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R1487

CAS No.:
449808-64-4
Catalog Number:
AG00DBB6
Molecular Formula:
C19H19ClF2N4O3
Molecular Weight:
424.8290
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$223
- +
10mg
98%
1 week
United States
$307
- +
25mg
98%
1 week
United States
$540
- +
50mg
98%
1 week
United States
$873
- +
100mg
98%
1 week
United States
$1373
- +
Product Description
Catalog Number:
AG00DBB6
Chemical Name:
R1487
CAS Number:
449808-64-4
Molecular Formula:
C19H19ClF2N4O3
Molecular Weight:
424.8290
MDL Number:
MFCD18711690
IUPAC Name:
6-(2,4-difluorophenoxy)-8-methyl-2-(oxan-4-ylamino)pyrido[2,3-d]pyrimidin-7-one;hydrochloride
InChI:
InChI=1S/C19H18F2N4O3.ClH/c1-25-17-11(10-22-19(24-17)23-13-4-6-27-7-5-13)8-16(18(25)26)28-15-3-2-12(20)9-14(15)21;/h2-3,8-10,13H,4-7H2,1H3,(H,22,23,24);1H
InChI Key:
RQHSAIGGUWVOBG-UHFFFAOYSA-N
SMILES:
Fc1ccc(c(c1)F)Oc1cc2cnc(nc2n(c1=O)C)NC1CCOCC1.Cl
Properties
Complexity:
602  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
424.111g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
424.833g/mol
Monoisotopic Mass:
424.111g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
76.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. Journal of medicinal chemistry 20110414
Some aspects of the reproductive endocrinology of the stallion and cryptorchid. Journal of reproduction and fertility. Supplement 19751001
Properties