum enhancement of the membrane contact site.

The Journal of biological chemistry 20030307

Deletion or replacement of the second EGF-like domain of protein S results in loss of APC cofactor activity.

Blood 20030215

Cloning and expression of rat coagulation factor VII.

Thrombosis research 20030215

Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence.

The Journal of biological chemistry 20030131

Identification of a gene encoding a typical gamma-carboxyglutamic acid domain in the tunicate Halocynthia roretzi.

Journal of thrombosis and haemostasis : JTH 20030101

Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile.

European journal of biochemistry 20021201

Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif.

The Journal of biological chemistry 20021108

Chronic disseminated intravascular coagulation and childhood-onset skin necrosis resulting from homozygosity for a protein C Gla domain mutation, Arg15Trp.

Journal of pediatric hematology/oncology 20021101

Gas6 binding to photoreceptor outer segments requires gamma-carboxyglutamic acid (Gla) and Ca(2+) and is required for OS phagocytosis by RPE cells in vitro.

Experimental eye research 20021001

Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells.

Journal of immunology (Baltimore, Md. : 1950) 20020901

High-performance liquid chromatography--mass spectrometry and electron-capture dissociation tandem mass spectrometry of osteocalcin. Determination of gamma-carboxyglutamic acid residues.

Journal of chromatography. A 20020712

Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo.

Blood 20020701

Growth characteristics, angiotensin II generation, and microarray-determined gene expression in vascular smooth muscle cells from young spontaneously hypertensive rats.

Journal of hypertension 20020701

Characteristics and composition of the vitamin K-dependent gamma-glutamyl carboxylase-binding domain on osteocalcin.

The Biochemical journal 20020515

gamma-Carboxyglutamic acid content of hepatocellular carcinoma-associated des-gamma-carboxy prothrombin.

Biochimica et biophysica acta 20020424

Detection of vitamin K-dependent proteins in venoms with a monoclonal antibody specific for gamma-carboxyglutamic acid.

Toxicon : official journal of the International Society on Toxinology 20020401

Effect of prothrombin and its activation fragments on calcium oxalate crystal growth and aggregation in undiluted human urine in vitro: relationship between protein structure and inhibitory activity.

Clinical science (London, England : 1979) 20020401

Structure and dynamics of zymogen human blood coagulation factor X.

Biophysical journal 20020301

A human antibody that inhibits factor IX/IXa function potently inhibits arterial thrombosis without increasing bleeding.

Arteriosclerosis, thrombosis, and vascular biology 20020301

Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated rats.

The Journal of biological chemistry 20020208

Localization of phosphatidylserine binding sites to structural domains of factor Xa.

The Journal of biological chemistry 20020118

Ca2+ binding to proteins containing gamma-carboxyglutamic acid residues.

Methods in molecular biology (Clifton, N.J.) 20020101

Effects of skeletal loading on bone mass and compensation mechanism in bone: a new insight into the 'mechanostat' theory.

Journal of bone and mineral metabolism 20020101

Identification of extrinsic blood coagulation pathway inhibitors from the tick Ornithodoros savignyi (Acari: Argasidae).

Experimental parasitology 20020101

Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain.

The Biochemical journal 20011201

Fourier-transform infrared spectroscopic study of Ca2+-binding to osteocalcin.

Calcified tissue international 20011201

A novel fluorescence assay to study propeptide interaction with gamma-glutamyl carboxylase.

Biochemistry 20011002

Matrix gamma-carboxyglutamic acid protein is a key regulator of PTH-mediated inhibition of mineralization in MC3T3-E1 osteoblast-like cells.

Endocrinology 20011001

Spin and fluorescent probing of the binding interface between tissue factor and factor VIIa at multiple sites.

Biophysical journal 20011001

An anti-EGF monoclonal antibody that detects intramolecular communication in factor IX.

Biochemical and biophysical research communications 20010907

Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B.

Blood 20010901

Structure-function relationships of the NMDA receptor antagonist conantokin peptides.

Current drug targets 20010901

A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels.

The Journal of biological chemistry 20010831

A comparative study of the adsorption of amino acids on to calcium minerals found in renal calculi.

Clinical science (London, England : 1979) 20010801

Expression and localization of MGP in rat tooth cementum.

Archives of oral biology 20010701

The omega-loop region of the human prothrombin gamma-carboxyglutamic acid domain penetrates anionic phospholipid membranes.

The Journal of biological chemistry 20010629

Functional preference of the constituent amino acid residues in a phage-library-based nonphosphorylated inhibitor of the Grb2-SH2 domain.

The journal of peptide research : official journal of the American Peptide Society 20010601

Induction of acquired factor IX inhibitors in cynomolgus monkey (Macaca fascicularis): a new primate model of hemophilia B.

Thrombosis research 20010515

Synthesis of gamma-carboxylated polypeptides by alpha-cells of the pancreatic islets.

Biochemical and biophysical research communications 20010504

Amino acid determinants for NMDA receptor inhibition by conantokin-T.

Journal of neurochemistry 20010501

Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy.

Obstetrics and gynecology 20010501

Total chemical synthesis of human matrix Gla protein.

Protein science : a publication of the Protein Society 20010401

On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila.

The Journal of biological chemistry 20010316

Sequence requirements for the N-methyl-D-aspartate receptor antagonist activity of conantokin-R.

The Journal of biological chemistry 20010309

Posttranslational modifications of recombinant myotube-synthesized human factor IX.

Blood 20010101

Novel vitamin K-dependent pathways regulating cell survival.

Apoptosis : an international journal on programmed cell death 20010101

1,25-Dihydroxyvitamin D3 promotes vitamin K2 metabolism in human osteoblasts.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20010101

Articular cartilage and changes in arthritis: noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage.

Arthritis research 20010101

Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.

Neuropharmacology 19980801

Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state.

Proceedings of the National Academy of Sciences of the United States of America 19970819

Carboxyl-terminal proteolytic processing of matrix Gla protein.

The Journal of biological chemistry 19911105

Synthesis of a gamma-carboxyglutamic acid containing heptapeptide corresponding to bovine prothrombin residues 17-23.

International journal of peptide and protein research 19861201

Gamma-carboxyglutamate in a neuroactive toxin.

The Journal of biological chemistry 19841210

Vitamin K dependent carboxylation: synthesis and biological properties of tetrazolyl analogues of pentapeptidic substrates.

Journal of medicinal chemistry 19840901

Vitamin K dependent carboxylation of glutamate residues to gamma-carboxyglutamate in microsomes from spleen and testes: comparison with liver, lung, and kidney.

Biochemistry 19830301

Vitamin K-dependent carboxylase: synthesis of an inhibitor of the glutamyl binding site.

FEBS letters 19830207

Mechanism of action of vitamin K: synthesis of gamma-carboxyglutamic acid.

CRC critical reviews in biochemistry 19800101